JP2013056886A5 - - Google Patents
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- Publication number
- JP2013056886A5 JP2013056886A5 JP2012221886A JP2012221886A JP2013056886A5 JP 2013056886 A5 JP2013056886 A5 JP 2013056886A5 JP 2012221886 A JP2012221886 A JP 2012221886A JP 2012221886 A JP2012221886 A JP 2012221886A JP 2013056886 A5 JP2013056886 A5 JP 2013056886A5
- Authority
- JP
- Japan
- Prior art keywords
- dioxo
- tert
- butyl
- dihydropyrimidin
- naphthalen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97288107P | 2007-09-17 | 2007-09-17 | |
| US60/972,881 | 2007-09-17 | ||
| US9679208P | 2008-09-13 | 2008-09-13 | |
| US61/096,792 | 2008-09-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525103A Division JP5734655B2 (ja) | 2007-09-17 | 2008-09-17 | 抗感染症ピリミジンおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013056886A JP2013056886A (ja) | 2013-03-28 |
| JP2013056886A5 true JP2013056886A5 (US07794700-20100914-C00152.png) | 2013-10-24 |
| JP5931683B2 JP5931683B2 (ja) | 2016-06-08 |
Family
ID=40308557
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525103A Active JP5734655B2 (ja) | 2007-09-17 | 2008-09-17 | 抗感染症ピリミジンおよびその使用 |
| JP2012221886A Expired - Fee Related JP5931683B2 (ja) | 2007-09-17 | 2012-10-04 | 抗感染症ピリミジンおよびその使用 |
| JP2015082240A Pending JP2015187106A (ja) | 2007-09-17 | 2015-04-14 | 抗感染症ピリミジンおよびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525103A Active JP5734655B2 (ja) | 2007-09-17 | 2008-09-17 | 抗感染症ピリミジンおよびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015082240A Pending JP2015187106A (ja) | 2007-09-17 | 2015-04-14 | 抗感染症ピリミジンおよびその使用 |
Country Status (22)
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2542099C2 (ru) | 2007-09-17 | 2015-02-20 | Эббви Бахамаз Лтд. | N-фенил-диоксо-гидропиримидины, используемые в качестве ингибитора вируса гепатита с (hcv) |
| UY31344A1 (es) | 2007-09-17 | 2009-04-30 | Metansulfonamidas n-(3-ter-butil-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-2-metoxi-aril) sustituidas, solvatos, hidratos, formas cristalinas y sus sales farmacéuticamente aceptables,proceso de preparación,composiciones y aplicaciones. | |
| DK2639226T3 (en) * | 2007-09-17 | 2016-12-19 | Abbvie Bahamas Ltd | Anti-infective pyrimidines and uses thereof |
| ES2383273T3 (es) * | 2008-07-23 | 2012-06-19 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
| JP2012503620A (ja) | 2008-09-26 | 2012-02-09 | エフ．ホフマン−ラ ロシュ アーゲー | Ｈｃｖを処置するためのピリンまたはピラジン誘導体 |
| EP2361242B1 (en) | 2008-10-17 | 2018-08-01 | Oryzon Genomics, S.A. | Oxidase inhibitors and their use |
| WO2010084160A1 (en) | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Phenylcyclopropylamine derivatives and their medical use |
| WO2010111437A1 (en) * | 2009-03-25 | 2010-09-30 | Abbott Laboratories | Antiviral compounds and uses thereof |
| AU2010240888A1 (en) | 2009-04-25 | 2011-11-17 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| TWI428332B (zh) | 2009-06-09 | 2014-03-01 | Hoffmann La Roche | 雜環抗病毒化合物 |
| CA2762675A1 (en) | 2009-06-24 | 2010-12-29 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compound |
| JP2013505218A (ja) | 2009-09-21 | 2013-02-14 | エフ．ホフマン−ラ ロシュ アーゲー | 複素環式抗ウイルス化合物 |
| MX338041B (es) | 2009-09-25 | 2016-03-30 | Oryzon Genomics Sa | Inhibidores de demetilasa-1 especificos de lisina y su uso. |
| EP2486002B1 (en) | 2009-10-09 | 2019-03-27 | Oryzon Genomics, S.A. | Substituted heteroaryl- and aryl- cyclopropylamine acetamides and their use |
