JP5928825B2 - 接着複合コアセルベートならびにそれを作製および使用する方法 - Google Patents

接着複合コアセルベートならびにそれを作製および使用する方法 Download PDF

Info

Publication number
JP5928825B2
JP5928825B2 JP2012521803A JP2012521803A JP5928825B2 JP 5928825 B2 JP5928825 B2 JP 5928825B2 JP 2012521803 A JP2012521803 A JP 2012521803A JP 2012521803 A JP2012521803 A JP 2012521803A JP 5928825 B2 JP5928825 B2 JP 5928825B2
Authority
JP
Japan
Prior art keywords
coacervate
group
polyanion
polycation
adhesive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012521803A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013500072A5 (https=
JP2013500072A (ja
Inventor
スチュアート，ラッセル，ジョン
シャオ，ホイ
Original Assignee
ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション filed Critical ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション
Publication of JP2013500072A publication Critical patent/JP2013500072A/ja
Publication of JP2013500072A5 publication Critical patent/JP2013500072A5/ja
Application granted granted Critical
Publication of JP5928825B2 publication Critical patent/JP5928825B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/06—Oxidation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/10—Acylation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/24—Homopolymers or copolymers of amides or imides
    • C08L33/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/24—Homopolymers or copolymers of amides or imides
    • C09D133/26—Homopolymers or copolymers of acrylamide or methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2800/00—Copolymer characterised by the proportions of the comonomers expressed
    • C08F2800/10—Copolymer characterised by the proportions of the comonomers expressed as molar percentages
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/20—Chemical modification of a polymer leading to a crosslinking, either explicitly or inherently
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F2810/00—Chemical modification of a polymer
    • C08F2810/30—Chemical modification of a polymer leading to the formation or introduction of aliphatic or alicyclic unsaturated groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Composite Materials (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Dental Preparations (AREA)
JP2012521803A 2009-07-23 2010-07-23 接着複合コアセルベートならびにそれを作製および使用する方法 Active JP5928825B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/508,280 2009-07-23
US12/508,280 US8283384B2 (en) 2008-01-24 2009-07-23 Adhesive complex coacervates and methods of making and using thereof
PCT/US2010/043009 WO2011011658A1 (en) 2009-07-23 2010-07-23 Adhesive complex coacervates and methods of making and using thereof

Publications (3)

Publication Number Publication Date
JP2013500072A JP2013500072A (ja) 2013-01-07
JP2013500072A5 JP2013500072A5 (https=) 2013-09-12
JP5928825B2 true JP5928825B2 (ja) 2016-06-01

Family

ID=43499829

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012521803A Active JP5928825B2 (ja) 2009-07-23 2010-07-23 接着複合コアセルベートならびにそれを作製および使用する方法

Country Status (7)

