JP2013514971A5 - - Google Patents
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- Publication number
- JP2013514971A5 JP2013514971A5 JP2012543843A JP2012543843A JP2013514971A5 JP 2013514971 A5 JP2013514971 A5 JP 2013514971A5 JP 2012543843 A JP2012543843 A JP 2012543843A JP 2012543843 A JP2012543843 A JP 2012543843A JP 2013514971 A5 JP2013514971 A5 JP 2013514971A5
- Authority
- JP
- Japan
- Prior art keywords
- microparticles
- implant
- poly
- lactide
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007943 implant Substances 0.000 claims 15
- 239000011859 microparticle Substances 0.000 claims 14
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 6
- -1 copoly (ether-ester) Polymers 0.000 claims 5
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 5
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 4
- 239000004952 Polyamide Substances 0.000 claims 4
- 229920002988 biodegradable polymer Polymers 0.000 claims 4
- 239000004621 biodegradable polymer Substances 0.000 claims 4
- 229920001577 copolymer Polymers 0.000 claims 4
- 229920006237 degradable polymer Polymers 0.000 claims 4
- 229920002647 polyamide Polymers 0.000 claims 4
- JJTUDXZGHPGLLC-ZXZARUISSA-N (3r,6s)-3,6-dimethyl-1,4-dioxane-2,5-dione Chemical compound C[C@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-ZXZARUISSA-N 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 3
- 239000002726 nonnucleoside reverse transcriptase inhibitor Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- ICGQLNMKJVHCIR-UHFFFAOYSA-N 1,3,2-dioxazetidin-4-one Chemical compound O=C1ONO1 ICGQLNMKJVHCIR-UHFFFAOYSA-N 0.000 claims 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 2
- 229920002732 Polyanhydride Polymers 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 229920003232 aliphatic polyester Polymers 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229920001519 homopolymer Polymers 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims 2
- 239000002745 poly(ortho ester) Substances 0.000 claims 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 2
- 229920001281 polyalkylene Polymers 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- UJGHGRGFKZWGMS-UHFFFAOYSA-N 1,3-dioxan-2-one Chemical compound O=C1OCCCO1.O=C1OCCCO1 UJGHGRGFKZWGMS-UHFFFAOYSA-N 0.000 claims 1
- KKGSHHDRPRINNY-UHFFFAOYSA-N 1,4-dioxan-2-one Chemical compound O=C1COCCO1.O=C1COCCO1 KKGSHHDRPRINNY-UHFFFAOYSA-N 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229920000117 poly(dioxanone) Polymers 0.000 claims 1
- YIBOMRUWOWDFLG-ONEGZZNKSA-N rilpivirine Chemical compound CC1=CC(\C=C\C#N)=CC(C)=C1NC1=CC=NC(NC=2C=CC(=CC=2)C#N)=N1 YIBOMRUWOWDFLG-ONEGZZNKSA-N 0.000 claims 1
- 229960002814 rilpivirine Drugs 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 230000029305 taxis Effects 0.000 claims 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28837309P | 2009-12-21 | 2009-12-21 | |
| US61/288,373 | 2009-12-21 | ||
| PCT/EP2010/070246 WO2011080141A2 (en) | 2009-12-21 | 2010-12-20 | Degradable removable implant for the sustained release of an active compound |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013514971A JP2013514971A (ja) | 2013-05-02 |
| JP2013514971A5 true JP2013514971A5 (enExample) | 2014-02-13 |
| JP5950825B2 JP5950825B2 (ja) | 2016-07-13 |
Family
ID=43743502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543843A Active JP5950825B2 (ja) | 2009-12-21 | 2010-12-20 | 活性化合物の持続放出のための分解性の取り外し可能なインプラント |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8784858B2 (enExample) |
| EP (1) | EP2515877B1 (enExample) |
| JP (1) | JP5950825B2 (enExample) |
| KR (1) | KR101798430B1 (enExample) |
