JP2013506639A5 - - Google Patents
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- Publication number
- JP2013506639A5 JP2013506639A5 JP2012531448A JP2012531448A JP2013506639A5 JP 2013506639 A5 JP2013506639 A5 JP 2013506639A5 JP 2012531448 A JP2012531448 A JP 2012531448A JP 2012531448 A JP2012531448 A JP 2012531448A JP 2013506639 A5 JP2013506639 A5 JP 2013506639A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- compound
- formula
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *C(C(C1=NC(*)=C(*)*1)=O)(I)I Chemical compound *C(C(C1=NC(*)=C(*)*1)=O)(I)I 0.000 description 20
- PQJGNSFZEGGFDP-UHFFFAOYSA-N CC(C)CC(C1SC(CCC=C2)=C2N1)=O Chemical compound CC(C)CC(C1SC(CCC=C2)=C2N1)=O PQJGNSFZEGGFDP-UHFFFAOYSA-N 0.000 description 1
- IHSWAXVALJQQHH-UHFFFAOYSA-N CC1SC(C(CCCCc2ccccc2)=O)=NC1CC(O)=O Chemical compound CC1SC(C(CCCCc2ccccc2)=O)=NC1CC(O)=O IHSWAXVALJQQHH-UHFFFAOYSA-N 0.000 description 1
- KKAIZYXTTAZXFM-DOFZRALJSA-N CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(c1ncc[s]1)=O Chemical compound CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(c1ncc[s]1)=O KKAIZYXTTAZXFM-DOFZRALJSA-N 0.000 description 1
- FJFVPRCVGZYKLW-UHFFFAOYSA-N CCCCCCCCc1ccc(CCCCC(c2nc(CC(OCC)=O)c[s]2)=O)cc1 Chemical compound CCCCCCCCc1ccc(CCCCC(c2nc(CC(OCC)=O)c[s]2)=O)cc1 FJFVPRCVGZYKLW-UHFFFAOYSA-N 0.000 description 1
- ZZEVFTHVFLUSMQ-UHFFFAOYSA-N CCCCCCOc1ccc(CCC(c2ncc[s]2)=O)cc1 Chemical compound CCCCCCOc1ccc(CCC(c2ncc[s]2)=O)cc1 ZZEVFTHVFLUSMQ-UHFFFAOYSA-N 0.000 description 1
- RYSJFVJZNUIROH-UHFFFAOYSA-N CCOC(CC1N=C(C(CCCCc2ccccc2)=O)SC1C)=O Chemical compound CCOC(CC1N=C(C(CCCCc2ccccc2)=O)SC1C)=O RYSJFVJZNUIROH-UHFFFAOYSA-N 0.000 description 1
- TXDCWKNQQRDWSA-UHFFFAOYSA-N CCOC(Cc1c[s]c(C(CCCCc(cc2)ccc2-c2ccccc2)=O)n1)=O Chemical compound CCOC(Cc1c[s]c(C(CCCCc(cc2)ccc2-c2ccccc2)=O)n1)=O TXDCWKNQQRDWSA-UHFFFAOYSA-N 0.000 description 1
- RLSFQYHAXBLCBR-UHFFFAOYSA-N CNC(c1nc(/[O]=C(\CCCCc2ccccc2)/c2ncc[s]2)c[s]1)=O Chemical compound CNC(c1nc(/[O]=C(\CCCCc2ccccc2)/c2ncc[s]2)c[s]1)=O RLSFQYHAXBLCBR-UHFFFAOYSA-N 0.000 description 1
- RKGDIPCRLQAWTF-UHFFFAOYSA-N COC(c1c[s]c(C(CCCCc(cc2)ccc2-c2ccccc2)=O)n1)=O Chemical compound COC(c1c[s]c(C(CCCCc(cc2)ccc2-c2ccccc2)=O)n1)=O RKGDIPCRLQAWTF-UHFFFAOYSA-N 0.000 description 1
- PKRTXQVTIJMLGE-UHFFFAOYSA-N O=C(CCCCc1cc(cccc2)c2cc1)c1nc(cccc2)c2[s]1 Chemical compound O=C(CCCCc1cc(cccc2)c2cc1)c1nc(cccc2)c2[s]1 PKRTXQVTIJMLGE-UHFFFAOYSA-N 0.000 description 1
- KTIZWGOVAMQNDW-UHFFFAOYSA-N O=C(CCCCc1ccccc1)c1nc(cccc2)c2[s]1 Chemical compound O=C(CCCCc1ccccc1)c1nc(cccc2)c2[s]1 KTIZWGOVAMQNDW-UHFFFAOYSA-N 0.000 description 1
- NDCYLDBUFWAIPG-UHFFFAOYSA-N O=C(CNC(Cc1ccccc1)=O)c1nc(cccc2)c2[s]1 Chemical compound O=C(CNC(Cc1ccccc1)=O)c1nc(cccc2)c2[s]1 NDCYLDBUFWAIPG-UHFFFAOYSA-N 0.000 description 1
- AVANAVVVGAMZMA-UHFFFAOYSA-N OC(C1N=C(C(CCCCc2ccccc2)=O)SC1)=O Chemical compound OC(C1N=C(C(CCCCc2ccccc2)=O)SC1)=O AVANAVVVGAMZMA-UHFFFAOYSA-N 0.000 description 1
- IHRLCNBSCIRRMD-UHFFFAOYSA-N OC(c1c[s]c(C(CCCCc(cc2)ccc2-c2ccccc2)=O)n1)=O Chemical compound OC(c1c[s]c(C(CCCCc(cc2)ccc2-c2ccccc2)=O)n1)=O IHRLCNBSCIRRMD-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24833809P | 2009-10-02 | 2009-10-02 | |
| US61/248,338 | 2009-10-02 | ||
| PCT/EP2010/064687 WO2011039365A1 (en) | 2009-10-02 | 2010-10-01 | Anti inflammatory 2-oxothiazoles and 2 -oxooxazoles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013506639A JP2013506639A (ja) | 2013-02-28 |