Country Link
US (3) US8283384B2 (https=)
EP (1) EP2456466B1 (https=)
JP (1) JP5928825B2 (https=)
CN (1) CN102548581A (https=)
AU (1) AU2010275504A1 (https=)
CA (1) CA2768501A1 (https=)
WO (1) WO2011011658A1 (https=)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8283384B2 (en) 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
WO2009094060A1 (en) 2008-01-24 2009-07-30 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
AU2009314106A1 (en) 2008-11-12 2010-05-20 Howmedica Osteonics Corp., Tetra calcium phosphate based organophosphorus compositions and methods
JP2012526155A (ja) * 2009-08-25 2012-10-25 ポステック アカデミー−インダストリー ファンデーション イガイ接着蛋白質またはその変異体に陰イオン性高分子が含まれたコアセルベート
CA2788998A1 (en) * 2010-02-26 2011-09-01 University Of Utah Research Foundation Adhesive complex coacervates produced from electrostatically associated block copolymers and methods for making and using the same
US9119605B2 (en) 2010-05-06 2015-09-01 Zimmer, Inc. Synthetic polymer adhesives and methods for making, using and delivering the same
CA3048850A1 (en) 2010-05-11 2011-11-17 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
WO2011149907A1 (en) * 2010-05-24 2011-12-01 University Of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof
EP2637708A2 (en) * 2010-11-12 2013-09-18 University of Utah Research Foundation Simple adhesive coacervates and methods of making and using thereof
WO2012158527A2 (en) 2011-05-13 2012-11-22 Howmedica Osteonics Organophosphorous & multivalent metal compound compositions & methods
CN104136602B (zh) * 2011-06-23 2017-06-09 成功大学 细胞组织胶黏剂
US20140220082A1 (en) * 2011-06-28 2014-08-07 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
CA2855347C (en) 2011-11-13 2019-03-05 Suneris Inc. In-situ cross-linkable polymeric compositions and methods thereof
WO2013074748A1 (en) * 2011-11-16 2013-05-23 The University Of North Carolina At Chapel Hill Gelatinous hydroxyapatite-nanocomposites
US9982169B2 (en) 2011-11-28 2018-05-29 Boxin Zhao Method and apparatus for adhesive bonding in an aqueous medium
EP2607446A1 (en) 2011-12-19 2013-06-26 Shell Internationale Research Maatschappij B.V. Method for consolidating and/or sealing a void in a subsurface formation
US20130273145A1 (en) * 2012-03-06 2013-10-17 Kci Licensing, Inc. Compositions, the preparation and use thereof
CA2889981A1 (en) 2012-10-29 2014-05-08 Ariste Medical, Inc. Polymer coating compositions and coated products
US10918588B2 (en) * 2012-11-09 2021-02-16 Colgate-Palmolive Company Block copolymers for tooth enamel protection
WO2014123665A1 (en) 2013-02-06 2014-08-14 Kci Licensing, Inc. Polymers, preparation and use thereof
EP2967414B1 (en) 2013-03-11 2019-12-18 University Of Utah Research Foundation Sensor systems
US20150018964A1 (en) * 2013-07-09 2015-01-15 Arthrex, Inc. Bone void plugs and methods of use
US20150086602A1 (en) * 2013-09-25 2015-03-26 Colorado State University Research Foundation Methods for coating bone allografts with periosteum-mimetic tissue engineering scaffolds
CN103751837B (zh) * 2014-01-20 2015-08-05 西南交通大学 可控交联仿生组织粘合剂及其用途
US9814778B2 (en) 2014-03-06 2017-11-14 The University Of Toledo Ionically crosslinked polyelectrolytes as underwater adhesives as controlled release vehicles
WO2015164524A1 (en) * 2014-04-22 2015-10-29 Ariste Medical, Inc. Methods and processes for application of drug delivery polymeric coatings
EP3169374B1 (en) * 2014-07-14 2022-01-05 University of Utah Research Foundation In situ solidifying complex coacervates and methods of making and using thereof
US9950194B2 (en) 2014-09-09 2018-04-24 Mevion Medical Systems, Inc. Patient positioning system
EP3221386A4 (en) * 2014-11-18 2018-09-26 University of Utah Research Foundation Polyphosphate hydrogels and methods of making and using thereof
