EA200600484A1 - Доставка физиологических агентов in situ при помощи гелей, включающих анионные полисахариды - Google Patents
Доставка физиологических агентов in situ при помощи гелей, включающих анионные полисахаридыInfo
- Publication number
- EA200600484A1 EA200600484A1 EA200600484A EA200600484A EA200600484A1 EA 200600484 A1 EA200600484 A1 EA 200600484A1 EA 200600484 A EA200600484 A EA 200600484A EA 200600484 A EA200600484 A EA 200600484A EA 200600484 A1 EA200600484 A1 EA 200600484A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- situ
- delivery
- polysaccharides
- anional
- gels
- Prior art date
Links
- 239000003795 chemical substances by application Substances 0.000 title 1
- 150000004676 glycans Chemical class 0.000 title 1
- 229920001282 polysaccharide Polymers 0.000 title 1
- 239000005017 polysaccharide Substances 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 238000011065 in-situ storage Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 210000001519 tissue Anatomy 0.000 abstract 2
- 229920001586 anionic polysaccharide Polymers 0.000 abstract 1
- 150000004836 anionic polysaccharides Chemical class 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000001124 body fluid Anatomy 0.000 abstract 1
- 239000010839 body fluid Substances 0.000 abstract 1
- 239000003349 gelling agent Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Настоящее изобретение относится к гелеобразующим композициям для доставки фармакологически активных веществ in situ в ткани, жидкости организма и слизистые оболочки животных в форме жидкостей, твердых веществ и порошков, которые содержат анионные полисахариды и, в частности, низшие метоксипектины в качестве гелеобразующих агентов, к способам получения и способам применения гелеобразующих композиций для доставки и пролонгированного высвобождения физиологически активного агента in situ и, в частности, вакцинных антигенов, в ткани и слизистые оболочки животного.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/652,622 US7494669B2 (en) | 2001-02-28 | 2003-08-29 | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
PCT/US2004/016146 WO2005023176A2 (en) | 2003-08-29 | 2004-05-24 | Delivery of physiologixal agents with in-situ gels comprising anionic polysaccharides |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200600484A1 true EA200600484A1 (ru) | 2006-10-27 |
EA010351B1 EA010351B1 (ru) | 2008-08-29 |
Family
ID=34273408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200600484A EA010351B1 (ru) | 2003-08-29 | 2004-05-24 | Доставка физиологических агентов in situ при помощи гелей, включающих анионные полисахариды |
Country Status (9)
Country | Link |
---|---|
US (1) | US7494669B2 (ru) |
EP (1) | EP1663111A4 (ru) |
JP (1) | JP4765020B2 (ru) |
KR (1) | KR20060127841A (ru) |
CN (1) | CN1874679A (ru) |
AU (1) | AU2004270101A1 (ru) |
CA (1) | CA2537290C (ru) |
EA (1) | EA010351B1 (ru) |
WO (1) | WO2005023176A2 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7705135B2 (en) | 1998-05-13 | 2010-04-27 | Nanotherapeutics, Inc. | Pharmaceutical compositions comprising aloe pectins, and methods for their production and use |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050113730A1 (en) * | 2003-11-24 | 2005-05-26 | Sca Hygiene Products Ab | Absorbent Article Containing A Skin Care Product |
PE20060468A1 (es) * | 2004-04-26 | 2006-07-06 | Cp Kelco Aps | Composicion dermoprotectora para controlar la alcalinidad de la piel que comprende polisacaridos de acido carboxilico |
US20060106117A1 (en) * | 2004-11-12 | 2006-05-18 | Kimberly-Clark Worldwide, Inc. | Compound and method for prevention and/or treatment of vaginal infections |
US20060223765A1 (en) * | 2005-03-30 | 2006-10-05 | Kimberly-Clark Worldwide, Inc. | Method for inhibiting and/or treating vaginal infection |
US7786176B2 (en) | 2005-07-29 | 2010-08-31 | Kimberly-Clark Worldwide, Inc. | Vaginal treatment composition containing xylitol |
KR20080081175A (ko) * | 2005-12-19 | 2008-09-08 | 코멘티스, 인코포레이티드 | 안구 투여를 위한 국소 메카밀라민 제형 및 그것의 사용 |
JP2010521215A (ja) * | 2007-03-13 | 2010-06-24 | バイオラインアールエックス リミテッド | 組織の修復を促進する方法 |
