NZ599595A - Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (s1p2) receptors - Google Patents
Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (s1p2) receptorsInfo
- Publication number
- NZ599595A NZ599595A NZ599595A NZ59959510A NZ599595A NZ 599595 A NZ599595 A NZ 599595A NZ 599595 A NZ599595 A NZ 599595A NZ 59959510 A NZ59959510 A NZ 59959510A NZ 599595 A NZ599595 A NZ 599595A
- Authority
- NZ
- New Zealand
- Prior art keywords
- dichlorophenyl
- hydrazinecarboxamide
- compounds
- sphingosine
- dimethylquinolin
- Prior art date
Links
- 150000003222 pyridines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- FPNRZKJVJGUCOW-UHFFFAOYSA-N 1-(2,6-dichloropyridin-4-yl)-3-[(4,8-dimethylquinolin-2-yl)amino]urea Chemical compound N1=C2C(C)=CC=CC2=C(C)C=C1NNC(=O)NC1=CC(Cl)=NC(Cl)=C1 FPNRZKJVJGUCOW-UHFFFAOYSA-N 0.000 abstract 1
- XDQJLXNLJHENBK-UHFFFAOYSA-N 1-(2,6-dichloropyridin-4-yl)-3-[(4-methylquinolin-2-yl)amino]urea Chemical compound N=1C2=CC=CC=C2C(C)=CC=1NNC(=O)NC1=CC(Cl)=NC(Cl)=C1 XDQJLXNLJHENBK-UHFFFAOYSA-N 0.000 abstract 1
- XELXFTLTXOLAHQ-UHFFFAOYSA-N 1-(3,5-dichlorophenyl)-3-[(4,5,8-trimethylquinolin-2-yl)amino]urea Chemical compound N1=C2C(C)=CC=C(C)C2=C(C)C=C1NNC(=O)NC1=CC(Cl)=CC(Cl)=C1 XELXFTLTXOLAHQ-UHFFFAOYSA-N 0.000 abstract 1
- BKWSFLNRRIKSGC-UHFFFAOYSA-N 1-(3,5-dichlorophenyl)-3-[(4,8-dimethylquinolin-2-yl)amino]urea Chemical compound N1=C2C(C)=CC=CC2=C(C)C=C1NNC(=O)NC1=CC(Cl)=CC(Cl)=C1 BKWSFLNRRIKSGC-UHFFFAOYSA-N 0.000 abstract 1
- IZYXAFZDAPSOAV-UHFFFAOYSA-N 1-(3,5-dichlorophenyl)-3-[(4-methyl-1,8-naphthyridin-2-yl)amino]urea Chemical compound N=1C2=NC=CC=C2C(C)=CC=1NNC(=O)NC1=CC(Cl)=CC(Cl)=C1 IZYXAFZDAPSOAV-UHFFFAOYSA-N 0.000 abstract 1
- OHKRXLXZZHSWJD-UHFFFAOYSA-N 1-(3,5-dichlorophenyl)-3-[(4-propan-2-yl-1,8-naphthyridin-2-yl)amino]urea Chemical compound N=1C2=NC=CC=C2C(C(C)C)=CC=1NNC(=O)NC1=CC(Cl)=CC(Cl)=C1 OHKRXLXZZHSWJD-UHFFFAOYSA-N 0.000 abstract 1
- OWXCWZQVBWXWBH-UHFFFAOYSA-N 1-(3,5-dichlorophenyl)-3-[(4-propan-2-ylquinolin-2-yl)amino]urea Chemical compound N=1C2=CC=CC=C2C(C(C)C)=CC=1NNC(=O)NC1=CC(Cl)=CC(Cl)=C1 OWXCWZQVBWXWBH-UHFFFAOYSA-N 0.000 abstract 1
- NQMYDNLQQJWODH-UHFFFAOYSA-N 1-(3,5-dichlorophenyl)-3-[(5,8-dimethyl-4-propan-2-ylquinolin-2-yl)amino]urea Chemical compound N=1C2=C(C)C=CC(C)=C2C(C(C)C)=CC=1NNC(=O)NC1=CC(Cl)=CC(Cl)=C1 NQMYDNLQQJWODH-UHFFFAOYSA-N 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000022873 Ocular disease Diseases 0.000 abstract 1
- 229940121846 Sphingosine 1-phosphate receptor agonist Drugs 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 208000019622 heart disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 230000006453 vascular barrier function Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24664209P | 2009-09-29 | 2009-09-29 | |
| PCT/US2010/050486 WO2011041287A1 (en) | 2009-09-29 | 2010-09-28 | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (s1p2) receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ599595A true NZ599595A (en) | 2014-03-28 |
Family
ID=43031503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ599595A NZ599595A (en) | 2009-09-29 | 2010-09-28 | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (s1p2) receptors |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8507682B2 (enExample) |
| EP (1) | EP2483245A1 (enExample) |
| JP (1) | JP2013506003A (enExample) |
| KR (1) | KR20120087932A (enExample) |
| CN (1) | CN102741232A (enExample) |
| AU (1) | AU2010300791A1 (enExample) |
| BR (1) | BR112012007095A2 (enExample) |
| CA (1) | CA2775587A1 (enExample) |
| IL (1) | IL218843A0 (enExample) |
| MX (1) | MX2012003718A (enExample) |
| NZ (1) | NZ599595A (enExample) |
| RU (1) | RU2012114718A (enExample) |