CN104623725B (zh) * 2014-12-31 2017-01-18 深圳清华大学研究院 生物粘合剂及其制备方法
US10611927B2 (en) 2015-05-26 2020-04-07 Japan Science And Technology Agency Catechol-containing adhesive hydrogel, composition for preparing adhesive hydrogel, and compositions each including said adhesive hydrogel
MX2017016865A (es) 2015-06-22 2018-09-06 Cresilon Inc Andamio de polimero adhesivo hermostatico altamente eficaz.
AU2016314146B2 (en) * 2015-09-01 2020-12-03 Trimph Ip Pty Ltd Bioactive polymer for bone regeneration
US10087344B2 (en) 2015-10-30 2018-10-02 E Ink Corporation Methods for sealing microcell containers with phenethylamine mixtures
CA2914315C (en) * 2015-12-09 2023-04-25 Nova Chemicals Corp. Hot fill process with closures made from high density unimodal polyethylene
CA2914353C (en) * 2015-12-10 2023-01-24 Nova Chemicals Corp. Hot fill process with closures made from high density polyethylene compositions
US9861562B2 (en) * 2015-12-16 2018-01-09 Colgate-Palmolive Company Occlusive personal care composition
AU2017245246A1 (en) 2016-03-29 2018-10-11 Safewhite, Inc. Polyelectrolyte dental adhesives for whitening teeth and teeth components
WO2018044124A1 (ko) * 2016-09-01 2018-03-08 포항공과대학교 산학협력단 신규한 줄기 세포 전달체 및 이의 제조 방법
US20200054786A1 (en) * 2016-10-13 2020-02-20 Allergan, Inc. Coacervate hyaluronan hydrogels for dermal filler applications
KR102092782B1 (ko) * 2016-11-16 2020-03-25 포항공과대학교 산학협력단 홍합 접착 단백질을 포함하는 신규한 지혈제 및 이의 제조 방법
CA3069968A1 (en) * 2017-07-19 2019-01-24 Dentsply Sirona Inc. Water-soluble hydrogel-based dental composition and methods of making and using same
TW201918244A (zh) * 2017-09-29 2019-05-16 美商安潔公司 聚電解質的牙科塗料
CA3084142C (en) * 2017-12-31 2024-03-12 Purdue Research Foundation Adhesives
CA3089480C (en) 2018-01-26 2025-05-27 Fluidx Medical Technology, Inc. APPARATUS AND METHOD FOR USING COMPLEX COACERVATES WITH IN SITU SOLIDIFICATION FOR VASCULAR OCLUSION
CN108371728B (zh) * 2018-03-09 2020-12-18 西南交通大学 一种用于组织修复的仿贻贝接触抗菌水凝胶的制备方法
CN109293947A (zh) * 2018-05-16 2019-02-01 华东理工大学 一种超高强度矿化水凝胶及其合成方法
JP7584301B2 (ja) 2018-06-11 2024-11-15 オキュジェン インコーポレイテッド 関節軟骨修復のための接着剤を含むスキャフォールド
CN110642980A (zh) * 2018-06-27 2020-01-03 华东理工大学 一种超高强度矿化水凝胶、合成方法及其应用
DE102019109150A1 (de) * 2019-04-08 2020-10-08 Mühlbauer Technology Gmbh Remineralisierendes Dentalmaterial
CN110180021B (zh) * 2019-06-17 2020-10-27 西南交通大学 贻贝仿生粘合剂-磷酸钙高强度骨修复材料、高强度复合CaP支架及其制备方法
KR102462168B1 (ko) * 2019-08-14 2022-11-02 (주)네이처글루텍 홍합접착단백질로 코팅된 치과용 임플란트
CN110373153B (zh) * 2019-08-22 2021-04-06 中国科学院长春应用化学研究所 一种高粘合强度的生物粘合剂及其制备方法
KR102386849B1 (ko) 2019-10-14 2022-04-13 포항공과대학교 산학협력단 면역치료를 위한 환경 반응형 접착성 항체전달체 및 이의 제조방법
WO2021087186A1 (en) * 2019-10-31 2021-05-06 Dentsply Sirona Inc. Dental varnish
CN111849386A (zh) * 2020-07-22 2020-10-30 上海交通大学 一种絮凝酵母生物粘合剂及其制备和使用方法
EP4208518A4 (en) * 2020-09-03 2024-10-16 Purdue Research Foundation PHOSPHATE-CONTAINING BIOMIMETIC POLYMERS AND RELATED USES
CN114010359B (zh) * 2021-04-30 2023-07-14 中国计量大学 用于协助口腔牙齿敷药治疗器具的制取方法
WO2023086358A1 (en) * 2021-11-10 2023-05-19 University Of Massachusetts Liquid complex coacervates, articles derived therefrom, and methods for the manufacture thereof
CN114210216B (zh) * 2021-12-07 2024-06-21 沈阳工业大学 一种离子液体改性聚多巴胺包覆的三氧化二铝制备混合基质膜的方法及应用
CN114225109B (zh) * 2021-12-22 2022-08-23 上海交通大学 一种人工神经鞘水凝胶修复系统及其制备方法和应用
CN115843780B (zh) * 2022-11-18 2023-06-20 广州瑞泰生物科技有限公司 生物膜保存液及其制备方法和应用
CN116942887B (zh) * 2023-07-21 2025-12-19 北京大学 一种高生物黏附性和高生物相容性的促周围神经损伤修复新型生物粘合剂的制备及应用
CN118697930B (zh) * 2024-05-23 2025-09-26 福建师范大学 一种即粘型强韧湿组织胶带及其制备方法
CN118872831A (zh) * 2024-07-18 2024-11-01 中国海洋大学 鲟鱼子酱卵黄高磷蛋白在制备香气包埋纳米颗粒中的应用
CN119345117B (zh) * 2024-10-30 2025-11-25 南京邮电大学 一种双重交联超声响应的透明质酸水凝胶的制备方法及其应用