| CN (1) | CN102740837B (enExample) |
| AU (1) | AU2010338425B2 (enExample) |
| BR (1) | BR112012015114B1 (enExample) |
| CA (1) | CA2784530C (enExample) |
| ES (1) | ES2600878T3 (enExample) |
| IL (1) | IL219685B (enExample) |
| MX (1) | MX2012007210A (enExample) |
| MY (1) | MY163383A (enExample) |
| NZ (1) | NZ600156A (enExample) |
| RU (1) | RU2593790C2 (enExample) |
| SG (1) | SG181759A1 (enExample) |
| UA (1) | UA112155C2 (enExample) |
| WO (1) | WO2011080141A2 (enExample) |
| ZA (1) | ZA201204583B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2916425A1 (en) * | 2013-06-20 | 2014-12-24 | Mercy Medical Research Institute | Extended release drug-delivery contact lenses and methods of making |
| ES3015612T3 (en) | 2014-08-15 | 2025-05-06 | Univ Johns Hopkins | Composite material for tissue restoration |
| WO2016149561A1 (en) * | 2015-03-17 | 2016-09-22 | Oak Crest Institute Of Science | Subdermal implants for the sustained delivery of water-soluble drugs |
| US11779435B2 (en) | 2015-08-26 | 2023-10-10 | Flexscrewdriver I.K.E. | Dental screwdriver |
| CN106702597B (zh) * | 2016-12-20 | 2019-06-18 | 华南理工大学 | 一种核-壳结构纳米纤维膜及其制备方法和应用 |
| BR112020000506A2 (pt) | 2017-07-11 | 2020-07-14 | Sustained Nano Systems Llc | formulações farmacêuticas hipercomprimidas |
| US20210402064A1 (en) | 2018-05-09 | 2021-12-30 | The Johns Hopkins University | Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration |
| WO2019217765A1 (en) | 2018-05-09 | 2019-11-14 | The Johns Hopkins University | Nanofiber-hydrogel composites for cell and tissue delivery |
| CN112423739A (zh) * | 2018-05-16 | 2021-02-26 | 斯贝洛克斯公司 | 过敏性鼻炎药物输送植入物 |
| CN113260350A (zh) | 2018-10-16 | 2021-08-13 | 三角研究所 | 皮下可生物降解储器装置 |
| MX2022012202A (es) * | 2020-04-07 | 2022-11-09 | Res Triangle Inst | Formulaciones de múltiples fármacos para dispositivo de depósito biodegradable subcutáneo. |
| EP4151673A4 (en) * | 2020-05-12 | 2024-03-20 | Laboratorios Farmacéuticos Rovi, S.A. | METHOD FOR THE PURIFICATION OF BIODEGRADABLE THERMOPLASTIC POLYMER PARTICLES FOR MEDICAL AND/OR PHARMACEUTICAL USE |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5182111A (en) | 1987-11-17 | 1993-01-26 | Boston University Research Foundation | In vivo delivery of active factors by co-cultured cell implants |
| JPH07503943A (ja) * | 1991-10-29 | 1995-04-27 | クローバー コンソリデイテッド，リミテッド | 封入及び薬剤放出に有用な架橋性の多糖類、ポリカチオン及び脂質 |
| US5798042A (en) | 1994-03-07 | 1998-08-25 | Regents Of The University Of California | Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters |
| US5651900A (en) | 1994-03-07 | 1997-07-29 | The Regents Of The University Of California | Microfabricated particle filter |
| US5645684A (en) | 1994-03-07 | 1997-07-08 | The Regents Of The University Of California | Multilayer high vertical aspect ratio thin film structures |
| JPH09512250A (ja) * | 1994-03-07 | 1997-12-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 細胞移植体の隔離に用いる微小加工カプセル |
| US5660680A (en) | 1994-03-07 | 1997-08-26 | The Regents Of The University Of California | Method for fabrication of high vertical aspect ratio thin film structures |
| CN1378445B (zh) | 1999-08-06 | 2013-02-06 | 得克萨斯系统大学评议会 | 药物释放生物可降解纤维植入物 |
| US7033603B2 (en) | 1999-08-06 | 2006-04-25 | Board Of Regents The University Of Texas | Drug releasing biodegradable fiber for delivery of therapeutics |
| WO2001025240A1 (en) | 1999-10-06 | 2001-04-12 | Tibotec Pharmaceuticals Ltd. | HEXAHYDROFURO'2,3-B!FURAN-3-YL-N- {3'(1,3-BENZODIOXOL -5- YLSULFONYL) (ISOBUTYL) AMINO! -1-BENZYL-2-HYDROXYPROPYL} CARBAMATE AS RETROVIRAL PROTEASE INHIBITOR |
