JP2013511277A5 - - Google Patents
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- JP2013511277A5 JP2013511277A5 JP2012540031A JP2012540031A JP2013511277A5 JP 2013511277 A5 JP2013511277 A5 JP 2013511277A5 JP 2012540031 A JP2012540031 A JP 2012540031A JP 2012540031 A JP2012540031 A JP 2012540031A JP 2013511277 A5 JP2013511277 A5 JP 2013511277A5
- Authority
- JP
- Japan
- Prior art keywords
- naturally occurring
- gene
- microorganism
- occurring microorganism
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 244000005700 microbiome Species 0.000 claims 12
- 230000000694 effects Effects 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 5
- 230000037430 deletion Effects 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 3
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 108010090279 galactose permease Proteins 0.000 claims 3
- 230000000813 microbial effect Effects 0.000 claims 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 108010078791 Carrier Proteins Proteins 0.000 claims 2
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- 108020005115 Pyruvate Kinase Proteins 0.000 claims 2
- 102000013009 Pyruvate Kinase Human genes 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000012239 gene modification Methods 0.000 claims 2
- 230000005017 genetic modification Effects 0.000 claims 2
- 235000013617 genetically modified food Nutrition 0.000 claims 2
- 229930029653 phosphoenolpyruvate Natural products 0.000 claims 2
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical compound OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- 101150100525 pykA gene Proteins 0.000 claims 2
- 101100389345 Bacillus subtilis (strain 168) ndoA gene Proteins 0.000 claims 1
- 101100244826 Escherichia coli (strain K12) pptA gene Proteins 0.000 claims 1
- 108010015895 Glycerone kinase Proteins 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 239000013611 chromosomal DNA Substances 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 101150005487 ftsI gene Proteins 0.000 claims 1
- 101150093502 galR gene Proteins 0.000 claims 1
- 101150040476 galS gene Proteins 0.000 claims 1
- 101150033931 gldA gene Proteins 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 101150037064 rpoA gene Proteins 0.000 claims 1
- 101150042391 rpoC gene Proteins 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 101150026570 ydcC gene Proteins 0.000 claims 1
- 101150084760 ydcD gene Proteins 0.000 claims 1
- 101150079492 ydcF gene Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28148109P | 2009-11-18 | 2009-11-18 | |
| US61/281,481 | 2009-11-18 | ||
| PCT/US2010/057119 WO2011063055A2 (en) | 2009-11-18 | 2010-11-17 | Engineering microbes for efficient production of chemicals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013511277A JP2013511277A (ja) | 2013-04-04 |
| JP2013511277A5 true JP2013511277A5 (enExample) | 2014-01-09 |
Family
ID=44060323
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540031A Pending JP2013511277A (ja) | 2009-11-18 | 2010-11-17 | 化学物質の効率的な生産のための微生物の改変 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9017976B2 (enExample) |
| EP (1) | EP2501797A4 (enExample) |
| JP (1) | JP2013511277A (enExample) |
| KR (2) | KR20120099258A (enExample) |
| CN (1) | CN102666838B (enExample) |
| BR (1) | BR112012011990A2 (enExample) |
| WO (1) | WO2011063055A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2501798B1 (en) * | 2009-11-18 | 2017-09-06 | Myriant Corporation | Metabolic evolution of escherchia coli strains that produce organic acids |
| CA2807561C (en) | 2010-08-06 | 2022-04-12 | Mascoma Corporation | Production of malonyl-coa derived products via anaerobic pathways |
| JP2015504688A (ja) * | 2012-01-30 | 2015-02-16 | ミリアント・コーポレイションＭｙｒｉａｎｔ Ｃｏｒｐｏｒａｔｉｏｎ | 遺伝子操作された微生物からのムコン酸の生成 |
| CN102994436A (zh) * | 2012-10-29 | 2013-03-27 | 江南大学 | 一种产减毒类脂a的大肠杆菌基因工程菌及其应用 |
| JP6085190B2 (ja) * | 2013-02-26 | 2017-02-22 | 花王株式会社 | 変異微生物及びそれを用いた有用物質の生産方法 |
| KR101594156B1 (ko) * | 2013-06-25 | 2016-02-15 | 씨제이제일제당 주식회사 | Ｌ-라이신 생산능이 향상된 미생물 및 그를 이용하여 ｌ-라이신을 생산하는 방법 |
| CA2919012C (en) * | 2013-07-23 | 2022-10-25 | Myriant Corporation | Method of producing succinic acid and other chemicals using facilitated diffusion for sugar import |
| WO2015034948A1 (en) | 2013-09-03 | 2015-03-12 | Myriant Corporation | A process for manufacturing acrylic acid, acrylonitrile and 1,4-butanediol from 1,3-propanediol |
| CN104046586B (zh) * | 2014-07-02 | 2016-08-17 | 山东大学 | 一株基因工程菌及其在生产(2r,3r)-2,3-丁二醇中的应用 |
| CN107208118A (zh) * | 2014-09-18 | 2017-09-26 | 基因组股份公司 | 具有提高的能源效率的非天然微生物 |
| US10301613B2 (en) | 2015-09-15 | 2019-05-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Targeted remodeling of prokaryotic genomes using CRISPR-nickases |
| JP7437116B2 (ja) | 2016-03-02 | 2024-02-22 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | 遺伝子操作された微生物からのムコン酸生成の改善 |
| HUE045261T2 (hu) | 2017-03-20 | 2019-12-30 | Forma Therapeutics Inc | Pirrolopirrol kompozíciók piruvát kináz (PKR) aktivátorokként |
| JP2020530271A (ja) | 2017-06-30 | 2020-10-22 | ピーティーティー グローバル ケミカル パブリック カンパニー リミテッド | 安定化されたコピー数の機能性ｄｎａ配列を有する微生物及び関連方法 |
| US12122778B2 (en) | 2018-09-19 | 2024-10-22 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| CN113166060B (zh) | 2018-09-19 | 2024-01-09 | 诺沃挪第克健康护理股份公司 | 用丙酮酸激酶激活化合物治疗镰状细胞病 |
| CN109251941B (zh) * | 2018-09-30 | 2020-11-06 | 江南大学 | 一种高产琥珀酸的大肠杆菌及其应用 |
| KR102129379B1 (ko) * | 2018-10-10 | 2020-07-02 | 한국과학기술원 | 고활성의 말산 탈수소효소가 도입된 숙신산 생성용 변이 미생물 및 이를 이용한 숙신산 제조방법 |
| ES3042390T3 (en) | 2019-09-19 | 2025-11-20 | Novo Nordisk Healthcare Ag | Pyruvate kinase r (pkr) activating compositions |
| CN113278641B (zh) * | 2020-05-27 | 2022-06-21 | 安徽华恒生物科技股份有限公司 | 生产l-缬氨酸的重组大肠杆菌、其构建方法及其应用 |
| IT202000013243A1 (it) | 2020-06-04 | 2021-12-04 | Novamont Spa | Processo per la purificazione di una miscela di dioli |
| IT202000031979A1 (it) | 2020-12-22 | 2022-06-22 | Novamont Spa | Processo di purificazione di una miscela comprendente dioli e acetali |
| IT202100006419A1 (it) | 2021-03-17 | 2022-09-17 | Novamont Spa | Recupero di dioli da una miscela |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| IT202100030572A1 (it) | 2021-12-02 | 2023-06-02 | Novamont Spa | 1,3-butandiolo purificato da una miscela di dioli |
| CN118546852B (zh) * | 2024-07-30 | 2024-10-18 | 北京化工大学 | 一种高效共利用葡萄糖、木糖生产丁二酸的基因工程菌及其应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69637492T2 (de) | 1995-05-05 | 2009-06-04 | Genencor International, Inc., Palo Alto | Anwendung von Glukosetransportmutanten zur Herstellung von Verbindungen des aromatischen Syntheseweges |
| WO1999053035A1 (en) | 1998-04-13 | 1999-10-21 | The University Of Georgia Research Foundation, Inc. | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US6989265B2 (en) | 2002-01-23 | 2006-01-24 | Wisconsin Alumni Research Foundation | Bacteria with reduced genome |
| US7303906B2 (en) | 2002-09-06 | 2007-12-04 | Wisconsin Alumni Research Foundation | Competent bacteria |
| WO2004033646A2 (en) | 2002-10-04 | 2004-04-22 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| US7232665B2 (en) | 2002-12-19 | 2007-06-19 | E. I. Du Pont De Nemours And Company | Mutations affecting carotenoid production |
