JP2013500072A5 - - Google Patents
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- Publication number
- JP2013500072A5 JP2013500072A5 JP2012521803A JP2012521803A JP2013500072A5 JP 2013500072 A5 JP2013500072 A5 JP 2013500072A5 JP 2012521803 A JP2012521803 A JP 2012521803A JP 2012521803 A JP2012521803 A JP 2012521803A JP 2013500072 A5 JP2013500072 A5 JP 2013500072A5
- Authority
- JP
- Japan
- Prior art keywords
- coacervate
- group
- polyanion
- polycation
- adhesive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920000447 polyanionic polymer Polymers 0.000 claims 26
- 239000000853 adhesive Substances 0.000 claims 24
- 230000001070 adhesive effect Effects 0.000 claims 24
- 238000004132 cross linking Methods 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 10
- 210000000988 bone and bone Anatomy 0.000 claims 10
- 238000004519 manufacturing process Methods 0.000 claims 10
- 239000002131 composite material Substances 0.000 claims 6
- 229920000058 polyacrylate Polymers 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 239000003999 initiator Substances 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 230000000269 nucleophilic effect Effects 0.000 claims 4
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 4
- 210000001519 tissue Anatomy 0.000 claims 4
- 125000003277 amino group Chemical group 0.000 claims 3
- 239000004053 dental implant Substances 0.000 claims 3
- 239000007800 oxidant agent Substances 0.000 claims 3
- 230000001590 oxidative effect Effects 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 2
- 229920000388 Polyphosphate Polymers 0.000 claims 2
- 238000004873 anchoring Methods 0.000 claims 2
- 239000012867 bioactive agent Substances 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920005615 natural polymer Polymers 0.000 claims 2
- 229930014626 natural product Natural products 0.000 claims 2
- 239000003505 polymerization initiator Substances 0.000 claims 2
- 238000006116 polymerization reaction Methods 0.000 claims 2
- 239000001205 polyphosphate Substances 0.000 claims 2
- 235000011176 polyphosphates Nutrition 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- VALXVSHDOMUUIC-UHFFFAOYSA-N 2-methylprop-2-enoic acid;phosphoric acid Chemical compound OP(O)(O)=O.CC(=C)C(O)=O VALXVSHDOMUUIC-UHFFFAOYSA-N 0.000 claims 1
- UDXXYUDJOHIIDZ-UHFFFAOYSA-N 2-phosphonooxyethyl prop-2-enoate Chemical compound OP(O)(=O)OCCOC(=O)C=C UDXXYUDJOHIIDZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical group NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 1
- 208000034693 Laceration Diseases 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 150000001336 alkenes Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- 125000005619 boric acid group Chemical group 0.000 claims 1
- 125000005620 boronic acid group Chemical group 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical group OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 125000003916 ethylene diamine group Chemical group 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- FQPSGWSUVKBHSU-UHFFFAOYSA-N methacrylamide Chemical group CC(=C)C(N)=O FQPSGWSUVKBHSU-UHFFFAOYSA-N 0.000 claims 1
- 102000035118 modified proteins Human genes 0.000 claims 1
- 108091005573 modified proteins Proteins 0.000 claims 1
- NQIMONOHVBBZKE-UHFFFAOYSA-N n-[2-(3,4-dihydroxyphenyl)ethyl]-2-methylprop-2-enamide Chemical compound CC(=C)C(=O)NCCC1=CC=C(O)C(O)=C1 NQIMONOHVBBZKE-UHFFFAOYSA-N 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N phosphonic acid group Chemical group P(O)(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 claims 1
