JP2013177406A5 - - Google Patents
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- Publication number
- JP2013177406A5 JP2013177406A5 JP2013092845A JP2013092845A JP2013177406A5 JP 2013177406 A5 JP2013177406 A5 JP 2013177406A5 JP 2013092845 A JP2013092845 A JP 2013092845A JP 2013092845 A JP2013092845 A JP 2013092845A JP 2013177406 A5 JP2013177406 A5 JP 2013177406A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- microparticles
- plga
- aggregating agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 239000011859 microparticle Substances 0.000 claims description 13
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 6
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 claims description 4
- 108010016076 Octreotide Proteins 0.000 claims description 4
- 229960002700 octreotide Drugs 0.000 claims description 4
- 229920002959 polymer blend Polymers 0.000 claims description 4
- 239000010419 fine particle Substances 0.000 claims description 2
- 230000002744 anti-aggregatory effect Effects 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 4
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims 3
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims 3
- 239000000178 monomer Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000008346 aqueous phase Substances 0.000 claims 2
- 239000012074 organic phase Substances 0.000 claims 2
- 239000003791 organic solvent mixture Substances 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 239000003708 ampul Substances 0.000 claims 1
- 239000008135 aqueous vehicle Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 230000001804 emulsifying effect Effects 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 229920000747 poly(lactic acid) Polymers 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000007873 sieving Methods 0.000 claims 1
- 238000000935 solvent evaporation Methods 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 239000007943 implant Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0526247.2 | 2005-12-22 | ||
| GB0526247A GB0526247D0 (en) | 2005-12-22 | 2005-12-22 | Organic compounds |
| EP06119086.4 | 2006-08-17 | ||
| EP06119086 | 2006-08-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546248A Division JP2009520727A (ja) | 2005-12-22 | 2006-12-20 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207464A Division JP6178772B2 (ja) | 2005-12-22 | 2014-10-08 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2016115579A Division JP2016216467A (ja) | 2005-12-22 | 2016-06-09 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013177406A JP2013177406A (ja) | 2013-09-09 |
| JP2013177406A5 true JP2013177406A5 (enExample) | 2016-08-04 |
| JP6239851B2 JP6239851B2 (ja) | 2017-11-29 |
Family
ID=37772904
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546248A Pending JP2009520727A (ja) | 2005-12-22 | 2006-12-20 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2013092845A Active JP6239851B2 (ja) | 2005-12-22 | 2013-04-25 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2014207464A Active JP6178772B2 (ja) | 2005-12-22 | 2014-10-08 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2016115579A Withdrawn JP2016216467A (ja) | 2005-12-22 | 2016-06-09 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008546248A Pending JP2009520727A (ja) | 2005-12-22 | 2006-12-20 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014207464A Active JP6178772B2 (ja) | 2005-12-22 | 2014-10-08 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
