|
CA529379A
(en)
*
|
1952-09-20 |
1956-08-21 |
Farbenfabriken Bayer Aktiengesellschaft |
Phosphonic ester
|
|
GB1309692A
(en)
|
1970-02-13 |
1973-03-14 |
Ucb Sa |
N-substituted lactams
|
|
GB1039113A
(en)
|
1964-08-06 |
1966-08-17 |
Ucb Sa |
New n-substituted lactams
|
|
JP2000319257A
(ja)
|
1969-01-06 |
2000-11-21 |
Eisai Co Ltd |
１−ベンジル−４−［（５，６−ジメトキシ−２−フルオロ−１−インダノン）−２−イル］メチルピペリジン
|
|
IT1045043B
(it)
*
|
1975-08-13 |
1980-04-21 |
Isf Spa |
Derivati pirrolidinici
|
|
BE864269A
(fr)
*
|
1977-03-03 |
1978-06-16 |
Parke Davis & Co |
Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire
|
|
ATE27T1
(de)
*
|
1978-05-08 |
1981-04-15 |
Ucb Sa |
Lactam-n-essigsaeuren und ihre amide, verfahren zu ihrer herstellung und heilmittel, die sie enthalten
|
|
US4654370A
(en)
*
|
1979-03-12 |
1987-03-31 |
Abbott Laboratories |
Glyceryl valproates
|
|
US4372960A
(en)
*
|
1980-12-12 |
1983-02-08 |
Warner-Lambert Company |
Quaternary derivatives of N-(substituted-aminoalkyl)-2-oxo-1-pyrrolidine-acetamides as cognition activators
|
|
FR2515179A1
(fr)
*
|
1981-07-24 |
1983-04-29 |
Hoffmann La Roche |
Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique
|
|
IL67623A
(en)
*
|
1983-01-05 |
1984-09-30 |
Teva Pharma |
1'-ethoxycarbonyloxyethyl ester of valproic acid,its preparation and pharmaceutical compositions containing it
|
|
IL72381A
(en)
*
|
1983-07-20 |
1988-03-31 |
Sanofi Sa |
Pharmaceutical composition based on valproic acid
|
|
GB8412358D0
(en)
*
|
1984-05-15 |
1984-06-20 |
Ucb Sa |
Pharmaceutical composition
|
|
GB8412357D0
(en)
*
|
1984-05-15 |
1984-06-20 |
Ucb Sa |
Pharmaceutical composition
|
|
US4668687A
(en)
*
|
1984-07-23 |
1987-05-26 |
Bristol-Myers Company |
Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
|
|
US4913906B1
(en)
*
|
1985-02-28 |
2000-06-06 |
Yissum Res Dev Co |
Controlled release dosage form of valproic acid
|
|
IL74497A
(en)
|
1985-03-05 |
1990-02-09 |
Proterra Ag |
Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
|
|
JPS6222785A
(ja)
*
|
1985-07-23 |
1987-01-30 |
Sanwa Kagaku Kenkyusho:Kk |
新規な２−オキソピロリジン化合物及びその塩、その製法並びにこれらを有効成分とする脳機能障害の予防及び治療剤
|
|
US4663318A
(en)
*
|
1986-01-15 |
1987-05-05 |
Bonnie Davis |
Method of treating Alzheimer's disease
|
|
US4816456A
(en)
*
|
1986-10-01 |
1989-03-28 |
Summers William K |
Administration of monoamine acridines in cholinergic neuronal deficit states
|
|
NL195004C
(nl)
*
|
1987-03-04 |
2003-11-04 |
Novartis Ag |
Fenylcarbamaat bevattend farmaceutisch preparaat.