- WDHYRUBXLGOLKR-UHFFFAOYSA-N phosphoric acid;prop-2-enoic acid Chemical compound OC(=O)C=C.OP(O)(O)=O WDHYRUBXLGOLKR-UHFFFAOYSA-N 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 229920000137 polyphosphoric acid Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000003011 styrenyl group Chemical group [H]\C(*)=C(/[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
- 125000000542 sulfonic acid group Chemical group 0.000 claims 1
- 239000002407 tissue scaffold Substances 0.000 claims 1
- 229920001567 vinyl ester resin Chemical group 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/508,280 US8283384B2 (en) | 2008-01-24 | 2009-07-23 | Adhesive complex coacervates and methods of making and using thereof |
| US12/508,280 | 2009-07-23 | ||
| PCT/US2010/043009 WO2011011658A1 (en) | 2009-07-23 | 2010-07-23 | Adhesive complex coacervates and methods of making and using thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013500072A JP2013500072A (ja) | 2013-01-07 |
| JP2013500072A5 true JP2013500072A5 (https=) | 2013-09-12 |
| JP5928825B2 JP5928825B2 (ja) | 2016-06-01 |
Family
ID=43499829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521803A Active JP5928825B2 (ja) | 2009-07-23 | 2010-07-23 | 接着複合コアセルベートならびにそれを作製および使用する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8283384B2 (https=) |
| EP (1) | EP2456466B1 (https=) |
| JP (1) | JP5928825B2 (https=) |
| CN (1) | CN102548581A (https=) |
| AU (1) | AU2010275504A1 (https=) |
| CA (1) | CA2768501A1 (https=) |
| WO (1) | WO2011011658A1 (https=) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5530934B2 (ja) | 2008-01-24 | 2014-06-25 | ユニバーシティ オブ ユタ リサーチ ファンデーション | 接着複合コアセルベートならびにその作製および使用方法 |
| US8283384B2 (en) | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| TWI501793B (zh) * | 2008-11-12 | 2015-10-01 | Howmedica Osteonics Corp | 以磷酸四鈣為主之有機磷組合物及方法 |
| WO2011025158A2 (ko) * | 2009-08-25 | 2011-03-03 | 포항공과대학교 산학협력단 | 홍합 접착 단백질 또는 이의 변이체에 음이온성 고분자가 포함된 코아세르베이트 |
| JP2013521342A (ja) * | 2010-02-26 | 2013-06-10 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | 静電会合したブロック共重合体から生成される接着複合コアセルベート並びにその作製及び使用方法 |
| US9119605B2 (en) | 2010-05-06 | 2015-09-01 | Zimmer, Inc. | Synthetic polymer adhesives and methods for making, using and delivering the same |
| AU2011250934B2 (en) | 2010-05-11 | 2016-02-25 | Howmedica Osteonics Corp., | Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods |
| US20110287067A1 (en) * | 2010-05-24 | 2011-11-24 | University Of Utah Research Foundation | Reinforced adhesive complex coacervates and methods of making and using thereof |
| CN103179992A (zh) * | 2010-11-12 | 2013-06-26 | 犹他大学研究基金会 | 简单的粘合剂凝聚层以及制备和使用方法 |
| US8765189B2 (en) | 2011-05-13 | 2014-07-01 | Howmedica Osteonic Corp. | Organophosphorous and multivalent metal compound compositions and methods |
| CN104136602B (zh) * | 2011-06-23 | 2017-06-09 | 成功大学 | 细胞组织胶黏剂 |
| AU2012275516A1 (en) * | 2011-06-28 | 2014-01-23 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| IN2014CN03524A (https=) | 2011-11-13 | 2015-10-09 | Suneris Inc | |
| US20140308364A1 (en) * | 2011-11-16 | 2014-10-16 | The University Of North Carolina At Chapel Hill | Gelatinous hydroxyapatite-nanocomposites |
| EP2798027A4 (en) * | 2011-11-28 | 2015-10-07 | Boxin Zhao | METHOD AND APPARATUS FOR COLLAGE ASSEMBLY IN AQUEOUS MEDIUM |
| EP2607446A1 (en) | 2011-12-19 | 2013-06-26 | Shell Internationale Research Maatschappij B.V. | Method for consolidating and/or sealing a void in a subsurface formation |
| WO2013134269A2 (en) * | 2012-03-06 | 2013-09-12 | Kci Licensing, Inc. | New compositions, the preparation and use thereof |