CN103083642B (zh) * | 2007-05-11 | 2015-11-18 | 芦荟研究实验室公司 | 用于皮肤增强的芦荟制剂 |
ES2625866T3 (es) | 2007-11-27 | 2017-07-20 | Algipharma As | Uso de oligómeros de alginatos para combatir las biopelículas |
JP2009209086A (ja) * | 2008-03-04 | 2009-09-17 | Masami Moriyama | 粘膜投与型ワクチン |
US7833829B2 (en) * | 2008-10-28 | 2010-11-16 | Honeywell International Inc. | MEMS devices and methods of assembling micro electromechanical systems (MEMS) |
GB2483203B (en) | 2009-06-03 | 2013-06-19 | Algipharma As | Treatment of acinetobacter with alginate oligomers and antibiotics |
GB0909529D0 (en) | 2009-06-03 | 2009-07-15 | Algipharma Ipr As | Alginate oligomers for the inhibition of microbial adherence to surfaces |
GB0909557D0 (en) | 2009-06-03 | 2009-07-15 | Algipharma Ipr As | Anti-microbial alginate oligomers |
JP2011057605A (ja) * | 2009-09-09 | 2011-03-24 | Masami Moriyama | 粘膜投与型ワクチン |
CN101703490B (zh) * | 2009-11-13 | 2013-08-07 | 杭州师范大学 | 聚多糖/无机纳米粒子杂化微纳米载药胶囊 |
US8852645B2 (en) | 2009-11-19 | 2014-10-07 | The Board Of Trustees Of The University Of Illinois | Self-assembled toroidal-spiral particles and manufacture and uses thereof |
WO2011079260A2 (en) * | 2009-12-23 | 2011-06-30 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Stabilized virus like particles having enhanced mucosal immunogenicity |
JP5996837B2 (ja) * | 2010-05-28 | 2016-09-21 | 小林製薬株式会社 | インフルエンザウイルスの感染抑制剤 |
FR2960775A1 (fr) * | 2010-06-07 | 2011-12-09 | Ethypharm Sa | Microgranules resistants au detournement |
ITVR20100140A1 (it) * | 2010-07-13 | 2012-01-14 | Eurocoating S P A | Materiale composito formato da pectina e da calcio fosfato e metodo per la sua realizzazione |
CN103209684A (zh) | 2010-09-13 | 2013-07-17 | 贝夫-厄克斯股份有限公司 | 包含异味掩蔽剂的含水药物递送系统 |
CN103648587B (zh) * | 2011-04-18 | 2021-09-17 | 乔治亚大学研究基金公司 | 疫苗递送方法 |
GB2490516A (en) * | 2011-05-03 | 2012-11-07 | Systagenix Wound Man Ip Co Bv | Polysaccharide mould for wound treatment |
GB201116010D0 (en) | 2011-09-15 | 2011-10-26 | Algipharma As | Use of alginate oligomers to enhance the effects of antifungal agents |
WO2013076305A1 (en) | 2011-11-25 | 2013-05-30 | Danmarks Tekniske Universitet | Formulation of solid nano-sized particles in a gel-forming system |
CN102429862B (zh) * | 2011-11-29 | 2013-05-01 | 江苏德达医药科技有限公司 | 一种聚维酮碘眼用缓释滴眼液 |
GB201322777D0 (en) | 2013-12-20 | 2014-02-05 | Algipharma As | Use of alginate oligomers as blood anticoagulants |
PT3212204T (pt) | 2014-10-28 | 2019-08-07 | Biovotec As | Partículas de membrana de ovos micronizados e uso dado para promover a cura de feridas |
US20160158174A1 (en) * | 2014-12-09 | 2016-06-09 | Intercontinental Great Brands Llc | Enteric-Coated Functional Food Ingredients And Methods For Making The Enteric-Coated Functional Food Ingredients |
EP3034070A1 (en) * | 2014-12-18 | 2016-06-22 | Omya International AG | Method for the production of a pharmaceutical delivery system |
KR102562736B1 (ko) * | 2015-01-30 | 2023-08-03 | 닛산 가가쿠 가부시키가이샤 | 혈관 평활근 세포의 배양 방법 |
KR101777910B1 (ko) * | 2015-04-30 | 2017-09-13 | 주식회사 제네웰 | 만성창상 치료용 조성물, 이의 제조방법 및 이를 이용한 만성창상 치료용 드레싱재 |
US11045578B2 (en) | 2015-06-24 | 2021-06-29 | Biovotec As | Tissue engineering scaffolds comprising particulate egg shell membrane |
MX2018002419A (es) | 2015-08-28 | 2018-11-29 | Ology Bioservices Inc | Vacuna de norovirus. |
GB201517639D0 (en) | 2015-10-06 | 2015-11-18 | Algipharma As | Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract |
GB201519923D0 (en) | 2015-11-11 | 2015-12-23 | Biovotec Dac And Biovotec As | Dry biocompatible disintegrateable films for delivering particulate egg shell membrane to a wound |
WO2017151651A1 (en) * | 2016-02-29 | 2017-09-08 | Belmont University | Pharmaceutical in situ gelling compositions |
GB201618291D0 (en) | 2016-10-28 | 2016-12-14 | Bergen Teknologioverf�Ring As | Novel immunotherapeutic treatments for tumours |
US10912858B2 (en) * | 2017-05-01 | 2021-02-09 | The Brigham And Women's Hospital, Inc. | Pectin-carboxymethylcellulose mesothelial sealants and protectants |
