JP2013510885A5 - - Google Patents
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- JP2013510885A5 JP2013510885A5 JP2012539065A JP2012539065A JP2013510885A5 JP 2013510885 A5 JP2013510885 A5 JP 2013510885A5 JP 2012539065 A JP2012539065 A JP 2012539065A JP 2012539065 A JP2012539065 A JP 2012539065A JP 2013510885 A5 JP2013510885 A5 JP 2013510885A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- composition
- compound
- nhch
- optical isomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims 25
- 150000001875 compounds Chemical class 0.000 claims 21
- 230000003287 optical Effects 0.000 claims 10
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 8
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- 201000006704 ulcerative colitis Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26130109P | 2009-11-13 | 2009-11-13 | |
| US61/261,301 | 2009-11-13 | ||
| US26247409P | 2009-11-18 | 2009-11-18 | |
| US61/262,474 | 2009-11-18 | ||
| PCT/US2010/056760 WO2011060392A1 (en) | 2009-11-13 | 2010-11-15 | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013235966A Division JP5982705B2 (ja) | 2009-11-13 | 2013-11-14 | 選択的スフィンゴシン−１−リン酸受容体変調因子および不斉合成方法 |
| JP2014229895A Division JP2015038145A (ja) | 2009-11-13 | 2014-11-12 | 選択的スフィンゴシン−１−リン酸受容体変調因子および不斉合成方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013510885A JP2013510885A (ja) | 2013-03-28 |
| JP2013510885A5 true JP2013510885A5 (US07846941-20101207-C00217.png) | 2014-01-09 |
| JP5650233B2 JP5650233B2 (ja) | 2015-01-07 |
Family
ID=43992106
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012539065A Active JP5650233B2 (ja) | 2009-11-13 | 2010-11-15 | 選択的スフィンゴシン−１−リン酸受容体変調因子および不斉合成方法 |
| JP2013235966A Active JP5982705B2 (ja) | 2009-11-13 | 2013-11-14 | 選択的スフィンゴシン−１−リン酸受容体変調因子および不斉合成方法 |
| JP2014229895A Pending JP2015038145A (ja) | 2009-11-13 | 2014-11-12 | 選択的スフィンゴシン−１−リン酸受容体変調因子および不斉合成方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013235966A Active JP5982705B2 (ja) | 2009-11-13 | 2013-11-14 | 選択的スフィンゴシン−１−リン酸受容体変調因子および不斉合成方法 |
| JP2014229895A Pending JP2015038145A (ja) | 2009-11-13 | 2014-11-12 | 選択的スフィンゴシン−１−リン酸受容体変調因子および不斉合成方法 |
Country Status (30)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7443550B2 (ja) | 2020-03-04 | 2024-03-05 | ヒーリオイースト ファーマシューティカル カンパニー リミテッド | 三環系化合物及びその使用 |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3868377A1 (en) | 2009-11-13 | 2021-08-25 | Receptos Llc | Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis |
| KR101781233B1 (ko) | 2009-11-13 | 2017-09-22 | 셀진 인터내셔널 Ii 에스에이알엘 | 스핑고신 1 포스페이트 수용체 조절자 및 카이랄 합성 방법 |
| US9481659B2 (en) | 2011-05-13 | 2016-11-01 | Celgene International Ii Sàrl | Selective heterocyclic sphingosine 1 phosphate receptor modulators |
| NZ702974A (en) * | 2012-06-21 | 2016-03-31 | Eisai R&D Man Co Ltd | Novel indanesulfamide derivative |
| WO2014158302A1 (en) * | 2013-03-25 | 2014-10-02 | Swenson Rolf Eric | Novel sphingosine 1-phosphate receptor antagonists |
| WO2015066515A1 (en) * | 2013-11-01 | 2015-05-07 | Receptos, Inc. | Selective sphingosine 1 phosphate receptor modulators and combination therapy therewith |
