JP2013505282A5 - - Google Patents

Download PDF

Info

Publication number
JP2013505282A5
JP2013505282A5 JP2012530248A JP2012530248A JP2013505282A5 JP 2013505282 A5 JP2013505282 A5 JP 2013505282A5 JP 2012530248 A JP2012530248 A JP 2012530248A JP 2012530248 A JP2012530248 A JP 2012530248A JP 2013505282 A5 JP2013505282 A5 JP 2013505282A5
Authority
JP
Japan
Prior art keywords
agonist
nicotinic acetylcholine
levodopa
acetylcholine receptor
dopamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2012530248A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013505282A (ja
JP6178074B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2010/063946 external-priority patent/WO2011036167A1/en
Publication of JP2013505282A publication Critical patent/JP2013505282A/ja
Publication of JP2013505282A5 publication Critical patent/JP2013505282A5/ja
Application granted granted Critical
Publication of JP6178074B2 publication Critical patent/JP6178074B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2012530248A 2009-09-22 2010-09-22 ニコチン性アセチルコリン受容体アルファ7アクティベーターの使用 Active JP6178074B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24465809P 2009-09-22 2009-09-22
US61/244,658 2009-09-22
PCT/EP2010/063946 WO2011036167A1 (en) 2009-09-22 2010-09-22 Use of nicotinic acetylcholine receptor alpha 7 activators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015237921A Division JP2016104743A (ja) 2009-09-22 2015-12-04 ニコチン性アセチルコリン受容体アルファ7アクティベーターの使用

Publications (3)

Publication Number Publication Date
JP2013505282A JP2013505282A (ja) 2013-02-14
JP2013505282A5 true JP2013505282A5 (enExample) 2013-11-07
JP6178074B2 JP6178074B2 (ja) 2017-08-09

Family

ID=42990156

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012530248A Active JP6178074B2 (ja) 2009-09-22 2010-09-22 ニコチン性アセチルコリン受容体アルファ7アクティベーターの使用
JP2015237921A Withdrawn JP2016104743A (ja) 2009-09-22 2015-12-04 ニコチン性アセチルコリン受容体アルファ7アクティベーターの使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015237921A Withdrawn JP2016104743A (ja) 2009-09-22 2015-12-04 ニコチン性アセチルコリン受容体アルファ7アクティベーターの使用

Country Status (22)