WO2019014194A1 (en) | 2017-07-11 | 2019-01-17 | DuPont Nutrition USA, Inc. | PROCESS FOR PREPARING STABLE COLOR PREPARATION OF ALKALINE METAL SALT OF MAGNESIUM CHLOROPHYLLINE OR ALKALINE-EARTH METAL SALT FROM NATURAL CHLOROPHYLLE SOURCES |
WO2019072877A1 (en) | 2017-10-10 | 2019-04-18 | Capsugel Belgium Nv | GETTING MULTIPARTICULAR COMPOSITIONS |
CA3079695A1 (en) * | 2017-11-08 | 2019-05-16 | Pasquale DEL GAUDIO | In situ gelifying powder |
EP3556398A1 (en) | 2018-04-16 | 2019-10-23 | Croda Denmark A/S | Phytates for use as a biomolecules delivery or adsorption system |
GB201908639D0 (en) | 2019-06-17 | 2019-07-31 | Algipharma Ipr As | Use of alginate oligomers in the anticoagulation therapy of subjects at risk of blood clots which have an abnormally dense microstructure |
US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
US11617744B2 (en) | 2019-12-09 | 2023-04-04 | Nico Ventures Trading Limited | Moist oral compositions |
US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
US11826462B2 (en) | 2019-12-09 | 2023-11-28 | Nicoventures Trading Limited | Oral product with sustained flavor release |
CN114146169B (zh) * | 2021-12-28 | 2023-08-25 | 佛山市正典生物技术有限公司 | 鸡球虫喷滴免疫用载体组合物及使用方法和鸡球虫喷滴免疫组合物 |
JPWO2024004159A1 (ru) * | 2022-06-30 | 2024-01-04 |
Family Cites Families (158)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2629665A (en) * | 1951-10-31 | 1953-02-24 | James B Gordon | Dietetic food product and method of preparing the same |
US3622559A (en) | 1967-11-01 | 1971-11-23 | Sunkist Growers Inc | Method for producing pectins having high resistance to breakage and high capability for gelling in the presence of calcium |
US3946110A (en) * | 1974-05-30 | 1976-03-23 | Peter, Strong Research And Development Company, Inc. | Medicinal compositions and methods of preparing the same |
US3982003A (en) | 1974-09-04 | 1976-09-21 | Mars Limited | Gelling and thickening agents |
US4016351A (en) | 1976-02-04 | 1977-04-05 | Eschinasi Emile H | Pectic substances with varying methoxyl content and process therefor |
HU179474B (en) * | 1978-02-24 | 1982-10-28 | Laszlo Gyarmati | Process for preparing solid oral pharmaceutical compositons with increased length of activity and with a regulated release of the active material |
US4305933A (en) | 1980-03-10 | 1981-12-15 | Wiczer Sol B | Thickened gelatinous edible alcoholic medicated carrier |
JPS607965B2 (ja) * | 1980-08-07 | 1985-02-28 | 帝人株式会社 | 鼻腔粘膜投与用粉剤の製造法 |
US4497838A (en) | 1982-02-17 | 1985-02-05 | Tropicana Products, Inc. | Process for the production of useful products from orange peel |
US4917890A (en) * | 1985-06-28 | 1990-04-17 | Carrington Laboratories, Inc. | Processes for preparation of aloe products, products produced thereby and compositions thereof |
US5443830A (en) | 1982-05-07 | 1995-08-22 | Carrington Laboratories, Inc. | Drink containing mucilaginous polysaccharides and its preparation |
US5308838A (en) | 1982-05-07 | 1994-05-03 | Carrington Laboratories, Inc. | Uses of aloe products |
US5118673A (en) | 1982-05-07 | 1992-06-02 | Carrington Laboratories, Inc. | Uses of aloe products |
US5106616A (en) | 1988-01-14 | 1992-04-21 | Carrington Laboratories, Inc. | Administration of acemannan |
US4966892A (en) | 1982-05-07 | 1990-10-30 | Carrington Laboratories, Inc. | Processes for preparation of aloe products products produced thereby and compositions thereof |
US4735935A (en) | 1985-12-17 | 1988-04-05 | Carrington Laboratories, Inc. | Process for preparation of aloe products products, produced thereby and compositions thereof |
US4851224A (en) | 1986-06-05 | 1989-07-25 | Carrington Laboratories, Inc. | Process for preparation of aloe products |
US5656587A (en) | 1982-09-24 | 1997-08-12 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Promotion of cell proliferation by use of transforming growth factor beta (TGF-β) |
US4500510A (en) * | 1982-09-29 | 1985-02-19 | Aquarium Pharmaceuticals, Inc. | Damaged fish tissue treating method and composition containing Aloe vera extract |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US5288498A (en) * | 1985-05-01 | 1994-02-22 | University Of Utah Research Foundation | Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments |
EP0188040B1 (en) * | 1985-01-11 | 1991-08-14 | Abbott Laboratories Limited | Slow release solid preparation |
US4959214A (en) | 1985-06-28 | 1990-09-25 | Carrington Laboratories Inc. | Processes for preparation of aloe products products produced thereby and compositions thereof |
US4957907A (en) | 1985-06-28 | 1990-09-18 | Carrington Laboratories Inc. | Process for preparation of aloe products |
US4847091A (en) * | 1985-11-29 | 1989-07-11 | Fisons Plc | Pharmaceutical composition including sodium cromoglycate |
DE3601132A1 (de) | 1986-01-16 | 1987-07-23 | Christian Bannert | Verfahren zur behandlung der schleimhaut |
DE3601923A1 (de) | 1986-01-23 | 1987-07-30 | Behringwerke Ag | Nasal applizierbares arzneimittel, verfahren zu seiner herstellung und seine verwendung |
US5552528A (en) | 1986-03-03 | 1996-09-03 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bovine b-endothelial cell growth factor |
US4725438A (en) * | 1986-05-29 | 1988-02-16 | Leazer Billie S | Aloe vera ointment |
FR2600250B1 (fr) * | 1986-06-23 | 1989-11-24 | Bio Serae | Procede pour conditionner une composition antibacterienne et composition antibacterienne conditionnee |
US5288500A (en) * | 1987-03-13 | 1994-02-22 | Benzon Pharma A/S | Oral composition containing particles comprising an active substance |
FR2613936B1 (fr) | 1987-04-17 | 1990-03-30 | Centre Nat Rech Scient | Application des resines constituees par des polymeres fonctionnels comme phase stationnaire en chromatographie d'affinite pour la purification des facteurs de croissance et procede de purification correspondant |
US5690954A (en) | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
DE3726797A1 (de) * | 1987-08-12 | 1989-02-23 | Bayer Ag | Arzneimittel fuer den bereich der mundhoehle |
US5059189A (en) | 1987-09-08 | 1991-10-22 | E. R. Squibb & Sons, Inc. | Method of preparing adhesive dressings containing a pharmaceutically active ingredient |
EP0308181A1 (en) * | 1987-09-14 | 1989-03-22 | Novo Nordisk A/S | Trans-mucosal delivery formulations and a method for preparation thereof |
GB8723846D0 (en) * | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
DE3886880T2 (de) * | 1987-10-15 | 1994-07-14 | Syntex Inc | Pulverförmige Zubereitungen zur intranasalen Verabreichung von Polypeptiden. |
US5246708A (en) * | 1987-10-28 | 1993-09-21 | Pro-Neuron, Inc. | Methods for promoting wound healing with deoxyribonucleosides |
US5064650A (en) | 1988-04-19 | 1991-11-12 | Southwest Research Institute | Controlled-release salt sensitive capsule for oral use and adhesive system |
US5438076A (en) * | 1988-05-03 | 1995-08-01 | Perio Products, Ltd. | Liquid polymer composition, and method of use |
US4925677A (en) * | 1988-08-31 | 1990-05-15 | Theratech, Inc. | Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents |
GB8826116D0 (en) * | 1988-11-08 | 1988-12-14 | Danbiosyst Ltd | Adhesive drug delivery composition |
EP1016716A3 (en) | 1989-01-31 | 2000-07-12 | RUBIN, Jeffrey S | Dna encoding a growth factor specific for epithelial cells |
US5356630A (en) | 1989-02-22 | 1994-10-18 | Massachusetts Institute Of Technology | Delivery system for controlled release of bioactive factors |
US5191067A (en) | 1989-04-27 | 1993-03-02 | The Salk Institute For Biological Studies | Fibroblast growth factor conjugates |
US5576288A (en) | 1989-04-27 | 1996-11-19 | The Salk Institute For Biological Studies | Fibroblast growth factor conjugates |
US5130418A (en) | 1989-05-02 | 1992-07-14 | California Biotechnology Inc. | Method to stabilize basic fibroblast growth factor |
US5599551A (en) * | 1989-06-06 | 1997-02-04 | Kelly; Patrick D. | Genital lubricants containing zinc as an anti-viral agent |
US5208031A (en) * | 1989-06-06 | 1993-05-04 | Kelly Patrick D | Sexual lubricants containing zinc as an anti-viral agent |
US5545673A (en) * | 1989-06-06 | 1996-08-13 | Kelly; Patrick D. | Method for reducing risk of infection by sexually transmitted viruses |