| CA2889981A1 (en) | 2012-10-29 | 2014-05-08 | Ariste Medical, Inc. | Polymer coating compositions and coated products |
| AU2013342209B2 (en) * | 2012-11-09 | 2016-05-26 | Colgate-Palmolive Company | Block copolymers for tooth enamel protection |
| EP2953992B1 (en) | 2013-02-06 | 2021-11-24 | 3M Innovative Properties Company | Polymers, preparation and use thereof |
| KR102242947B1 (ko) | 2013-03-11 | 2021-04-22 | 유니버시티 오브 유타 리서치 파운데이션 | 센서 시스템들 |
| US20150018964A1 (en) * | 2013-07-09 | 2015-01-15 | Arthrex, Inc. | Bone void plugs and methods of use |
| WO2015048322A1 (en) * | 2013-09-25 | 2015-04-02 | Colorado State University Research Foundation | Methods for coating bone allografts with periosteum-mimetic tissue engineering scaffolds |
| CN103751837B (zh) * | 2014-01-20 | 2015-08-05 | 西南交通大学 | 可控交联仿生组织粘合剂及其用途 |
| US9814778B2 (en) | 2014-03-06 | 2017-11-14 | The University Of Toledo | Ionically crosslinked polyelectrolytes as underwater adhesives as controlled release vehicles |
| AU2015249769A1 (en) | 2014-04-22 | 2016-11-10 | Ariste Medical, Llc. | Methods and processes for application of drug delivery polymeric coatings |
| US9913927B2 (en) * | 2014-07-14 | 2018-03-13 | University Of Utah Research Foundation | In situ solidifying complex coacervates and methods of making and using thereof |
| US9950194B2 (en) | 2014-09-09 | 2018-04-24 | Mevion Medical Systems, Inc. | Patient positioning system |
| US20170354756A1 (en) * | 2014-11-18 | 2017-12-14 | University Of Utah Research Foundation | Polyphosphate hydrogels and methods of making and using thereof |
| CN104623725B (zh) * | 2014-12-31 | 2017-01-18 | 深圳清华大学研究院 | 生物粘合剂及其制备方法 |
| WO2016190400A1 (ja) * | 2015-05-26 | 2016-12-01 | 国立研究開発法人科学技術振興機構 | カテコール含有接着性ハイドロゲル、接着性ハイドロゲル作製用組成物、及び該接着性ハイドロゲルを応用した組成物 |
| CN107708750A (zh) | 2015-06-22 | 2018-02-16 | 克里斯伦公司 | 高度有效的止血粘附性聚合物支架 |
| DK3344304T3 (da) * | 2015-09-01 | 2021-09-13 | Trimph Ip Pty Ltd | Bioaktiv polymer til knogleregenerering |
| US10087344B2 (en) | 2015-10-30 | 2018-10-02 | E Ink Corporation | Methods for sealing microcell containers with phenethylamine mixtures |
| CA2914315C (en) * | 2015-12-09 | 2023-04-25 | Nova Chemicals Corp. | Hot fill process with closures made from high density unimodal polyethylene |
| CA2914353C (en) * | 2015-12-10 | 2023-01-24 | Nova Chemicals Corp. | Hot fill process with closures made from high density polyethylene compositions |
| US9861562B2 (en) * | 2015-12-16 | 2018-01-09 | Colgate-Palmolive Company | Occlusive personal care composition |
| KR20180124132A (ko) | 2016-03-29 | 2018-11-20 | 세이프화이트 인코포레이티드 | 치아 및 치아 구성요소의 미백을 위한 고분자 전해질 치과용 접착제 |
| WO2018044124A1 (ko) * | 2016-09-01 | 2018-03-08 | 포항공과대학교 산학협력단 | 신규한 줄기 세포 전달체 및 이의 제조 방법 |
| AU2016426150B2 (en) * | 2016-10-13 | 2022-06-30 | Allergan, Inc. | Coacervate hyaluronan hydrogels for dermal filler applications |
| WO2018093161A1 (ko) * | 2016-11-16 | 2018-05-24 | 포항공과대학교 산학협력단 | 홍합 접착 단백질을 포함하는 신규한 지혈제 및 이의 제조 방법 |
| WO2019018664A1 (en) * | 2017-07-19 | 2019-01-24 | Dentsply Sirona Inc. | HYDROSOLUBLE HYDROGEL BASED DENTAL COMPOSITION AND METHODS OF MAKING AND USING SAME |
| TW201918244A (zh) * | 2017-09-29 | 2019-05-16 | 美商安潔公司 | 聚電解質的牙科塗料 |
| AU2017445170B2 (en) * | 2017-12-31 | 2022-03-24 | Purdue Research Foundation | Adhesives |
| AU2019212513B2 (en) | 2018-01-26 | 2024-10-31 | Fluidx Medical Technology, Llc | Apparatus and method of using in situ solidifying complex coacervates for vascular occlusion |
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| CN109293947A (zh) * | 2018-05-16 | 2019-02-01 | 华东理工大学 | 一种超高强度矿化水凝胶及其合成方法 |