Country Link
US (3) US10537539B2 (enExample)
EP (1) EP2480228B1 (enExample)
JP (2) JP6178074B2 (enExample)
KR (1) KR20120068878A (enExample)
CN (2) CN110051670A (enExample)
AU (1) AU2010299967B2 (enExample)
BR (1) BR112012006346A2 (enExample)
CA (1) CA2774801C (enExample)
CL (1) CL2012000702A1 (enExample)
EA (1) EA036742B1 (enExample)
ES (1) ES2614930T3 (enExample)
IL (1) IL218299A (enExample)
JO (1) JO3250B1 (enExample)
MA (1) MA33590B1 (enExample)
MX (1) MX359011B (enExample)
NZ (1) NZ598316A (enExample)
PH (1) PH12012500554A1 (enExample)
SG (1) SG178832A1 (enExample)
TN (1) TN2012000082A1 (enExample)
TW (1) TWI558398B (enExample)
WO (1) WO2011036167A1 (enExample)
ZA (1) ZA201201066B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
JO3250B1 (ar) * 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
KR20180101641A (ko) 2010-05-17 2018-09-12 포럼 파마슈티칼즈 인크. (R)-7-클로로-N-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 히드로클로리드 모노히드레이트의 결정질 형태
MX2013008704A (es) * 2011-01-27 2013-08-21 Novartis Ag Uso de activadores del receptor de acetil-colina nicotinico alfa-7.
MX344701B (es) 2011-02-03 2017-01-03 Lupin Ltd Derivados de pirrol como moduladores de nachr alfa 7.
AP3649A (en) 2011-02-23 2016-03-18 Lupin Ltd Heteroaryl derivatives as alpha7 nachr modulators
MX2013010698A (es) * 2011-03-18 2014-02-17 Novartis Ag Combinaciones de activadores del receptor de acetil-colina nicotinico alfa-7 y antagonistas del receptor de glutamato metabotropico 5 (mglur5) para usarse en la discinesia inducida por dopamina en la enfermedad de parkinson.
CA2829860A1 (en) 2011-03-31 2012-10-04 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
EP2729455B1 (en) 2011-07-05 2016-09-14 Lupin Limited Biaryl derivatives as nachr modulators
CA2852268C (en) * 2011-10-20 2020-08-25 Novartis Ag Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
IN2014MN01756A (enExample) 2012-03-06 2015-07-03 Lupin Ltd
EP3461481A1 (en) 2012-05-08 2019-04-03 Forum Pharmaceuticals Inc. Methods of maintaining, treating or improving cognitive function
US8729263B2 (en) * 2012-08-13 2014-05-20 Novartis Ag 1,4-disubstituted pyridazine analogs there of and methods for treating SMN-deficiency-related conditions
WO2014072957A1 (en) 2012-11-12 2014-05-15 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
JP6338223B2 (ja) * 2013-01-15 2018-06-06 ノバルティス アーゲー アルファ7ニコチン性アセチルコリン受容体アゴニストの使用
ES2865736T3 (es) * 2013-01-15 2021-10-15 Novartis Ag Uso de agonistas del receptor de acetilcolina nicotínico alfa 7
WO2014111839A1 (en) 2013-01-16 2014-07-24 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
JP2016512225A (ja) 2013-03-13 2016-04-25 ルピン・リミテッドLupin Limited アルファー7nachrモジュレータとしてのピロール誘導体
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
EP3010899A1 (en) 2013-06-17 2016-04-27 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
EA030631B1 (ru) * 2013-07-31 2018-09-28 Новартис Аг 1,4-дизамещенные аналоги пиридазинхинолина и способы лечения состояний, связанных с smn-дефицитом
US20150313891A1 (en) * 2014-05-02 2015-11-05 Abbvie Inc. Neuronal nicotinic agonists and methods of use
CA2960644C (en) 2014-09-09 2021-06-29 Merial, Inc. Mammalian cell lines expressing functional nematode acetylcholine receptors and use thereof for high-throughput screening assays
EP3233087B1 (en) 2014-12-16 2019-10-02 Axovant Sciences GmbH Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
JP2018516973A (ja) 2015-06-10 2018-06-28 フォーラム・ファーマシューティカルズ・インコーポレイテッドForum Pharmaceuticals Inc. α7−ニコチン性アセチルコリン受容体のアゴニストとしてのアミノベンゾイソオキサゾール化合物
WO2017027600A1 (en) 2015-08-12 2017-02-16 Forum Pharmaceuticals, Inc. GEMINAL SUBSTITUTED AMINOBENZISOXAZOLE COMPOUNDS AS AGONISTS OF α7-NICOTINIC ACETYLCHOLINE RECEPTORS
AU2016340798A1 (en) * 2015-10-20 2018-04-26 Axovant Sciences Gmbh Aminoisoxazoline compounds as agonists of alpha7-nicotinic acetylcholine receptors