US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
US5422340A (en) | 1989-09-01 | 1995-06-06 | Ammann; Arthur J. | TGF-βformulation for inducing bone growth |
US5158934A (en) | 1989-09-01 | 1992-10-27 | Genentech, Inc. | Method of inducing bone growth using TGF-β |
JP2911496B2 (ja) * | 1989-09-11 | 1999-06-23 | 帝國製薬株式会社 | 生理活性ポリペプチド含有高吸収性経膣剤 |
US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
GB2237510B (en) * | 1989-11-04 | 1993-09-15 | Danbiosyst Uk | Small particle drug compositions for nasal administration |
US5512306A (en) * | 1992-06-19 | 1996-04-30 | Pharmica Ab | Smoking substitute |
US5188825A (en) * | 1989-12-28 | 1993-02-23 | Iles Martin C | Freeze-dried dosage forms and methods for preparing the same |
US5284659A (en) * | 1990-03-30 | 1994-02-08 | Cherukuri Subraman R | Encapsulated flavor with bioadhesive character in pressed mints and confections |
US5217954A (en) | 1990-04-04 | 1993-06-08 | Scios Nova Inc. | Formulations for stabilizing fibroblast growth factor |
IL98087A (en) * | 1990-05-04 | 1996-11-14 | Perio Prod Ltd | Preparation for dispensing drugs in the colon |
US5612211A (en) | 1990-06-08 | 1997-03-18 | New York University | Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors |
SE9002339L (sv) * | 1990-07-04 | 1992-01-05 | Kabi Pharmacia Ab | Terapeutisk komposition och foerfarande foer dess framstaellning |
US5714458A (en) | 1990-07-18 | 1998-02-03 | Farmitalia Carlo Erba S.R.L. | Stable pharmaceutical compositions containing a fibroblast growth factor |
US5071644A (en) | 1990-08-07 | 1991-12-10 | Mediventures, Inc. | Topical drug delivery with thermo-irreversible gels |
KR930006431B1 (ko) | 1990-10-11 | 1993-07-16 | 재단법인 한국화학연구소 | 약물의 미세캡슐화 방법 |
DK0486862T3 (da) | 1990-11-23 | 1996-06-24 | American Cyanamid Co | Kimær fibrolast-vækstfaktor |
US5215758A (en) * | 1991-09-11 | 1993-06-01 | Euroceltique, S.A. | Controlled release matrix suppository for pharmaceuticals |
US5192802A (en) * | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
US5318780A (en) | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
EP0547648B2 (en) | 1991-11-14 | 1999-12-22 | Dsm N.V. | Improved process for the production of juices from fruits and vegetables |
US6033712A (en) * | 1994-05-13 | 2000-03-07 | Ei Du Pont De Nemours And Company | Gel production from plant matter |
US5266318A (en) | 1991-12-09 | 1993-11-30 | Royale Renaissance, Inc. | Skin therapeutic mixture containing cold-processsed aloe vera extract, with yellow sap and aloin removed |
CA2125579C (en) | 1991-12-17 | 2005-06-21 | Richard C. Fuisz | Ulcer prevention treatment composition and method |
DE4201172C1 (en) | 1992-01-17 | 1993-07-22 | Alfatec-Pharma Gmbh, 6900 Heidelberg, De | Pellets contg. Aloe vera extract - useful, e.g. as antiinflammatory of antibiotic agents, or for treating gastric ulcers |
US5578307A (en) | 1992-01-17 | 1996-11-26 | Alfatec-Pharma Gmbh | Shaped articles containing plant extract(s), in particular pellets, and their pharmaceutical or cosmetic use |
AU659723B2 (en) | 1992-02-14 | 1995-05-25 | Kaken Pharmaceutical Co., Ltd. | Remedy for airway diseases |
US6197346B1 (en) * | 1992-04-24 | 2001-03-06 | Brown Universtiy Research Foundation | Bioadhesive microspheres and their use as drug delivery and imaging systems |
US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
US5703047A (en) | 1992-09-21 | 1997-12-30 | Board Of Regents, The University Of Texas System | Methods and treatments for corneal healing with growth factors |
US5589451A (en) | 1992-09-21 | 1996-12-31 | Board Of Regents, The University Of Texas System | Methods and treaments for corneal healing with hepatocyte and keratinocyte growth factors |
US5645827A (en) * | 1992-09-30 | 1997-07-08 | Union Carbide Chemicals & Plastics Technology Corporation | Muco-adhesive polymers |
JP3266674B2 (ja) * | 1992-11-19 | 2002-03-18 | クミアイ化学工業株式会社 | 植物成長調整剤組成物 |
GB9310412D0 (en) * | 1993-05-20 | 1993-07-07 | Danbiosyst Uk | Nasal nicotine system |
US5409703A (en) * | 1993-06-24 | 1995-04-25 | Carrington Laboratories, Inc. | Dried hydrogel from hydrophilic-hygroscopic polymer |