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458360A (en) 1966-08-17 1969-07-29 Us Army Alkaline cell having silver-magnesium alloy electrode
US3458460A (en) 1967-11-27 1969-07-29 Hooker Chemical Corp Unsaturated polyesters cross-linked by diels-alder reaction
US3947396A (en) * 1972-04-28 1976-03-30 The Dow Chemical Company Coacervation of anion-containing aqueous disperse systems with amphoteric polyelectrolytes
US3950296A (en) * 1972-04-28 1976-04-13 The Dow Chemical Company Reversible coacervation of anion-containing aqueous disperse systems with amphoteric polyelectrolytes
US4767463A (en) 1987-04-15 1988-08-30 Union Carbide Corporation Glycosaminoglycan and cationic polymer combinations
US4913743A (en) 1987-04-15 1990-04-03 Biomatrix, Inc. Processes for managing keratinous material using glycosaminoglycan and cationic polymer combinations
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
TW328535B (en) 1993-07-02 1998-03-21 Novartis Ag Functional photoinitiators and their manufacture
WO1995006056A1 (en) 1993-08-20 1995-03-02 University Of Medicine & Dentistry Of New Jersey Bridged polycationic polymer-oligonucleotide conjugates and methods for preparing same
JP2002515932A (ja) * 1997-04-18 2002-05-28 カリフォルニア インスティチュート オブ テクノロジー 多機能性ポリマー性組織コーティング
DE19810965A1 (de) 1998-03-13 1999-09-16 Aventis Res & Tech Gmbh & Co Nanopartikel, Verfahren zu ihrer Herstellung und ihre Verwendung
US6428978B1 (en) 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
DE69918159T2 (de) 1998-11-20 2005-03-17 The University Of Connecticut, Farmington Verfahren und vorrichtung zur steuerung der gewebeimplantat-interaktionen
JP2002535046A (ja) 1999-01-22 2002-10-22 セント・ジュード・メディカル・インコーポレーテッド 基質／接着剤成分複合体
US6312725B1 (en) * 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
AU5995400A (en) 1999-07-08 2001-01-30 Quantumbeam Limited Signalling system
US6916488B1 (en) * 1999-11-05 2005-07-12 Biocure, Inc. Amphiphilic polymeric vesicles
US20020006886A1 (en) 1999-11-19 2002-01-17 Peter William Beerse Personal care articles comprising cationic polymer coacervate compositions
EP1263801B1 (en) * 2000-03-13 2006-05-24 BioCure, Inc. Tissue bulking and coating compositions
US20040013738A1 (en) 2000-08-02 2004-01-22 Andreas Voigt Encapsulation of liquid template particles
US6488870B1 (en) 2000-11-27 2002-12-03 Xerox Corporation Encapsulation process
JP2004523624A (ja) * 2001-02-26 2004-08-05 デューク ユニバーシティ 新規なデンドリティックポリマー、およびその生物医学的使用
US6568398B2 (en) * 2001-03-07 2003-05-27 Edgar C. Cohen Method for hemostasis
US6562361B2 (en) * 2001-05-02 2003-05-13 3M Innovative Properties Company Pheromone immobilized in stable hydrogel microbeads
FR2824756B1 (fr) 2001-05-16 2005-07-08 Mainelab Microcapsules a base de proteines vegetales
JP2005508663A (ja) * 2001-06-07 2005-04-07 サーモディックス，インコーポレイティド 架橋性マクロマー
US6559233B2 (en) 2001-07-13 2003-05-06 Rhodia Chimie Composition comprising a copolymer at least two charged blocks and type of opposite charge
US7204997B2 (en) 2002-01-29 2007-04-17 Supratek Pharma Inc. Responsive microgel and methods related thereto
WO2003077964A1 (en) * 2002-03-11 2003-09-25 First Water Limited Absorbent hydrogels
JP4058283B2 (ja) 2002-03-22 2008-03-05 株式会社リコー 振動検出装置
US7060798B2 (en) * 2002-05-13 2006-06-13 State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University Modified protein adhesives and lignocellulosic composites made from the adhesives
US6958848B2 (en) * 2002-05-23 2005-10-25 E Ink Corporation Capsules, materials for use therein and electrophoretic media and displays containing such capsules
US6800663B2 (en) 2002-10-18 2004-10-05 Alkermes Controlled Therapeutics Inc. Ii, Crosslinked hydrogel copolymers
US8105652B2 (en) 2002-10-24 2012-01-31 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof
CN1446590A (zh) 2003-01-21 2003-10-08 华东理工大学 新型聚肽/磷酸钙复合骨水泥
DE10334753A1 (de) * 2003-07-30 2005-03-10 Constr Res & Tech Gmbh Selbstvernetzende hochmolekulare Polyurethan-Dispersion
AU2004267422B2 (en) 2003-08-11 2010-03-18 University Of Utah Research Foundation Crosslinking within coordination complexes
