JP2013056901A5 - - Google Patents
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- Publication number
- JP2013056901A5 JP2013056901A5 JP2012231759A JP2012231759A JP2013056901A5 JP 2013056901 A5 JP2013056901 A5 JP 2013056901A5 JP 2012231759 A JP2012231759 A JP 2012231759A JP 2012231759 A JP2012231759 A JP 2012231759A JP 2013056901 A5 JP2013056901 A5 JP 2013056901A5
- Authority
- JP
- Japan
- Prior art keywords
- ethanol
- propanol
- iso
- solution
- stability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
- 229960004592 isopropanol Drugs 0.000 description 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 description 2
- 229960002707 bendamustine Drugs 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000008364 bulk solution Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64435405P | 2005-01-14 | 2005-01-14 | |
| US60/644,354 | 2005-01-14 | ||
| US11/330,868 US8436190B2 (en) | 2005-01-14 | 2006-01-12 | Bendamustine pharmaceutical compositions |
| US11/330,868 | 2006-01-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551416A Division JP2008526991A (ja) | 2005-01-14 | 2006-01-13 | ベンダムスチン製薬学的組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013056901A JP2013056901A (ja) | 2013-03-28 |
| JP2013056901A5 true JP2013056901A5 (enExample) | 2015-04-09 |
| JP5726833B2 JP5726833B2 (ja) | 2015-06-03 |
Family
ID=36678237
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551416A Pending JP2008526991A (ja) | 2005-01-14 | 2006-01-13 | ベンダムスチン製薬学的組成物 |
| JP2012231759A Active JP5726833B2 (ja) | 2005-01-14 | 2012-10-19 | ベンダムスチン製薬学的組成物 |
| JP2012231760A Active JP5688195B2 (ja) | 2005-01-14 | 2012-10-19 | ベンダムスチン製薬学的組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551416A Pending JP2008526991A (ja) | 2005-01-14 | 2006-01-13 | ベンダムスチン製薬学的組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012231760A Active JP5688195B2 (ja) | 2005-01-14 | 2012-10-19 | ベンダムスチン製薬学的組成物 |
Country Status (19)
| Country | Link |
|---|---|
| US (9) | US8436190B2 (enExample) |
| EP (2) | EP2574334A1 (enExample) |
| JP (3) | JP2008526991A (enExample) |
| KR (4) | KR101648495B1 (enExample) |
| CN (1) | CN102078305B (enExample) |
| AR (1) | AR052877A1 (enExample) |
| AU (1) | AU2006204817B2 (enExample) |
| BR (1) | BRPI0606332A2 (enExample) |
| CA (1) | CA2593582A1 (enExample) |
| EA (1) | EA013324B1 (enExample) |
| ES (1) | ES2405611T3 (enExample) |
| IL (1) | IL184394A0 (enExample) |
| MX (1) | MX2007008562A (enExample) |
| MY (1) | MY157661A (enExample) |
| NO (1) | NO343659B1 (enExample) |
| NZ (1) | NZ556435A (enExample) |
| SG (1) | SG158870A1 (enExample) |
| TW (1) | TWI380830B (enExample) |
| WO (1) | WO2006076620A2 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| HUE026303T2 (hu) | 2005-07-25 | 2016-06-28 | Emergent Product Dev Seattle | B-sejt csökkentés CD37-specifikus és CD20-specifikus kapcsoló molekulák alkalmazásával |
| US20090082416A1 (en) * | 2007-09-25 | 2009-03-26 | Protia, Llc | Deuterium-enriched bendamustine |
| ES2583804T3 (es) * | 2007-10-09 | 2016-09-22 | Us Worldmeds Llc | Composiciones de codisolventes y métodos para la administración mejorada de agentes terapéuticos de dantroleno |
| AR072777A1 (es) * | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| AU2009234277B2 (en) * | 2008-04-11 | 2014-12-04 | Aptevo Research And Development Llc | CD37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
| JP5670335B2 (ja) * | 2008-09-25 | 2015-02-18 | セファロン、インク. | ベンダムスチン液体製剤 |
| JP2012508749A (ja) * | 2008-11-13 | 2012-04-12 | インディアナ・ユニバーシティ・リサーチ・アンド・テクノロジー・コーポレーション | 多発性骨髄腫治療のためのベンダムスチン、ドキソルビシンおよびボルテゾミブの併用 |
| UA107186C2 (xx) * | 2008-12-03 | 2014-12-10 | Тверді форми дозування бендамустину | |
| HRP20140204T1 (hr) * | 2008-12-03 | 2014-04-11 | Astellas Deutschland Gmbh | Oralni oblici doziranja bendamustina |
| MX2011007557A (es) * | 2009-01-15 | 2011-08-12 | Cephalon Inc | Formas nuevas de bendamustina como base libre. |
| PT2389375E (pt) | 2009-01-23 | 2015-09-17 | Euro Celtique Sa | Derivados de ácido hidroxâmico |
| RU2591804C2 (ru) * | 2009-02-25 | 2016-07-20 | Супратек Фарма, Инк. | Композиции бендамустина и циклополисахарида |
