JP2013515729A5 - - Google Patents
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- JP2013515729A5 JP2013515729A5 JP2012546092A JP2012546092A JP2013515729A5 JP 2013515729 A5 JP2013515729 A5 JP 2013515729A5 JP 2012546092 A JP2012546092 A JP 2012546092A JP 2012546092 A JP2012546092 A JP 2012546092A JP 2013515729 A5 JP2013515729 A5 JP 2013515729A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolo
- fluoro
- pyridin
- aminocyclohexylamino
- ylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 pyrazol-4-yl Chemical group 0.000 claims description 34
- 150000001875 compounds Chemical class 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 22
- GKECDORWWXXNRY-UHFFFAOYSA-N 2h-pyridin-3-one Chemical compound O=C1CN=CC=C1 GKECDORWWXXNRY-UHFFFAOYSA-N 0.000 claims description 4
- BSLMYSMDBCERIF-LLVKDONJSA-N (2r)-2-[[7-fluoro-4-(5-methylfuran-2-yl)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C1=CC=C(C)O1 BSLMYSMDBCERIF-LLVKDONJSA-N 0.000 claims description 3
- FGNXLVIOOATBPG-CYBMUJFWSA-N (2r)-2-[(7-fluoro-3-oxo-4-pyrazolo[1,5-a]pyridin-3-yl-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl)amino]-4-methylpentanamide Chemical compound C1=NN2C=CC=CC2=C1C1=C(C(=O)NC2)C2=C(F)C(N[C@H](CC(C)C)C(N)=O)=N1 FGNXLVIOOATBPG-CYBMUJFWSA-N 0.000 claims description 2
- JJLZPPPPMCXNMR-SNVBAGLBSA-N (2r)-2-[(7-fluoro-3-oxo-4-thiophen-2-yl-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl)amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C1=CC=CS1 JJLZPPPPMCXNMR-SNVBAGLBSA-N 0.000 claims description 2
- CIGKEEPNOLLPRK-LLVKDONJSA-N (2r)-2-[(7-fluoro-3-oxo-4-thiophen-3-yl-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl)amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C=1C=CSC=1 CIGKEEPNOLLPRK-LLVKDONJSA-N 0.000 claims description 2
- XXXHWWOKBAILHE-CQSZACIVSA-N (2r)-2-[[4-(1-benzofuran-3-yl)-7-fluoro-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C1=CC=C2C(C=3N=C(C(=C4CNC(=O)C4=3)F)N[C@H](CC(C)C)C(N)=O)=COC2=C1 XXXHWWOKBAILHE-CQSZACIVSA-N 0.000 claims description 2
- KDUTVDRIWILGKD-CYBMUJFWSA-N (2r)-2-[[4-(1-cyclopropylpyrazol-4-yl)-7-fluoro-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C(=C1)C=NN1C1CC1 KDUTVDRIWILGKD-CYBMUJFWSA-N 0.000 claims description 2
- HZWOOJCFQCXZBU-LLVKDONJSA-N (2r)-2-[[4-(4-cyanothiophen-2-yl)-7-fluoro-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C1=CC(C#N)=CS1 HZWOOJCFQCXZBU-LLVKDONJSA-N 0.000 claims description 2
- JTHONIAHQFULQN-LLVKDONJSA-N (2r)-2-[[4-(5-cyanothiophen-2-yl)-7-fluoro-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C1=CC=C(C#N)S1 JTHONIAHQFULQN-LLVKDONJSA-N 0.000 claims description 2
- XRGNIAJRYCAFFV-SNVBAGLBSA-N (2r)-2-[[4-[1-(difluoromethyl)pyrazol-4-yl]-7-fluoro-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C=1C=NN(C(F)F)C=1 XRGNIAJRYCAFFV-SNVBAGLBSA-N 0.000 claims description 2
- MBLSIKKPQOPSNQ-SECBINFHSA-N (2r)-2-[[7-fluoro-3-oxo-4-(1,3-thiazol-5-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C1=CN=CS1 MBLSIKKPQOPSNQ-SECBINFHSA-N 0.000 claims description 2
- BAWQWVQBXIDYII-LLVKDONJSA-N (2r)-2-[[7-fluoro-4-(1-methylpyrazol-4-yl)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C=1C=NN(C)C=1 BAWQWVQBXIDYII-LLVKDONJSA-N 0.000 claims description 2