| JP2016115579A Withdrawn JP2016216467A (ja) | 2005-12-22 | 2016-06-09 | オクトレオチドおよび２種またはそれ以上のポリラクチドコグリコリドポリマーを含む徐放性製剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (7) | US20090004283A1 (enExample) |
| EP (3) | EP2359809B1 (enExample) |
| JP (4) | JP2009520727A (enExample) |
| KR (5) | KR20130024987A (enExample) |
| CN (1) | CN103251929A (enExample) |
| AR (1) | AR058591A1 (enExample) |
| AU (1) | AU2006328950B2 (enExample) |
| BR (2) | BRPI0620063B8 (enExample) |
| CA (1) | CA2631811C (enExample) |
| CL (1) | CL2018003398A1 (enExample) |
| EC (1) | ECSP088560A (enExample) |
| ES (2) | ES2492641T3 (enExample) |
| IL (1) | IL191842A0 (enExample) |
| IN (1) | IN2015DN03936A (enExample) |
| MA (1) | MA30064B1 (enExample) |
| NO (1) | NO20082988L (enExample) |
| PE (1) | PE20071139A1 (enExample) |
| PL (2) | PL2359809T3 (enExample) |
| PT (2) | PT2359809T (enExample) |
| RU (1) | RU2464972C2 (enExample) |
| TW (2) | TWI469788B (enExample) |
| WO (1) | WO2007071395A1 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY150450A (en) | 2007-06-06 | 2014-01-30 | Debiopharm Res & Mfg Sa | Slow release pharmaceutical composition made of microparticles |
| US8470360B2 (en) * | 2008-04-18 | 2013-06-25 | Warsaw Orthopedic, Inc. | Drug depots having different release profiles for reducing, preventing or treating pain and inflammation |
| ES2324009B1 (es) * | 2007-11-23 | 2010-05-21 | Gp Pharm S.A. | Composicion farmaceutica de liberacion sostenida de somatostatina o un analogo suyo. |
| AU2013201877B2 (en) * | 2008-01-30 | 2015-01-29 | Novartis Ag | Sustained release formulation comprising octreotide and three linear polylactide-co-glycolide polymers |
| PT2247282E (pt) | 2008-01-30 | 2014-11-11 | Novartis Ag | Formulação de libertação controlada compreendendo octreotido e três polímeros lineares de polilactido-coglicolido |
| AU2015201581B2 (en) * | 2008-09-17 | 2017-03-09 | Amryt Endo, Inc. | Pharmaceutical Compositions and Related Methods of Delivery |
| JP5623406B2 (ja) | 2008-09-17 | 2014-11-12 | キアズマ インコーポレイテッド | 医薬組成物および関連する送達方法 |
| US20100151033A1 (en) * | 2008-12-15 | 2010-06-17 | Novartis Ag | Octreotide depot formulation with constantly high exposure levels |
| WO2010085609A2 (en) * | 2009-01-23 | 2010-07-29 | Surmodics Pharmaceuticals, Inc. | Controlled release systems from polymer blends |
| EP2595604B1 (en) * | 2010-07-21 | 2016-03-30 | Allergan, Inc. | Method of controlling initial drug release of sirna from sustained-release implants |
| GB201016433D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Apparatus and method for making solid beads |
| GB201016436D0 (en) | 2010-09-30 | 2010-11-17 | Q Chip Ltd | Method of making solid beads |
| US20120156304A1 (en) * | 2010-12-15 | 2012-06-21 | Thomas Tice | Branched polyol polyesters, blends, and pharmaceutical formulations comprising same |
| PL3199146T3 (pl) | 2011-04-25 | 2020-03-31 | Shan Dong Luye Pharmaceutical Co., Ltd. | Kompozycja mikrosfery rysperydonu o przedłużonym uwalnianiu |
| CN102488619B (zh) * | 2011-12-05 | 2014-08-06 | 上海交通大学 | 连续生产艾塞那肽微球的装置及控制微球释放速度的方法 |
| WO2016084849A1 (ja) * | 2014-11-25 | 2016-06-02 | Cbc株式会社 | ヤヌス微粒子及びその製造方法 |
| EP3253401B1 (en) | 2015-02-03 | 2025-04-02 | Amryt Endo, Inc. | Treating acromegaly with oral octreotide |
| JP6165356B2 (ja) * | 2015-06-26 | 2017-07-19 | オリンパス株式会社 | 内視鏡システム |
| US12396951B2 (en) * | 2016-12-27 | 2025-08-26 | Upexmed Co. Ltd. | Prevention of local tumor recurrence following surgery using sustainedand/or delayed release of medicaments contained in micro-particles |