| BR112020025396A8 (pt) | 2018-06-11 | 2023-05-09 | krom James | Estrutura com adesivo para reparo da cartilagem articular |
| CN110642980A (zh) * | 2018-06-27 | 2020-01-03 | 华东理工大学 | 一种超高强度矿化水凝胶、合成方法及其应用 |
| DE102019109150A1 (de) * | 2019-04-08 | 2020-10-08 | Mühlbauer Technology Gmbh | Remineralisierendes Dentalmaterial |
| CN110180021B (zh) * | 2019-06-17 | 2020-10-27 | 西南交通大学 | 贻贝仿生粘合剂-磷酸钙高强度骨修复材料、高强度复合CaP支架及其制备方法 |
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| KR102386849B1 (ko) | 2019-10-14 | 2022-04-13 | 포항공과대학교 산학협력단 | 면역치료를 위한 환경 반응형 접착성 항체전달체 및 이의 제조방법 |
| CA3159190A1 (en) * | 2019-10-31 | 2021-05-06 | Dentsply Sirona Inc. | Dental varnish |
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| CN118872831A (zh) * | 2024-07-18 | 2024-11-01 | 中国海洋大学 | 鲟鱼子酱卵黄高磷蛋白在制备香气包埋纳米颗粒中的应用 |
| CN119345117B (zh) * | 2024-10-30 | 2025-11-25 | 南京邮电大学 | 一种双重交联超声响应的透明质酸水凝胶的制备方法及其应用 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3458360A (en) | 1966-08-17 | 1969-07-29 | Us Army | Alkaline cell having silver-magnesium alloy electrode |
| US3458460A (en) | 1967-11-27 | 1969-07-29 | Hooker Chemical Corp | Unsaturated polyesters cross-linked by diels-alder reaction |
| US3950296A (en) * | 1972-04-28 | 1976-04-13 | The Dow Chemical Company | Reversible coacervation of anion-containing aqueous disperse systems with amphoteric polyelectrolytes |
| US3947396A (en) * | 1972-04-28 | 1976-03-30 | The Dow Chemical Company | Coacervation of anion-containing aqueous disperse systems with amphoteric polyelectrolytes |
| US4767463A (en) | 1987-04-15 | 1988-08-30 | Union Carbide Corporation | Glycosaminoglycan and cationic polymer combinations |
| US4913743A (en) | 1987-04-15 | 1990-04-03 | Biomatrix, Inc. | Processes for managing keratinous material using glycosaminoglycan and cationic polymer combinations |
| US5529914A (en) | 1990-10-15 | 1996-06-25 | The Board Of Regents The Univeristy Of Texas System | Gels for encapsulation of biological materials |
| TW328535B (en) | 1993-07-02 | 1998-03-21 | Novartis Ag | Functional photoinitiators and their manufacture |
| WO1995006056A1 (en) | 1993-08-20 | 1995-03-02 | University Of Medicine & Dentistry Of New Jersey | Bridged polycationic polymer-oligonucleotide conjugates and methods for preparing same |
| JP2002515932A (ja) * | 1997-04-18 | 2002-05-28 | カリフォルニア インスティチュート オブ テクノロジー | 多機能性ポリマー性組織コーティング |
| DE19810965A1 (de) | 1998-03-13 | 1999-09-16 | Aventis Res & Tech Gmbh & Co | Nanopartikel, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US6428978B1 (en) | 1998-05-08 | 2002-08-06 | Cohesion Technologies, Inc. | Methods for the production of gelatin and full-length triple helical collagen in recombinant cells |
| ATE269114T1 (de) | 1998-11-20 | 2004-07-15 | Univ Connecticut | Verfahren und vorrichtung zur steuerung der gewebeimplantat-interaktionen |
| JP2002535046A (ja) | 1999-01-22 | 2002-10-22 | セント・ジュード・メディカル・インコーポレーテッド | 基質／接着剤成分複合体 |
| US6312725B1 (en) * | 1999-04-16 | 2001-11-06 | Cohesion Technologies, Inc. | Rapid gelling biocompatible polymer composition |
| WO2001005071A1 (en) | 1999-07-08 | 2001-01-18 | Quantumbeam Limited | Signalling system |
| US6916488B1 (en) * | 1999-11-05 | 2005-07-12 | Biocure, Inc. | Amphiphilic polymeric vesicles |
| US20020006886A1 (en) | 1999-11-19 | 2002-01-17 | Peter William Beerse | Personal care articles comprising cationic polymer coacervate compositions |
| JP5460939B2 (ja) * | 2000-03-13 | 2014-04-02 | バイオコンパティブルズ ユーケー リミテッド | ヒドロゲル生物医学用製品 |
| US20040013738A1 (en) | 2000-08-02 | 2004-01-22 | Andreas Voigt | Encapsulation of liquid template particles |
