JP2016522261A5 - - Google Patents

Info

Publication number

JP2016522261A5

JP2016522261A5 JP2016521553A JP2016521553A JP2016522261A5 JP 2016522261 A5 JP2016522261 A5 JP 2016522261A5 JP 2016521553 A JP2016521553 A JP 2016521553A JP 2016521553 A JP2016521553 A JP 2016521553A JP 2016522261 A5 JP2016522261 A5 JP 2016522261A5

Authority

JP

Japan

Prior art keywords

agent

therapeutic

patient

kit

solid support

Prior art date

2014-06-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000011230 binding agent Substances 0.000 claims 16
• 239000003814 drug Substances 0.000 claims 15
• 229940124597 therapeutic agent Drugs 0.000 claims 15
• 239000007787 solid Substances 0.000 claims 9
• 239000000032 diagnostic agent Substances 0.000 claims 7
• 229940039227 diagnostic agent Drugs 0.000 claims 7
• 239000000203 mixture Substances 0.000 claims 7
• 210000000056 organ Anatomy 0.000 claims 7
• 210000001519 tissue Anatomy 0.000 claims 7
• 230000001225 therapeutic effect Effects 0.000 claims 6
• HTJMXYRLEDBSLT-UHFFFAOYSA-N 1,2,4,5-tetrazine Chemical group C1=NN=CN=N1 HTJMXYRLEDBSLT-UHFFFAOYSA-N 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• URYYVOIYTNXXBN-UPHRSURJSA-N cyclooctene Chemical compound C1CCC\C=C/CC1 URYYVOIYTNXXBN-UPHRSURJSA-N 0.000 claims 3
• 239000004913 cyclooctene Substances 0.000 claims 3
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
• 229940072056 alginate Drugs 0.000 claims 2
• 235000010443 alginic acid Nutrition 0.000 claims 2
• 229920000615 alginic acid Polymers 0.000 claims 2
• 239000000017 hydrogel Substances 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• URYYVOIYTNXXBN-OWOJBTEDSA-N trans-cyclooctene Chemical group C1CCC\C=C\CC1 URYYVOIYTNXXBN-OWOJBTEDSA-N 0.000 claims 2
• 206010031252 Osteomyelitis Diseases 0.000 claims 1
• DPOPAJRDYZGTIR-UHFFFAOYSA-N Tetrazine Chemical compound C1=CN=NN=N1 DPOPAJRDYZGTIR-UHFFFAOYSA-N 0.000 claims 1
• 108010059993 Vancomycin Proteins 0.000 claims 1
• 150000001345 alkine derivatives Chemical class 0.000 claims 1
• 150000001540 azides Chemical class 0.000 claims 1
• 210000000988 bone and bone Anatomy 0.000 claims 1
• MYPYJXKWCTUITO-KIIOPKALSA-N chembl3301825 Chemical group O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)C(O)[C@H](C)O1 MYPYJXKWCTUITO-KIIOPKALSA-N 0.000 claims 1
• 230000008878 coupling Effects 0.000 claims 1
• 238000010168 coupling process Methods 0.000 claims 1
• 238000005859 coupling reaction Methods 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 1
• 229960003165 vancomycin Drugs 0.000 claims 1
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1