US5453492A (en) | 1993-07-28 | 1995-09-26 | La Jolla Cancer Research Foundation | 60 kDa transforming growth factor-β-binding protein and its use to detect or purify TGF-β |
US5464815A (en) | 1993-09-08 | 1995-11-07 | Genentech, Inc. | Inhibition of heparin-binding |
US5435997A (en) * | 1994-02-08 | 1995-07-25 | Burns; Michael J. | Topical agent and method for the treatment of pseudofolliculitis barbae |
ES2225840T3 (es) | 1994-03-08 | 2005-03-16 | Osteosa Liquidation Trust | Utilizacion de factores de crecimiento de fibroblasto para estimular el crecimiento oseo. |
US5656598A (en) | 1994-03-08 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Use of fibroblast growth factors to stimulate bone growth |
US5503822A (en) * | 1994-04-01 | 1996-04-02 | Schulman; Jerome M. | Medicated gel |
US5571531A (en) | 1994-05-18 | 1996-11-05 | Mcmaster University | Microparticle delivery system with a functionalized silicone bonded to the matrix |
GB9412394D0 (en) * | 1994-06-21 | 1994-08-10 | Danbiosyst Uk | Colonic drug delivery composition |
US5849327A (en) | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
JPH08198772A (ja) * | 1994-11-25 | 1996-08-06 | Kirin Brewery Co Ltd | 顆粒球コロニー刺激因子含有粉末経鼻投与製剤 |
US5674495A (en) | 1995-02-27 | 1997-10-07 | Purdue Research Foundation | Alginate-based vaccine compositions |
CA2216919C (en) * | 1995-03-28 | 2007-09-18 | Fidia Advanced Biopolymers Srl | Nanospheres comprising a biocompatible polysaccharide |
US5612053A (en) * | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
US5753622A (en) | 1995-05-10 | 1998-05-19 | University Technologies International, Inc. | Use of epidermal growth factor as a gastrointestinal therapeutic agent |
US5693775A (en) | 1995-05-12 | 1997-12-02 | The Johns Hopkins University School Of Medicine | Fibroblast growth factor homologous factor-1 (FHF-1) and methods of use |
JP3098401B2 (ja) * | 1995-07-12 | 2000-10-16 | 株式会社エルティーティー研究所 | 経鼻投与用製剤 |
GB9514438D0 (en) * | 1995-07-14 | 1995-09-13 | Danisco | Stabilisation process and an enzyme for use in such a process |
US5900238A (en) * | 1995-07-27 | 1999-05-04 | Immunex Corporation | Vaccine delivery system |
US5902796A (en) * | 1995-09-22 | 1999-05-11 | Carrington Laboratories, Inc. | Bioactive factors of aloe vera plants |
US5656734A (en) | 1995-10-30 | 1997-08-12 | Systems Bio-Industries | Methods for making pectin and pectocellulosic products |
GB9525083D0 (en) * | 1995-12-07 | 1996-02-07 | Danbiosyst Uk | Vaccine compositions |
GB9600272D0 (en) * | 1996-01-06 | 1996-03-06 | Univ Nottingham | Polymers |
US5840332A (en) | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
US6231888B1 (en) * | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
US5760102A (en) * | 1996-02-20 | 1998-06-02 | Carrington Laboratories, Inc. | Uses of denture adhesive containing aloe extract |
DK0893992T3 (da) * | 1996-04-16 | 2004-06-01 | Novartis Consumer Health Sa | Hurtigt sönderdelende oral doseringsform |
AU732978B2 (en) * | 1996-07-10 | 2001-05-03 | Coloplast A/S | Adhesive agent and use of such agent |
GB9707934D0 (en) * | 1997-04-18 | 1997-06-04 | Danbiosyst Uk | Improved delivery of drugs to mucosal surfaces |
US6210710B1 (en) * | 1997-04-28 | 2001-04-03 | Hercules Incorporated | Sustained release polymer blend for pharmaceutical applications |
US6197327B1 (en) * | 1997-06-11 | 2001-03-06 | Umd, Inc. | Device and method for treatment of dysmenorrhea |
US6416779B1 (en) * | 1997-06-11 | 2002-07-09 | Umd, Inc. | Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections |
US5874094A (en) * | 1997-08-05 | 1999-02-23 | Costello; Jeremiah | Cream formulation for topical application |
AR017512A1 (es) * | 1997-08-22 | 2001-09-12 | Smithkline Beecham Corp | Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas |
CA2304958C (en) * | 1997-09-26 | 2008-12-30 | Noven Pharmaceuticals, Inc. | Bioadhesive compositions and methods for topical administration of active agents |
JP4234803B2 (ja) * | 1997-10-27 | 2009-03-04 | 久光製薬株式会社 | 薬物放出速度が制御された医薬組成物 |