|
|
FI91401C
(fi)
|
1987-03-17 |
1994-06-27 |
Hoechst Roussel Pharma |
Menetelmä terapeuttisesti aktiivisten substituoitujen 9-aminotetrahydroakriinien ja niille läheisten yhdisteiden valmistamiseksi
|
|
DE3709230A1
(de)
*
|
1987-03-20 |
1988-10-06 |
Desitin Arzneimittel Gmbh |
Neues calciumsalz der valproinsaeure
|
|
IT1225462B
(it)
|
1987-04-03 |
1990-11-14 |
Mediolanum Farmaceutici Srl |
Sali organici di derivati della fisostigmina
|
|
US5002955A
(en)
*
|
1987-04-23 |
1991-03-26 |
Hoechst-Roussel Pharmaceuticals Inc. |
Fused heteroalkylene quinolinamines and use as cholinergic agents
|
|
JP2755403B2
(ja)
|
1987-05-04 |
1998-05-20 |
デイービス、ボニー |
アルツハイマー病の治療のための化合物
|
|
US5187165A
(en)
|
1987-05-15 |
1993-02-16 |
Hoechst-Roussel Pharmaceuticals Inc. |
Memory enhancing and analgesic 1,2,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b]indoles
|
|
FI95572C
(fi)
|
1987-06-22 |
1996-02-26 |
Eisai Co Ltd |
Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
|
|
JPS6422883A
(en)
*
|
1987-07-17 |
1989-01-25 |
Sanwa Kagaku Kenkyusho Co |
1-pyrrolidine acetamide derivative, its salt, production thereof and prophylactic and remedial agent for cereral dysfunction containing said derivative and salt as active ingredient
|
|
ATE68346T1
(de)
*
|
1987-07-22 |
1991-11-15 |
Farvalsa Ag |
Feuchtigkeitsstabile feste valproinsaeurezubereitung und verfahren zu ihrer herstellung.
|
|
US4950658A
(en)
*
|
1988-12-06 |
1990-08-21 |
Board Of Trustees Of Southern Illinois Univ. |
Method of medical treatment of Alzheimer's disease
|
|
FR2643556B1
(fr)
*
|
1989-02-27 |
1993-03-05 |
Sanofi Sa |
Composition pharmaceutique a liberation prolongee d'acide valproique
|
|
EP0403713A1
(en)
|
1989-06-22 |
1990-12-27 |
Merrell Dow Pharmaceuticals Inc. |
Novel acetylcholinesterase inhibitors
|
|
US5693668A
(en)
|
1989-06-22 |
1997-12-02 |
Merrell Pharmaceuticals Inc. |
Acetylcholinesterase inhibitors
|
|
IT1231477B
(it)
*
|
1989-07-12 |
1991-12-07 |
Sigma Tau Ind Farmaceuti |
(pirrolidin-2-one-1-il) acetammidi quali attivatori dei processi di apprendimento e della memoria e composizioni farmaceutiche comprendenti tali composti
|
|
US4999430A
(en)
|
1989-07-31 |
1991-03-12 |
Warner-Lambert Company |
Derivatives of 1,2,3,4-tetrahydro-9-acrisinamine
|
|
DE3927049A1
(de)
|
1989-08-16 |
1991-02-21 |
Sandoz Ag |
Halogenalkyl-phenyl-ketone und deren hydrate, ihre herstellung und verwendung
|
|
US5387590A
(en)
|
1989-08-30 |
1995-02-07 |
Pfizer Inc. |
Benzazabicyclic carbamates as novel cholinesterase inhibitors
|
|
US4914102A
(en)
*
|
1989-09-28 |
1990-04-03 |
Hoechst Roussel Pharmaceuticals, Inc. |
N-aminocarbamates related to physostigmine, pharmacentical compositions and use
|
|
NZ237241A
(en)
*
|
1990-03-02 |
1993-11-25 |
Pharmetrix Corp |
Method for increasing the storage stability of physostigmine
|
|
EP0445095A1
(en)
|
1990-03-02 |
1991-09-04 |
Uni Patent Ab |
Equipment for preventing separation in bulk materials
|
|
JP2807577B2
(ja)
|
1990-06-15 |
1998-10-08 |
エーザイ株式会社 |
環状アミド誘導体
|
|
US5102891A
(en)
|
1990-07-23 |
1992-04-07 |
Hoechst-Roussel Pharmaceuticals Inc. |
1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
|
|
US5264442A
(en)
*
|
1990-08-13 |
1993-11-23 |
Hoechst-Roussel Pharmaceuticals Incorporated |
Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
|
|
TW200462B
(enExample)
|
1990-09-27 |
1993-02-21 |
Hoechst Roussel Pharma |
|
|
US5190951A
(en)
|
1990-10-19 |
1993-03-02 |
Ss Pharmaceutical Co., Ltd. |
Quinoline derivatives
|
|
JP2965675B2
(ja)
|
1990-11-21 |
1999-10-18 |
エーザイ株式会社 |
（―）―１―ベンジル―４―〔（５，６―ジメトキシ―１―インダノン）―２―イル〕メチルピペリジンの製造方法
|
|
TW197435B
(enExample)
|
1990-11-22 |
1993-01-01 |
Takeda Pharm Industry Co Ltd |
|
|
US5668117A
(en)
|
1991-02-22 |
1997-09-16 |
Shapiro; Howard K. |
Methods of treating neurological diseases and etiologically related symptomology using carbonyl trapping agents in combination with previously known medicaments
|
|
US5334720A
(en)
|
1991-03-07 |
1994-08-02 |
Fisons Corporation |
Diphenyl-1-(aminoalkyl)-2-piperidinone and -2-pyrrolidinone derivatives having anticonvulsant properties
|
|
ES2188584T3
(es)
|
1991-03-28 |
2003-07-01 |
Eisai Co Ltd |
Derivados heterociclicos de amina.
