JP2013500990A5 - - Google Patents

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JP2013500990A5
JP2013500990A5 JP2012523061A JP2012523061A JP2013500990A5 JP 2013500990 A5 JP2013500990 A5 JP 2013500990A5 JP 2012523061 A JP2012523061 A JP 2012523061A JP 2012523061 A JP2012523061 A JP 2012523061A JP 2013500990 A5 JP2013500990 A5 JP 2013500990A5
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amino acid
item
compound according
acid residues
compound
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JP2012523061A
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Japanese (ja)
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JP5270799B2 (ja
JP2013500990A (ja
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Priority claimed from PCT/US2010/043792 external-priority patent/WO2011014707A2/en
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Publication of JP2013500990A5 publication Critical patent/JP2013500990A5/ja
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JP2012523061A 2009-07-29 2010-07-29 副甲状腺ホルモンを低減する治療剤 Active JP5270799B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US22969509P 2009-07-29 2009-07-29
US61/229,695 2009-07-29
US25581609P 2009-10-28 2009-10-28
US61/255,816 2009-10-28
US31363510P 2010-03-12 2010-03-12
US61/313,635 2010-03-12
PCT/US2010/043792 WO2011014707A2 (en) 2009-07-29 2010-07-29 Therapeutic agents for reducing parathyroid hormone levels

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013099331A Division JP5764613B2 (ja) 2009-07-29 2013-05-09 副甲状腺ホルモンを低減する治療剤

Publications (3)

Publication Number Publication Date
JP2013500990A JP2013500990A (ja) 2013-01-10
JP2013500990A5 true JP2013500990A5 (OSRAM) 2013-04-18
JP5270799B2 JP5270799B2 (ja) 2013-08-21

Family

ID=43527590

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2012523061A Active JP5270799B2 (ja) 2009-07-29 2010-07-29 副甲状腺ホルモンを低減する治療剤
JP2013099331A Active JP5764613B2 (ja) 2009-07-29 2013-05-09 副甲状腺ホルモンを低減する治療剤
JP2014023488A Pending JP2014094967A (ja) 2009-07-29 2014-02-10 副甲状腺ホルモンを低減する治療剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2013099331A Active JP5764613B2 (ja) 2009-07-29 2013-05-09 副甲状腺ホルモンを低減する治療剤
JP2014023488A Pending JP2014094967A (ja) 2009-07-29 2014-02-10 副甲状腺ホルモンを低減する治療剤

Country Status (29)