| CA2981743A1 (en) | 2015-04-06 | 2016-10-13 | Auspex Pharmaceuticals, Inc. | Deuterium-substituted oxadiazoles |
| US11111223B2 (en) | 2016-06-14 | 2021-09-07 | Receptos Llc | Crystalline forms of ozanimod and ozanimod hydrochloride, and processes for preparation thereof |
| US11192886B2 (en) | 2016-07-22 | 2021-12-07 | Medshine Discovery Inc. | S1P1 agonist and application thereof |
| CN109563059A (zh) * | 2016-08-19 | 2019-04-02 | 苏州科睿思制药有限公司 | 奥扎莫德的晶型及其制备方法 |
| EP3508481A4 (en) * | 2016-09-14 | 2019-07-10 | Crystal Pharmaceutical (Suzhou) Co., Ltd. | CRYSTALLINE FORM OF OZANIMOD HYDROCHLORIDE AND PROCESS FOR PREPARING THE SAME |
| CN108137516A (zh) * | 2016-09-14 | 2018-06-08 | 杭州领业医药科技有限公司 | 奥扎莫德的晶型、其制备方法及药物组合物 |
| EP3518922A1 (en) * | 2016-09-29 | 2019-08-07 | Celgene International II Sarl | Compounds and methods for treating lupus |
| WO2018157813A1 (zh) * | 2017-02-28 | 2018-09-07 | 南京明德新药研发股份有限公司 | 螺环类化合物及其应用 |
| WO2018184185A1 (zh) * | 2017-04-07 | 2018-10-11 | 杭州领业医药科技有限公司 | 奥扎莫德加成盐晶型、制备方法及药物组合物和用途 |
| CN108727291A (zh) * | 2017-04-21 | 2018-11-02 | 宁波爱诺医药科技有限公司 | 奥扎莫德及其中间体的制备方法 |
| CN108727292A (zh) * | 2017-04-21 | 2018-11-02 | 宁波爱诺医药科技有限公司 | 一种奥扎莫德及其中间体的制备方法 |
| WO2018208855A1 (en) | 2017-05-08 | 2018-11-15 | Celgene International Ii Sarl | Sphingosine 1 phosphate receptor agonists for neuroprotection |
| CN110997645B (zh) * | 2017-05-22 | 2023-10-10 | 埃吉斯制药公司 | 奥扎尼莫德的制备方法 |
| US10660879B2 (en) | 2017-06-23 | 2020-05-26 | Enzo Biochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
| CA3061201A1 (en) | 2017-06-23 | 2018-12-27 | Enzo Biochem, Inc. | Sphingosine pathway modulating compounds for the treatment of cancers |
| CN109280035B (zh) * | 2017-07-19 | 2023-06-09 | 广东东阳光药业有限公司 | 奥扎莫德的多晶型及其制备方法 |
| CN110944982A (zh) * | 2017-08-31 | 2020-03-31 | 苏州科睿思制药有限公司 | 奥扎莫德盐酸盐的晶型及其制备方法 |
| WO2019058290A1 (en) * | 2017-09-20 | 2019-03-28 | Suven Life Sciences Limited | IMPROVED PROCESS FOR THE PREPARATION OF AZANIMOD A-AMINO COMPOUND |
| WO2019094409A1 (en) | 2017-11-07 | 2019-05-16 | Teva Pharmaceuticals International Gmbh | Salts and solid state forms of ozanimod |
| CN107857760A (zh) * | 2017-11-21 | 2018-03-30 | 南京天翔医药科技有限公司 | 鞘氨醇‑1‑磷酸受体调节剂及其应用 |
| JP2021511375A (ja) * | 2018-01-18 | 2021-05-06 | シージャーヂュアン・サガシティー・ニュー・ドラッグ・デヴェロップメント・カンパニー・リミテッド | 三環式化合物の結晶形、塩形及びその製造方法 |
| EP3769759B1 (en) | 2018-03-20 | 2023-11-15 | Eisai R&D Management Co., Ltd. | Combination of an indanesulfamide derivative with perampanel for use in the treatment of epilepsy |
| CN110615747A (zh) * | 2018-06-20 | 2019-12-27 | 广东东阳光药业有限公司 | 一种二氢茚中间体的制备方法 |
| CN112771028A (zh) | 2018-09-12 | 2021-05-07 | 细胞制药有限公司 | 用于制备奥扎莫德及其中间体(s)-1-氨基-2,3-二氢-1h-茚基-4-甲腈的方法 |
| AR116479A1 (es) * | 2018-09-25 | 2021-05-12 | Quim Sintetica S A | Intermediarios para la síntesis de ozanimod y procedimiento para la preparación del mencionado agonista del receptor de esfingosina-1-fosfato y de dichos intermediarios |
| US11390593B2 (en) | 2018-12-07 | 2022-07-19 | Synthon B.V. | Process for preparing ozanimod |
| US20220144788A1 (en) * | 2019-03-29 | 2022-05-12 | Receptos Llc | Sphingosine 1 phosphate receptor modulators |
