JP2013513802A5 - - Google Patents
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- Publication number
- JP2013513802A5 JP2013513802A5 JP2012543290A JP2012543290A JP2013513802A5 JP 2013513802 A5 JP2013513802 A5 JP 2013513802A5 JP 2012543290 A JP2012543290 A JP 2012543290A JP 2012543290 A JP2012543290 A JP 2012543290A JP 2013513802 A5 JP2013513802 A5 JP 2013513802A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- ions
- sample
- ion
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002500 ions Chemical class 0.000 claims 66
- 239000002243 precursor Substances 0.000 claims 22
- 239000000523 sample Substances 0.000 claims 20
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 19
- 238000000034 method Methods 0.000 claims 18
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 11
- 238000004949 mass spectrometry Methods 0.000 claims 10
- -1 vitamin D 2 ions Chemical class 0.000 claims 9
- 238000000605 extraction Methods 0.000 claims 8
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 4
- 239000012472 biological sample Substances 0.000 claims 4
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims 4
- 238000004885 tandem mass spectrometry Methods 0.000 claims 4
- 238000004458 analytical method Methods 0.000 claims 2
- 238000013467 fragmentation Methods 0.000 claims 2
- 238000006062 fragmentation reaction Methods 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 238000004811 liquid chromatography Methods 0.000 claims 2
- 238000002552 multiple reaction monitoring Methods 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000004611 spectroscopical analysis Methods 0.000 claims 1
- 239000011710 vitamin D Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28593809P | 2009-12-11 | 2009-12-11 | |
| US28594309P | 2009-12-11 | 2009-12-11 | |
| US61/285,938 | 2009-12-11 | ||
| US61/285,943 | 2009-12-11 | ||
| PCT/US2010/059765 WO2011072163A1 (en) | 2009-12-11 | 2010-12-09 | Mass spectrometric determination of non-derivatized, non-metabolized vitamin d |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015152480A Division JP6290145B2 (ja) | 2009-12-11 | 2015-07-31 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013513802A JP2013513802A (ja) | 2013-04-22 |
| JP2013513802A5 true JP2013513802A5 (https=) | 2014-01-30 |
| JP6113504B2 JP6113504B2 (ja) | 2017-04-12 |
Family
ID=44145925
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012543290A Active JP6113504B2 (ja) | 2009-12-11 | 2010-12-09 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP2015152480A Active JP6290145B2 (ja) | 2009-12-11 | 2015-07-31 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP2018020278A Active JP6728254B2 (ja) | 2009-12-11 | 2018-02-07 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015152480A Active JP6290145B2 (ja) | 2009-12-11 | 2015-07-31 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
| JP2018020278A Active JP6728254B2 (ja) | 2009-12-11 | 2018-02-07 | 非誘導体化非代謝化ビタミンｄの質量分析法による決定 |
Country Status (6)
| Country | Link |
|---|---|
| US (8) | US20110240840A1 (https=) |
| EP (1) | EP2510339B1 (https=) |
| JP (3) | JP6113504B2 (https=) |
| CN (1) | CN102753964A (https=) |
| CA (1) | CA2783797C (https=) |
| WO (2) | WO2011072168A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745226B2 (en) * | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| US7977117B2 (en) | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
| CN102812356B (zh) | 2009-12-11 | 2017-08-08 | 奎斯特诊断投资公司 | 多重样品中的甾族化合物的质谱法 |
| US20110240840A1 (en) | 2009-12-11 | 2011-10-06 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of cookson-derivatized, non-metabolized vitamin d |
| EP2528443B1 (en) * | 2010-01-25 | 2017-01-11 | DH Technologies Development Pte. Ltd. | Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof |
| WO2014149847A2 (en) | 2013-03-15 | 2014-09-25 | Riaz Abrar | Ionization within ion trap using photoionization and electron ionization |
| US20160282371A1 (en) * | 2015-03-28 | 2016-09-29 | Quantalytical Labs Inc. | Solid Phase Extraction, Derivatization with Crown Ethers, and Mass Spectrometry, Methods, Reagents and Kits |
| CN105403631B (zh) * | 2015-10-28 | 2017-12-08 | 浙江省疾病预防控制中心 | 一种快速检测保健食品中维生素d3含量的方法 |
| WO2018198043A1 (en) * | 2017-04-28 | 2018-11-01 | Waters Technologies Corporation | Methods for quantifying total vitamin d |
| US20210088486A1 (en) * | 2018-01-29 | 2021-03-25 | Dh Technologies Development Pte. Ltd. | Methods and systems for detection of vitamin d metabolites |
| CN111999372A (zh) * | 2020-07-09 | 2020-11-27 | 山东师范大学 | 可高通量筛选喹喔啉衍生物合成条件的微液滴电喷雾装置及方法 |
| WO2023155000A1 (en) * | 2022-02-15 | 2023-08-24 | Mcmaster University | High throughput rapid screening of vitamin d |
Family Cites Families (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3030084A (en) | 1958-11-06 | 1962-04-17 | Tillotson Mfg Co | Charge forming apparatus |
| US4332591A (en) * | 1978-01-19 | 1982-06-01 | Sumitomo Chemical Company, Limited | Analytical method and apparatus for the determination of total nitrogen contents in aqueous systems |
| US5030772A (en) | 1990-02-14 | 1991-07-09 | Deluca Hector F | Process for preparing vitamin D2 compounds and the corresponding 1 α-hydroxylated derivatives |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| JPH06341980A (ja) | 1993-02-24 | 1994-12-13 | Kureha Chem Ind Co Ltd | ビタミンｄ３誘導体の定量法 |
| ATE242485T1 (de) | 1993-05-28 | 2003-06-15 | Baylor College Medicine | Verfahren und massenspektrometer zur desorption und ionisierung von analyten |
| JP2968910B2 (ja) | 1993-07-14 | 1999-11-02 | ヤマサ醤油株式会社 | １α，２５（ＯＨ）２ビタミンＤ３に対する抗体及びその用途 |
| WO1995033279A1 (en) | 1994-05-31 | 1995-12-07 | University Of Warwick | Tandem mass spectrometry apparatus |
| DE19531152A1 (de) | 1994-12-15 | 1996-06-20 | Bayer Ag | Substituierte N-Aryl-Stickstoffheterocyclen |
| US5614408A (en) * | 1995-10-18 | 1997-03-25 | The United States Of America As Represented By The Secretary Of Agricultural | Monoclonal antibodies to potato, tomato, and eggplant glycoalkaloids and assays for the same |
| US5772874A (en) | 1995-11-02 | 1998-06-30 | Cohesive Technologies, Inc. | High performance liquid chromatography method and apparatus |
| WO1997026532A1 (en) | 1996-01-19 | 1997-07-24 | Cohesive Technologies, Inc. | High performance liquid chromatography method and apparatus |
| DE69738206T2 (de) | 1996-11-06 | 2008-07-17 | Sequenom, Inc., San Diego | DNA-Diagnostik mittels Massenspektrometrie |
| US5916523A (en) * | 1996-12-04 | 1999-06-29 | Antek Instruments, Inc. | Methods for near simultaneous chemiluminescent sulfur and nitrogen detection |
| AU7497798A (en) * | 1997-05-16 | 1998-12-08 | F. Hoffmann-La Roche Ag | 3-epi compounds of vitamin d3 and uses thereof |
| GB9717926D0 (en) | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
| GB9719187D0 (en) | 1997-09-09 | 1997-11-12 | Glaxo Group Ltd | Compounds |
| JP2002502086A (ja) | 1998-01-23 | 2002-01-22 | アナリティカ オブ ブランフォード インコーポレーテッド | 表面からの質量分光測定 |
| WO1999067211A1 (de) | 1998-06-25 | 1999-12-29 | Immundiagnostik Gesellschaft Für Produktion Und Vertrieb Von Labordiagnostika Mbh | FUNKTIONELLE VITAMIN-D-DERIVATE UND VERFAHREN ZUR BESTIMMUNG VON 25-HYDROXY- UND 1α,25-DIHYDROXY-VITAMIN-D |
| US20020045606A1 (en) | 1999-12-02 | 2002-04-18 | Reddy Satyanarayana G. | Esters of vitamin D3 and uses thereof |
| GB0029729D0 (en) | 2000-12-06 | 2001-01-17 | Ids Ltd | Method for detection of vitamin D metabolites |