Country Link
US (11) US8999932B2 (OSRAM)
EP (5) EP3808363B1 (OSRAM)
JP (3) JP5270799B2 (OSRAM)
KR (1) KR101781841B1 (OSRAM)
CN (2) CN102711789B (OSRAM)
AU (1) AU2010278897B2 (OSRAM)
BR (1) BR112012002143B8 (OSRAM)
CA (1) CA2769525C (OSRAM)
CY (3) CY1118388T1 (OSRAM)
DK (2) DK3192520T3 (OSRAM)
ES (2) ES2729051T3 (OSRAM)
FR (1) FR17C1009I2 (OSRAM)
HR (2) HRP20161614T1 (OSRAM)
HU (3) HUE043838T2 (OSRAM)
IL (1) IL217749A (OSRAM)
LT (3) LT2459208T (OSRAM)
LU (1) LUC00008I2 (OSRAM)
MX (1) MX2012001213A (OSRAM)
NO (1) NO2017021I1 (OSRAM)
NZ (1) NZ597922A (OSRAM)
PL (2) PL2459208T3 (OSRAM)
PT (2) PT3192520T (OSRAM)
RU (1) RU2557654C3 (OSRAM)
SG (2) SG178143A1 (OSRAM)
SI (2) SI2459208T1 (OSRAM)
SM (3) SMT201700014B (OSRAM)
TW (1) TWI520744B (OSRAM)
WO (1) WO2011014707A2 (OSRAM)
ZA (1) ZA201200726B (OSRAM)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008067199A2 (en) 2006-11-16 2008-06-05 Kai Pharmaceuticals, Inc. Polycationic calcium modulator peptides for the treatment of hyperparathyroidism and hypercalcemic disorders
RU2557654C3 (ru) * 2009-07-29 2017-07-05 Каи Фармасьютикалз, Инк. Терапевтические агенты для снижения уровней паратиреоидного гормона
KR101493717B1 (ko) 2010-03-04 2015-02-16 아지노모토 가부시키가이샤 알킬아민 유도체
WO2011108724A1 (ja) 2010-03-04 2011-09-09 味の素株式会社 糖尿病又は肥満症の予防又は治療剤
JP5796570B2 (ja) 2010-03-24 2015-10-21 味の素株式会社 グルタミン酸エステル誘導体又はその塩
EP2554165A4 (en) 2010-04-02 2014-04-30 Ajinomoto Kk PROPHYLACTIC OR THERAPEUTIC ACTIVE AGAINST DIABETES OR ADIPOSITAS
PT2717896T (pt) * 2011-06-08 2016-12-23 Kai Pharmaceuticals Inc Agentes terapêuticos para a regulação do fósforo sérico
AU2012335009B2 (en) * 2011-11-10 2017-08-31 Kai Pharmaceuticals, Inc. Calcimimetics and methods for their use
JP2015514771A (ja) 2012-04-17 2015-05-21 ブラウン ユニバーシティ 神経保護性組成物および使用方法
US20200354428A9 (en) 2013-06-23 2020-11-12 Wisconsin Alumni Research Foundation Analogues of parathyroid hormone (1-34) that function as agonists of the parathyroid hormone receptor-1 and display modified activity profiles
EA030220B1 (ru) 2013-06-28 2018-07-31 Эмджен Инк. Устойчивая жидкая композиция, содержащая amg-416 (этелкалцетид)
PT3126373T (pt) * 2014-04-03 2020-04-24 Amgen Inc Método para a produção do amg 416
CN105504012A (zh) * 2014-09-30 2016-04-20 深圳翰宇药业股份有限公司 一种多肽的制备方法
WO2016065042A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
US9616109B2 (en) 2014-10-22 2017-04-11 Extend Biosciences, Inc. Insulin vitamin D conjugates
JP6783787B2 (ja) * 2015-03-26 2020-11-11 アムジェン インコーポレイテッド エテルカルセチドの調製のための液相方法
US9336841B1 (en) * 2015-04-16 2016-05-10 Taiwan Semiconductor Manufacturing Co., Ltd. Pipeline register with data alignment therein
CN106928320B (zh) * 2015-12-31 2021-01-15 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
CN106928321B (zh) * 2015-12-31 2019-07-26 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
WO2018044468A1 (en) * 2016-08-30 2018-03-08 Wisconsin Alumni Research Foundation COMBINATION OF LOW DOSE 2-METHYLENE-19-NOR-(20S)-1α, 25-DIHYDROXYVITAMIN D3 AND CALCIMIMETICS TO TREAT SECONDARY HYPERPARATHYROIDISM
SG11202003835PA (en) * 2017-11-07 2020-05-28 Alphacore Pharma Llc Methods of treating and protecting against cardiac disease, cardiovascular disease and related conditions and symptoms
RU2020123405A (ru) 2017-12-20 2022-01-20 ЕА Фарма Ко., Лтд. Лекарственная композиция для профилактики или лечения вторичного гиперпаратиреоза при поддерживающем диализе
KR101933685B1 (ko) * 2018-06-29 2018-12-28 주식회사 에스알바이오텍 약물이 코팅된 마이크로 니들 및 이의 제조방법
JP2022536222A (ja) * 2018-11-02 2022-08-15 アンパサンド バイオファーマシューティカルズ インコーポレイテッド 局所的に施用される緩衝液によるカチオン過負荷および電解質平衡異常のリスクの管理
CA3124687A1 (en) 2019-04-03 2020-10-08 Ea Pharma Co., Ltd. Medicinal composition having excellent stability
BR112022011127A2 (pt) * 2019-12-09 2022-08-23 Beijing Tuo Jie Biopharmaceutical Co Ltd Composto agonista do receptor de detecção de cálcio e aplicação do mesmo
WO2021226064A1 (en) * 2020-05-04 2021-11-11 University Of Louisville Research Foundation, Inc. Artificial intelligence-based systems and methods for dosing of pharmacologic agents
AU2021338639B2 (en) * 2020-09-10 2024-05-23 Shaanxi Micot Pharmaceutical Technology Co., Ltd. Bispecific fusion polypeptide compound
US11359134B2 (en) 2020-10-19 2022-06-14 Saudi Arabian Oil Company Treatment fluids and methods for recovering hydrocarbons from a subterranean formation
CN117500820A (zh) * 2021-06-08 2024-02-02 北京拓界生物医药科技有限公司 钙敏感受体激动剂化合物的盐酸盐及药物组合物和其应用
CN117295510A (zh) * 2021-06-08 2023-12-26 北京拓界生物医药科技有限公司 一种钙敏感受体激动剂的组合物及其应用
IL319526A (en) 2022-09-30 2025-05-01 Extend Biosciences Inc Long-acting parathyroid hormone
WO2025054169A1 (en) * 2023-09-05 2025-03-13 Wake Forest University Health Sciences Compositions and methods for topical treatment