- ORFPWEPWRPUBLL-GFCCVEGCSA-N (2r)-2-[[7-fluoro-4-(1-methylpyrazol-4-yl)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-n,4-dimethylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(=O)NC)=NC=1C=1C=NN(C)C=1 ORFPWEPWRPUBLL-GFCCVEGCSA-N 0.000 claims description 2
- KUOCWDDVPWWSKP-SNVBAGLBSA-N (2r)-2-[[7-fluoro-4-(2-methyl-1,3-thiazol-5-yl)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C1=CN=C(C)S1 KUOCWDDVPWWSKP-SNVBAGLBSA-N 0.000 claims description 2
- UZPROEIMLUTQLE-LLVKDONJSA-N (2r)-2-[[7-fluoro-4-(4-methylthiophen-2-yl)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C1=CC(C)=CS1 UZPROEIMLUTQLE-LLVKDONJSA-N 0.000 claims description 2
- NHPYANOEODOMDL-LLVKDONJSA-N (2r)-2-[[7-fluoro-4-(5-methylthiophen-2-yl)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C1=CC=C(C)S1 NHPYANOEODOMDL-LLVKDONJSA-N 0.000 claims description 2
- GEKOIFFWMZQBDJ-SNVBAGLBSA-N (2r)-2-[[7-fluoro-4-(furan-2-yl)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C1=CC=CO1 GEKOIFFWMZQBDJ-SNVBAGLBSA-N 0.000 claims description 2
- NTOQJLGNEKUUHL-LLVKDONJSA-N (2r)-2-[[7-fluoro-4-(furan-3-yl)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]-4-methylpentanamide Chemical compound C=12C(=O)NCC2=C(F)C(N[C@H](CC(C)C)C(N)=O)=NC=1C=1C=COC=1 NTOQJLGNEKUUHL-LLVKDONJSA-N 0.000 claims description 2
- IZLQWNFMZKOICR-OAHLLOKOSA-N (2r)-4-methyl-2-[[4-(3-methylsulfonylanilino)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridin-6-yl]amino]pentanamide Chemical compound N=1C(N[C@H](CC(C)C)C(N)=O)=CC=2CNC(=O)C=2C=1NC1=CC=CC(S(C)(=O)=O)=C1 IZLQWNFMZKOICR-OAHLLOKOSA-N 0.000 claims description 2
- UXHMPPWAKKPFSX-UHFFFAOYSA-N 6-[(2-amino-3,3,3-trifluoropropyl)amino]-4-(3-methylanilino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CC1=CC=CC(NC=2C=3C(=O)NCC=3C=C(NCC(N)C(F)(F)F)N=2)=C1 UXHMPPWAKKPFSX-UHFFFAOYSA-N 0.000 claims description 2
- ZSWNYKLXHIEKMU-VIFPVBQESA-N 6-[(3s)-3-aminopyrrolidin-1-yl]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound C1=NN(C)C=C1C1=NC(N2C[C@@H](N)CC2)=C(F)C2=C1C(=O)NC2 ZSWNYKLXHIEKMU-VIFPVBQESA-N 0.000 claims description 2
- PNRLUYPLNOPXDL-MLGOLLRUSA-N 6-[[(1r,2r)-2-amino-3,3-difluorocyclohexyl]amino]-4-(1-cyclopropylpyrazol-4-yl)-7-fluoro-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound C1CCC(F)(F)[C@H](N)[C@@H]1NC1=NC(C2=CN(N=C2)C2CC2)=C(C(=O)NC2)C2=C1F PNRLUYPLNOPXDL-MLGOLLRUSA-N 0.000 claims description 2
- FCVUZQDOZYEBBN-RHSMWYFYSA-N 6-[[(1r,2r)-2-amino-3,3-difluorocyclohexyl]amino]-4-(3-methylanilino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CC1=CC=CC(NC=2C=3C(=O)NCC=3C=C(N[C@H]3[C@H](C(F)(F)CCC3)N)N=2)=C1 FCVUZQDOZYEBBN-RHSMWYFYSA-N 0.000 claims description 2
- HYXZKQNQMCBUBO-NOZJJQNGSA-N 6-[[(1r,2r)-2-amino-3,3-difluorocyclohexyl]amino]-4-[1-(difluoromethyl)pyrazol-4-yl]-7-fluoro-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound C1CCC(F)(F)[C@H](N)[C@@H]1NC1=NC(C2=CN(N=C2)C(F)F)=C(C(=O)NC2)C2=C1F HYXZKQNQMCBUBO-NOZJJQNGSA-N 0.000 claims description 2
- XOTZDLZZONOQJK-QMTHXVAHSA-N 6-[[(1r,2r)-2-amino-3,3-difluorocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound C1=NN(C)C=C1C1=NC(N[C@H]2[C@H](C(F)(F)CCC2)N)=C(F)C2=C1C(=O)NC2 XOTZDLZZONOQJK-QMTHXVAHSA-N 0.000 claims description 2