GB9725084D0 (en) * | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
EP1035833B1 (en) * | 1997-12-02 | 2005-08-31 | Archimedes Development Limited | Compositions for nasal administration |
US6383495B1 (en) * | 1997-12-08 | 2002-05-07 | Council Of Scientific & Industrial Research | Herbal formulation useful for treatment of skin disorders |
GB9726916D0 (en) * | 1997-12-19 | 1998-02-18 | Danbiosyst Uk | Nasal formulation |
US6290964B1 (en) * | 1998-03-06 | 2001-09-18 | Kathleen Shupe | Antimicrobial agents isolated from aloe vera |
US6423345B2 (en) * | 1998-04-30 | 2002-07-23 | Acusphere, Inc. | Matrices formed of polymer and hydrophobic compounds for use in drug delivery |
US5929051A (en) * | 1998-05-13 | 1999-07-27 | Carrington Laboratories, Inc. | Aloe pectins |
US6313103B1 (en) * | 1998-05-13 | 2001-11-06 | Carrington Laboratories, Inc. | Pectic substance as a growth factor stabilizer |
FR2778566B1 (fr) * | 1998-05-15 | 2001-07-20 | Sep Tarral | Preparations pectiques utilisables comme support de medicament |
US6033651A (en) * | 1998-06-10 | 2000-03-07 | Revlon Consumer Products Corporation | Gel cosmetic compositions |
KR20000011247A (ko) * | 1998-07-23 | 2000-02-25 | 김윤 | 다당류를이용한대장선택성약물전달조성물및약학제제 |
US6063915A (en) * | 1998-07-30 | 2000-05-16 | Hercules Incorporated | Carrageenan compositions and methods for their production |
US6080783A (en) * | 1998-09-01 | 2000-06-27 | Gum Tech International, Inc. | Method and composition for delivering zinc to the nasal membrane |
US6060078A (en) * | 1998-09-28 | 2000-05-09 | Sae Han Pharm Co., Ltd. | Chewable tablet and process for preparation thereof |
US6531152B1 (en) * | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
GB9828861D0 (en) * | 1998-12-31 | 1999-02-17 | Danbiosyst Uk | Compositions |
US6552024B1 (en) * | 1999-01-21 | 2003-04-22 | Lavipharm Laboratories Inc. | Compositions and methods for mucosal delivery |
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
DE60030418T2 (de) * | 1999-03-17 | 2007-08-30 | Coloplast A/S | Druckempfindliche klebstoffzusammensetzung |
US6375963B1 (en) * | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
GB9924797D0 (en) * | 1999-10-20 | 1999-12-22 | West Pharm Serv Drug Res Ltd | Compound |
DE60025019T2 (de) * | 1999-10-29 | 2006-08-24 | Nektar Therapeutics, San Carlos | Trockenpulverzusammensetzungen mit verbesserter dispersivität |
WO2003024427A1 (en) * | 1999-12-20 | 2003-03-27 | Temple University Of The Commonwealth System Of Higher Education | Tableted oral extended release dosage form |
EP1110550B2 (en) * | 1999-12-22 | 2007-04-04 | DSM IP Assets B.V. | Composition comprising ascorbic acid as a principal component and pectin |
AU2001231000A1 (en) * | 2000-01-19 | 2001-07-31 | Pharmaceutical Discovery Corporation | Dry powder formulations of antihistamine for nasal administration |
US6228387B1 (en) * | 2000-01-27 | 2001-05-08 | Murray Borod | Integrated comprehensive hemorrhoid treatment compositions and regimen |
JP4711520B2 (ja) * | 2000-03-21 | 2011-06-29 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
US6368639B1 (en) * | 2000-03-24 | 2002-04-09 | Council Of Scientific And Industrial Research | Herbal skin care formulation and a process for the preparation thereof |
US6248360B1 (en) * | 2000-06-21 | 2001-06-19 | International Health Management Associates, Inc. | Complexes to improve oral absorption of poorly absorbable antibiotics |
US6365200B1 (en) * | 2000-07-19 | 2002-04-02 | Jason C. Birnholz | Topical skin sensitizer |
ES2387537T3 (es) * | 2000-09-13 | 2012-09-25 | Glaxosmithkline Llc | Composiciones farmacéuticas para la administración sostenida de péptidos |
US6596297B2 (en) * | 2000-10-30 | 2003-07-22 | New York Blood Center, Inc. | Biodegradable microbicidal vaginal barrier device |
US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
ES2250711T3 (es) * | 2001-09-03 | 2006-04-16 | Dsm Ip Assets B.V. | Composiciones que comprenden pectina y acido ascorbico. |
US20030186271A1 (en) * | 2001-11-19 | 2003-10-02 | Robin Hwang | Pharmaceutical compositions in particulate form |