US7544770B2 (en) 2003-08-29 2009-06-09 Louisiana Tech Foundation, Inc. Multilayer films, coatings, and microcapsules comprising polypeptides
EP1518568B1 (en) 2003-09-25 2009-05-27 Wageningen Universiteit, Agrotechnologie en Voedingswetenschappen Complex coacervate core micelles as anti-fouling agents
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US20050148512A1 (en) 2003-11-10 2005-07-07 Angiotech International Ag Medical implants and fibrosis-inducing agents
US7780873B2 (en) * 2004-02-23 2010-08-24 Texas A&M University System Bioactive complexes compositions and methods of use thereof
WO2007024972A2 (en) 2005-08-22 2007-03-01 Quick-Med Technologies, Inc. Non-leaching absorbent wound dressing
US7854924B2 (en) * 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
WO2006078282A2 (en) 2004-04-28 2006-07-27 Angiotech Biomaterials Corporation Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
WO2006023207A2 (en) * 2004-08-19 2006-03-02 The United States Of America As Represented By The Secretary Of Health And Human Services, Nih Coacervate of anionic and cationic polymer forming microparticles for the sustained release of therapeutic agents
US20060039950A1 (en) 2004-08-23 2006-02-23 Zhengrong Zhou Multi-functional biocompatible coatings for intravascular devices
US20060116682A1 (en) 2004-11-18 2006-06-01 Longo Marc N Surgical implant and methods of making and using the same
US7795359B2 (en) * 2005-03-04 2010-09-14 Novartis Ag Continuous process for production of polymeric materials
EP1888729A4 (en) 2005-06-01 2009-07-08 Rhodia KOAZERVATSYSTEME WITH ANTI-GROUNDING AND ANTI-DEPOSITION PROPERTIES ON HYDROPHILIC SURFACES
EP1940423B1 (en) * 2005-09-09 2014-04-16 Duke University Tissue engineering methods and compositions
WO2007082061A2 (en) * 2006-01-11 2007-07-19 Hyperbranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
US9198981B2 (en) * 2006-02-01 2015-12-01 The University Of Kentucky Modulation of angiogenesis
CN101405037A (zh) 2006-02-27 2009-04-08 新加坡科技研究局 可固化骨粘固剂
AU2007283772B2 (en) * 2006-08-04 2013-03-07 Kensey Nash Corporation Biomimetic compounds and synthetic methods therefor
DE102007015698B4 (de) 2007-03-27 2009-05-14 Innotere Gmbh Implantatmaterial auf Basis eines Polymersystems und dessen Verwendung sowie Applikationsset
JP2009084224A (ja) 2007-09-28 2009-04-23 Fujifilm Corp マイクロカプセル及びその製造方法
ES2718612T3 (es) * 2007-12-20 2019-07-03 Evonik Corp Procedimiento para preparar micropartículas que tienen un bajo volumen de disolvente residual
WO2009094060A1 (en) 2008-01-24 2009-07-30 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
US8283384B2 (en) 2008-01-24 2012-10-09 University Of Utah Research Foundation Adhesive complex coacervates and methods of making and using thereof
BRPI0911004B1 (pt) 2008-07-18 2022-05-17 Quick-Med Technologies, Inc Método de preparação de um artigo antimicrobiano e artigo antimicrobiano
US9012429B2 (en) 2008-08-16 2015-04-21 Synedgen, Inc. Methods and compositions for the prevention of and treatment of infections utilizing chitosan-derivative compounds
JP2009084292A (ja) 2008-11-14 2009-04-23 Cell-Medicine Inc 免疫アジュバント
US8618250B2 (en) 2009-07-17 2013-12-31 The Texas A&M University System Designer collagens and use thereof
CA3004707C (en) 2009-09-02 2022-05-31 Synedgen Inc. Methods and compositions for disrupting biofilm utilizing chitosan-derivative compounds
CA2788998A1 (en) 2010-02-26 2011-09-01 University Of Utah Research Foundation Adhesive complex coacervates produced from electrostatically associated block copolymers and methods for making and using the same
WO2011149907A1 (en) 2010-05-24 2011-12-01 University Of Utah Research Foundation Reinforced adhesive complex coacervates and methods of making and using thereof
EP2637708A2 (en) 2010-11-12 2013-09-18 University of Utah Research Foundation Simple adhesive coacervates and methods of making and using thereof
CA2855347C (en) 2011-11-13 2019-03-05 Suneris Inc. In-situ cross-linkable polymeric compositions and methods thereof
EP3169374B1 (en) 2014-07-14 2022-01-05 University of Utah Research Foundation In situ solidifying complex coacervates and methods of making and using thereof