RU2020105929A (ru) 2017-08-04 2021-09-06 Скайхоук Терапьютикс, Инк. Способы и композиции для модулирования сплайсинга
JP7603592B2 (ja) 2019-02-05 2024-12-20 スカイホーク・セラピューティクス・インコーポレーテッド スプライシングを調節するための方法および組成物
EP3920926A4 (en) 2019-02-05 2022-10-19 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
CN119638696A (zh) 2019-02-06 2025-03-18 斯基霍克疗法公司 用于调节剪接的方法和组合物
WO2020163544A1 (en) 2019-02-06 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566368B2 (en) * 1994-04-22 2003-05-20 Pentech Pharmaceuticals, Inc. Apomorphine-containing dosage form for ameliorating male erectile dysfunction
US5990168A (en) 1996-04-18 1999-11-23 Alberta Cancer Board Methods and compositions for the treatment of ataxia telangiectasia
US7214686B2 (en) * 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
US6908631B1 (en) * 1997-12-01 2005-06-21 Nicogen, Inc. Therapeutic and diagnostic methods dependent on CYP2A enzymes
US6432975B1 (en) 1998-12-11 2002-08-13 Targacept, Inc. Pharmaceutical compositions and methods for use
US6953855B2 (en) 1998-12-11 2005-10-11 Targacept, Inc. 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
DE69939498D1 (de) 1998-12-16 2008-10-16 Univ South Florida Exo-S-Mecamylamin-Formulierung
FR2804430B1 (fr) 2000-01-28 2002-03-22 Sanofi Synthelabo Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique
GB0010955D0 (en) 2000-05-05 2000-06-28 Novartis Ag Organic compounds
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
DE10156719A1 (de) 2001-11-19 2003-05-28 Bayer Ag Heteroarylcarbonsäureamide
GB0128996D0 (en) 2001-12-04 2002-01-23 Novartis Ag Organic compounds
DE10211415A1 (de) 2002-03-15 2003-09-25 Bayer Ag Bicyclische N-Biarylamide
DE10211416A1 (de) 2002-03-15 2003-09-25 Bayer Ag Essig- und Propionsäureamide
SE0201943D0 (sv) 2002-06-20 2002-06-20 Astrazeneca Ab New use
DE10234424A1 (de) 2002-07-29 2004-02-12 Bayer Ag Benzothiophen-, Benzofuran- und Indolharnstoffe
CA2493245A1 (en) 2002-08-14 2004-02-26 Neurosearch A/S Novel quinuclidine derivatives and their use
EP2298759A1 (en) 2002-08-30 2011-03-23 Memory Pharmaceuticals Corporation Anabaseine derivatives useful in the treatment of neurodegenerative diseases
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
PL210065B1 (pl) 2002-09-25 2011-11-30 Memory Pharm Corp Związki indazole, benzotiazole i benzoizotiazole, kompozycje farmaceutyczne je zawierające oraz zastosowanie związków
WO2004074245A2 (en) 2003-02-14 2004-09-02 Memory Pharmaceuticals Corporation Monkey alpha-7 nicotinic acetylcholine receptor and methods of use thereof
JP2006519208A (ja) 2003-02-27 2006-08-24 ニューロサーチ、アクティーゼルスカブ 新規ジアザビシクロアリール誘導体
US20050065178A1 (en) 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
CA2549969A1 (en) 2003-10-31 2005-05-19 Astrazeneca Ab Alkynes ii
CN1871001A (zh) 2003-10-31 2006-11-29 阿斯利康(瑞典)有限公司 炔烃ⅲ
CA2549967A1 (en) 2003-10-31 2005-05-19 Astrazeneca Ab Alkynes i
FR2862647B1 (fr) 2003-11-25 2008-07-04 Aventis Pharma Sa Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant
CA2551486A1 (en) 2003-12-22 2006-06-22 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US20050245531A1 (en) 2003-12-22 2005-11-03 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
BRPI0417323A (pt) 2003-12-22 2007-03-27 Memory Pharm Corp indóis, 1h-indazóis, 1,2-benzisoxazóis, e 1,2-benzisotiazóis, composto, composição farmacêutica e usos dos mesmos
JP2007520526A (ja) 2004-02-04 2007-07-26 ノイロサーチ アクティーゼルスカブ コリン作動性受容体モジュレーターとしてのジアザビシクロアリール誘導体
US20080227772A1 (en) 2004-02-04 2008-09-18 Neurosearch A/S Diazabicyclic Aryl Derivatives as Nicotinic Acetylcholine Receptor Ligands
JP2007524682A (ja) 2004-02-12 2007-08-30 メルク エンド カムパニー インコーポレーテッド 代謝調節型グルタミン酸受容体−5の調節物質としてのビピリジルアミド
CA2560741C (en) 2004-03-25 2013-08-06 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
