JP2013506003A5 - - Google Patents
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- Publication number
- JP2013506003A5 JP2013506003A5 JP2012532230A JP2012532230A JP2013506003A5 JP 2013506003 A5 JP2013506003 A5 JP 2013506003A5 JP 2012532230 A JP2012532230 A JP 2012532230A JP 2012532230 A JP2012532230 A JP 2012532230A JP 2013506003 A5 JP2013506003 A5 JP 2013506003A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- isopropyl
- methoxy
- pyrazolo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24664209P | 2009-09-29 | 2009-09-29 | |
| US61/246,642 | 2009-09-29 | ||
| PCT/US2010/050486 WO2011041287A1 (en) | 2009-09-29 | 2010-09-28 | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (s1p2) receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013506003A JP2013506003A (ja) | 2013-02-21 |
| JP2013506003A5 true JP2013506003A5 (enExample) | 2013-11-14 |
Family
ID=43031503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532230A Pending JP2013506003A (ja) | 2009-09-29 | 2010-09-28 | スフィンゴシン−１−リン酸−２（ｓ１ｐ２）受容体のサブタイプ選択的調節因子としての縮合環ピリジン化合物 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8507682B2 (enExample) |
| EP (1) | EP2483245A1 (enExample) |
| JP (1) | JP2013506003A (enExample) |
| KR (1) | KR20120087932A (enExample) |
| CN (1) | CN102741232A (enExample) |
| AU (1) | AU2010300791A1 (enExample) |
| BR (1) | BR112012007095A2 (enExample) |
| CA (1) | CA2775587A1 (enExample) |
| IL (1) | IL218843A0 (enExample) |
| MX (1) | MX2012003718A (enExample) |
| NZ (1) | NZ599595A (enExample) |
| RU (1) | RU2012114718A (enExample) |
| SG (1) | SG10201406178WA (enExample) |
| WO (1) | WO2011041287A1 (enExample) |
| ZA (1) | ZA201202366B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104334556B (zh) | 2012-03-26 | 2017-05-17 | 爱若优生物科技有限公司 | 新型1‑磷酸鞘氨醇受体拮抗剂 |
| WO2014158302A1 (en) * | 2013-03-25 | 2014-10-02 | Swenson Rolf Eric | Novel sphingosine 1-phosphate receptor antagonists |
| JP6867165B2 (ja) * | 2014-06-02 | 2021-04-28 | ダルハウジー ユニバーシティー | Ｓ１ｐｒ２の阻害による家族性滲出性硝子体網膜症の処置 |
| HK1246288A1 (zh) * | 2015-06-01 | 2018-09-07 | Dalhousie University | S1pr2拮抗剂及其用途 |
| US10858358B2 (en) | 2015-06-01 | 2020-12-08 | Dalhousie University | S1PR2 antagonists and uses therefor |
| US10487082B2 (en) | 2015-06-01 | 2019-11-26 | Dalhousie University | S1PR2 antagonists and uses therefor |
| CN107382965A (zh) * | 2017-08-14 | 2017-11-24 | 河南科技大学第附属医院 | 具有抗肿瘤活性的新型s1p‑1受体激动剂药物分子的合成方法 |
| CN113896646B (zh) * | 2020-07-06 | 2023-06-02 | 浙江海森药业股份有限公司 | 一种4-甲基-3-氧代-n-苯基戊酰胺的高效绿色制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0146810A3 (de) | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| US5110987A (en) | 1988-06-17 | 1992-05-05 | Emory University | Method of preparing sphingosine derivatives |
| ZA902794B (en) | 1989-04-18 | 1991-04-24 | Duphar Int Res | New 3-n substituted carbamoyl-indole derivatives |
| US5294722A (en) | 1992-04-16 | 1994-03-15 | E. R. Squibb & Sons, Inc. | Process for the preparation of imidazoles useful in angiotensin II antagonism |
| US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| US6235912B1 (en) | 1997-03-12 | 2001-05-22 | Takara Shuzo Co., Ltd. | Sphingosine analogues |
| JP4091250B2 (ja) | 1997-09-11 | 2008-05-28 | タカラバイオ株式会社 | スフィンゴシン類誘導体及び医薬組成物 |
| AU2001264313A1 (en) * | 2000-06-20 | 2002-01-02 | Japan Tobacco Inc. | Pyrazolopyridine compounds and use thereof as drugs |
| US20020183762A1 (en) | 2001-06-01 | 2002-12-05 | Ams Research Corporation | Bone anchor inserters and methods |
| DE60221391T2 (de) | 2001-06-20 | 2008-04-17 | Wyeth | Substituierte indolsäurederivate als inhibitoren von plasminogen-aktivator-inhibitor-1 (pai-1) |
| US20040235794A1 (en) * | 2001-09-04 | 2004-11-25 | Shinji Nakade | Remedies for respiratory diseases comprising sphingosine-1-phosphate receptor controller |
| WO2003051876A1 (en) * | 2001-12-14 | 2003-06-26 | Japan Tobacco Inc. | Pyrazolopyridine derivatives and medicinal use thereof |
| GB0206876D0 (en) * | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| KR20050004214A (ko) | 2002-05-31 | 2005-01-12 | 에자이 가부시키가이샤 | 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물 |
| WO2008154470A1 (en) | 2007-06-08 | 2008-12-18 | University Of Connecticut | Nhibitor of the receptor activity of the s1p2 receptor for inhibiting pathological angiogenesis in the eye |
| WO2009074969A2 (en) * | 2007-12-12 | 2009-06-18 | University Of Lausanne | Sphingosine-1-phosphate, analogs and antagonists for use as medicaments |
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2010
- 2010-09-28 MX MX2012003718A patent/MX2012003718A/es active IP Right Grant
- 2010-09-28 BR BR112012007095A patent/BR112012007095A2/pt not_active IP Right Cessation
- 2010-09-28 KR KR1020127010718A patent/KR20120087932A/ko not_active Withdrawn
- 2010-09-28 SG SG10201406178WA patent/SG10201406178WA/en unknown
- 2010-09-28 US US13/498,499 patent/US8507682B2/en not_active Expired - Fee Related
- 2010-09-28 AU AU2010300791A patent/AU2010300791A1/en not_active Abandoned
- 2010-09-28 JP JP2012532230A patent/JP2013506003A/ja active Pending
- 2010-09-28 RU RU2012114718/04A patent/RU2012114718A/ru not_active Application Discontinuation
- 2010-09-28 CN CN2010800492699A patent/CN102741232A/zh active Pending
- 2010-09-28 NZ NZ599595A patent/NZ599595A/en not_active IP Right Cessation
- 2010-09-28 EP EP10763267A patent/EP2483245A1/en not_active Withdrawn
- 2010-09-28 CA CA2775587A patent/CA2775587A1/en not_active Abandoned
- 2010-09-28 WO PCT/US2010/050486 patent/WO2011041287A1/en not_active Ceased
-
2012
- 2012-03-26 IL IL218843A patent/IL218843A0/en unknown
- 2012-04-02 ZA ZA2012/02366A patent/ZA201202366B/en unknown
-
2013
- 2013-06-27 US US13/929,451 patent/US8703797B2/en not_active Expired - Fee Related