| CN102413816A (zh) * | 2009-04-28 | 2012-04-11 | 赛福伦公司 | 苯达莫司汀的口服制剂 |
| WO2010144675A1 (en) | 2009-06-10 | 2010-12-16 | Plus Chemicals Sa | Polymorphs of bendamustine hcl and processes for preparation thereof |
| US8389558B2 (en) * | 2009-07-20 | 2013-03-05 | Supratek Pharma Inc. | Bendamustine amphiphilic anionic compositions |
| US20110015245A1 (en) * | 2009-07-20 | 2011-01-20 | Valery Alakhov | Bendamustine amphiphilic cationic compositions |
| EP3895694A1 (en) | 2010-01-28 | 2021-10-20 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| WO2011103150A2 (en) * | 2010-02-18 | 2011-08-25 | Cephalon, Inc. | Lyophilized preparations of bendamustine |
| DK2575784T3 (en) * | 2010-06-02 | 2018-10-15 | Astellas Deutschland Gmbh | ORAL DOSAGE FORMS OF BENDAMUSTIN |
| JO3659B1 (ar) | 2010-06-02 | 2020-08-27 | Astellas Deutschland Gmbh | أشكال جرعات بينداموستين عن طريق الفم وإستخداماته العلاجية |
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| US8383663B2 (en) | 2010-07-19 | 2013-02-26 | Supratek Pharma Inc. | Bendamustine anionic-catioinic cyclopolysaccharide compositions |
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| EP2675460A4 (en) | 2011-02-18 | 2014-07-09 | Kythera Biopharmaceuticals Inc | TREATMENT OF FAT TISSUE UNDER CHIN |
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| JP2015506989A (ja) * | 2012-02-14 | 2015-03-05 | イーグル・ファーマシューティカルズ・インコーポレーテッド | ベンダムスチン製剤 |
| DK2827862T3 (da) | 2012-03-20 | 2024-02-12 | Eagle Pharmaceuticals Inc | Formuleringer af bendamustin |
| RS58744B1 (sr) | 2012-03-20 | 2019-06-28 | Eagle Pharmaceuticals Inc | Tečna kompozicija za upotrebu u postupku lečenja stanja koja reaguju na bendamustin kod pacijenata kojima su potrebne smanjene zapremine za davanje |
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| US20230241218A1 (en) * | 2012-07-10 | 2023-08-03 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| US9801859B2 (en) * | 2012-09-18 | 2017-10-31 | Innopharma Licensing, Llc | Bendamustine formulations |
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| JP2016153374A (ja) * | 2013-06-25 | 2016-08-25 | シンバイオ製薬株式会社 | 炎症性疾患を治療又は予防するための医薬組成物 |
| CN103351347A (zh) * | 2013-07-29 | 2013-10-16 | 东南大学 | 盐酸苯达莫司汀杂质dce的制备方法 |
| JP6571657B2 (ja) * | 2013-08-27 | 2019-09-04 | ボウドウリス バシリオス | ベンダムスチンの薬学的組成物 |
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| WO2015054550A1 (en) * | 2013-10-11 | 2015-04-16 | Luitpold Pharmaceuticals, Inc. | Bendamustine pharmaceutical compositions |
| IN2014CH00151A (enExample) * | 2014-01-13 | 2015-07-17 | Hetero Research Foundation | |
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| US10342769B2 (en) * | 2014-11-14 | 2019-07-09 | Navinta Iii Inc | Carmustine pharmaceutical composition |
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| US10905677B2 (en) | 2016-08-31 | 2021-02-02 | Navinta, Llc | Bendamustine solution formulations |
| US11826466B2 (en) | 2016-08-31 | 2023-11-28 | Navinta, Llc | Bendamustine solution formulations |
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| EP3836921B1 (en) | 2018-08-17 | 2025-10-08 | Hospira Australia Pty Ltd | Liquid bendamustine pharmaceutical compositions |
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- 2006-01-13 SG SG201000184-0A patent/SG158870A1/en unknown
- 2006-01-13 KR KR1020187014177A patent/KR20180056804A/ko not_active Ceased
- 2006-01-13 JP JP2007551416A patent/JP2008526991A/ja active Pending
- 2006-01-13 ES ES06718390T patent/ES2405611T3/es active Active
- 2006-01-13 EA EA200701511A patent/EA013324B1/ru unknown
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- 2006-01-13 BR BRPI0606332-2A patent/BRPI0606332A2/pt not_active Application Discontinuation
- 2006-01-13 MX MX2007008562A patent/MX2007008562A/es active IP Right Grant
- 2006-01-13 EP EP12191786A patent/EP2574334A1/en not_active Withdrawn
- 2006-01-13 CN CN201010621759.3A patent/CN102078305B/zh active Active
- 2006-01-13 EP EP06718390A patent/EP1863452B1/en not_active Revoked
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