JP2013507905A5 - - Google Patents

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Publication number

JP2013507905A5

JP2013507905A5 JP2012526977A JP2012526977A JP2013507905A5 JP 2013507905 A5 JP2013507905 A5 JP 2013507905A5 JP 2012526977 A JP2012526977 A JP 2012526977A JP 2012526977 A JP2012526977 A JP 2012526977A JP 2013507905 A5 JP2013507905 A5 JP 2013507905A5

Authority

JP

Japan

Prior art keywords

oligonucleotide

based compound

protein

disease

nucleotide

Prior art date

2010-08-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 108091034117 Oligonucleotide Proteins 0.000 claims 29
• 150000001875 compounds Chemical class 0.000 claims 19
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
• 239000002773 nucleotide Substances 0.000 claims 7
• 108090000623 proteins and genes Proteins 0.000 claims 6
• 102000004169 proteins and genes Human genes 0.000 claims 6
• 230000000295 complement effect Effects 0.000 claims 5
• 201000010099 disease Diseases 0.000 claims 5
• 102000002689 Toll-like receptor Human genes 0.000 claims 4
• 108020000411 Toll-like receptor Proteins 0.000 claims 4
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 4
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• 239000003757 phosphotransferase inhibitor Substances 0.000 claims 2
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• 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims 1
• 208000023275 Autoimmune disease Diseases 0.000 claims 1
• 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 claims 1
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• 208000035473 Communicable disease Diseases 0.000 claims 1
• 108020004414 DNA Proteins 0.000 claims 1
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• 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims 1
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• 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims 1
• 101001098868 Homo sapiens Proprotein convertase subtilisin/kexin type 9 Proteins 0.000 claims 1
• 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 claims 1
• 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 1
• 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 1
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• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• 208000031888 Mycoses Diseases 0.000 claims 1
• 102000010168 Myeloid Differentiation Factor 88 Human genes 0.000 claims 1
• 108010077432 Myeloid Differentiation Factor 88 Proteins 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 102100038955 Proprotein convertase subtilisin/kexin type 9 Human genes 0.000 claims 1
• 108091030071 RNAI Proteins 0.000 claims 1
• 108091028664 Ribonucleotide Proteins 0.000 claims 1
• 108010002687 Survivin Proteins 0.000 claims 1
• 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 1
• 102100024333 Toll-like receptor 2 Human genes 0.000 claims 1
• 102100024324 Toll-like receptor 3 Human genes 0.000 claims 1
• 102100039360 Toll-like receptor 4 Human genes 0.000 claims 1
• 102100039357 Toll-like receptor 5 Human genes 0.000 claims 1
• 102100039387 Toll-like receptor 6 Human genes 0.000 claims 1
• 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
• 102100033110 Toll-like receptor 8 Human genes 0.000 claims 1
• 102100033117 Toll-like receptor 9 Human genes 0.000 claims 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 1
• 208000036142 Viral infection Diseases 0.000 claims 1
• 208000037883 airway inflammation Diseases 0.000 claims 1
• 125000005600 alkyl phosphonate group Chemical group 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
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• 239000005547 deoxyribonucleotide Substances 0.000 claims 1
• 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
• NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
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• 230000014509 gene expression Effects 0.000 claims 1
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• 230000002401 inhibitory effect Effects 0.000 claims 1
• 101150024228 mdm2 gene Proteins 0.000 claims 1
• YACKEPLHDIMKIO-UHFFFAOYSA-L methylphosphonate(2-) Chemical compound CP([O-])([O-])=O YACKEPLHDIMKIO-UHFFFAOYSA-L 0.000 claims 1
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
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• 108091092562 ribozyme Proteins 0.000 claims 1
• 208000017520 skin disease Diseases 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
• 230000003612 virological effect Effects 0.000 claims 1