| KR102142026B1 (ko) * | 2017-05-31 | 2020-08-06 | 주식회사 대웅제약 | 방출제어가 용이한 서방성 약물 미립자의 제조방법 |
| JP7704740B2 (ja) | 2019-09-16 | 2025-07-08 | アムジエン・インコーポレーテツド | 薬物送達デバイスの外部滅菌の方法 |
| CN111214643A (zh) * | 2020-03-11 | 2020-06-02 | 苏州善湾生物医药科技有限公司 | 一种基于皮下凝胶缓释的奥曲肽组合物、制备方法及应用 |
| KR20220163418A (ko) * | 2020-05-08 | 2022-12-09 | 엠. 테크닉 가부시키가이샤 | 생리 활성 물질이 균일하게 분산된 마이크로스피어 및 그것을 함유하는 서방성 제제 |
| KR20220163417A (ko) | 2020-05-08 | 2022-12-09 | 엠. 테크닉 가부시키가이샤 | 주제가 균일하게 분산된 마이크로스피어 및 그것을 함유하는 서방성 제제 |
| CN119112804A (zh) | 2020-05-08 | 2024-12-13 | M技术株式会社 | 均匀分散有生理活性物质的微球及含有其的缓释制剂 |
| US11141457B1 (en) | 2020-12-28 | 2021-10-12 | Amryt Endo, Inc. | Oral octreotide therapy and contraceptive methods |
Family Cites Families (27)
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| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| CY1327A (en) | 1979-11-27 | 1986-06-27 | Sandoz Ag | Novel polypeptides,processes for their production,pharmaceutical compositions comprising said polypeptides and their use |
| US4675189A (en) * | 1980-11-18 | 1987-06-23 | Syntex (U.S.A.) Inc. | Microencapsulation of water soluble active polypeptides |
| US4897268A (en) * | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| PH30995A (en) * | 1989-07-07 | 1997-12-23 | Novartis Inc | Sustained release formulations of water soluble peptides. |
| HU221294B1 (en) * | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
| US5538739A (en) * | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
| MY107937A (en) * | 1990-02-13 | 1996-06-29 | Takeda Chemical Industries Ltd | Prolonged release microcapsules. |
| CH683149A5 (fr) | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
| WO1993015722A1 (en) * | 1992-02-07 | 1993-08-19 | Syntex (Usa) Inc. | Controlled delivery of pharmaceuticals from preformed porous microparticles |
| KR100260632B1 (ko) * | 1992-12-28 | 2000-07-01 | 성재갑 | 이식형 소마토트로핀 조성물 |
| US5603960A (en) * | 1993-05-25 | 1997-02-18 | O'hagan; Derek T. | Preparation of microparticles and method of immunization |
| US5417982A (en) * | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| US6447796B1 (en) * | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| DE69719367T2 (de) * | 1996-12-20 | 2003-10-16 | Takeda Chemical Industries, Ltd. | Verfahren zur herstellung einer zusammensetzung mit verzoegerter abgabe |
| AR012448A1 (es) * | 1997-04-18 | 2000-10-18 | Ipsen Pharma Biotech | Composicion en forma de microcapsulas o de implantes que comprende un excipiente biodegradable, polimero o co-polimero, o una mezcla de talesexcipientes, y una sustancia activa o una mezcla de sustancias activas, procedimiento para la preparacion de una sustancia soluble en agua de elevada |
| JP2002511075A (ja) * | 1997-06-04 | 2002-04-09 | デビオ ルシェルシュ ファルマスティク ソシエテ アノニム | 薬学的活性成分の制御放出のためのインプラント及びその製造方法 |
| ES2169980B1 (es) * | 1999-12-17 | 2003-11-01 | Lipotec Sa | Microcapsulas para la liberacion prolongada de farmacos. |
| KR100392501B1 (ko) * | 2000-06-28 | 2003-07-22 | 동국제약 주식회사 | 다중 에멀젼법에 의한 서방출성 미립구의 제조방법 |
| ATE374598T1 (de) * | 2002-03-15 | 2007-10-15 | Alrise Biosystems Gmbh | Mikropartikel und verfahren zur deren herstellung |
| US7368126B2 (en) * | 2002-11-06 | 2008-05-06 | Guohua Chen | Controlled release depot formulations |
| US20040097419A1 (en) * | 2002-11-19 | 2004-05-20 | Holger Petersen | Organic compounds |
| KR100466637B1 (ko) * | 2003-06-26 | 2005-01-13 | 주식회사 펩트론 | 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법 |
