WO2008092072A3 - Modulators of the metabotropic glutamate receptor subtype 5 and uses thereof - Google Patents

Modulators of the metabotropic glutamate receptor subtype 5 and uses thereof Download PDF

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Publication number
WO2008092072A3
WO2008092072A3 PCT/US2008/052032 US2008052032W WO2008092072A3 WO 2008092072 A3 WO2008092072 A3 WO 2008092072A3 US 2008052032 W US2008052032 W US 2008052032W WO 2008092072 A3 WO2008092072 A3 WO 2008092072A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
glutamate receptor
metabotropic glutamate
pharmaceutically acceptable
receptor subtype
Prior art date
Application number
PCT/US2008/052032
Other languages
French (fr)
Other versions
WO2008092072A2 (en
Inventor
Amy Hauck Newman
Santosh Shripad Kulkarni
Original Assignee
Us Gov Health & Human Serv
Amy Hauck Newman
Santosh Shripad Kulkarni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Amy Hauck Newman, Santosh Shripad Kulkarni filed Critical Us Gov Health & Human Serv
Publication of WO2008092072A2 publication Critical patent/WO2008092072A2/en
Publication of WO2008092072A3 publication Critical patent/WO2008092072A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Disclosed are compounds and pharmaceutically acceptable salts, which are modulators of the metabotropic glutamate receptor 5, for use in treating drug abuse and other mental disorders, for example, a compound of Formula (I), wherein X, Y, and R1-R4 are as described or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions and methods of use thereof, which involves administering a therapeutically effective amount of a compound or pharmaceutically acceptable salt to a patient.
PCT/US2008/052032 2007-01-26 2008-01-25 Modulators of the metabotropic glutamate receptor subtype 5 and uses thereof WO2008092072A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88669907P 2007-01-26 2007-01-26
US60/886,699 2007-01-26

Publications (2)

Publication Number Publication Date
WO2008092072A2 WO2008092072A2 (en) 2008-07-31
WO2008092072A3 true WO2008092072A3 (en) 2008-11-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/052032 WO2008092072A2 (en) 2007-01-26 2008-01-25 Modulators of the metabotropic glutamate receptor subtype 5 and uses thereof

Country Status (1)

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WO (1) WO2008092072A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008319308B2 (en) * 2007-10-31 2013-01-31 Merck Sharp & Dohme Corp. P2X3, receptor antagonists for treatment of pain
WO2011035174A1 (en) 2009-09-17 2011-03-24 Vanderbilt University Substituted heteroarylamine carboxamide analogs as mglur5 negative allosteric modulators and methods of making and using the same
CA2828877A1 (en) * 2011-03-03 2012-09-07 Vanderbilt University 6-alkyl-n-(pyridin-2-yl)-4-aryloxypicolinamide analogs as mglur5 negative allosteric modulators and methods of making and using the same
CA2931097A1 (en) 2013-11-19 2015-05-28 Vanderbilt University Substituted imidazopyridine and triazolopyridine compounds as negative allosteric modulators of mglur5
US9533982B2 (en) 2014-03-20 2017-01-03 Vanderbilt University Substituted bicyclic heteroaryl carboxamide analogs as mGluR5 negative allosteric modulators
US9550778B2 (en) 2014-10-03 2017-01-24 Vanderbilt University Substituted 6-aryl-imidazopyridine and 6-aryl-triazolopyridine carboxamide analogs as negative allosteric modulators of mGluR5
US20230146180A1 (en) * 2020-02-11 2023-05-11 Syngenta Crop Protection Ag Pesticidally active cyclic amine compounds
WO2023043823A1 (en) * 2021-09-14 2023-03-23 Vanderbilt University Phenyl core compounds as mglu5 negative allosteric modulators and methods of making and using the same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005079802A1 (en) * 2004-02-12 2005-09-01 Merck & Co., Inc. Bipyridyl amides as modulators of metabotropic glutamate receptor-5

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005079802A1 (en) * 2004-02-12 2005-09-01 Merck & Co., Inc. Bipyridyl amides as modulators of metabotropic glutamate receptor-5

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KULKARNI ET AL: "Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 16, no. 13, 1 July 2006 (2006-07-01), pages 3371 - 3375, XP005461926, ISSN: 0960-894X *
KULKARNI ET AL: "Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 17, no. 7, 4 January 2007 (2007-01-04), pages 2074 - 2079, XP005922544, ISSN: 0960-894X *

Also Published As

Publication number Publication date
WO2008092072A2 (en) 2008-07-31

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