|
|
US5750542A
(en)
|
1993-09-28 |
1998-05-12 |
Pfizer |
Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors
|
|
US5104880A
(en)
|
1991-05-01 |
1992-04-14 |
Mayo Foundation For Medical Education And Research |
Huperzine a analogs as acetylcholinesterase inhibitors
|
|
SK279285B6
(sk)
*
|
1991-05-02 |
1998-09-09 |
Daiichi Pharmaceutical Co. |
Použitie n-(2,6-dimetylfenyl)-2-(2-oxo-1-pyrolidin
|
|
FR2677019B1
(fr)
|
1991-05-27 |
1994-11-25 |
Pf Medicament |
Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique.
|
|
US5106856A
(en)
*
|
1991-06-07 |
1992-04-21 |
Hoechst-Roussel Pharmaceuticals Inc. |
[(Arylalkylpiperidin-4-yl)methyl]-2a,3,4,5-tetrahydro-1(2H)-acenaphthylen-1-ones and related compounds
|
|
FR2679555B1
(fr)
|
1991-07-25 |
1993-11-19 |
Fabre Medicament Pierre |
Nouveaux derives de l'uree, leur preparation et leur application en therapeutique.
|
|
CA2113115A1
(en)
|
1991-07-29 |
1993-02-18 |
Vlad E. Gregor |
Quinazoline derivatives as acetylcholinesterase inhibitors
|
|
IT1251166B
(it)
|
1991-08-09 |
1995-05-04 |
Chiesi Farma Spa |
Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono
|
|
US5246947A
(en)
*
|
1991-09-23 |
1993-09-21 |
Hoechst-Roussel Pharmaceuticals Incorporated |
Substituted pyridinylamino-1,2-benzisothiazoles and their use for treating depression
|
|
US5231093A
(en)
*
|
1991-10-01 |
1993-07-27 |
Hoechst-Roussel Pharmaceuticals Incorporated |
Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
|
|
TW263504B
(enExample)
|
1991-10-03 |
1995-11-21 |
Pfizer |
|
|
ES2042384B1
(es)
|
1991-12-26 |
1994-06-01 |
Boehringer Ingelheim Espana |
Procedimiento para obtener derivados bis-piridinicos.
|
|
EP0619814A1
(en)
|
1991-12-31 |
1994-10-19 |
Fujisawa Pharmaceutical Co., Ltd. |
Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity
|
|
AU4275793A
(en)
|
1992-02-25 |
1993-09-13 |
Warner-Lambert Company |
Cytoprotective compositions containing pyruvate and antioxidants
|
|
US5439930A
(en)
*
|
1992-04-14 |
1995-08-08 |
Russian-American Institute For New Drug Development |
Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects
|
|
IT1254996B
(it)
*
|
1992-06-25 |
1995-10-11 |
Mediolanum Farmaceutici Srl |
Esteri amminoalchilcarbammici dell'eserolina atti all'impiego come anticolinesterasici e relativo procedimento di preparazione
|
|
US5440023A
(en)
*
|
1992-09-18 |
1995-08-08 |
Beckman Instruments, Inc. |
Method for making valproic acid derivatives
|
|
EP0611769A1
(en)
|
1993-02-16 |
1994-08-24 |
Merrell Dow Pharmaceuticals Inc. |
Silylated acetylcholinesterase inhibitors
|
|
AU4982293A
(en)
|
1993-03-02 |
1994-09-26 |
Fujisawa Pharmaceutical Co., Ltd. |
Novel heterocyclic compound
|
|
EP0627400A1
(en)
|
1993-06-04 |
1994-12-07 |
Merrell Dow Pharmaceuticals Inc. |
Aromatic acetylcholinesterase inhibitors
|
|
SE9302080D0
(sv)
|
1993-06-16 |
1993-06-16 |
Ab Astra |
New compounds
|
|
GB9319732D0
(en)
*
|
1993-09-24 |
1993-11-10 |
Ucb Sa |
Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety
|
|
US5468733A
(en)
|
1993-09-30 |
1995-11-21 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
|
US5744476A
(en)
|
1994-06-27 |
1998-04-28 |
Interneuron Pharmaceuticals, Inc. |
Dopamine D1 agonists for the treatment of dementia
|
|
US5516759A
(en)
*
|
1994-12-08 |
1996-05-14 |
Tap Holdings Inc. |
LHRH antagonists having lactam groups at the N-terminus
|
|
US5603176A
(en)
|
1995-02-27 |
1997-02-18 |
Hasbro, Inc. |
Simulated suspended animation biosphere
|
|
IL118279A
(en)
|
1995-06-07 |
2006-10-05 |
Abbott Lab |
Compounds 3 - Pyridyloxy (or Thio) Alkyl Heterocyclic Pharmaceutical Compositions Containing Them and Their Uses for Preparing Drugs to Control Synaptic Chemical Transmission
|
|
IL115113A
(en)
|
1995-08-31 |
2002-11-10 |
Israel State |
3-carbamoyloxy pyridinium derivatives and pharmaceutical compositions containing them
|
|
ES2100129B1
(es)
|
1995-10-11 |
1998-02-16 |
Medichem Sa |
Nuevos compuestos aminopiridinicos policiclicos inhibidores de acetilcolinesterasa, procedimiento para su preparacion y su utilizacion.
