JP2013507115A5 - - Google Patents

Info

Publication number

JP2013507115A5

JP2013507115A5 JP2012532622A JP2012532622A JP2013507115A5 JP 2013507115 A5 JP2013507115 A5 JP 2013507115A5 JP 2012532622 A JP2012532622 A JP 2012532622A JP 2012532622 A JP2012532622 A JP 2012532622A JP 2013507115 A5 JP2013507115 A5 JP 2013507115A5

Authority

JP

Japan

Prior art keywords

seq

polypeptide

amino acid

polypeptide complex

constant domain

Prior art date

2010-10-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

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• 229920001184 polypeptide Polymers 0.000 claims 25
• 108090000765 processed proteins & peptides Proteins 0.000 claims 25
• 102000004196 processed proteins & peptides Human genes 0.000 claims 25
• 125000003275 alpha amino acid group Chemical group 0.000 claims 9
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 4
• 208000035475 disorder Diseases 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 230000027455 binding Effects 0.000 claims 3
• 206010012601 diabetes mellitus Diseases 0.000 claims 3
• 208000027866 inflammatory disease Diseases 0.000 claims 3
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 2
• 201000001119 neuropathy Diseases 0.000 claims 2
• 230000007823 neuropathy Effects 0.000 claims 2
• 208000033808 peripheral neuropathy Diseases 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 208000002249 Diabetes Complications Diseases 0.000 claims 1
• 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
• 206010012655 Diabetic complications Diseases 0.000 claims 1
• 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
• 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
• 206010019280 Heart failures Diseases 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 206010024641 Listeriosis Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
• 208000017442 Retinal disease Diseases 0.000 claims 1
• 206010038923 Retinopathy Diseases 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 206010040070 Septic Shock Diseases 0.000 claims 1
• 206010047115 Vasculitis Diseases 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 125000000539 amino acid group Chemical group 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 206010002022 amyloidosis Diseases 0.000 claims 1
• 206010003246 arthritis Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 239000007795 chemical reaction product Substances 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 208000033679 diabetic kidney disease Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000012634 fragment Substances 0.000 claims 1
• 230000036252 glycation Effects 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 201000001881 impotence Diseases 0.000 claims 1
• 208000028774 intestinal disease Diseases 0.000 claims 1
• 208000017169 kidney disease Diseases 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 208000010125 myocardial infarction Diseases 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 230000036303 septic shock Effects 0.000 claims 1
• 230000009870 specific binding Effects 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 208000019553 vascular disease Diseases 0.000 claims 1