JP2007534692A (ja) 2004-04-22 2007-11-29 メモリー・ファーマシューティカルズ・コーポレイション インドール、1h−インダゾール、1,2−ベンズイソキサゾール、1,2−ベンゾイソチアゾール、ならびにその調製および使用
DE602005027452D1 (de) 2004-05-07 2011-05-26 Memory Pharm Corp 1h-indazole, benzothiazole, 1,2-benzisoxazole, 1,2-benzisothiazole und chromone und deren herstellung und verwendungen
EP1751150A2 (en) 2004-05-19 2007-02-14 Neurosearch A/S Novel azabicyclic aryl derivatives
GB0412019D0 (en) 2004-05-28 2004-06-30 Novartis Ag Organic compounds
PE20060437A1 (es) * 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) * 2004-07-14 2004-08-18 Novartis Ag Organic compounds
WO2006040352A1 (en) 2004-10-15 2006-04-20 Neurosearch A/S Novel azabicyclic aryl derivatives and their medical use
GB0424564D0 (en) * 2004-11-05 2004-12-08 Novartis Ag Organic compounds
EP1814888A1 (en) * 2004-11-15 2007-08-08 Pfizer Products Incorporated Azabenzoxazoles for the treatment of cns disorders
CA2587826A1 (en) 2004-11-15 2006-05-18 Pfizer Products Inc. Azabenzoxazoles for the treatment of cns disorders
EP1819709B1 (en) 2004-11-30 2009-02-11 Neurosearch A/S Novel diazabicyclic aryl derivatives as cholinergy ligands
AU2005319248A1 (en) 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
US20060142349A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc Methods of modulating the activities of alpha-7 nicotinic acetylcholine receptor
WO2006087306A2 (en) 2005-02-16 2006-08-24 Neurosearch A/S Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
JP4318744B2 (ja) 2005-03-31 2009-08-26 ファイザー・プロダクツ・インク シクロペンタピリジンおよびテトラヒドロキノリン誘導体
FR2884822B1 (fr) 2005-04-22 2007-06-29 Aventis Pharma Sa Derives de triazines, leur preparation et leur application en therapeutique
CA2605561C (en) 2005-04-22 2018-06-12 Cedars-Sinai Medical Center Methods using kcnc3 gene mutations for spinocerebellar ataxia 13 (sca13)
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
US8629163B2 (en) 2007-10-31 2014-01-14 University Of Kentucky Research Foundation Tetrakis-quaternary ammonium salts and methods for modulating neuronal nicotinic acteylcholine receptors
CN101312968A (zh) 2005-09-23 2008-11-26 记忆药物公司 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑、吡唑并吡啶、异噻唑并吡啶及其制备和用途
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
CN101316849A (zh) 2005-11-09 2008-12-03 记忆药物公司 1h-吲唑、苯并噻唑、1,2-苯并异噁唑、1,2-苯并异噻唑和色酮及其制备和用途
RU2008110911A (ru) 2005-12-06 2010-01-20 Ньюросерч А/С (DK) Новые диазабициклические арильные производные и их медицинское применение
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
KR20080076962A (ko) 2005-12-20 2008-08-20 노파르티스 아게 대사성 글루타메이트 수용체 조절제로서의 니코틴산 유도체
US7662965B2 (en) 2006-01-26 2010-02-16 Cornerstone Therapeutics, Inc. Anabaseine derivatives, pharmaceutical compositions and method of use thereof
WO2007085036A1 (en) 2006-01-26 2007-08-02 Medizinische Universität Wien Treatment of friedreich' s ataxia
EP1987033B1 (en) 2006-02-14 2010-08-25 NeuroSearch A/S Diazabicycloalkane derivatives and their medical use
AU2007217040A1 (en) 2006-02-17 2007-08-30 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
RU2008137604A (ru) 2006-02-22 2010-03-27 Арнольд МЮННИК (FR) Применение деферипрона и способ лечения и/или профилактики атаксии фридрейха, возникающей вследствие внутриклеточного нарушения обмена железа
RU2008138532A (ru) * 2006-03-27 2010-04-10 Пфайзер Продактс Инк. (Us) Стандарты варениклина и контроль примесей
TW200813067A (en) 2006-05-17 2008-03-16 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
WO2007135121A1 (en) 2006-05-23 2007-11-29 Neurosearch A/S Novel 8,10-diaza-bicyclo[4.3.1]decane derivatives and their medical use
US20090186880A1 (en) 2006-05-23 2009-07-23 Dan Peters Novel 1,4-diaza-bicyclo[3.2.2]nonane derivatives and their medical use
WO2007138038A1 (en) 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their medical use