| US6488870B1 (en) | 2000-11-27 | 2002-12-03 | Xerox Corporation | Encapsulation process |
| MXPA03007665A (es) * | 2001-02-26 | 2004-03-16 | Univ Duke | Polimeros dendriticos novedosos y sus usos biomedicos. |
| US6568398B2 (en) * | 2001-03-07 | 2003-05-27 | Edgar C. Cohen | Method for hemostasis |
| US6562361B2 (en) * | 2001-05-02 | 2003-05-13 | 3M Innovative Properties Company | Pheromone immobilized in stable hydrogel microbeads |
| FR2824756B1 (fr) | 2001-05-16 | 2005-07-08 | Mainelab | Microcapsules a base de proteines vegetales |
| CA2449964A1 (en) * | 2001-06-07 | 2002-12-19 | Surmodics, Inc. | Crosslinkable macromers |
| US6559233B2 (en) | 2001-07-13 | 2003-05-06 | Rhodia Chimie | Composition comprising a copolymer at least two charged blocks and type of opposite charge |
| US7204997B2 (en) | 2002-01-29 | 2007-04-17 | Supratek Pharma Inc. | Responsive microgel and methods related thereto |
| CA2476777A1 (en) * | 2002-03-11 | 2003-09-25 | First Water Limited | Absorbent hydrogels |
| JP4058283B2 (ja) | 2002-03-22 | 2008-03-05 | 株式会社リコー | 振動検出装置 |
| US7060798B2 (en) * | 2002-05-13 | 2006-06-13 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University | Modified protein adhesives and lignocellulosic composites made from the adhesives |
| US6958848B2 (en) * | 2002-05-23 | 2005-10-25 | E Ink Corporation | Capsules, materials for use therein and electrophoretic media and displays containing such capsules |
| US6800663B2 (en) | 2002-10-18 | 2004-10-05 | Alkermes Controlled Therapeutics Inc. Ii, | Crosslinked hydrogel copolymers |
| US8105652B2 (en) | 2002-10-24 | 2012-01-31 | Massachusetts Institute Of Technology | Methods of making decomposable thin films of polyelectrolytes and uses thereof |
| CN1446590A (zh) | 2003-01-21 | 2003-10-08 | 华东理工大学 | 新型聚肽/磷酸钙复合骨水泥 |
| DE10334753A1 (de) * | 2003-07-30 | 2005-03-10 | Constr Res & Tech Gmbh | Selbstvernetzende hochmolekulare Polyurethan-Dispersion |
| WO2005019421A2 (en) | 2003-08-11 | 2005-03-03 | University Of Utah Research Foundation | Crosslinking within coordination complexes |
| US7544770B2 (en) | 2003-08-29 | 2009-06-09 | Louisiana Tech Foundation, Inc. | Multilayer films, coatings, and microcapsules comprising polypeptides |
| EP1518568B1 (en) | 2003-09-25 | 2009-05-27 | Wageningen Universiteit, Agrotechnologie en Voedingswetenschappen | Complex coacervate core micelles as anti-fouling agents |
| US7608674B2 (en) * | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
| WO2005065079A2 (en) | 2003-11-10 | 2005-07-21 | Angiotech International Ag | Medical implants and fibrosis-inducing agents |
| US7780873B2 (en) * | 2004-02-23 | 2010-08-24 | Texas A&M University System | Bioactive complexes compositions and methods of use thereof |
| WO2007024972A2 (en) | 2005-08-22 | 2007-03-01 | Quick-Med Technologies, Inc. | Non-leaching absorbent wound dressing |
| US7854924B2 (en) * | 2004-03-30 | 2010-12-21 | Relypsa, Inc. | Methods and compositions for treatment of ion imbalances |
| CN104174071A (zh) | 2004-04-28 | 2014-12-03 | 安希奥设备国际有限责任公司 | 用于形成交联生物材料的组合物和系统及关联的制备方法与用途 |
| US8728526B2 (en) * | 2004-08-19 | 2014-05-20 | The United States of America, Represented by Secretary of Department of Health and Human Services, NIH | Coacervate microparticles useful for the sustained release administration of therapeutic agents |
| US20060039950A1 (en) | 2004-08-23 | 2006-02-23 | Zhengrong Zhou | Multi-functional biocompatible coatings for intravascular devices |
| US20060116682A1 (en) | 2004-11-18 | 2006-06-01 | Longo Marc N | Surgical implant and methods of making and using the same |