|
|
ES2197255T3
(es)
|
1995-11-17 |
2004-01-01 |
MERCK & CO. INC. |
Nuevos compuestos de arilo sustituido utiles como moduladores de los receptores de acetilcolina.
|
|
US5783584A
(en)
|
1995-12-11 |
1998-07-21 |
Mayo Foundation For Medical Education And Research |
THA analogs useful as cholinesterase inhibitors
|
|
GB9606736D0
(en)
|
1996-02-19 |
1996-06-05 |
Shire International Licensing |
Therapeutic method
|
|
EP0892796B1
(en)
|
1996-04-12 |
2001-10-24 |
Aventis Pharmaceuticals Inc. |
Isatin derivatives as acetylcholinesterase inhibitors and analgesics
|
|
WO1997046526A1
(en)
|
1996-06-07 |
1997-12-11 |
Eisai Co., Ltd. |
Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
|
|
TW513409B
(en)
|
1996-06-07 |
2002-12-11 |
Eisai Co Ltd |
Polymorphs of donepezil hydrochloride
|
|
CA2180703A1
(en)
|
1996-07-08 |
1998-01-09 |
Paul Marie Victor Gilis |
Fast-dissolving galanthamine hydrobromide tablet
|
|
AU4078997A
(en)
|
1996-08-22 |
1998-03-06 |
New York University |
Cholinesterase inhibitors for treatment of parkinson's disease
|
|
IT1285801B1
(it)
*
|
1996-10-10 |
1998-06-24 |
Sigma Tau Ind Farmaceuti |
Procedimento migliorato per la preparazione dell'acido valproico
|
|
AU5716898A
(en)
|
1997-01-08 |
1998-08-03 |
Warner-Lambert Company |
Acetylcholinesterase inhibitors in combination with muscarinic agonists for the treatment of alzheimer's disease
|
|
DK0971713T3
(da)
|
1997-03-03 |
2003-09-22 |
Eisai Co Ltd |
Anvendelse af cholinesteraseinhibitorer til behandling af opmærksomhedsforstyrrelser
|
|
GB9716879D0
(en)
|
1997-08-08 |
1997-10-15 |
Shire Int Licensing Bv |
Treatment of attention deficit disorders
|
|
AU8742198A
(en)
|
1997-08-15 |
1999-03-08 |
Shire International Licensing B.V. |
Use of cholinesterase inhibitor for treating diseases associated with pro teolytic enzyme activity
|
|
US6479523B1
(en)
|
1997-08-26 |
2002-11-12 |
Emory University |
Pharmacologic drug combination in vagal-induced asystole
|
|
EP1048653B1
(en)
|
1997-12-05 |
2004-03-03 |
Eisai Co., Ltd. |
Donepezil polycrystals and process for producing the same
|
|
US6131106A
(en)
*
|
1998-01-30 |
2000-10-10 |
Sun Microsystems Inc |
System and method for floating-point computation for numbers in delimited floating point representation
|
|
GB9805561D0
(en)
|
1998-03-16 |
1998-05-13 |
Merck Sharp & Dohme |
A combination of therapeutic agents
|
|
US6262081B1
(en)
|
1998-07-10 |
2001-07-17 |
Dupont Pharmaceuticals Company |
Composition for and method of treating neurological disorders
|
|
US6218383B1
(en)
|
1998-08-07 |
2001-04-17 |
Targacept, Inc. |
Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
|
|
IL125809A
(en)
|
1998-08-17 |
2005-08-31 |
Finetech Lab Ltd |
Process and intermediates for production of donepezil and related compounds
|
|
IT1304904B1
(it)
|
1998-09-11 |
2001-04-05 |
Eisai Co Ltd |
Derivati anticolinesterasici per il trattamento delle sindromidolorose funzionali e/o organiche
|
|
IL142588A0