WO2007138039A1 (en) 2006-05-30 2007-12-06 Neurosearch A/S Novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidinyl derivatives and their medical use
CA2659512C (en) 2006-06-06 2015-09-08 Critical Therapeutics, Inc. Novel piperazines, pharmaceutical compositions and methods of use thereof
US8178678B2 (en) 2006-06-16 2012-05-15 University Of Kentucky Research Foundation Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
EP2044029B1 (en) 2006-07-14 2011-01-26 Pfizer Products Inc. Tartrate salt of (7s)-7-[(5-fluoro-2-methyl-benzyl)oxy]-2-[(2r)-2-methylpiperazin-1-yl]-6,7-dihydro-5h-cyclopenta[b]pyridine
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
CL2008000119A1 (es) 2007-01-16 2008-05-16 Wyeth Corp Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.
AU2008216032A1 (en) 2007-02-16 2008-08-21 Memory Pharmaceuticals Corporation 6 ' substituted indole and indazole derivatives having 5-HT6 receptor affinity
EP2322168A1 (en) * 2007-04-02 2011-05-18 Parkinson's Institute Methods and Compositions for Reduction of Side Effects of Therapeutic Treatments
KR20100031578A (ko) 2007-05-24 2010-03-23 메모리 파마슈티칼스 코포레이션 5-ht6 수용체 친화성을 갖는 4'-치환된 화합물
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
JP2010536789A (ja) 2007-08-15 2010-12-02 メモリー・ファーマシューティカルズ・コーポレイション 5−ht6受容体親和性を有する3’置換化合物
DE602008005928D1 (de) 2007-10-01 2011-05-12 Comentis Inc 1h-indol-3-carbonsäure-chinuclidin-4-ylmethylesterderivate als liganden für den nikotinischen alpha-7-acetylcholinrezeptor zur behandlung von alzheimer-krankheit
MX2010003156A (es) 2007-10-04 2010-04-01 Hoffmann La Roche Derivados de aril amida substituida con tetrazol y usos de los mismos.
CN101815512B (zh) 2007-10-04 2013-04-24 弗·哈夫曼-拉罗切有限公司 环丙基芳基酰胺衍生物和其用途
WO2009066107A1 (en) 2007-11-21 2009-05-28 Astrazeneca Ab Use of a nicotinic receptor agonist
CA2714232A1 (en) 2008-02-05 2009-08-13 Pfizer Inc. Pyridinyl amides for the treatment of cns and metabolic disorders
AU2009215436A1 (en) 2008-02-19 2009-08-27 Myocept Inc. Postsynaptically targeted chemodenervation agents and their methods of use
US9463190B2 (en) 2008-03-31 2016-10-11 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
KR20100135911A (ko) 2008-04-17 2010-12-27 글락소 그룹 리미티드 니코틴성 아세틸콜린 수용체 아형 알파-7의 조절인자로서의 인돌
WO2009128058A1 (en) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Psycho-pharmaceuticals
EP2300012A4 (en) 2008-05-23 2011-07-06 Univ South Florida METHOD FOR TREATING PERIPHERAL SENSORY NERVE LOSS WITH COMPOUNDS WITH NICOTIC ACIDYLCHOLINE RECEPTOR EFFECT
US20100016297A1 (en) 2008-06-24 2010-01-21 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100022581A1 (en) 2008-07-02 2010-01-28 Memory Pharmaceuticals Corporation Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity
US20100029629A1 (en) 2008-07-25 2010-02-04 Memory Pharmaceuticals Corporation Acyclic compounds having 5-ht6 receptor affinity
US20100056531A1 (en) 2008-08-22 2010-03-04 Memory Pharmaceuticals Corporation Alkyl-substituted 3' compounds having 5-ht6 receptor affinity
US20100056491A1 (en) 2008-08-29 2010-03-04 Memory Pharmaceuticals Corporation 4'-amino cyclic compounds having 5-ht6 receptor affinity
BRPI0920187A2 (pt) 2008-10-13 2019-08-27 Hoffmann La Roche método sem diazônio para fabricar um indazol intermediário na síntese de amidas bicíclicas do ácido 5-(triflúor-metóxi)-1h-3-indazol-carboxílico
US20110262407A1 (en) 2008-11-11 2011-10-27 Targacept, Inc. Treatment with alpha7 selective ligands
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
BRPI1014247A2 (pt) 2009-06-17 2016-04-12 Targacept Inc reversão da discinesia induzida pela l-dopa por ligantes de receptores nocotínicos neuronais.
US20120157464A1 (en) 2009-07-23 2012-06-21 Novartis Ag Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives for the treatment or prevention of ataxia
JO3250B1 (ar) * 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7

