JP2011504596A5 - - Google Patents
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- JP2011504596A5 JP2011504596A5 JP2010534957A JP2010534957A JP2011504596A5 JP 2011504596 A5 JP2011504596 A5 JP 2011504596A5 JP 2010534957 A JP2010534957 A JP 2010534957A JP 2010534957 A JP2010534957 A JP 2010534957A JP 2011504596 A5 JP2011504596 A5 JP 2011504596A5
- Authority
- JP
- Japan
- Prior art keywords
- analyte
- sample
- derivative
- derivatizing
- derivatizing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000012491 analyte Substances 0.000 claims 56
- 238000000034 method Methods 0.000 claims 23
- 239000003795 chemical substances by application Substances 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 13
- 238000013375 chromatographic separation Methods 0.000 claims 7
- 150000003862 amino acid derivatives Chemical class 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 238000004445 quantitative analysis Methods 0.000 claims 5
- 238000004949 mass spectrometry Methods 0.000 claims 4
- 238000011002 quantification Methods 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 238000004587 chromatography analysis Methods 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 claims 2
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 2
- 238000000451 chemical ionisation Methods 0.000 claims 2
- 238000003795 desorption Methods 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 238000004811 liquid chromatography Methods 0.000 claims 2
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 239000000090 biomarker Substances 0.000 claims 1
- 238000000132 electrospray ionisation Methods 0.000 claims 1
- 238000010265 fast atom bombardment Methods 0.000 claims 1
- 238000004128 high performance liquid chromatography Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims 1
- 229920005615 natural polymer Polymers 0.000 claims 1
- 238000004305 normal phase HPLC Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000005086 pumping Methods 0.000 claims 1
- 238000004007 reversed phase HPLC Methods 0.000 claims 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US428807P | 2007-11-26 | 2007-11-26 | |
| PCT/US2008/012938 WO2009070233A1 (en) | 2007-11-26 | 2008-11-20 | Internal standards and methods for use in quantitatively measuring analytes in a sample |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011504596A JP2011504596A (ja) | 2011-02-10 |
| JP2011504596A5 true JP2011504596A5 (https=) | 2012-01-12 |
Family
ID=40678890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010534957A Pending JP2011504596A (ja) | 2007-11-26 | 2008-11-20 | サンプル中の分析物を定量測定する際に使用するための内部標準および方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US20100285593A1 (https=) |
| EP (1) | EP2215460A4 (https=) |
| JP (1) | JP2011504596A (https=) |
| WO (1) | WO2009070233A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2959270B1 (fr) * | 2010-04-27 | 2012-09-21 | Total Sa | Procede de detection de composes de tracage pour l'exploitation d'hydrocarbures |
| WO2012016042A2 (en) * | 2010-07-29 | 2012-02-02 | Dr. Reddy's Laboratories Ltd. | Glatiramer acetate molecular weight markers |
| CN103282770B (zh) * | 2011-01-07 | 2015-08-12 | 株式会社日立高新技术 | 质量分析装置、分析法和校准试样 |
| US8506797B2 (en) * | 2011-04-10 | 2013-08-13 | Therapeutic Proteins International, LLC | Downstream bioprocessing device |
| CN103782166B (zh) * | 2011-06-06 | 2018-01-16 | 沃特世科技公司 | 用于定量样品中目标分析物的组合物、方法和试剂盒 |
| US10436790B2 (en) | 2011-09-28 | 2019-10-08 | Waters Technologies Corporation | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals |
| US11352325B2 (en) | 2011-09-28 | 2022-06-07 | Waters Technologies Corporation | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals |
| EP3974412A1 (en) | 2011-09-28 | 2022-03-30 | Waters Technologies Corporation | Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals |
| JP5958288B2 (ja) * | 2012-11-06 | 2016-07-27 | 株式会社島津製作所 | 液体クロマトグラフィー−ｍａｌｄｉ質量分析法 |
| JP6199592B2 (ja) * | 2013-04-15 | 2017-09-20 | 株式会社 資生堂 | 分析方法 |
| WO2016069764A1 (en) | 2014-10-30 | 2016-05-06 | Waters Technologies Corporation | Methods for the rapid preparation of labeled glycosylamines and for the analysis of glycosylated biomolecules producing the same |
| WO2016077548A1 (en) | 2014-11-13 | 2016-05-19 | Waters Technologies Corporation | Methods for liquid chromatography calibration for rapid labeled n-glycans |
| EP3271715B1 (en) * | 2015-03-16 | 2024-03-13 | Waters Technologies Corporation | Methods for analyte detection and quantification using threshold analyte calibration |
| JP7109374B2 (ja) | 2016-04-14 | 2022-07-29 | エフ．ホフマン－ラ ロシュ アーゲー | 体液の試料中の標的分析物の濃度を決定するための方法 |