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869473A (en) 1988-08-02 1999-02-09 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US5602116A (en) 1988-08-02 1997-02-11 Bone Care International, Inc. Method for treating and preventing secondary hyperparathyroidism
CA1333616C (en) * 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5246925A (en) 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
WO1992008476A1 (en) * 1990-11-07 1992-05-29 The Scripps Research Institute Peptides that inhibit platelet binding of adhesion molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
CA2145214A1 (en) 1995-02-28 1996-08-29 Rick E. Preddie Agents for pre-symptomatic diagnosis, prevention and cure huntington's disease (hd) in humans
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5688489A (en) * 1995-09-15 1997-11-18 Resolution Pharmaceuticals, Inc. Non-receptor mediated imaging agents
US6147186A (en) 1996-07-31 2000-11-14 The General Hospital Corporation Parathyroid hormone-related peptide analogs
US5895368A (en) * 1996-09-23 1999-04-20 Medisystems Technology Corporation Blood set priming method and apparatus
WO1998017299A1 (en) * 1996-10-18 1998-04-30 The Board Of Trustees Of The Leland Stanford Junior University Isozyme-specific activators of protein kinase c, methods and compositions
WO1998033812A1 (en) * 1997-02-05 1998-08-06 Brigham And Women's Hospital, Inc. Mast cell protease peptide inhibitors
WO1998051324A1 (en) * 1997-05-14 1998-11-19 Rhone-Poulenc Rorer Pharmaceuticals Inc. Peptide parathyroid hormone analogs
EP0975370B9 (en) * 1997-05-21 2004-11-03 The Board Of Trustees Of The Leland Stanford Junior University Composition and method for enhancing transport across biological membranes
US6258774B1 (en) 1998-03-19 2001-07-10 University Of Medicine And Dentistry Of New Jersey Carrier for in vivo delivery of a therapeutic agent
US7399489B2 (en) 1999-01-14 2008-07-15 Amylin Pharmaceuticals, Inc. Exendin analog formulations
JP2000336099A (ja) * 1999-05-27 2000-12-05 Sekisui Chem Co Ltd ペプチド及びｃ型肝炎抗体検出用試薬
US6051567A (en) 1999-08-02 2000-04-18 Abbott Laboratories Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol
US6274169B1 (en) 1999-08-02 2001-08-14 Abbott Laboratories Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol
US20020068342A1 (en) * 2000-02-09 2002-06-06 Rami Khosravi Novel nucleic acid and amino acid sequences and novel variants of alternative splicing
EP2070911A2 (en) 2000-07-18 2009-06-17 Bone Care International, Inc. Stabilized 1Alpha-Hydroxy vitamin D
DE10041126A1 (de) 2000-08-22 2002-04-04 Aventis Res & Tech Gmbh & Co DNA-bindende Peptiddomänen und ein Verfahren zur Bereitstellung solcher Domänen
US20080249016A1 (en) * 2000-09-18 2008-10-09 Sanos Bioscience A/S Use of GLP-2 in a combination treatment for bone-related disorders
US20020168354A1 (en) * 2000-11-10 2002-11-14 Daria Mochly-Rosen psiepsilonRack peptide composition and method for protection against tissue damage due to ischemia