Similar Documents

Publication Publication Date Title
JP2013505282A5 (enExample)
HRP20200600T1 (hr) Tapentadol za sprječavanje i liječenje depresije i tjeskobe
CN101534809B (zh) 取代的2-氨基1,2,3,4-四氢化萘在制备预防、减轻和/或治疗各类疼痛的药物中的用途
WO2009127974A3 (ko) 심혈관계 질환 치료용 약제학적 제제
PE20142319A1 (es) Tratamiento de esclerosis multiple con combinacion de laquinimod y acetato de glatiramero
EA201270221A1 (ru) Лечение болезни крона с применением лаквинимода
EP2444072A3 (en) Non-mucoadhesive film dosage forms
JP2015523407A5 (enExample)
NZ597378A (en) Treatment of multiple sclerosis with laquinimod
NZ714963A (en) Compositions and methods for treating anemia
AR090885A1 (es) Uso de laquinimod en alta dosis para el tratamiento de la esclerosis multiple
JP2013541583A5 (enExample)
MX336657B (es) Prevencion de hipoglucemia en pacientes con diabetes sacarina de tipo 2.
NZ605469A (en) Nalbuphine-based formulations and uses thereof
WO2007012022A3 (en) Unit dose form with ibuprofen-famotidine admixture
WO2008067991A3 (en) Skin-friendly drug complexes for transdermal administration
MX2020001342A (es) Uso de gaboxadol en el tratamiento contra diabetes y afecciones relacionadas.
JP2013536837A5 (enExample)
MX2009011900A (es) Curacion de herida diabetica.
MX2013005482A (es) Composicion farmaceutica que contiene sales de citrato y bicarbonato, y su uso para el tratamiento de la cistinuria.
UA111480C2 (uk) ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ЛІКУВАННЯ СИНДРОМУ ПОДРАЗНЕНОГО КИШЕЧНИКУ, ЯКА ВВОДИТЬСЯ ПЕРОРАЛЬНО, ЩО МІСТИТЬ ТРИМЕБУТИН, СИМЕТИКОН, α-D-ГАЛАКТОЗИДАЗУ, І СПОСІБ ЇЇ ОТРИМАННЯ
WO2008008882A3 (en) Glucocorticoid receptor modulator and methods of use
MX341660B (es) Agonista del receptor de ghrelina para el tratamiento de caquexia.
JP2011500589A5 (enExample)
JP2016505050A5 (enExample)