- IBRCKLBEVCEQHD-LSDHHAIUSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(1-benzofuran-3-yl)-7-fluoro-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound N[C@H]1CCCC[C@H]1NC1=NC(C=2C3=CC=CC=C3OC=2)=C(C(=O)NC2)C2=C1F IBRCKLBEVCEQHD-LSDHHAIUSA-N 0.000 claims description 2
- NLHMXERGXZJVSA-LSDHHAIUSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(1-benzothiophen-3-yl)-7-fluoro-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound N[C@H]1CCCC[C@H]1NC1=NC(C=2C3=CC=CC=C3SC=2)=C(C(=O)NC2)C2=C1F NLHMXERGXZJVSA-LSDHHAIUSA-N 0.000 claims description 2
- RBAFUBZTBXELTG-LSDHHAIUSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(1-cyclopropylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound N[C@H]1CCCC[C@H]1NC(N=C1C2=CN(N=C2)C2CC2)=CC2=C1C(=O)NC2 RBAFUBZTBXELTG-LSDHHAIUSA-N 0.000 claims description 2
- FFDWUYASOWCJJD-UONOGXRCSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(1-ethylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound C1=NN(CC)C=C1C1=NC(N[C@H]2[C@H](CCCC2)N)=CC2=C1C(=O)NC2 FFDWUYASOWCJJD-UONOGXRCSA-N 0.000 claims description 2
- BIRMRVDNUGHXQF-QWHCGFSZSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound C1=NN(C)C=C1C1=NC(N[C@H]2[C@H](CCCC2)N)=CC2=C1C(=O)NC2 BIRMRVDNUGHXQF-QWHCGFSZSA-N 0.000 claims description 2
- LOFXHRXBASKCPJ-LSDHHAIUSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(1h-indazol-6-ylamino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound N[C@H]1CCCC[C@H]1NC(N=C1NC=2C=C3NN=CC3=CC=2)=CC2=C1C(=O)NC2 LOFXHRXBASKCPJ-LSDHHAIUSA-N 0.000 claims description 2
- BCQZEYKBUNMINW-DTWKUNHWSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(2-amino-1,3-thiazol-5-yl)-7-fluoro-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound N[C@H]1CCCC[C@H]1NC1=NC(C=2SC(N)=NC=2)=C(C(=O)NC2)C2=C1F BCQZEYKBUNMINW-DTWKUNHWSA-N 0.000 claims description 2
- UITJPHZNGQVUHM-JKSUJKDBSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(3-methylanilino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CC1=CC=CC(NC=2C=3C(=O)NCC=3C=C(N[C@H]3[C@H](CCCC3)N)N=2)=C1 UITJPHZNGQVUHM-JKSUJKDBSA-N 0.000 claims description 2
- UOBUBZWFFCOCAE-DLBZAZTESA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(3-methylanilino)-3-oxo-1,2-dihydropyrrolo[3,4-c]pyridine-7-carbonitrile Chemical compound CC1=CC=CC(NC=2C=3C(=O)NCC=3C(C#N)=C(N[C@H]3[C@H](CCCC3)N)N=2)=C1 UOBUBZWFFCOCAE-DLBZAZTESA-N 0.000 claims description 2
- ZHCYNQAPDHKDTK-ZWKOTPCHSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(3-methylanilino)-7-(2-methylpyrazol-3-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CC1=CC=CC(NC=2C=3C(=O)NCC=3C(=C(N[C@H]3[C@H](CCCC3)N)N=2)C=2N(N=CC=2)C)=C1 ZHCYNQAPDHKDTK-ZWKOTPCHSA-N 0.000 claims description 2
- JCKXIUBFRBOHRV-DLBZAZTESA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(3-methylanilino)-7-prop-2-enoyl-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CC1=CC=CC(NC=2C=3C(=O)NCC=3C(C(=O)C=C)=C(N[C@H]3[C@H](CCCC3)N)N=2)=C1 JCKXIUBFRBOHRV-DLBZAZTESA-N 0.000 claims description 2
- JHMLNISRSWFRDP-JKSUJKDBSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(3-methylsulfonylanilino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CS(=O)(=O)C1=CC=CC(NC=2C=3C(=O)NCC=3C=C(N[C@H]3[C@H](CCCC3)N)N=2)=C1 JHMLNISRSWFRDP-JKSUJKDBSA-N 0.000 claims description 2
