CN102859364A - 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法 - Google Patents

通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法 Download PDF

Info

Publication number
CN102859364A
CN102859364A CN2011800112675A CN201180011267A CN102859364A CN 102859364 A CN102859364 A CN 102859364A CN 2011800112675 A CN2011800112675 A CN 2011800112675A CN 201180011267 A CN201180011267 A CN 201180011267A CN 102859364 A CN102859364 A CN 102859364A
Authority
CN
China
Prior art keywords
peg
haemoglobin
conjugate
oxygen
mal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800112675A
Other languages
English (en)
Chinese (zh)
Inventor
A·马拉瓦立
K·D·梵德格里夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sangart Inc
Original Assignee
Sangart Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sangart Inc filed Critical Sangart Inc
Publication of CN102859364A publication Critical patent/CN102859364A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2011800112675A 2010-02-25 2011-02-23 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法 Pending CN102859364A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30823810P 2010-02-25 2010-02-25
US61/308,238 2010-02-25
PCT/US2011/025888 WO2011106396A1 (en) 2010-02-25 2011-02-23 Methods for preparing peg-hemoglobin conjugates using reduced reactant ratios

Publications (1)

Publication Number Publication Date
CN102859364A true CN102859364A (zh) 2013-01-02

Family

ID=44507180

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800112675A Pending CN102859364A (zh) 2010-02-25 2011-02-23 通过减少反应物比例制备聚乙二醇-血红蛋白缀合物的方法

Country Status (8)

Country Link
US (1) US9493616B2 (enExample)
EP (1) EP2539715B1 (enExample)
JP (1) JP2013520512A (enExample)
KR (1) KR20130067243A (enExample)
CN (1) CN102859364A (enExample)
AU (2) AU2011220885A1 (enExample)
CA (1) CA2791122C (enExample)
WO (1) WO2011106396A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013240141B2 (en) 2012-03-29 2017-11-02 Sangart, Inc. Diaspirin crosslinked PEGgylated hemoglobin
MX358784B (es) 2012-04-03 2018-09-04 Sangart Inc Compuestos de nitroxilo activados con succinimida y metodos para el uso de los mismos para nitroxilacion de proteinas.
JP7387597B2 (ja) 2017-07-18 2023-11-28 ヴァーテック・バイオ・インコーポレイテッド ヘモグロビンを含む代用血液及び作製方法
US11857605B2 (en) 2021-03-01 2024-01-02 Billion King International Limited Thiosuccinyl-crosslinked hemoglobin conjugates and methods of use and preparation thereof
WO2023091642A1 (en) * 2021-11-18 2023-05-25 Virginia Commonwealth University Modular field-stable bio-artificial blood substitute
WO2025219465A1 (en) * 2024-04-19 2025-10-23 Danmarks Tekniske Universitet Hemoglobin-based oxygen carrier

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585484A (en) * 1995-04-19 1996-12-17 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Hemoglobin crosslinkers
CN1332646A (zh) * 1998-10-15 2002-01-23 桑伽特股份有限公司 生产无基质血红蛋白的方法
CN1519266A (zh) * 2003-01-22 2004-08-11 中国科学院过程工程研究所 带单甲氧基聚乙二醇长尾的蛋白质修饰剂及制法和用途
WO2004076474A2 (en) * 2003-02-26 2004-09-10 Intermune, Inc. Polyethylene glycol modified interferon compositions and methods of use thereof
CN1630527A (zh) * 2002-01-11 2005-06-22 桑格特公司 包含高氧亲和力的修饰血红蛋白的氧气输送方法和组合物
US20050159339A1 (en) * 2002-03-25 2005-07-21 Acharya Seetharama A. Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof
CN1741812A (zh) * 2002-12-23 2006-03-01 犹太大学阿尔伯特爱因斯坦医学院 修饰的血红蛋白及其制备方法
US20060111275A1 (en) * 2001-07-19 2006-05-25 Acharya Seetharama A Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy alkylene glycols
WO2008136888A2 (en) * 2007-03-13 2008-11-13 Albert Einstein College Of Medicine Of Yeshiva University Second generation low oxygen affinity pegylated hemoglobins as oxygen-carrying plasma expanders