(en)
|
1998-10-16 |
2002-03-10 |
Janssen Pharmaceutica Nv |
Therapy for improving cognition
|
|
AU1738800A
(en)
|
1998-11-23 |
2000-06-13 |
Bonnie Davis |
Dosage formulations for acetylcholinesterase inhibitors
|
|
ATE306264T1
(de)
|
1998-12-11 |
2005-10-15 |
Bonnie M Davis |
Verwendung von acetylcholinesterase inhibitoren zur modulierung der hypothalamus-hypophysen- gonadenachse
|
|
US6277866B1
(en)
*
|
1999-03-03 |
2001-08-21 |
Eisai Co., Ltd. |
1-benzyl-4[(5,6-dimethoxy-2-fluoro-1-indanon)-2-yl]methylpiperidine
|
|
JP4242032B2
(ja)
|
1999-03-03 |
2009-03-18 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
４−置換ピペリジン誘導体フッ化物
|
|
ES2211056T3
(es)
|
1999-03-31 |
2004-07-01 |
Eisai Co., Ltd. |
Composiciones estabilizadas que contienen farmacos nootropicos.
|
|
EP1050303A3
(en)
|
1999-04-27 |
2003-01-15 |
Pfizer Products Inc. |
Methods and compositions for treating age-related behavioral disorders in companion animals
|
|
US6524616B1
(en)
|
1999-06-25 |
2003-02-25 |
Wake Forest University Health Services |
Compositions and methods for treating or preventing neurodegeneration and cognitive decline and dysfunction associated with alzheimer's disease, aging, other dementia related disorders and estrogen deficiency related conditions
|
|
JP4242048B2
(ja)
|
1999-09-01 |
2009-03-18 |
エーザイ・アール・アンド・ディー・マネジメント株式会社 |
４−置換ピペリジン誘導体
|
|
CN1167682C
(zh)
|
1999-09-22 |
2004-09-22 |
先灵公司 |
毒蕈碱拮抗剂
|
|
GB0004297D0
(en)
|
2000-02-23 |
2000-04-12 |
Ucb Sa |
2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
|
|
WO2001066114A1
(en)
|
2000-03-03 |
2001-09-13 |
Eisai Co., Ltd. |
Novel methods using cholinesterase inhibitors
|
|
US20030144255A1
(en)
|
2000-03-06 |
2003-07-31 |
Bain Allen I |
Compositions for prevention and treatment of dementia
|
|
US6706741B2
(en)
|
2000-04-13 |
2004-03-16 |
Eisai Co., Ltd. |
Acetylcholinesterase inhibitors containing 1-benzyl-pyridinium salts
|
|
US20010036949A1
(en)
|
2000-05-09 |
2001-11-01 |
Coe Jotham Wadsworth |
Pharmaceutical composition and method of treatment of diseases of cognitive dysfunction in a mammal
|
|
US6756385B2
(en)
*
|
2000-07-31 |
2004-06-29 |
Pfizer Inc. |
Imidazole derivatives
|
|
US20020151591A1
(en)
|
2000-10-17 |
2002-10-17 |
Anabella Villalobos |
Combination use of acetylcholinesterase inhibitors and GABAa inverse agonists for the treatment of cognitive disorders
|
|
CN1484527A
(zh)
*
|
2000-12-28 |
2004-03-24 |
��һ��������ҩ��ʽ���� |
神经性疼痛治疗和预防药
|
|
US6610326B2
(en)
*
|
2001-02-16 |
2003-08-26 |
Andrx Corporation |
Divalproex sodium tablets
|
|
JP2004523557A
(ja)
*
|
2001-02-23 |
2004-08-05 |
ジョンズ・ホプキンス・ユニバーシティ |
チック、振せん、および関連疾患の治療
|
|
EP1372620A2
(en)
|
2001-03-15 |
2004-01-02 |
Saegis Pharmaceuticals |
Methods for restoring cognitive function following systemic stress
|
|
DE60208630T2
(de)
*
|
2001-05-11 |
2006-08-17 |
Pfizer Products Inc., Groton |
Thiazolderivate und ihre Verwendung als cdk-Inhibitoren
|
|
EP1395560A1
(en)
|