- VHBREDNCCOLHGT-JKSUJKDBSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-(4-fluoro-3-methylanilino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound C1=C(F)C(C)=CC(NC=2C=3C(=O)NCC=3C=C(N[C@H]3[C@H](CCCC3)N)N=2)=C1 VHBREDNCCOLHGT-JKSUJKDBSA-N 0.000 claims description 2
- WELNIAICBOVSLC-WDEREUQCSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-4-[1-(difluoromethyl)pyrazol-4-yl]-7-fluoro-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound N[C@H]1CCCC[C@H]1NC1=NC(C2=CN(N=C2)C(F)F)=C(C(=O)NC2)C2=C1F WELNIAICBOVSLC-WDEREUQCSA-N 0.000 claims description 2
- QGIZHMIRSUGPQA-LSDHHAIUSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-chloro-4-(3-methylanilino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CC1=CC=CC(NC=2C=3C(=O)NCC=3C(Cl)=C(N[C@H]3[C@H](CCCC3)N)N=2)=C1 QGIZHMIRSUGPQA-LSDHHAIUSA-N 0.000 claims description 2
- XLLZLRGOFITEPW-NWDGAFQWSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-1,1-dimethyl-4-(1-methylpyrazol-4-yl)-2h-pyrrolo[3,4-c]pyridin-3-one Chemical compound C1=NN(C)C=C1C1=NC(N[C@H]2[C@H](CCCC2)N)=C(F)C2=C1C(=O)NC2(C)C XLLZLRGOFITEPW-NWDGAFQWSA-N 0.000 claims description 2
- DDFCHGYRRJNLDH-CLGJWYQZSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-1-methyl-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CC1NC(=O)C(C(=N2)C3=CN(C)N=C3)=C1C(F)=C2N[C@@H]1CCCC[C@@H]1N DDFCHGYRRJNLDH-CLGJWYQZSA-N 0.000 claims description 2
- XYDQHRTVTJCMOX-WDEREUQCSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-4-(2-methyl-1,3-thiazol-5-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound S1C(C)=NC=C1C1=NC(N[C@H]2[C@H](CCCC2)N)=C(F)C2=C1C(=O)NC2 XYDQHRTVTJCMOX-WDEREUQCSA-N 0.000 claims description 2
- QSLDDROANYSPRV-LSDHHAIUSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-4-(3-methylanilino)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CC1=CC=CC(NC=2C=3C(=O)NCC=3C(F)=C(N[C@H]3[C@H](CCCC3)N)N=2)=C1 QSLDDROANYSPRV-LSDHHAIUSA-N 0.000 claims description 2
- HPFJFZGOUINWHT-NWDGAFQWSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-4-(4-methylthiophen-2-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound CC1=CSC(C=2C=3C(=O)NCC=3C(F)=C(N[C@H]3[C@H](CCCC3)N)N=2)=C1 HPFJFZGOUINWHT-NWDGAFQWSA-N 0.000 claims description 2
- JVWJCIFIORGGQG-NWDGAFQWSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-4-(5-methylthiophen-2-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound S1C(C)=CC=C1C1=NC(N[C@H]2[C@H](CCCC2)N)=C(F)C2=C1C(=O)NC2 JVWJCIFIORGGQG-NWDGAFQWSA-N 0.000 claims description 2
- NHGIXSAEPXILDH-QWHCGFSZSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-4-imidazo[1,2-a]pyridin-3-yl-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound N[C@H]1CCCC[C@H]1NC1=NC(C=2N3C=CC=CC3=NC=2)=C(C(=O)NC2)C2=C1F NHGIXSAEPXILDH-QWHCGFSZSA-N 0.000 claims description 2
- BRUXXXWLFWMGMH-UONOGXRCSA-N 6-[[(1r,2s)-2-aminocyclohexyl]amino]-7-fluoro-4-pyrazolo[1,5-a]pyridin-3-yl-1,2-dihydropyrrolo[3,4-c]pyridin-3-one Chemical compound N[C@H]1CCCC[C@H]1NC1=NC(C2=C3C=CC=CN3N=C2)=C(C(=O)NC2)C2=C1F BRUXXXWLFWMGMH-UONOGXRCSA-N 0.000 claims description 2
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