| SG (1) | SG10201406178WA (enExample) |
| WO (1) | WO2011041287A1 (enExample) |
| ZA (1) | ZA201202366B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013148460A1 (en) | 2012-03-26 | 2013-10-03 | Swenson Rolf E | Novel sphingosine 1-phosphate receptor antagonists |
| WO2014158302A1 (en) * | 2013-03-25 | 2014-10-02 | Swenson Rolf Eric | Novel sphingosine 1-phosphate receptor antagonists |
| CA2953208C (en) * | 2014-06-02 | 2022-05-10 | Dalhousie University | Treatment of familial exudative vitreoretinopathy through s1pr2 inhibition |
| US10487082B2 (en) | 2015-06-01 | 2019-11-26 | Dalhousie University | S1PR2 antagonists and uses therefor |
| US10858358B2 (en) | 2015-06-01 | 2020-12-08 | Dalhousie University | S1PR2 antagonists and uses therefor |
| CN107849038A (zh) * | 2015-06-01 | 2018-03-27 | 达尔豪西大学 | S1pr2拮抗剂及其用途 |
| CN107382965A (zh) * | 2017-08-14 | 2017-11-24 | 河南科技大学第附属医院 | 具有抗肿瘤活性的新型s1p‑1受体激动剂药物分子的合成方法 |
| CN113896646B (zh) * | 2020-07-06 | 2023-06-02 | 浙江海森药业股份有限公司 | 一种4-甲基-3-氧代-n-苯基戊酰胺的高效绿色制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0146810A3 (de) | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| US5110987A (en) | 1988-06-17 | 1992-05-05 | Emory University | Method of preparing sphingosine derivatives |
| ZA902794B (en) | 1989-04-18 | 1991-04-24 | Duphar Int Res | New 3-n substituted carbamoyl-indole derivatives |
| US5294722A (en) | 1992-04-16 | 1994-03-15 | E. R. Squibb & Sons, Inc. | Process for the preparation of imidazoles useful in angiotensin II antagonism |
| US5403851A (en) | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| JP4001929B2 (ja) | 1997-03-12 | 2007-10-31 | タカラバイオ株式会社 | スフィンゴシン類縁化合物 |
| AU9002298A (en) | 1997-09-11 | 1999-03-29 | Takara Shuzo Co., Ltd. | Sphingosine derivatives and medicinal composition |
| WO2001098301A1 (en) * | 2000-06-20 | 2001-12-27 | Japan Tobacco Inc. | Pyrazolopyridine compounds and use thereof as drugs |
| US20020183762A1 (en) | 2001-06-01 | 2002-12-05 | Ams Research Corporation | Bone anchor inserters and methods |
| WO2003000253A1 (en) | 2001-06-20 | 2003-01-03 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| JPWO2003020313A1 (ja) * | 2001-09-04 | 2004-12-16 | 小野薬品工業株式会社 | スフィンゴシン−１−リン酸受容体調節剤からなる呼吸器疾患治療剤 |
| WO2003051876A1 (en) * | 2001-12-14 | 2003-06-26 | Japan Tobacco Inc. | Pyrazolopyridine derivatives and medicinal use thereof |
| GB0206876D0 (en) * | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| US7429609B2 (en) | 2002-05-31 | 2008-09-30 | Eisai R & D Management Co., Ltd. | Pyrazole compound and medicinal composition containing the same |
| WO2008154470A1 (en) | 2007-06-08 | 2008-12-18 | University Of Connecticut | Nhibitor of the receptor activity of the s1p2 receptor for inhibiting pathological angiogenesis in the eye |
| WO2009074969A2 (en) * | 2007-12-12 | 2009-06-18 | University Of Lausanne | Sphingosine-1-phosphate, analogs and antagonists for use as medicaments |
-
2010
- 2010-09-28 CA CA2775587A patent/CA2775587A1/en not_active Abandoned
- 2010-09-28 RU RU2012114718/04A patent/RU2012114718A/ru not_active Application Discontinuation
- 2010-09-28 KR KR1020127010718A patent/KR20120087932A/ko not_active Withdrawn
- 2010-09-28 WO PCT/US2010/050486 patent/WO2011041287A1/en not_active Ceased
- 2010-09-28 MX MX2012003718A patent/MX2012003718A/es active IP Right Grant
- 2010-09-28 SG SG10201406178WA patent/SG10201406178WA/en unknown
- 2010-09-28 US US13/498,499 patent/US8507682B2/en not_active Expired - Fee Related
- 2010-09-28 BR BR112012007095A patent/BR112012007095A2/pt not_active IP Right Cessation
- 2010-09-28 NZ NZ599595A patent/NZ599595A/en not_active IP Right Cessation