| US7795359B2 (en) * | 2005-03-04 | 2010-09-14 | Novartis Ag | Continuous process for production of polymeric materials |
| WO2006130709A2 (en) | 2005-06-01 | 2006-12-07 | Rhodia Inc. | Coacervate systems having soil anti-adhesion and anti-deposition properties on hydrophilic surfaces |
| AU2006287306A1 (en) * | 2005-09-09 | 2007-03-15 | Duke University | Tissue engineering methods and compositions |
| CA2635374C (en) * | 2006-01-11 | 2015-12-08 | Hyperbranch Medical Technology, Inc. | Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices |
| US9198981B2 (en) * | 2006-02-01 | 2015-12-01 | The University Of Kentucky | Modulation of angiogenesis |
| CN101405037A (zh) | 2006-02-27 | 2009-04-08 | 新加坡科技研究局 | 可固化骨粘固剂 |
| US7622533B2 (en) * | 2006-08-04 | 2009-11-24 | Nerites Corporation | Biomimetic compounds and synthetic methods therefor |
| DE102007015698B4 (de) | 2007-03-27 | 2009-05-14 | Innotere Gmbh | Implantatmaterial auf Basis eines Polymersystems und dessen Verwendung sowie Applikationsset |
| JP2009084224A (ja) | 2007-09-28 | 2009-04-23 | Fujifilm Corp | マイクロカプセル及びその製造方法 |
| WO2009085952A1 (en) * | 2007-12-20 | 2009-07-09 | Brookwood Pharmaceuticals, Inc. | Process for preparing microparticles having a low residual solvent volume |
| US8283384B2 (en) | 2008-01-24 | 2012-10-09 | University Of Utah Research Foundation | Adhesive complex coacervates and methods of making and using thereof |
| JP5530934B2 (ja) * | 2008-01-24 | 2014-06-25 | ユニバーシティ オブ ユタ リサーチ ファンデーション | 接着複合コアセルベートならびにその作製および使用方法 |
| BRPI0911004B1 (pt) | 2008-07-18 | 2022-05-17 | Quick-Med Technologies, Inc | Método de preparação de um artigo antimicrobiano e artigo antimicrobiano |
| WO2010021930A1 (en) | 2008-08-16 | 2010-02-25 | Synedgen, Inc. | Prevention and treatment of mrsa infections with chitosan-derivatives |
| JP2009084292A (ja) | 2008-11-14 | 2009-04-23 | Cell-Medicine Inc | 免疫アジュバント |
| EP2454367B1 (en) | 2009-07-17 | 2013-10-16 | The Texas A&M University System | Designer collagens and uses thereof |
| CA3004707C (en) | 2009-09-02 | 2022-05-31 | Synedgen Inc. | Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds |
| JP2013521342A (ja) | 2010-02-26 | 2013-06-10 | ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション | 静電会合したブロック共重合体から生成される接着複合コアセルベート並びにその作製及び使用方法 |
| US20110287067A1 (en) * | 2010-05-24 | 2011-11-24 | University Of Utah Research Foundation | Reinforced adhesive complex coacervates and methods of making and using thereof |
| CN103179992A (zh) | 2010-11-12 | 2013-06-26 | 犹他大学研究基金会 | 简单的粘合剂凝聚层以及制备和使用方法 |
| IN2014CN03524A (https=) | 2011-11-13 | 2015-10-09 | Suneris Inc | |
| US9913927B2 (en) | 2014-07-14 | 2018-03-13 | University Of Utah Research Foundation | In situ solidifying complex coacervates and methods of making and using thereof |
-
2009
- 2009-07-23 US US12/508,280 patent/US8283384B2/en active Active
-
2010
- 2010-07-23 CA CA2768501A patent/CA2768501A1/en not_active Abandoned
- 2010-07-23 AU AU2010275504A patent/AU2010275504A1/en not_active Abandoned
- 2010-07-23 JP JP2012521803A patent/JP5928825B2/ja active Active
- 2010-07-23 CN CN2010800383973A patent/CN102548581A/zh active Pending
- 2010-07-23 EP EP10802933.1A patent/EP2456466B1/en active Active
- 2010-07-23 WO PCT/US2010/043009 patent/WO2011011658A1/en not_active Ceased
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2012
- 2012-09-14 US US13/617,882 patent/US9913926B2/en active Active
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2018
- 2018-03-12 US US15/918,423 patent/US10517987B2/en active Active
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