JP2013116104A5 - - Google Patents
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- JP2013116104A5 JP2013116104A5 JP2012259228A JP2012259228A JP2013116104A5 JP 2013116104 A5 JP2013116104 A5 JP 2013116104A5 JP 2012259228 A JP2012259228 A JP 2012259228A JP 2012259228 A JP2012259228 A JP 2012259228A JP 2013116104 A5 JP2013116104 A5 JP 2013116104A5
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- nucleic acid
- acid sequence
- acoas
- acid molecule
- human organism
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Claims (24)
- 長鎖PUFA遊離脂肪酸（FFA）のアシル-CoAへの変換を触媒するアシル-CoAシンテターゼ（ACoAS）をコードする核酸配列を含む、単離された核酸分子であって、核酸配列がSEQ ID NO：89のアミノ酸配列を有するACoASと少なくとも90％のアミノ酸配列同一性を有するアシル-CoAシンテターゼ（ACoAS）をコードする、核酸分子。
- 核酸配列が、SEQ ID NO：89のアミノ酸配列を有するアシル-CoAシンテターゼ（ACoAS）をコードする、請求項1記載の単離された核酸分子。
- 核酸配列が、SEQ ID NO：88を含む、請求項1記載の単離された核酸分子。
- 請求項1〜3のいずれか一項記載の核酸分子によってコードされる、単離されたタンパク質。
- 発現制御配列と機能的に連結された、請求項1〜3のいずれか一項記載の核酸分子を含む組換え核酸分子。
- 請求項5記載の組換え核酸分子を含む組換え宿主細胞。
- 微生物である、請求項6記載の組換え宿主細胞。
- 植物細胞である、請求項6記載の組換え宿主細胞。
- 請求項1〜3のいずれか一項記載の単離された核酸分子を発現するように遺伝的に改変されている、遺伝的に改変された非ヒト生物。
- 請求項3記載の単離された核酸分子を発現するように遺伝的に改変されている、遺伝的に改変された非ヒト生物。
- PUFAシンターゼおよびホスホパンテテイニルトランスフェラーゼ（PPTアーゼ）を発現する、請求項9〜10のいずれか一項記載の遺伝的に改変された非ヒト生物。
- 前記シンターゼおよびPPTアーゼを発現するように遺伝的に改変されている、請求項11記載の遺伝的に改変された非ヒト生物。
- PUFAを発現させるために非ヒト生物を形質転換するための方法であって、PUFAシンターゼをコードする核酸分子、ホスホパンテテイニルトランスフェラーゼ（PPTアーゼ）をコードする核酸分子、および請求項1〜3のいずれか一項記載の核酸分子によって非ヒト生物を形質転換する段階を含む方法。
- 非ヒト生物が、該非ヒト生物によって発現される脂肪酸シンターゼ（FAS）を欠失または不活性化させるための遺伝的改変を含む、請求項13記載の方法。
- 非ヒト生物が、該非ヒト生物における、マロニルCoAをめぐるPUFAシンターゼとの競合を減少させるため、またはマロニルCoAのレベルを上昇させるための遺伝的改変を含む、請求項13記載の方法。
- 非ヒト生物が植物である、請求項13記載の方法。
- 非ヒト生物が微生物である、請求項13記載の方法。
- 非ヒト生物が動物である、請求項13記載の方法。
- 動物細胞である、請求項6記載の組換え宿主細胞。
- 核酸配列が、SEQ ID NO：89のアミノ酸配列を有するACoASと少なくとも95％のアミノ酸配列同一性を有するアシル-CoAシンテターゼ（ACoAS）をコードする、請求項１記載の単離された核酸分子。
- 核酸配列が、SEQ ID NO：89のアミノ酸配列を有するACoASと少なくとも96％のアミノ酸配列同一性を有するアシル-CoAシンテターゼ（ACoAS）をコードする、請求項１記載の単離された核酸分子。
- 核酸配列が、SEQ ID NO：89のアミノ酸配列を有するACoASと少なくとも97％のアミノ酸配列同一性を有するアシル-CoAシンテターゼ（ACoAS）をコードする、請求項１記載の単離された核酸分子。
- 核酸配列が、SEQ ID NO：89のアミノ酸配列を有するACoASと少なくとも98％のアミノ酸配列同一性を有するアシル-CoAシンテターゼ（ACoAS）をコードする、請求項１記載の単離された核酸分子。
- 核酸配列が、SEQ ID NO：89のアミノ酸配列を有するACoASと少なくとも99％のアミノ酸配列同一性を有するアシル-CoAシンテターゼ（ACoAS）をコードする、請求項１記載の単離された核酸分子。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78320506P | 2006-03-15 | 2006-03-15 | |
| US60/783,205 | 2006-03-15 | ||
| US78461606P | 2006-03-21 | 2006-03-21 | |
| US60/784,616 | 2006-03-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500611A Division JP5227302B2 (ja) | 2006-03-15 | 2007-03-15 | Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013219079A Division JP2014087338A (ja) | 2006-03-15 | 2013-10-22 | Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013116104A JP2013116104A (ja) | 2013-06-13 |
| JP2013116104A5 true JP2013116104A5 (ja) | 2014-01-09 |
Family
ID=38510298
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500612A Pending JP2009529891A (ja) | 2006-03-15 | 2007-03-15 | 多価不飽和脂肪酸を含む植物種子油 |
| JP2009500611A Expired - Fee Related JP5227302B2 (ja) | 2006-03-15 | 2007-03-15 | Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法 |
| JP2012259228A Pending JP2013116104A (ja) | 2006-03-15 | 2012-11-28 | Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法 |
| JP2013219079A Withdrawn JP2014087338A (ja) | 2006-03-15 | 2013-10-22 | Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009500612A Pending JP2009529891A (ja) | 2006-03-15 | 2007-03-15 | 多価不飽和脂肪酸を含む植物種子油 |
| JP2009500611A Expired - Fee Related JP5227302B2 (ja) | 2006-03-15 | 2007-03-15 | Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013219079A Withdrawn JP2014087338A (ja) | 2006-03-15 | 2013-10-22 | Ｐｕｆａポリケチドシンターゼ系を用いた異種生物における多価不飽和脂肪酸の生産方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US20070245431A1 (ja) |
| EP (3) | EP2653557A1 (ja) |
| JP (4) | JP2009529891A (ja) |
| KR (3) | KR101506347B1 (ja) |
| CN (1) | CN104073505A (ja) |
| AU (2) | AU2007226511A1 (ja) |
| BR (1) | BRPI0709317A2 (ja) |
| CA (2) | CA2647150A1 (ja) |
| ES (1) | ES2527875T3 (ja) |
| HK (1) | HK1126253A1 (ja) |
| IL (2) | IL194078A (ja) |
| MX (3) | MX339812B (ja) |
| TW (2) | TW200813222A (ja) |
| WO (3) | WO2007106905A2 (ja) |
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