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2161086B2 (de) 1971-12-09 1975-04-24 Anton Cramer & Co, 4402 Greven Daunen- und federndichtes Gewebe
DE2449885C3 (de) 1974-10-21 1980-04-30 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US4001200A (en) 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4001401A (en) 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
JPS57206622A (en) 1981-06-10 1982-12-18 Ajinomoto Co Inc Blood substitute
US4529719A (en) 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
CA1312009C (en) 1986-11-10 1992-12-29 Carl W. Rausch Extra pure semi-synthetic blood substitute
US5449759A (en) 1987-05-16 1995-09-12 Somatogen, Inc. Hemoglobins with intersubunit desulfide bonds
US5234903A (en) 1989-11-22 1993-08-10 Enzon, Inc. Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute
US5650388A (en) 1989-11-22 1997-07-22 Enzon, Inc. Fractionated polyalkylene oxide-conjugated hemoglobin solutions
JP4583510B2 (ja) 1997-02-28 2010-11-17 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア 無細胞系による酸素輸送の最適化のための方法と組成物
ATE478674T1 (de) 2004-08-31 2010-09-15 Sangart Inc Verfahren zur verbesserung der hämodynamischen stabilität mit sauerstoff-tragenden zusammensetzungen
EP1863503B1 (en) 2005-03-07 2019-05-22 Sangart, Inc. Composition for delivering carbon monoxide (co) and nitric ozide (no) co to tissue using heme proteins as carriers
US8021858B2 (en) 2008-09-22 2011-09-20 Sangart, Inc. Method for making polyalkylene oxide modified hemoglobin
WO2011056799A1 (en) 2009-11-05 2011-05-12 Sangart, Inc. Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585484A (en) * 1995-04-19 1996-12-17 Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University Hemoglobin crosslinkers
CN1332646A (zh) * 1998-10-15 2002-01-23 桑伽特股份有限公司 生产无基质血红蛋白的方法
US20060111275A1 (en) * 2001-07-19 2006-05-25 Acharya Seetharama A Size enhanced hemoglobins: surface decoration and crosslinking of the protein with polyoxy alkylene glycols
CN1630527A (zh) * 2002-01-11 2005-06-22 桑格特公司 包含高氧亲和力的修饰血红蛋白的氧气输送方法和组合物
US20050159339A1 (en) * 2002-03-25 2005-07-21 Acharya Seetharama A. Pegylated non-hypertensive hemoglobins, methods of preparing same, and uses thereof
CN1741812A (zh) * 2002-12-23 2006-03-01 犹太大学阿尔伯特爱因斯坦医学院 修饰的血红蛋白及其制备方法
CN1519266A (zh) * 2003-01-22 2004-08-11 中国科学院过程工程研究所 带单甲氧基聚乙二醇长尾的蛋白质修饰剂及制法和用途
WO2004076474A2 (en) * 2003-02-26 2004-09-10 Intermune, Inc. Polyethylene glycol modified interferon compositions and methods of use thereof
WO2008136888A2 (en) * 2007-03-13 2008-11-13 Albert Einstein College Of Medicine Of Yeshiva University Second generation low oxygen affinity pegylated hemoglobins as oxygen-carrying plasma expanders

Also Published As

Publication number Publication date
EP2539715B1 (en) 2021-12-22
AU2017232073A1 (en) 2017-10-12
WO2011106396A1 (en) 2011-09-01
US20130217860A1 (en) 2013-08-22
US9493616B2 (en) 2016-11-15
CA2791122C (en) 2019-08-27
AU2011220885A1 (en) 2012-09-06
AU2017232073B2 (en) 2019-01-31
EP2539715A1 (en) 2013-01-02
JP2013520512A (ja) 2013-06-06
CA2791122A1 (en) 2011-09-01
EP2539715A4 (en) 2016-03-02
KR20130067243A (ko) 2013-06-21

Similar Documents

Publication Publication Date Title
AU2017232073B2 (en) Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios
WO2013142135A1 (en) Method of enhancing efficacy of blood transfusions
JP6668515B2 (ja) ジアスピリン架橋ｐｅｇヘモグロビン
CA2906878C (en) Polyalkylene oxide valerate hemoglobin conjugates
CN101039684A (zh) 使用氧载体组合物增强血液动力稳定性的方法
US8609815B2 (en) Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant
Jin et al. Chemically modified porcine hemoglobins and their biological properties
US20120282236A1 (en) Method of delivering oxygen using peg-hemoglobin conjugates with enhanced nitrite reductase activity
HK1177255A (en) Methods for preparing peg-hemoglobin conjugates using reduced reactant ratios

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1177255

Country of ref document: HK

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20130102

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1177255

Country of ref document: HK