| DE10314618A1 (de) | 2003-04-01 | 2004-10-14 | Degussa Ag | Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| JP4829117B2 (ja) | 2003-10-21 | 2011-12-07 | カーギル，インコーポレイティド | モナチンおよびモナチン前駆体の製造 |
| KR100576342B1 (ko) | 2004-02-05 | 2006-05-03 | 씨제이 주식회사 | ｇａｌＲ 유전자가 불활성화된 Ｌ-쓰레오닌 생성 미생물,그를 제조하는 방법 및 상기 미생물을 이용한Ｌ-쓰레오닌의 제조방법 |
| US20050181488A1 (en) | 2004-02-12 | 2005-08-18 | Akhverdian Valery Z. | Method for producing L-threonine using bacteria belonging to the genus Escherichia |
| EP3130676A1 (en) | 2004-08-27 | 2017-02-15 | Rice University | Mutant e. coli strain with increased succinic acid production |
| KR20070065870A (ko) | 2004-09-17 | 2007-06-25 | 라이스 유니버시티 | 다량의 숙신산염을 생산하는 세균 |
| AU2005308101A1 (en) | 2004-11-26 | 2006-06-01 | Kyowa Hakko Kirin Co., Ltd. | Industrially useful microorganism |
| KR100630836B1 (ko) | 2005-04-08 | 2006-10-02 | 한국과학기술원 | 인-실리코 분석을 통한 균주 개량방법 |
| US7524660B2 (en) | 2005-05-05 | 2009-04-28 | E.I. Du Pont De Nemours And Company | Utilization of fructose in microbial production strains |
| ES2401339T3 (es) | 2005-08-10 | 2013-04-18 | University Of Florida Research Foundation, Inc. | Materiales y métodos para producción eficiente de ácido láctico |
| CA2626900C (en) | 2005-08-20 | 2013-07-23 | Scarab Genomics, Llc | Reduced genome e. coli |
| US20070111294A1 (en) | 2005-09-09 | 2007-05-17 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of succinate |
| DE102005047596A1 (de) | 2005-10-05 | 2007-04-12 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien |
| CN101321866B (zh) | 2005-10-13 | 2012-11-14 | 花王株式会社 | 新型枯草杆菌突变株 |
| JP5242550B2 (ja) * | 2006-03-31 | 2013-07-24 | ライス ユニバーシティー | グリセロールの嫌気醗酵 |
| KR100885616B1 (ko) | 2006-06-26 | 2009-02-24 | 씨제이제일제당 (주) | 글리세롤을 이용한 아미노산의 생산 방법 |
| CN104694449B (zh) | 2007-03-20 | 2018-05-22 | 佛罗里达大学研究基金公司 | 用于有效生产琥珀酸和苹果酸的材料和方法 |
| TW200909585A (en) | 2007-03-23 | 2009-03-01 | Metabolic Explorer Sa | Metabolically engineered microorganism useful for the production of 1,2-propanediol |
| WO2008116851A1 (en) | 2007-03-23 | 2008-10-02 | Metabolic Explorer | Metabolically engineered microorganism useful for the production of acetol |
| EP2158323A4 (en) * | 2007-05-18 | 2011-06-22 | Microbia Prec Engineering Inc | PRODUCTION OF ORGANIC ACID BY PILZ CELLS |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| WO2009043372A1 (en) | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| WO2009061429A2 (en) * | 2007-11-06 | 2009-05-14 | Massachusetts Institute Of Technology | Global transcription machinery engineering targeting the rnap alpha subunit (rpoa) |
| EP2241630B1 (en) | 2007-12-06 | 2016-06-01 | Ajinomoto Co., Inc. | A method for producing an organic acid |
| WO2010051527A2 (en) | 2008-10-31 | 2010-05-06 | Gevo, Inc. | Engineered microorganisms capable of producing target compounds under anaerobic conditions |
| CA2756705C (en) | 2009-04-02 | 2017-04-11 | University Of Florida Research Foundation, Inc. | Engineered bacterial cells for succinate production |
-
2010
- 2010-11-17 BR BR112012011990A patent/BR112012011990A2/pt not_active Application Discontinuation
- 2010-11-17 JP JP2012540031A patent/JP2013511277A/ja active Pending
- 2010-11-17 WO PCT/US2010/057119 patent/WO2011063055A2/en not_active Ceased
- 2010-11-17 US US13/503,999 patent/US9017976B2/en active Active
- 2010-11-17 KR KR20127015612A patent/KR20120099258A/ko not_active Ceased
- 2010-11-17 KR KR1020167025628A patent/KR20160114184A/ko not_active Ceased
- 2010-11-17 EP EP10832141.5A patent/EP2501797A4/en not_active Withdrawn
- 2010-11-17 CN CN201080052398.3A patent/CN102666838B/zh active Active
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