| JP2013506639A5 true JP2013506639A5 (https=) | 2013-08-15 |
| JP6012468B2 JP6012468B2 (ja) | 2016-10-25 |
Family
ID=43221889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012531448A Expired - Fee Related JP6012468B2 (ja) | 2009-10-02 | 2010-10-01 | 抗炎症性２−オキソチアゾールおよび２−オキソオキサゾール |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9597318B2 (https=) |
| EP (2) | EP2482815B1 (https=) |
| JP (1) | JP6012468B2 (https=) |
| KR (4) | KR20190082985A (https=) |
| CN (3) | CN103772312B (https=) |
| AU (1) | AU2010302584B2 (https=) |
| CA (1) | CA2782797C (https=) |
| DK (1) | DK2482815T3 (https=) |
| IN (1) | IN2012DN02982A (https=) |
| NO (1) | NO2482815T3 (https=) |
| WO (1) | WO2011039365A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2782797C (en) | 2009-10-02 | 2018-08-07 | Avexxin As | Anti inflammatory 2-oxothiazoles and 2 -oxooxazoles |
| GB201205394D0 (en) | 2012-03-27 | 2012-05-09 | Adlens Ltd | Improvements in or relating to deformable non-round membrane assemblies |
| GB201221329D0 (en) * | 2012-11-27 | 2013-01-09 | Avexxin As | Dermatitis treatment |
| CN105102438B (zh) | 2013-01-29 | 2019-04-30 | 埃维克辛公司 | 抗炎症和抗肿瘤的2-氧代噻唑类和2-氧代噻吩类化合物 |
| GB201307331D0 (en) * | 2013-04-23 | 2013-05-29 | Norwegian Univ Sci & Tech Ntnu | Compound |
| GB201409363D0 (en) | 2014-05-27 | 2014-07-09 | Avexxin As | Skin cancer treatment |
| GB201413695D0 (en) | 2014-08-01 | 2014-09-17 | Avexxin As | Compound |
| GB201604318D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| GB201604316D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| GB2550363A (en) * | 2016-05-16 | 2017-11-22 | Avexxin As | Compound |
| EP3515422A1 (en) | 2016-09-21 | 2019-07-31 | Avexxin AS | Pharmaceutical composition |
| AU2017353450B2 (en) * | 2016-11-04 | 2020-09-10 | Avexxin As | Combination therapy comprising a thiazole and a secosteroid to treat skin conditions |
| JP2019532980A (ja) * | 2016-11-04 | 2019-11-14 | アヴェクシン エーエス | 皮膚症状を治療するためのチアゾールおよび副腎皮質ステロイドを含む併用療法 |
| JP7169584B2 (ja) * | 2018-01-30 | 2022-11-11 | 公立大学法人横浜市立大学 | オーキシン生合成阻害活性を有する新規化合物、その製造方法及びその用途 |
| GB201806663D0 (en) | 2018-04-24 | 2018-06-06 | Avexxin As | 2-Oxothiazole compositions for treatment of fibrotic disease |
| EP3677259A1 (en) * | 2019-01-07 | 2020-07-08 | Mosaiques Diagnostics And Therapeutics AG | Use of arachidonyl trifluoromethyl ketone |
| GB202117609D0 (en) | 2021-12-06 | 2022-01-19 | Coegin Pharma Ab | 2-Oxothiazole compositions for treatment of T-cell acute lymphoblastic leukaemia |
| CN115028597B (zh) * | 2022-04-29 | 2024-03-26 | 闽都创新实验室 | 一种tempo连续脱氢环化制备苯并恶唑类衍生物的方法和应用 |
| WO2025125241A1 (en) | 2023-12-15 | 2025-06-19 | Coegin Pharma Ab | Pharmaceutical composition |
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| DE2063901A1 (en) | 1970-12-28 | 1972-07-20 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Phenylalkylaminoalkylthiazoles - as antiphlogistics |
| US5177215A (en) | 1984-11-12 | 1993-01-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic compounds and pharmaceutical use thereof |
| PH22520A (en) | 1984-11-12 | 1988-10-17 | Yamanouchi Pharma Co Ltd | Heterocyclic compounds having 4-lover alkyl-3-hydroxy-2-lower alkyl phenoxy-lower alkylene-y-group, and process of producing them |