| TWI284048B (en) | 2000-01-27 | 2007-07-21 | Zentaris Ag | Compressed microparticles for dry injection |
| US20040115268A1 (en) * | 2000-04-26 | 2004-06-17 | Control Delivery Systems, Inc. | Systemic delivery of antiviral agents |
| DE10050199A1 (de) | 2000-10-11 | 2002-04-25 | Ethicon Gmbh | Flächiges Implantat mit im Ultraschall detektierbaren Elementen |
| WO2002092054A2 (en) * | 2001-05-11 | 2002-11-21 | Ortho-Mcneil Pharmaceutical, Inc. | Immune modulation device for use in animals |
| MY169670A (en) | 2003-09-03 | 2019-05-08 | Tibotec Pharm Ltd | Combinations of a pyrimidine containing nnrti with rt inhibitors |
| WO2004022033A1 (en) | 2002-09-04 | 2004-03-18 | Microchips, Inc. | Method and device for the controlled delivery of parathyroid hormone |
| US20040156878A1 (en) | 2003-02-11 | 2004-08-12 | Alireza Rezania | Implantable medical device seeded with mammalian cells and methods of treatment |
| TW201414495A (zh) * | 2005-04-04 | 2014-04-16 | Tibotec Pharm Ltd | Ｈｉｖ-感染之預防 |
| CA2603851A1 (en) | 2005-04-11 | 2006-10-19 | The Board Of Trustees Of The Leland Stanford Junior Unversity | Multi-layer structure having a predetermined layer pattern including an agent |
| US20060252049A1 (en) | 2005-05-04 | 2006-11-09 | Shuler Richard O | Growth-promoting and immunizing subcutaneous implant |
| US7261529B2 (en) | 2005-09-07 | 2007-08-28 | Southwest Research Institute | Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents |
| PL1981506T6 (pl) * | 2006-01-20 | 2021-07-12 | Janssen Sciences Ireland Uc | Długoterminowe leczenie zakażenia HIV z zastosowaniem TCM278 |
| US20080081064A1 (en) * | 2006-09-28 | 2008-04-03 | Surmodics, Inc. | Implantable Medical Device with Apertures for Delivery of Bioactive Agents |
| WO2008156632A1 (en) * | 2007-06-12 | 2008-12-24 | Concert Pharmaceuticals, Inc. | Azapeptide derivatives |
| WO2009046299A2 (en) | 2007-10-04 | 2009-04-09 | Boston Scientific Scimed, Inc | Implantable drug depot for intrathecal drug delivery system for pain management |
| US20110257111A1 (en) * | 2008-10-24 | 2011-10-20 | Harbeson Scott L | Hydroxyethlamino Sulfonamide Derivatives |
| CN102711834B (zh) | 2008-12-24 | 2015-08-26 | 爱尔兰詹森科学公司 | 治疗hiv的可植入装置 |
-
2010
- 2010-12-20 ES ES10803585.8T patent/ES2600878T3/es active Active
- 2010-12-20 NZ NZ600156A patent/NZ600156A/en not_active IP Right Cessation
- 2010-12-20 US US13/515,380 patent/US8784858B2/en active Active
- 2010-12-20 AU AU2010338425A patent/AU2010338425B2/en active Active
- 2010-12-20 SG SG2012044541A patent/SG181759A1/en unknown
- 2010-12-20 MX MX2012007210A patent/MX2012007210A/es active IP Right Grant
- 2010-12-20 JP JP2012543843A patent/JP5950825B2/ja active Active
- 2010-12-20 CA CA2784530A patent/CA2784530C/en active Active
- 2010-12-20 EP EP10803585.8A patent/EP2515877B1/en active Active
- 2010-12-20 KR KR1020127016179A patent/KR101798430B1/ko active Active
- 2010-12-20 UA UAA201206035A patent/UA112155C2/uk unknown
- 2010-12-20 WO PCT/EP2010/070246 patent/WO2011080141A2/en not_active Ceased
- 2010-12-20 RU RU2012131282/15A patent/RU2593790C2/ru active
- 2010-12-20 BR BR112012015114-2A patent/BR112012015114B1/pt not_active IP Right Cessation
- 2010-12-20 CN CN201080058303.9A patent/CN102740837B/zh not_active Expired - Fee Related
- 2010-12-20 MY MYPI2012002730A patent/MY163383A/en unknown
-
2012
- 2012-05-09 IL IL219685A patent/IL219685B/en active IP Right Grant
- 2012-06-20 ZA ZA2012/04583A patent/ZA201204583B/en unknown
-
2014
- 2014-06-10 US US14/300,607 patent/US10744235B2/en active Active
-
2020
- 2020-06-30 US US16/917,269 patent/US11395867B2/en active Active
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