Also Published As

Publication number Publication date
JP2013500072A (ja) 2013-01-07
EP2456466A4 (en) 2014-07-23
US20180272027A1 (en) 2018-09-27
AU2010275504A1 (en) 2012-02-02
US9913926B2 (en) 2018-03-13
US20130189313A1 (en) 2013-07-25
US20100120923A1 (en) 2010-05-13
WO2011011658A1 (en) 2011-01-27
EP2456466B1 (en) 2019-05-08
CN102548581A (zh) 2012-07-04
US10517987B2 (en) 2019-12-31
EP2456466A1 (en) 2012-05-30
CA2768501A1 (en) 2011-01-27
US8283384B2 (en) 2012-10-09

Similar Documents

Publication Publication Date Title
JP5928825B2 (ja) 接着複合コアセルベートならびにそれを作製および使用する方法
JP5530934B2 (ja) 接着複合コアセルベートならびにその作製および使用方法
US9999700B1 (en) Simple coacervates and methods of use thereof
CA2799818A1 (en) Reinforced adhesive complex coacervates and methods of making and using thereof
AU2014203210A1 (en) Adhesive complex coacervates and methods of making and using thereof
HK1186131A (en) Adhesive complex coacervates and methods of making and using thereof
HK1186417A (en) Simple adhesive coacervates and methods of making and using thereof
AU2011258511A1 (en) Reinforced adhesive complex coacervates and methods of making and using thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130723

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20130723

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140812

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141110

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20141117

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20141210

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150113

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150721

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151021

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151120

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20151221

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160114

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160315

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160413

R150 Certificate of patent or registration of utility model

Ref document number: 5928825

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250