| JPS62142168A (ja) | 1985-10-16 | 1987-06-25 | Mitsubishi Chem Ind Ltd | チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤 |
| NZ229761A (en) | 1988-07-12 | 1991-10-25 | Ici Pharma | Substituted thiazole derivatives for use as inhibitors of enzyme 5-lipoxygenase; pharmaceutical compositions and preparatory processes |
| US5272986A (en) | 1991-05-13 | 1993-12-28 | British Gas Plc | Towing swivel for pipe inspection or other vehicle |
| TW263504B (https=) | 1991-10-03 | 1995-11-21 | Pfizer | |
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| US5273986A (en) | 1992-07-02 | 1993-12-28 | Hoffmann-La Roche Inc. | Cycloalkylthiazoles |
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| DE19638408A1 (de) * | 1996-09-19 | 1998-03-26 | Merckle Gmbh | 1-Substituierte 3-Acyl-4,5-dimethylpyrrol-2-carbonsäuren und 3-Acylindol-2-carbonsäuren sowie ihre Derivate als Hemmstoffe der cytosolischen Phospholipase A¶2¶ |
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| JP2009527483A (ja) * | 2006-02-17 | 2009-07-30 | ザ・スクリプス・リサーチ・インステイチユート | 脂肪酸アミドヒドロラーゼの調節因子としてのオキサゾールケトン |
| WO2008013963A2 (en) * | 2006-07-28 | 2008-01-31 | University Of Connecticut | Fatty acid amide hydrolase inhibitors |
| KR20090115749A (ko) | 2007-02-26 | 2009-11-05 | 산텐 세이야꾸 가부시키가이샤 | 우레이드기와 아미노카르보닐기를 치환기로서 갖는 신규 피롤 유도체 |
| CN101627007A (zh) * | 2007-03-05 | 2010-01-13 | 弗·哈夫曼-拉罗切有限公司 | 用作食欲肽拮抗剂的氨基酰胺 |
| EP2161997A4 (en) * | 2007-05-31 | 2011-04-06 | Scripps Research Inst | TRICYCLIC INHIBITORS OF FATTY ACID AMIDHYDROLASE |
| CA2782797C (en) | 2009-10-02 | 2018-08-07 | Avexxin As | Anti inflammatory 2-oxothiazoles and 2 -oxooxazoles |
| US20130231468A1 (en) | 2010-11-22 | 2013-09-05 | Takeshi Yamashita | Rare earth metal complex |
| CN105102438B (zh) | 2013-01-29 | 2019-04-30 | 埃维克辛公司 | 抗炎症和抗肿瘤的2-氧代噻唑类和2-氧代噻吩类化合物 |
| GB201413695D0 (en) * | 2014-08-01 | 2014-09-17 | Avexxin As | Compound |
-
2010
- 2010-10-01 CA CA2782797A patent/CA2782797C/en active Active
- 2010-10-01 CN CN201310675185.1A patent/CN103772312B/zh not_active Expired - Fee Related
- 2010-10-01 KR KR1020197018997A patent/KR20190082985A/ko not_active Withdrawn
- 2010-10-01 IN IN2982DEN2012 patent/IN2012DN02982A/en unknown
- 2010-10-01 KR KR1020187028820A patent/KR101997163B1/ko not_active Expired - Fee Related
- 2010-10-01 AU AU2010302584A patent/AU2010302584B2/en not_active Ceased
- 2010-10-01 EP EP10759934.2A patent/EP2482815B1/en not_active Not-in-force
- 2010-10-01 CN CN201080056033.8A patent/CN102647984B/zh not_active Expired - Fee Related
- 2010-10-01 EP EP18170271.3A patent/EP3431084A1/en not_active Withdrawn
- 2010-10-01 DK DK10759934.2T patent/DK2482815T3/en active
- 2010-10-01 NO NO10759934A patent/NO2482815T3/no unknown
- 2010-10-01 CN CN201510086534.5A patent/CN104892542B/zh not_active Expired - Fee Related
- 2010-10-01 KR KR1020177008521A patent/KR101907535B1/ko not_active Expired - Fee Related
- 2010-10-01 WO PCT/EP2010/064687 patent/WO2011039365A1/en not_active Ceased
- 2010-10-01 KR KR1020127011173A patent/KR20120089701A/ko not_active Ceased
- 2010-10-01 JP JP2012531448A patent/JP6012468B2/ja not_active Expired - Fee Related
- 2010-10-04 US US12/897,510 patent/US9597318B2/en not_active Expired - Fee Related
-
2017
- 2017-02-24 US US15/442,568 patent/US10370344B2/en active Active
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