| US11035832B2 (en) | 2016-06-21 | 2021-06-15 | Waters Technologies Corporation | Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties |
| CN109641846A (zh) | 2016-06-21 | 2019-04-16 | 沃特世科技公司 | 通过用于增强的ms信号的还原胺化的聚糖和其他生物分子的荧光标记 |
| EP3479103B1 (en) | 2016-07-01 | 2022-04-20 | Waters Technologies Corporation | Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation |
| CN107860856A (zh) * | 2016-09-22 | 2018-03-30 | 中美华世通生物医药科技（武汉）有限公司 | 测定盐酸阿考替胺原料药中残留溶剂的方法 |
| JP6739080B2 (ja) * | 2016-11-17 | 2020-08-12 | 学校法人東京理科大学 | ビタミンｄの定量方法、質量分析装置およびビタミンｄ定量用試薬キット |
| EP3559655B1 (en) | 2016-12-23 | 2024-07-03 | Roche Diagnostics GmbH | Method for identifying a reagent during a process in an analysis system |
| WO2018115247A1 (en) | 2016-12-23 | 2018-06-28 | Roche Diagnostics Gmbh | Method for identifying a reagent during a process in an analysis system |
| CN106680407A (zh) * | 2017-01-06 | 2017-05-17 | 中国工程物理研究院核物理与化学研究所 | 一种用于分析氢同位素混合气体的毛细管色谱柱 |
| CN106770856B (zh) * | 2017-01-22 | 2018-05-22 | 中国工程物理研究院核物理与化学研究所 | 一种用于分析氢同位素混合气体的填充色谱柱 |
| CN106872630B (zh) * | 2017-03-29 | 2018-07-24 | 山东大学 | 与重度少弱精子症相关的生物标志物的筛选与应用 |
| KR102108855B1 (ko) * | 2017-10-30 | 2020-05-12 | 한국표준과학연구원 | 안정동위원소 표지 핵산을 내부표준물질로 활용하는 핵산 정량 방법 및 이의 용도 |
| CN108344762B (zh) * | 2018-02-23 | 2020-09-25 | 中国科学院长春应用化学研究所 | 一种可降解塑料制品中聚乳酸含量的检测方法 |
| JP7259873B2 (ja) * | 2019-02-07 | 2023-04-18 | 株式会社島津製作所 | 分析方法、分析装置およびプログラム |
| KR102923781B1 (ko) | 2020-08-05 | 2026-02-04 | 주식회사 엘지화학 | 중수소화 화합물의 분석방법, 소자 제조용 중수소화 화합물의 선별방법 및 전자 소자의 제조방법 |
| WO2022206806A1 (zh) * | 2021-03-31 | 2022-10-06 | 荣昌生物制药(烟台)股份有限公司 | 一种采用lc-ms/ms检测adc中dtpa含量的方法 |
| CN113419007B (zh) * | 2021-06-23 | 2022-11-29 | 江苏豪思睦可生物科技有限公司 | 一种用于检测样本中目标氨基酸和肌酐的方法及其检测试剂盒 |
| CN114755319A (zh) * | 2022-03-08 | 2022-07-15 | 上海市第六人民医院 | 一种快速定量唾液中氨基酸及其衍生物的方法和试剂盒 |
| GB202408095D0 (en) * | 2024-06-07 | 2024-07-24 | Micromass Ltd | Calibration of analyte amount in mass spectrometry |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4940658A (en) * | 1986-11-20 | 1990-07-10 | University Patents, Inc. | Assay for sulfhydryl amino acids and methods for detecting and distinguishing cobalamin and folic acid deficency |
| US5296599A (en) * | 1991-09-19 | 1994-03-22 | Millipore Corporation | Activated carbamates compounds |
| US6790669B1 (en) * | 1999-07-13 | 2004-09-14 | The Dow Chemical Company | Method for chemical analysis of biological material |
| US6316205B1 (en) * | 2000-01-28 | 2001-11-13 | Genelabs Diagnostics Pte Ltd. | Assay devices and methods of analyte detection |
| US6808933B1 (en) * | 2000-10-19 | 2004-10-26 | Agilent Technologies, Inc. | Methods of enhancing confidence in assays for analytes |
| EP2317307B1 (en) * | 2002-02-14 | 2013-11-20 | Ajinomoto Co., Inc. | Method of analyzing amino- and/or imino-functional compounds, and analytical reagent |
| US6652625B1 (en) * | 2002-07-24 | 2003-11-25 | Perkin Elmer Instruments Llc | Analyte pre-concentrator for gas chromatography |
| WO2005000226A2 (en) * | 2003-06-06 | 2005-01-06 | Diversa Corporation | Mixed bed multi-dimensional chromatography systems and methods of making and using them |
| EP1750126B1 (en) * | 2004-05-26 | 2015-09-16 | Ajinomoto Co., Inc. | Method and apparatus for analyzing aminofunctional compound |
| US7700364B2 (en) * | 2004-10-12 | 2010-04-20 | Quest Diagnostics Investments Incorporated | Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry |
| EP1666884B1 (en) * | 2004-11-04 | 2009-04-01 | GermedIQ Forschungs- und Entwicklungsgesellschaft mbH | Method for determination of arginine, methylated arginines and derivatives thereof |
| DK1875401T3 (da) * | 2005-06-30 | 2014-04-07 | Biocrates Life Sciences Ag | Indretning til kvantitativ analyse af en metabolitprofil |
| JP5091861B2 (ja) * | 2005-07-25 | 2012-12-05 | メタノミクス ゲーエムベーハー | クロマトグラフィー／マススペクトロメトリーを用いてサンプルを分析する手段と方法 |
| ES2403733T3 (es) * | 2005-10-05 | 2013-05-21 | Commonwealth Scientific And Industrial Research Organisation | Proteínas de seda |
| WO2008150488A1 (en) * | 2007-06-01 | 2008-12-11 | Laboratory Corporation Of America Holdings | Methods and systems for quantification of peptides and other analytes |
-
2008
- 2008-11-20 JP JP2010534957A patent/JP2011504596A/ja active Pending
- 2008-11-20 WO PCT/US2008/012938 patent/WO2009070233A1/en not_active Ceased
- 2008-11-20 US US12/676,011 patent/US20100285593A1/en not_active Abandoned
- 2008-11-20 EP EP08855298A patent/EP2215460A4/en not_active Withdrawn
-
2012
- 2012-12-07 US US13/708,252 patent/US20130102478A1/en not_active Abandoned
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