| CA2778206A1 (en) * | 2009-11-21 | 2011-05-26 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| AU2010333338A1 (en) * | 2009-12-14 | 2012-08-02 | Merck Patent Gmbh | Sphingosine kinase inhibitors |
| CN102652134A (zh) * | 2009-12-14 | 2012-08-29 | 弗·哈夫曼-拉罗切有限公司 | 杂环抗病毒化合物 |
| US9616058B2 (en) | 2010-02-24 | 2017-04-11 | Oryzon Genomics, S.A. | Potent selective LSD1 inhibitors and dual LSD1/MAO-B inhibitors for antiviral use |
| US9186337B2 (en) | 2010-02-24 | 2015-11-17 | Oryzon Genomics S.A. | Lysine demethylase inhibitors for diseases and disorders associated with Hepadnaviridae |
| US9216952B2 (en) | 2010-03-23 | 2015-12-22 | Abbvie Inc. | Process for preparing antiviral compound |
| MX2012012111A (es) | 2010-04-19 | 2013-05-30 | Oryzon Genomics Sa | Inhibidores de demetilasa-1 especifica de lisina y su uso. |
| US9255074B2 (en) | 2010-07-16 | 2016-02-09 | Abbvie Inc. | Process for preparing antiviral compounds |
| US8975443B2 (en) | 2010-07-16 | 2015-03-10 | Abbvie Inc. | Phosphine ligands for catalytic reactions |
| NZ605471A (en) | 2010-07-16 | 2015-02-27 | Abbvie Bahamas Ltd | Phosphine ligands for catalytic reactions |
| AU2011278927B2 (en) | 2010-07-16 | 2015-05-21 | Abbvie Ireland Unlimited Company | Process for preparing antiviral compounds |
| RS57331B1 (sr) | 2010-07-29 | 2018-08-31 | Oryzon Genomics Sa | Inhibitori demetilaze za lsd1 zasnovani na arilciklopropilaminu i njihova medicinska upotreba |
| US9006449B2 (en) | 2010-07-29 | 2015-04-14 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as LSD1 inhibitors |
| WO2012020725A1 (ja) * | 2010-08-10 | 2012-02-16 | 塩野義製薬株式会社 | Ｎｐｙ ｙ５受容体拮抗作用を有するヘテロ環誘導体 |
| US9061966B2 (en) | 2010-10-08 | 2015-06-23 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
| EP3981395A1 (en) | 2011-02-08 | 2022-04-13 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| CN102675092B (zh) * | 2011-03-14 | 2014-11-05 | 江苏中丹药物研究有限公司 | 一种制备2-芳基-2,2-二甲基乙酸甲酯的方法 |
| US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
| CN107266345B (zh) | 2011-10-20 | 2021-08-17 | 奥瑞泽恩基因组学股份有限公司 | 作为lsd1抑制剂的(杂)芳基环丙胺化合物 |
| PE20141692A1 (es) | 2011-10-20 | 2014-11-08 | Oryzon Genomics Sa | Compuestos de (hetero) aril ciclopropilamina como inhibidores de lsd1 |
| CN104383541A (zh) | 2011-10-21 | 2015-03-04 | 艾伯维公司 | 用于治疗hcv的包含至少两种直接抗病毒剂和利巴韦林但无干扰素的方法 |
| DK2583680T1 (da) * | 2011-10-21 | 2015-01-19 | Abbvie Inc | Mono (PSI-7977) eller kombinationsbehandling af DAA til anvendelse ved behandling af HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| CA2882624A1 (en) | 2012-08-21 | 2014-02-27 | Shashank Shekhar | Process for preparing antiviral compounds |
| EP2908808A1 (en) | 2012-10-18 | 2015-08-26 | Abbvie Inc. | Formulations of pyrimidinedione derivative compounds |
| WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
| WO2015197028A1 (en) * | 2014-06-28 | 2015-12-30 | Sunshine Lake Pharma Co., Ltd. | Compounds as hepatitis c virus (hcv) inhibitors and uses thereof in medicine |
| WO2016105547A1 (en) | 2014-12-24 | 2016-06-30 | Concert Pharmaceuticals, Inc. | Deuterated dasabuvir |
| EP3560911B1 (en) * | 2016-03-17 | 2021-05-05 | FMC Corporation | Process for converting s-enantiomer to its racemic form |
| CA3022119A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| CN108290844B (zh) * | 2016-05-27 | 2021-04-30 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的萘环化合物及药物组合物及其应用 |
| CN110483496B (zh) * | 2019-07-17 | 2021-05-04 | 杭州市西溪医院 | 一类具有尿嘧啶-苯并噻唑结构衍生物、其制备方法及抗hcv药物的应用 |