- 2010-09-28 JP JP2012532230A patent/JP2013506003A/ja active Pending
- 2010-09-28 CN CN2010800492699A patent/CN102741232A/zh active Pending
- 2010-09-28 EP EP10763267A patent/EP2483245A1/en not_active Withdrawn
- 2010-09-28 AU AU2010300791A patent/AU2010300791A1/en not_active Abandoned
-
2012
- 2012-03-26 IL IL218843A patent/IL218843A0/en unknown
- 2012-04-02 ZA ZA2012/02366A patent/ZA201202366B/en unknown
-
2013
- 2013-06-27 US US13/929,451 patent/US8703797B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20120208840A1 (en) | 2012-08-16 |
| CA2775587A1 (en) | 2011-04-07 |
| US8703797B2 (en) | 2014-04-22 |
| SG10201406178WA (en) | 2014-11-27 |
| EP2483245A1 (en) | 2012-08-08 |
| IL218843A0 (en) | 2012-06-28 |
| ZA201202366B (en) | 2012-12-27 |
| US8507682B2 (en) | 2013-08-13 |
| RU2012114718A (ru) | 2013-11-10 |
| WO2011041287A1 (en) | 2011-04-07 |
| MX2012003718A (es) | 2012-06-28 |
| CN102741232A (zh) | 2012-10-17 |
| KR20120087932A (ko) | 2012-08-07 |
| JP2013506003A (ja) | 2013-02-21 |
| US20130296361A1 (en) | 2013-11-07 |
| AU2010300791A1 (en) | 2012-04-19 |
| BR112012007095A2 (pt) | 2016-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ599595A (en) | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (s1p2) receptors | |
| WO2007112322A3 (en) | Indole compounds having sphingosine-1-phosphate (s1p) receptor agonist and/or antagonist biological activity | |
| MX2009007334A (es) | Compuestos de amida del acido indol-3-carboxilico 6-substituido que tienen actividad antagonista biologica del receptor esfingosina-1-fosfato (s1p). | |
| MX2010007588A (es) | Compuestos de amida del acido indol-3-carboxilico 6-substituido que tienen actividad antagonista biologica del receptor de esfingosina-1-fosfato (s1p). | |
| PH12012501800A1 (en) | 2,3 dihydro- 1h - inden- 1 - yl -2,7 -diazaspirol [ 3.5 ] nonane derivatives and their use as antagonists or inverse agonists of the ghrelin receptor | |
| WO2007095561A3 (en) | Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity | |
| MX2012004848A (es) | Compuestos heterociclicos triciclicos. | |
| MX2011011156A (es) | COMPUESTOS DIAMIDA QUE TIENE ACTIVIDAD COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS Y COMO AGONISTAS DE LOS RECEPTORES ANDRENERGICOS ß2. | |
| MX2013004491A (es) | Boronatos como inhibidores de arginasa. | |
| WO2009106980A3 (en) | Indazole derivatives | |
| WO2008007211A8 (en) | Substituted n-bicyclicalkyl bicyclic carboxyamide compounds | |
| WO2011112766A3 (en) | Heterocyclic inhibitors of histamine receptors for the treatment of disease | |
| ATE530524T1 (de) | Substituierte sulfonamid-derivate | |
| WO2012177893A3 (en) | Trpm8 antagonists and their use in treatments | |
| MY181731A (en) | Azole benzene derivative | |
| HK1220386A1 (zh) | Ep4受体拮抗剂在软骨疾病的治疗中的用途 | |
| WO2010123959A3 (en) | 2,5-disubstituted arylsulfonamide ccr3 antagonists | |
| SG10202000463YA (en) | 2-acylaminothiazole derivative or salt thereof | |
| MX2012001160A (es) | Agonistas del receptor de esfingosina-1-fosfato. | |
| JP2013506003A5 (enExample) | ||
| WO2011132901A3 (en) | Novel benzamide derivatives | |
| AU2013260056A8 (en) | Compounds with TRPV4 activity, compositions and associated methods thereof | |
| PT2523960E (pt) | Derivados heterocíclicos de ácidos carboxílicos com um anel oxazolopirimidina substituído em 2,5 | |
| WO2011031818A3 (en) | Histamine h3 inverse agonists and antagonists and methods of use thereof | |
| HK1172337A (en) | Condensed ring pyridine compounds as subtype-selective modulators of sphingosine-1-phosphate-2 (s1p2) receptors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 28 SEP 2017 BY COMPUTER PACKAGES INC Effective date: 20140910 |
|
| LAPS | Patent lapsed |