JP2004002320A (ja) * | 2002-03-04 | 2004-01-08 | Medorekkusu:Kk | 生体内で相転移する液状マトリックスおよび液状経口製剤 |
-
2003
- 2003-08-29 US US10/652,622 patent/US7494669B2/en not_active Expired - Fee Related
-
2004
- 2004-05-24 CN CNA2004800248478A patent/CN1874679A/zh active Pending
- 2004-05-24 KR KR1020067004256A patent/KR20060127841A/ko not_active Application Discontinuation
- 2004-05-24 JP JP2006524618A patent/JP4765020B2/ja not_active Expired - Fee Related
- 2004-05-24 EP EP04753044A patent/EP1663111A4/en not_active Withdrawn
- 2004-05-24 CA CA2537290A patent/CA2537290C/en not_active Expired - Fee Related
- 2004-05-24 EA EA200600484A patent/EA010351B1/ru not_active IP Right Cessation
- 2004-05-24 AU AU2004270101A patent/AU2004270101A1/en not_active Abandoned
- 2004-05-24 WO PCT/US2004/016146 patent/WO2005023176A2/en active Application Filing
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7705135B2 (en) | 1998-05-13 | 2010-04-27 | Nanotherapeutics, Inc. | Pharmaceutical compositions comprising aloe pectins, and methods for their production and use |
Also Published As
Publication number | Publication date |
---|---|
CA2537290A1 (en) | 2005-03-17 |
CN1874679A (zh) | 2006-12-06 |
JP2007504129A (ja) | 2007-03-01 |
US20050084534A1 (en) | 2005-04-21 |
EP1663111A2 (en) | 2006-06-07 |
WO2005023176A2 (en) | 2005-03-17 |
EA010351B1 (ru) | 2008-08-29 |
KR20060127841A (ko) | 2006-12-13 |
WO2005023176A3 (en) | 2006-06-15 |
CA2537290C (en) | 2013-07-09 |
AU2004270101A1 (en) | 2005-03-17 |
US7494669B2 (en) | 2009-02-24 |
EP1663111A4 (en) | 2009-10-21 |
JP4765020B2 (ja) | 2011-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA200600484A1 (ru) | Доставка физиологических агентов in situ при помощи гелей, включающих анионные полисахариды | |
MD20070267A (en) | Gastroresistant pharmaceutical formulation containing rifaximin | |
BR0008590A (pt) | Agente de entrega polimérico, composição, formade unidade de dosagem, método para administrarum agente biologicamente ativo a um animalnecessitando o agente, método para preparar umacomposição; e composto | |
EP2322215A3 (en) | Combination treatment for non-hematologic malignancies using an anti-IGF-1R antibody | |
RU2350333C3 (ru) | Применение ивермектина для лечения дерматологических расстройств | |
WO2007040469A3 (en) | Chloroquine coupled compositions and methods for their synthesis | |
MY167123A (en) | Conveniently implantable sustained release drug compositions | |
UA74443C2 (ru) | Лиганды 5-нт рецептора и их применение | |
NO20075136L (no) | Nye liposompreparater | |
EP1790340A3 (en) | Combination chemotherapy | |
TW200806318A (en) | Uses of anti-insulin-like growth factor I receptor antibodies | |
EP2626368A3 (en) | Insulin-oligomer conjugates, formulations and uses thereof | |
MY145790A (en) | Composition | |
BR0114799A (pt) | Compostos de ácido cianofenoxi carboxìlico e composições para liberar agentes ativos | |
ATE432689T1 (de) | Arzneimittelformulierungen mit verzögerter freisetzung mit einem trägerpeptid | |
EA200702522A1 (ru) | Система доставки лекарств в полость рта и способы ее применения | |
AR053977A1 (es) | Composiciones farmaceuticas con enmascaramiento de sabor | |
CR8473A (es) | Composicion farmaceutica de vinflunina para administracion parenteral y proceso de preparacion de dicha composicion | |
MX2007007099A (es) | Implante formado in situ para animales. | |
MXPA04005420A (es) | Composicion farmaceutica que comprende un agonista de receptor de 5ht1. | |
DE602006020666D1 (de) | Methoden und Zusammensetzungen zur Beruhigung von Mund- und Nasenschleimhäuten | |
EA200701525A1 (ru) | Фармацевтическая полимерная композиция для перорального введения тербуталина сульфата с контролируемым высвобождением | |
EP1759707A3 (en) | Canine tumor treatment method, pharmaceutical formulation applied thereto and method of cryogenically preserving cells used therewith | |
TH59782A3 (th) | สารผสมของกาแลนแทมีนชนิดปลดปล่อยที่มีการควบคุม | |
Ahmad et al. | Bioadhesive Vaginal Gels of Novel Antimicrobial Combinations from Herbal Sources. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |