MX2012003718A - Compuestos de piridina de anillo condensado como moduladores selectivos de subtipo de receptores de esfingosina-1-fosfato-2 (s1p2). - Google Patents
Compuestos de piridina de anillo condensado como moduladores selectivos de subtipo de receptores de esfingosina-1-fosfato-2 (s1p2).Info
- Publication number
- MX2012003718A MX2012003718A MX2012003718A MX2012003718A MX2012003718A MX 2012003718 A MX2012003718 A MX 2012003718A MX 2012003718 A MX2012003718 A MX 2012003718A MX 2012003718 A MX2012003718 A MX 2012003718A MX 2012003718 A MX2012003718 A MX 2012003718A
- Authority
- MX
- Mexico
- Prior art keywords
- isopropyl
- group
- alkyl
- pyrazolo
- dimethyl
- Prior art date
Links
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
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- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
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| US24664209P | 2009-09-29 | 2009-09-29 | |
| PCT/US2010/050486 WO2011041287A1 (en) | 2009-09-29 | 2010-09-28 | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (s1p2) receptors |
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| MX2012003718A true MX2012003718A (es) | 2012-06-28 |
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| AU2013240139B2 (en) | 2012-03-26 | 2017-02-23 | Arroyo Biosciences L.L.C. | Novel sphingosine 1-phosphate receptor antagonists |
| WO2014158302A1 (en) * | 2013-03-25 | 2014-10-02 | Swenson Rolf Eric | Novel sphingosine 1-phosphate receptor antagonists |
| EP3148550B1 (en) * | 2014-06-02 | 2020-10-28 | Dalhousie University | Treatment of familial exudative vitreoretinopathy through s1pr2 inhibition |
| US10487082B2 (en) | 2015-06-01 | 2019-11-26 | Dalhousie University | S1PR2 antagonists and uses therefor |
| US10858358B2 (en) | 2015-06-01 | 2020-12-08 | Dalhousie University | S1PR2 antagonists and uses therefor |
| AU2016273436B2 (en) * | 2015-06-01 | 2021-01-28 | Dalhousie University | S1PR2 antagonists and uses therefor |
| CN107382965A (zh) * | 2017-08-14 | 2017-11-24 | 河南科技大学第附属医院 | 具有抗肿瘤活性的新型s1p‑1受体激动剂药物分子的合成方法 |
| CN113896646B (zh) * | 2020-07-06 | 2023-06-02 | 浙江海森药业股份有限公司 | 一种4-甲基-3-氧代-n-苯基戊酰胺的高效绿色制备方法 |
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| EP0146810A3 (de) | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| US5110987A (en) | 1988-06-17 | 1992-05-05 | Emory University | Method of preparing sphingosine derivatives |
| NZ233285A (en) | 1989-04-18 | 1992-06-25 | Duphar Int Res | Imidazole-substituted carbamoyl-indoles and condensed analogues thereof and pharmaceutical compositions |
| US5294722A (en) | 1992-04-16 | 1994-03-15 | E. R. Squibb & Sons, Inc. | Process for the preparation of imidazoles useful in angiotensin II antagonism |
| US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| ATE314342T1 (de) | 1997-03-12 | 2006-01-15 | Takara Bio Inc | Spingosinanaloga |
| WO1999012890A1 (fr) | 1997-09-11 | 1999-03-18 | Takara Shuzo Co., Ltd. | Derives de sphingosine et composition medicamenteuse |
| WO2001098301A1 (en) * | 2000-06-20 | 2001-12-27 | Japan Tobacco Inc. | Pyrazolopyridine compounds and use thereof as drugs |
| US20020183762A1 (en) | 2001-06-01 | 2002-12-05 | Ams Research Corporation | Bone anchor inserters and methods |
| US7074817B2 (en) | 2001-06-20 | 2006-07-11 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| JPWO2003020313A1 (ja) * | 2001-09-04 | 2004-12-16 | 小野薬品工業株式会社 | スフィンゴシン−１−リン酸受容体調節剤からなる呼吸器疾患治療剤 |
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| CN1656079A (zh) | 2002-05-31 | 2005-08-17 | 卫材株式会社 | 吡唑化合物和含有该化合物的药物组合物 |
| US20090004207A1 (en) | 2007-06-08 | 2009-01-01 | Timothy Tun Hla | Methods and Compositions for Inhibiting Pathological Angiogenesis in the Eye |
| WO2009074969A2 (en) * | 2007-12-12 | 2009-06-18 | University Of Lausanne | Sphingosine-1-phosphate, analogs and antagonists for use as medicaments |
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| CN102741232A (zh) | 2012-10-17 |
| US20130296361A1 (en) | 2013-11-07 |
| SG10201406178WA (en) | 2014-11-27 |
| US20120208840A1 (en) | 2012-08-16 |
| WO2011041287A1 (en) | 2011-04-07 |
| CA2775587A1 (en) | 2011-04-07 |
| ZA201202366B (en) | 2012-12-27 |
| JP2013506003A (ja) | 2013-02-21 |
| KR20120087932A (ko) | 2012-08-07 |
| IL218843A0 (en) | 2012-06-28 |
| EP2483245A1 (en) | 2012-08-08 |
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