| WO2020205481A1 (en) * | 2019-03-29 | 2020-10-08 | Celgene International Ii Sarl | Sphingosine 1 phosphate receptor modulators |
| WO2020205483A1 (en) * | 2019-03-29 | 2020-10-08 | Celgene International Ii Sarl | Sphingosine 1 phosphate receptor modulators |
| EP3959204A4 (en) * | 2019-04-26 | 2022-12-28 | Receptos Llc | SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATOR |
| CN112062785B (zh) * | 2019-06-11 | 2023-06-27 | 广东东阳光药业有限公司 | 奥扎莫德及其中间体的制备方法 |
| US20220259163A1 (en) | 2019-07-16 | 2022-08-18 | Synthon B.V. | Improved process for preparing ozanimod |
| AU2020372647A1 (en) | 2019-10-31 | 2022-06-16 | Idorsia Pharmaceuticals Ltd | Combination of a CXCR7 antagonist with an S1P1 receptor modulator |
| AU2021205465A1 (en) * | 2020-01-06 | 2022-07-14 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
| WO2021175223A1 (zh) * | 2020-03-04 | 2021-09-10 | 南京明德新药研发有限公司 | 苯并2-氮杂螺[4.4]壬烷类化合物及其应用 |
| US11554111B2 (en) * | 2020-03-17 | 2023-01-17 | Enzo Biochem, Inc. | Sphingosine pathway modulating compounds for the treatment of coronavirus infection |
| EP4126826A1 (en) | 2020-04-02 | 2023-02-08 | Synthon B.V. | Crystalline form of ozanimod hydrochloride |
| CN111620788B (zh) * | 2020-04-20 | 2022-09-30 | 广东莱佛士制药技术有限公司 | 一种制备(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法 |
| JP2024510647A (ja) * | 2021-04-09 | 2024-03-08 | ヒーリオイースト ファーマシューティカル カンパニー リミテッド | オキサジアゾール置換スピロ環系化合物とその使用 |
| EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
| WO2023152767A1 (en) | 2022-02-11 | 2023-08-17 | Mylan Laboratories Limited | Polymorphic forms of ozanimod hydrochloride |
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2010
- 2010-11-15 EP EP20215106.4A patent/EP3868377A1/en not_active Withdrawn
- 2010-11-15 ES ES18160667T patent/ES2858337T3/es active Active
- 2010-11-15 CA CA2780772A patent/CA2780772C/en active Active
- 2010-11-15 CA CA2986521A patent/CA2986521C/en active Active
- 2010-11-15 PL PL18160667T patent/PL3406142T3/pl unknown
- 2010-11-15 LT LTEP18160667.4T patent/LT3406142T/lt unknown
- 2010-11-15 AU AU2010319983A patent/AU2010319983B2/en active Active
- 2010-11-15 NO NO10830880A patent/NO2498610T3/no unknown
- 2010-11-15 DK DK10830880.0T patent/DK2498610T3/en active
- 2010-11-15 HU HUE10830880A patent/HUE037535T2/hu unknown
- 2010-11-15 EP EP18160667.4A patent/EP3406142B8/en active Active
- 2010-11-15 RS RS20180647A patent/RS57253B1/sr unknown
- 2010-11-15 JP JP2012539065A patent/JP5650233B2/ja active Active
- 2010-11-15 MX MX2012005560A patent/MX2012005560A/es active IP Right Grant
- 2010-11-15 PT PT108308800T patent/PT2498610T/pt unknown
- 2010-11-15 RS RS20210360A patent/RS61829B1/sr unknown
- 2010-11-15 PL PL10830880T patent/PL2498610T3/pl unknown
- 2010-11-15 EP EP10830880.0A patent/EP2498610B2/en active Active
- 2010-11-15 BR BR112012011427A patent/BR112012011427B8/pt active IP Right Grant
- 2010-11-15 EA EA201290323A patent/EA024801B1/ru not_active IP Right Cessation
- 2010-11-15 CN CN201510295907.XA patent/CN105061350B/zh active Active