WO2002057413A2 (en) * 2001-01-18 2002-07-25 The Board Of Trustees Of The Leland Stanford Junior University Peptides for activation and inhibition of delta pkc
US20030091640A1 (en) 2001-02-08 2003-05-15 Srinivasan Ramanathan Enhanced oral and transcompartmental delivery of therapeutic or diagnostic agents
US20030036627A1 (en) * 2001-02-16 2003-02-20 Montelaro Ronald C. Virus derived antimicrobial peptides
CA2439178C (en) 2001-02-23 2013-06-04 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity
US6998404B2 (en) 2001-08-08 2006-02-14 Genomed, Llc Treatment or prevention of acute renal failure
WO2003014078A2 (en) 2001-08-08 2003-02-20 The Research Foundation Of The State University Of New York Muc7d1 peptides as antifungal and antibacterial agents
US7060023B2 (en) 2001-09-25 2006-06-13 The Foundry Inc. Pericardium reinforcing devices and methods of using them
US7037897B2 (en) * 2001-10-31 2006-05-02 Abbott Laboratories TRI-, TETRA-, and penta-peptides having antiangiogenic activity
JP2005287302A (ja) 2002-04-03 2005-10-20 Haruhiko Fujiwara ポリペプチドの架橋方法
US20040018976A1 (en) * 2002-05-14 2004-01-29 Feder John N. Polynucleotide encoding novel human G-protein coupled receptors, and splice variants thereof
AU2004291277A1 (en) 2003-11-05 2005-06-02 Intercell Ag Compositions comprising melittin-derved peptides and methods for the potentiation of immune responses against target antigens
CA2549052A1 (en) * 2003-12-11 2005-06-30 The Board Of Trustees Of The Leland Stanford Junior University Isozyme-specific antagonists of protein kinase c
US7939634B2 (en) 2004-01-27 2011-05-10 Compugen Ltd. Polynucleotides encoding polypeptides and methods using same
JP2008508294A (ja) * 2004-07-27 2008-03-21 ジェンザイム・コーポレイション 骨の再生のためのチロトロピンの使用法
US7265092B2 (en) * 2004-09-30 2007-09-04 Kai Pharmaceuticals, Inc. Pharmaceutical formulation
DE102005013846A1 (de) 2005-03-24 2006-10-05 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
KR100687932B1 (ko) * 2005-08-09 2007-02-27 삼성전자주식회사 영상표시장치 및 영상표시방법
JP2009511426A (ja) * 2005-08-30 2009-03-19 アコロジックス インコーポレイティッド ミネラルおよび骨格代謝の調節
WO2008067199A2 (en) * 2006-11-16 2008-06-05 Kai Pharmaceuticals, Inc. Polycationic calcium modulator peptides for the treatment of hyperparathyroidism and hypercalcemic disorders
KR101775929B1 (ko) 2007-01-19 2017-09-07 카이 파마슈티컬즈 안정성 및 전달 효율을 증가시키기 위한 펩타이드 조성물의 변형
WO2009046220A2 (en) * 2007-10-02 2009-04-09 Mdrna, Inc. Lipopeptides for delivery of nucleic acids
US8716437B2 (en) 2007-12-07 2014-05-06 Steven A. Goldstein Identification of toxin ligands
US20090318351A1 (en) * 2008-03-12 2009-12-24 Kevin Grimes Method of treating acute st-elevation myocardial infarction with a delta pkc antagonist
RU2557654C3 (ru) * 2009-07-29 2017-07-05 Каи Фармасьютикалз, Инк. Терапевтические агенты для снижения уровней паратиреоидного гормона
PT2717896T (pt) * 2011-06-08 2016-12-23 Kai Pharmaceuticals Inc Agentes terapêuticos para a regulação do fósforo sérico
AU2012335009B2 (en) 2011-11-10 2017-08-31 Kai Pharmaceuticals, Inc. Calcimimetics and methods for their use

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