2001-05-23 |
2004-03-10 |
Ucb, S.A. |
2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivativ es for the treatment of epilepsy and other neurological disorders
|
|
US8354438B2
(en)
|
2001-08-08 |
2013-01-15 |
Michael Chez |
Neurological functions
|
|
US20040192759A1
(en)
*
|
2001-08-22 |
2004-09-30 |
Eiichi Otomo |
Use of nefiracetam for treating neurodegeneration
|
|
WO2003020289A1
(en)
|
2001-08-30 |
2003-03-13 |
Ortho-Mcneil Pharmaceutical, Inc. |
Treatment of dementia and memory disorders with anticonvulsants and acetylcholinesterase inhibitors
|
|
US6495700B1
(en)
|
2002-01-09 |
2002-12-17 |
Axonyx, Inc. |
Process for producing phenserine and its analog
|
|
US6759552B2
(en)
|
2002-03-28 |
2004-07-06 |
Council Of Scientific And Industrial Research |
Compound as cholinesterase inhibitor and its isolation from fungus sporotrichum species
|
|
WO2003082820A1
(en)
|
2002-03-29 |
2003-10-09 |
Eisai Co., Ltd. |
(1-indanone)-(1,2,3,6-tetrahydropyridine) derivative
|
|
ES2315494T3
(es)
|
2002-04-26 |
2009-04-01 |
Schering Corporation |
Antagonistas muscarinicos.
|
|
AU2003298514A1
(en)
|
2002-05-17 |
2004-05-04 |
Eisai Co., Ltd. |
Methods and compositions using cholinesterase inhibitors
|
|
EP1509232B1
(en)
|
2002-05-31 |
2008-11-19 |
H. Lundbeck A/S |
A combination of an nmda-antagonist and acetylcholine esterase inhibitors for the treatment of alzheimer's disease
|
|
US20040116506A1
(en)
*
|
2002-06-20 |
2004-06-17 |
Krusz John Claude |
Use of levetiracetam for treating or preventing acute headaches
|
|
US7557137B2
(en)
*
|
2002-08-05 |
2009-07-07 |
Bristol-Myers Squibb Company |
Gamma-lactams as beta-secretase inhibitors
|
|
US7635709B2
(en)
|
2002-09-26 |
2009-12-22 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Compositions and methods for bowel care in individuals with chronic intestinal pseudo-obstruction
|
|
GB0223494D0
(en)
|
2002-10-09 |
2002-11-13 |
Neuropharma Sa |
Dual binding site acetylcholinesterase inhibitors for the treatment of alzheimer's disease
|
|
AU2003274353B2
(en)
*
|
2002-10-24 |
2007-04-05 |
Merz Pharma Gmbh & Co. Kgaa |
Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors
|
|
NZ540288A
(en)
|
2002-11-22 |
2009-06-26 |
Univ Johns Hopkins |
Target for therapy of cognitive impairment
|
|
US7090985B2
(en)
*
|
2002-12-03 |
2006-08-15 |
Ucb, S.A. |
Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases
|
|
WO2004051222A2
(en)
*
|
2002-12-03 |
2004-06-17 |
Ucb, S.A. |
Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases
|
|
WO2004052348A2
(en)
|
2002-12-11 |
2004-06-24 |
Pharmacia & Upjohn Company Llc |
Treatment of diseases with combinations of alpha 7 nicotinic acetylcholine receptor agonists and other compounds
|
|
MXPA05009435A
(es)
|
2003-03-06 |
2005-11-23 |
Celgene Corp |
Metodos de uso y composiciones que contienen medicamentos inhibidores selectivos de citocina para el tratamiento y manejo de alteraciones del sistema nervioso central.