- 2010-11-15 DK DK18160667.4T patent/DK3406142T3/da active
- 2010-11-15 MY MYPI2012002084A patent/MY161854A/en unknown
- 2010-11-15 KR KR1020167035297A patent/KR101752124B1/ko active IP Right Grant
- 2010-11-15 ES ES10830880.0T patent/ES2673160T3/es active Active
- 2010-11-15 SI SI201032063T patent/SI3406142T1/sl unknown
- 2010-11-15 MY MYPI2016002092A patent/MY189750A/en unknown
- 2010-11-15 LT LTEP10830880.0T patent/LT2498610T/lt unknown
- 2010-11-15 KR KR1020127015292A patent/KR101721716B1/ko active IP Right Grant
- 2010-11-15 NZ NZ599915A patent/NZ599915A/en unknown
- 2010-11-15 EA EA201690391A patent/EA035768B1/ru not_active IP Right Cessation
- 2010-11-15 HU HUE18160667A patent/HUE054000T2/hu unknown
- 2010-11-15 WO PCT/US2010/056760 patent/WO2011060392A1/en active Application Filing
- 2010-11-15 BR BR122018077504A patent/BR122018077504B8/pt active IP Right Grant
- 2010-11-15 CN CN201080061144.8A patent/CN102762100B/zh active Active
- 2010-11-15 TR TR2018/07912T patent/TR201807912T4/tr unknown
- 2010-11-15 SG SG10201407357PA patent/SG10201407357PA/en unknown
- 2010-11-15 PT PT181606674T patent/PT3406142T/pt unknown
- 2010-11-15 SI SI201031704T patent/SI2498610T1/en unknown
- 2010-11-15 US US12/946,819 patent/US8362048B2/en active Active
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2012
- 2012-05-09 IL IL219691A patent/IL219691B/en active IP Right Grant
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2013
- 2013-01-14 US US13/740,661 patent/US20130231326A1/en not_active Abandoned
- 2013-03-14 HK HK16100726.3A patent/HK1213874A1/zh unknown
- 2013-03-14 HK HK13103206.9A patent/HK1175948A1/xx unknown
- 2013-11-14 JP JP2013235966A patent/JP5982705B2/ja active Active
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2014
- 2014-11-12 JP JP2014229895A patent/JP2015038145A/ja active Pending
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2015
- 2015-02-26 US US14/632,675 patent/US9388147B2/en active Active
- 2015-12-04 PH PH12015502708A patent/PH12015502708A1/en unknown
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2017
- 2017-01-13 US US15/406,128 patent/US10239846B2/en active Active
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2018
- 2018-06-05 HR HRP20180874TT patent/HRP20180874T1/hr unknown
- 2018-06-12 CY CY20181100611T patent/CY1120338T1/el unknown
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2019
- 2019-07-09 IL IL267956A patent/IL267956B/en active IP Right Grant
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2020
- 2020-11-18 NO NO2020039C patent/NO2020039I1/no unknown
- 2020-11-18 HU HUS2000045C patent/HUS2000045I1/hu unknown
- 2020-11-18 FR FR20C1059C patent/FR20C1059I2/fr active Active
- 2020-11-18 LT LTPA2020533C patent/LTC2498610I2/lt unknown
- 2020-11-19 CY CY2020035C patent/CY2020035I2/el unknown
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2021
- 2021-03-17 HR HRP20210446TT patent/HRP20210446T1/hr unknown
- 2021-03-22 CY CY20211100241T patent/CY1124121T1/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7443550B2 (ja) | 2020-03-04 | 2024-03-05 | ヒーリオイースト ファーマシューティカル カンパニー リミテッド | 三環系化合物及びその使用 |