| US7087395B1 (en) | 2001-01-16 | 2006-08-08 | Quest Diagnostics Investments Incorporated | Vitamin D assay |
| WO2003046148A2 (en) | 2001-11-29 | 2003-06-05 | Thermo Finnigan Llc | Polypeptide quantitation |
| WO2004002996A1 (ja) | 2002-06-27 | 2004-01-08 | Chugai Seiyaku Kabushiki Kaisya | フェロセン化合物およびその用途 |
| EP2186879B1 (en) | 2002-10-03 | 2016-11-23 | Norman Leigh Anderson | High sensitivity quantitation of peptides by mass spectrometry |
| US7632686B2 (en) | 2002-10-03 | 2009-12-15 | Anderson Forschung Group | High sensitivity quantitation of peptides by mass spectrometry |
| CA2519626C (en) | 2003-04-14 | 2013-06-18 | Georgetown University | Thyroid hormone analysis by mass spectrometry with minimal sample preparation |
| WO2004090525A1 (en) * | 2003-04-14 | 2004-10-21 | Georgetown University | Steroid hormone analysis by mass spectrometry |
| US6977143B1 (en) | 2003-09-08 | 2005-12-20 | Quest Diagnostics Investments Incorporated | Determination of testosterone by mass spectrometry |
| CA2545685A1 (en) * | 2003-11-14 | 2005-06-02 | Irm Llc | Fluorous labeling for selective processing of biologically-derived samples |
| JP4555994B2 (ja) | 2003-12-19 | 2010-10-06 | 日立化成工業株式会社 | バックライト装置及び液晶表示装置 |
| BRPI0418756A (pt) | 2004-05-19 | 2007-09-11 | Merck & Co Inc | composições e métodos para inibir a reabsorção óssea |
| CA2480549A1 (fr) | 2004-09-15 | 2006-03-15 | Phytronix Technologies Inc. | Source d'ionisation pour spectrometre de masse |
| US20060094039A1 (en) | 2004-09-20 | 2006-05-04 | Ron Rosenfeld | Diagnosis of fetal aneuploidy |
| US7700365B2 (en) | 2004-10-29 | 2010-04-20 | Mayo Foundation For Medical Education And Research | Vitamin D deficiencies |
| US20070037286A1 (en) | 2005-02-09 | 2007-02-15 | Subhasish Purkayastha | Thyroxine-containing compound analysis methods |
| WO2006107339A2 (en) | 2005-03-31 | 2006-10-12 | Georgetown University | Free thyroxine and free triiodothyronine analysis by mass spectrometry |
| US7972867B2 (en) * | 2005-04-06 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites by mass spectrometry |
| EP1886112B1 (en) | 2005-04-06 | 2014-07-09 | Washington University St. Louis | Methods for measuring the metabolism of neurally derived biomolecules in vivo |
| US7745226B2 (en) | 2005-04-06 | 2010-06-29 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin D metabolites |
| US20060236886A1 (en) | 2005-04-20 | 2006-10-26 | Agfa-Gevaert | Process for the offset printing of a catalytic species via a hydrophilic phase |
| JP2009509992A (ja) | 2005-09-29 | 2009-03-12 | エフ．ホフマン−ラ ロシュ アーゲー | ２５−ヒドロキシビタミンｄに対する抗体 |
| US20070105179A1 (en) | 2005-11-09 | 2007-05-10 | Dionex Corporation | Methods of detecting N-and O-linked oligosaccharides in glycoproteins |
| US7855057B2 (en) | 2006-03-23 | 2010-12-21 | Millipore Corporation | Protein splice variant/isoform discrimination and quantitative measurements thereof |
| US7989760B2 (en) | 2006-05-24 | 2011-08-02 | SWCE Inc. | Extraction detection system and method |
| US7935921B2 (en) * | 2006-05-26 | 2011-05-03 | Laboratory Corporation Of America Holdings | Methods and systems for the quantitative analysis of biomarkers |
| CA2649338C (en) | 2006-06-06 | 2011-07-12 | F.Hoffman-La Roche Ag | Improved measurement of vitamin d |
| US7906341B2 (en) | 2006-06-30 | 2011-03-15 | Dh Technologies Development Pte, Ltd. | Methods, mixtures, kits and compositions pertaining to analyte determination |
| WO2008027861A1 (en) | 2006-08-30 | 2008-03-06 | Ge Healthcare Bio-Sciences Corp. | System and method for characterizing membranes and membrane filtration devices |
| US7999084B2 (en) * | 2007-05-16 | 2011-08-16 | Agilent Technologies, Inc. | Devices and methods for reducing matrix effects |