| EP1660039B1 (en) * | 2003-07-18 | 2016-09-28 | Oakwood Laboratories L.L.C. | Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions |
| CA2533592C (en) * | 2003-07-23 | 2015-11-10 | Pr Pharmaceuticals, Inc. | Controlled release compositions |
| MY158342A (en) * | 2003-11-14 | 2016-09-30 | Novartis Ag | Pharmaceutical composition |
| NZ553149A (en) * | 2004-08-12 | 2010-01-29 | Quest Pharmaceutical Services | Use of inositol hexaphosphate or inositol hexasulphate to complex biologically active compounds for the preparation of controlled release pharmaceutical compositions |
-
2006
- 2006-12-20 ES ES06841059.6T patent/ES2492641T3/es active Active
- 2006-12-20 EP EP10175382.0A patent/EP2359809B1/en active Active
- 2006-12-20 KR KR1020137004518A patent/KR20130024987A/ko not_active Ceased
- 2006-12-20 PL PL10175382T patent/PL2359809T3/pl unknown
- 2006-12-20 BR BRPI0620063A patent/BRPI0620063B8/pt active IP Right Grant
- 2006-12-20 KR KR1020137004517A patent/KR101458728B1/ko active Active
- 2006-12-20 CA CA2631811A patent/CA2631811C/en active Active
- 2006-12-20 PT PT101753820T patent/PT2359809T/pt unknown
- 2006-12-20 CN CN2013101523825A patent/CN103251929A/zh active Pending
- 2006-12-20 EP EP19188892.4A patent/EP3603623A1/en not_active Withdrawn
- 2006-12-20 EP EP06841059.6A patent/EP1968549B1/en active Active
- 2006-12-20 AU AU2006328950A patent/AU2006328950B2/en active Active
- 2006-12-20 KR KR1020087014985A patent/KR101245919B1/ko active Active
- 2006-12-20 PE PE2006001665A patent/PE20071139A1/es not_active Application Discontinuation
- 2006-12-20 AR ARP060105668A patent/AR058591A1/es unknown
- 2006-12-20 KR KR1020137004520A patent/KR20130024988A/ko not_active Ceased
- 2006-12-20 PT PT68410596T patent/PT1968549E/pt unknown
- 2006-12-20 IN IN3936DEN2015 patent/IN2015DN03936A/en unknown
- 2006-12-20 WO PCT/EP2006/012313 patent/WO2007071395A1/en not_active Ceased
- 2006-12-20 ES ES10175382T patent/ES2755032T3/es active Active
- 2006-12-20 US US12/158,345 patent/US20090004283A1/en not_active Abandoned
- 2006-12-20 RU RU2008129626/15A patent/RU2464972C2/ru active
- 2006-12-20 KR KR1020147031146A patent/KR20140133968A/ko not_active Ceased
- 2006-12-20 BR BR122019027412A patent/BR122019027412B8/pt active IP Right Grant
- 2006-12-20 JP JP2008546248A patent/JP2009520727A/ja active Pending
- 2006-12-20 PL PL06841059T patent/PL1968549T3/pl unknown
- 2006-12-21 TW TW95148218A patent/TWI469788B/zh active
- 2006-12-21 TW TW103107772A patent/TWI468172B/zh active
-
2008
- 2008-05-29 IL IL191842A patent/IL191842A0/en unknown
- 2008-06-18 MA MA31048A patent/MA30064B1/fr unknown
- 2008-06-19 EC EC2008008560A patent/ECSP088560A/es unknown
- 2008-07-02 NO NO20082988A patent/NO20082988L/no not_active Application Discontinuation
-
2013
- 2013-04-25 JP JP2013092845A patent/JP6239851B2/ja active Active
-
2014
- 2014-10-08 JP JP2014207464A patent/JP6178772B2/ja active Active
- 2014-10-16 US US14/516,016 patent/US20150037420A1/en not_active Abandoned
-
2015
- 2015-12-22 US US14/977,801 patent/US20160120935A1/en not_active Abandoned
-
2016
- 2016-06-09 JP JP2016115579A patent/JP2016216467A/ja not_active Withdrawn
-
2018
- 2018-01-17 US US15/873,473 patent/US20180140662A1/en not_active Abandoned
- 2018-11-29 CL CL2018003398A patent/CL2018003398A1/es unknown
-
2020
- 2020-03-10 US US16/813,864 patent/US20200206306A1/en not_active Abandoned
-
2022
- 2022-06-07 US US17/834,014 patent/US20220296675A1/en not_active Abandoned
-
2024
- 2024-11-22 US US18/956,119 patent/US20250082718A1/en active Pending
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