|
|
ITMI20030573A1
(it)
*
|
2003-03-24 |
2004-09-25 |
Nikem Research Srl |
Composti ad azione nootropica, loro preparazione,
|
|
US20040191334A1
(en)
|
2003-03-24 |
2004-09-30 |
Pang-Chui Shaw |
Use of transhinone derivates as cholinesterase inhibitors in treating related diseases
|
|
TW200508197A
(en)
|
2003-03-31 |
2005-03-01 |
Ucb Sa |
Indolone-acetamide derivatives, processes for preparing them and their uses
|
|
US7732162B2
(en)
*
|
2003-05-05 |
2010-06-08 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
|
|
AR044152A1
(es)
*
|
2003-05-09 |
2005-08-24 |
Bayer Corp |
Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
|
|
GB0322140D0
(en)
|
2003-09-22 |
2003-10-22 |
Pfizer Ltd |
Combinations
|
|
EP2269608A3
(en)
|
2003-10-16 |
2011-02-16 |
NeuroSearch AS |
Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor
|
|
JP4676961B2
(ja)
|
2003-10-21 |
2011-04-27 |
コルシド・ファーマシューティカルズ・インコーポレイテッド |
コリンエステラーゼを阻害し、薬理活性物質を放出するカルバモイルエステル類
|
|
WO2005054188A1
(en)
|
2003-12-02 |
2005-06-16 |
Ucb, S.A. |
Imidazole derivatives, processes for preparing them and their uses
|
|
US20050222123A1
(en)
|
2004-01-27 |
2005-10-06 |
North Shore-Long Island Jewish Research Institute |
Cholinesterase inhibitors for treating inflammation
|
|
WO2005074535A2
(en)
|
2004-01-30 |
2005-08-18 |
Eisai Co., Ltd. |
Cholinesterase inhibitors for spinal cord disorders
|
|
US20050182044A1
(en)
|
2004-02-17 |
2005-08-18 |
Bruinsma Gosse B. |
Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
|
|
US20070213388A1
(en)
|
2004-03-19 |
2007-09-13 |
Bruinsma Gosse B |
Acetylcholinesterase Inhibitors and N-Methyl-D-Aspartate Antagonists Useful in the Treatment of of Cognitive Disorders
|
|
WO2006034196A1
(en)
*
|
2004-09-17 |
2006-03-30 |
Lifelike Biomatic Inc. |
Compositions for enhancing memory and methods therefor
|
|
US9186345B2
(en)
|
2004-10-12 |
2015-11-17 |
Hakon Hakonarson |
Method of treating skin diseases
|
|
WO2006060082A1
(en)
|
2004-10-22 |
2006-06-08 |
THE GOVERNMENT OF THE U.S.A. as represented by THE SEC., DEPT. OF HEALTH & HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH |
Tricyclic compounds, preparation thereof and use thereof as cholinesterase activity inhibitors
|
|
WO2006071274A2
(en)
|
2004-12-23 |
2006-07-06 |
Voyager Pharmaceutical Corporation |
Leuprolide acetate and acetylcholinesterase inhibitors or nmda receptor antagonists for the treatment of alzheimer’s disease
|
|
WO2006070394A1
(en)
|
2004-12-28 |
2006-07-06 |
Council Of Scientific And Industrial Research |
Substituted carbamic acid quinolin-6-yl esters useful as acetylcholinesterase inhibitors
|
|
WO2006076569A2
(en)
*
|
2005-01-12 |
2006-07-20 |
Bristol-Myers Squibb Company |
Bicyclic heterocycles as cannabinoid receptor modulators
|
|
FR2881618B1
(fr)
|
2005-02-10 |
2007-04-13 |
Centre Nat Rech Scient |
Utilisation de composes derives de pyrimidinetrione en tant qu'inhibiteurs de l'acetylcholinesterase, compositions contenant ces derives et leurs utilisations en tant qu'insecticides
|
|
WO2006102750A1
(en)
*
|
2005-03-30 |
2006-10-05 |
Genpharm Inc. |
Combined-step process for pharmaceutical compositions
|
|
JP5666087B2
(ja)
*
|
2005-04-06 |
2015-02-12 |
アダマス・ファーマシューティカルズ・インコーポレーテッド |
Ｃｎｓ関連疾患の治療のための方法及び組成物
|
|
JP2008542323A
(ja)
|
2005-06-01 |
2008-11-27 |
ユセベ ファルマ ソシエテ アノニム |
２−オキソ−１−ピロリジン誘導体、その製造方法及びその使用
|
|
EP1731149A1
(en)
*
|
2005-06-08 |
2006-12-13 |
Ucb S.A. |
Use of 2-oxo-1-pyrrolidone derivatives for the treatment of diseases characterized by progressive myoclonic epilepsy
|
|
EP2682481A3
(en)
|
2005-08-03 |
2014-09-17 |
The Johns-Hopkins University |