| US7807172B2 (en) | 2007-06-13 | 2010-10-05 | University Of Washington | Methods and compositions for detecting thyroglobulin in a biological sample |
| JP4883540B2 (ja) | 2007-06-21 | 2012-02-22 | 国立大学法人福井大学 | 同位体化合物を標識として使用するタンパク質の分析方法 |
| JP5080945B2 (ja) | 2007-11-09 | 2012-11-21 | 株式会社日立ハイテクノロジーズ | 質量分析装置および質量分析方法 |
| US7972868B2 (en) | 2007-11-28 | 2011-07-05 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| US8030084B2 (en) | 2007-12-06 | 2011-10-04 | Quest Diagnostics Investments Incorporated | Thyroglobulin quantitation by mass spectrometry |
| WO2010019566A2 (en) | 2008-08-11 | 2010-02-18 | Mayo Foundation For Medical Education And Research | Methods for determining levels of 1,25 dihydroxy vitamin d2 and d3 |
| WO2010099108A2 (en) | 2009-02-24 | 2010-09-02 | Mayo Foundation For Medical Education And Research | Multiplexing derivatized anayltes using mass spectroscopy |
| US7977117B2 (en) * | 2009-12-03 | 2011-07-12 | Quest Diagnostics Investments Incorprated | Vitamin D metabolite determination utilizing mass spectrometry following derivatization |
| US8034627B2 (en) | 2009-12-03 | 2011-10-11 | Quest Diagnostics Investments Incorporated | Methods for detecting dihydroxyvitamin D metabolites by mass spectrometry |
| CN102812356B (zh) | 2009-12-11 | 2017-08-08 | 奎斯特诊断投资公司 | 多重样品中的甾族化合物的质谱法 |
| US20110240840A1 (en) | 2009-12-11 | 2011-10-06 | Quest Diagnostics Investments Incorporated | Mass spectrometric determination of cookson-derivatized, non-metabolized vitamin d |
| EP2528443B1 (en) | 2010-01-25 | 2017-01-11 | DH Technologies Development Pte. Ltd. | Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof |
| EP2548015A1 (en) | 2010-03-15 | 2013-01-23 | Anderson Forschung Group, Inc. | Improved mass spectrometric assays for peptides |
| WO2012058614A1 (en) | 2010-10-29 | 2012-05-03 | Cohesive Technologies Inc. | Lc-ms separation and detection of vitamin d metabolites |
| JPWO2012111249A1 (ja) | 2011-02-14 | 2014-07-03 | 学校法人麻布獣医学園 | 質量分析法における質量変化を検出する方法及び安定同位体標識タンパク質の絶対量の定量方法 |
| US9140695B2 (en) | 2012-01-18 | 2015-09-22 | University Of Utah Research Foundation | Methods for analysis of free and autoantibody-bound biomarkers and associated compositions, devices, and systems |
| WO2014047316A1 (en) | 2012-09-20 | 2014-03-27 | Quest Diagnostics Investments Incorporated | Thyroglobulin quantitation by mass spectroscopy |
| JP7209363B2 (ja) | 2020-04-13 | 2023-01-20 | リオモ インク | スタビリティ評価システム、プログラム及び方法 |
-
2010
- 2010-12-09 US US12/964,717 patent/US20110240840A1/en not_active Abandoned
- 2010-12-09 JP JP2012543290A patent/JP6113504B2/ja active Active
- 2010-12-09 CA CA2783797A patent/CA2783797C/en active Active
- 2010-12-09 WO PCT/US2010/059771 patent/WO2011072168A1/en not_active Ceased
- 2010-12-09 EP EP10836711.1A patent/EP2510339B1/en not_active Not-in-force
- 2010-12-09 CN CN2010800635404A patent/CN102753964A/zh active Pending
- 2010-12-09 US US12/964,710 patent/US20120025067A1/en not_active Abandoned
- 2010-12-09 WO PCT/US2010/059765 patent/WO2011072163A1/en not_active Ceased
-
2015
- 2015-07-31 JP JP2015152480A patent/JP6290145B2/ja active Active
-
2016
- 2016-06-27 US US15/194,009 patent/US20170115314A1/en not_active Abandoned
-
2018
- 2018-02-07 JP JP2018020278A patent/JP6728254B2/ja active Active
- 2018-08-01 US US16/051,849 patent/US10753950B2/en active Active
-
2020
- 2020-08-24 US US17/001,425 patent/US11280799B2/en active Active
-
2022
- 2022-03-21 US US17/700,320 patent/US11549954B2/en active Active
- 2022-12-30 US US18/091,726 patent/US11852636B2/en active Active
-
2023
- 2023-11-07 US US18/503,388 patent/US20240077503A1/en active Pending
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