Methods for characterizing and treating cognitive impairment in aging and disease
|
|
GB0517740D0
(en)
*
|
2005-08-31 |
2005-10-12 |
Novartis Ag |
Organic compounds
|
|
US20090018148A1
(en)
*
|
2005-12-07 |
2009-01-15 |
Ucb Pharma, S.A. |
Xanthine Derivatives, Processes For Preparing Them And Their Uses
|
|
US20100216734A1
(en)
*
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
|
EP2001463B1
(en)
|
2006-03-20 |
2013-07-03 |
Council of Scientific and Industrial Research |
A pharmaceutical composition useful as acetyl cholinesterase inhibitors
|
|
WO2007127474A2
(en)
|
2006-04-28 |
2007-11-08 |
Northwestern University |
Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
|
|
WO2007134077A2
(en)
*
|
2006-05-09 |
2007-11-22 |
Braincells, Inc. |
5 ht receptor mediated neurogenesis
|
|
US7858611B2
(en)
*
|
2006-05-09 |
2010-12-28 |
Braincells Inc. |
Neurogenesis by modulating angiotensin
|
|
US20080014271A1
(en)
*
|
2006-07-13 |
2008-01-17 |
Ucb, S.A. |
Novel pharmaceutical compositions comprising levetiracetam
|
|
WO2008021666A2
(en)
*
|
2006-08-18 |
2008-02-21 |
Morton Grove Pharmaceuticals, Inc. |
Stable liquid levetiracetam compositions and methods
|
|
US20080103105A1
(en)
*
|
2006-09-22 |
2008-05-01 |
Braincells, Inc. |
HMG CoA REDUCTASE MEDIATED MODULATION OF NEUROGENESIS
|
|
BRPI0718437A2
(pt)
|
2006-10-27 |
2013-11-19 |
Medivation Neurology Inc |
Métodos e terapias de combinação para tratar a doença de alzheimer usando, entre outros, dimebon e dolepezil
|
|
EP2114166A4
(en)
|
2006-12-11 |
2011-05-25 |
Reviva Pharmaceuticals Inc |
COMPOSITIONS, SYNTHESIS, AND METHODS OF USING INDANONE-BASED CHOLINESTERASE INHIBITORS
|
|
WO2008074896A1
(en)
|
2006-12-21 |
2008-06-26 |
Prendergast Patrick T |
Compositions and methods for treatment of chronic neurological disorders
|
|
MX2009008288A
(es)
|
2007-02-02 |
2009-12-01 |
Colucid Pharmaceuticals Inc |
Compuestos que inhiben la colinesterasa.
|
|
WO2008095221A1
(en)
*
|
2007-02-07 |
2008-08-14 |
Gosforth Centre (Holdings) Pty Ltd |
Treatment of adhd
|
|
WO2008132142A2
(en)
|
2007-04-27 |
2008-11-06 |
Ucb Pharma S.A. |
New heterocyclic derivatives useful for the treatment of cns disorders
|
|
US7846930B2
(en)
|
2007-05-18 |
2010-12-07 |
Janssen Pharmaceutica Nv |
Diaryl-substituted tetrahydroisoquinolines as histamine H3 receptor and serotonin transporter modulators
|
|
RU2339620C1
(ru)
|
2007-07-09 |
2008-11-27 |
Общество С Ограниченной Ответственностью "Фармвинг" |
Оксалат n, n-диметил-2-n, n-диметиламинометилпиридил-3-карбамат, обладающий антихолинэстеразной активностью и способностью улучшать когнитивные функции
|
|
EP2164489A2
(en)
*
|
2007-07-13 |
2010-03-24 |
Eisai R&D Management Co., Ltd. |
Combination of ampa receptor antagonists and acetylcholinesterase inhibitors for the treatment of neuropathic pain
|
|
US20090176740A1
(en)
*
|
2007-11-30 |
2009-07-09 |
Phillips Ii Dauglas James |
Treatment of neurological conditions by the co-administration of aniracetam and l-alpha glycerylphosphorylcholine
|
|
US20110212944A1
(en)
|
2008-07-01 |
2011-09-01 |
Julie Liu |
2-oxo-1-pyrrolidine derivatives
|
|
US9125898B2
(en)
*
|
2008-11-14 |
2015-09-08 |
Neurotune Ag |
Acetam derivatives for pain relief
|
|
US20100125094A1
(en)
|
2008-11-17 |
2010-05-20 |
Auspex Pharmaceuticals, Inc. |
Pyrrolidinyl modulators of nicotinic acetylcholine receptors
|
|
US20100172979A1
(en)
*
|
2008-12-24 |
2010-07-08 |
Zhongshui Yu |
Controlled-release formulations
|
|
US8846411B2
(en)
|
2009-06-11 |
2014-09-30 |
Microgenics Corporation |
Derivatives, reagents, and immunoassay for detecting levetiracetam
|