| CN111518036A (zh) * | 2020-04-29 | 2020-08-11 | 杭州勇诚睿生物科技有限公司 | 一种达沙布韦关键中间体的制备方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4239888A (en) * | 1974-11-04 | 1980-12-16 | Pfizer Inc. | 1-Phenyluracils |
| JPS60243017A (ja) * | 1984-05-16 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | 抗けいれん組成物 |
| AU627906B2 (en) * | 1989-07-14 | 1992-09-03 | Nissan Chemical Industries Ltd. | Uracil derivatives and herbicides containing the same as active ingredient |
| US5084084A (en) * | 1989-07-14 | 1992-01-28 | Nissan Chemical Industries Ltd. | Uracil derivatives and herbicides containing the same as active ingredient |
| US5162326A (en) * | 1990-02-15 | 1992-11-10 | Takeda Chemical Industries, Ltd. | Pyrimidinedione derivatives, their production and use |
| NL9001075A (US07794700-20100914-C00152.png) * | 1990-05-04 | 1991-12-02 | Duphar Int Res | |
| EP0489480A1 (en) * | 1990-12-05 | 1992-06-10 | Nissan Chemical Industries Ltd. | Uracil derivatives and herbicides containing the same as active ingredient |
| JPH05213755A (ja) | 1992-02-07 | 1993-08-24 | Nikko Kyodo Co Ltd | 肝臓障害治療薬 |
| DE19528305A1 (de) | 1995-08-02 | 1997-02-06 | Bayer Ag | Substituierte Phenyluracile |
| SI1237878T1 (sl) | 1999-12-06 | 2007-08-31 | Hoffmann La Roche | 4-pirimidinil-n-acil-l-fenilanin |
| US6380387B1 (en) * | 1999-12-06 | 2002-04-30 | Hoffmann-La Roche Inc. | 4-Pyrimidinyl-n-acyl-l phenylalanines |
| IL167958A (en) * | 2000-02-04 | 2010-11-30 | Sumitomo Chemical Co | 2-thio 3-hydroxypyridine derivatives |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| JP2005522443A (ja) * | 2002-02-14 | 2005-07-28 | フアーマセツト・リミテツド | 改変フッ素化ヌクレオシド類似体 |
| JP2006508997A (ja) * | 2002-11-28 | 2006-03-16 | シエーリング アクチエンゲゼルシャフト | Ｃｈｋ−、Ｐｄｋ−およびＡｋｔ−阻害性ピリミジン、それらの製造および薬剤としての使用 |
| KR100589964B1 (ko) * | 2003-06-13 | 2006-06-19 | 주식회사 엘지생명과학 | Ｃ형 간염 바이러스의 억제제 |
| JP2007501189A (ja) * | 2003-08-01 | 2007-01-25 | ジェネラブス テクノロジーズ，インコーポレイテッド | フラビウイルス科に対する二環式イミダゾール誘導体 |
| US7163937B2 (en) | 2003-08-21 | 2007-01-16 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| BRPI0511834A (pt) * | 2004-07-14 | 2008-01-08 | Ptc Therapeutics Inc | métodos por tratar hepatite c |
| AR057986A1 (es) * | 2005-11-21 | 2008-01-09 | Japan Tobacco Inc | Compuesto heterociclico y su uso farmaceutico |
| DK2639226T3 (en) * | 2007-09-17 | 2016-12-19 | Abbvie Bahamas Ltd | Anti-infective pyrimidines and uses thereof |
| RU2542099C2 (ru) | 2007-09-17 | 2015-02-20 | Эббви Бахамаз Лтд. | N-фенил-диоксо-гидропиримидины, используемые в качестве ингибитора вируса гепатита с (hcv) |
| UY31344A1 (es) | 2007-09-17 | 2009-04-30 | Metansulfonamidas n-(3-ter-butil-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-2-metoxi-aril) sustituidas, solvatos, hidratos, formas cristalinas y sus sales farmacéuticamente aceptables,proceso de preparación,composiciones y aplicaciones. | |
| ES2383273T3 (es) | 2008-07-23 | 2012-06-19 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
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2008
- 2008-09-17 DK DK12182277.9T patent/DK2639226T3/en active
- 2008-09-17 CA CA2849420A patent/CA2849420C/en active Active
- 2008-09-17 CA CA2699986A patent/CA2699986C/en not_active Expired - Fee Related
- 2008-09-17 PL PL08832330T patent/PL2203431T3/pl unknown
- 2008-09-17 PT PT11171399T patent/PT2368882E/pt unknown
- 2008-09-17 EP EP12182277.9A patent/EP2639226B1/en not_active Not-in-force
- 2008-09-17 PL PL12182277T patent/PL2639226T3/pl unknown
- 2008-09-17 DK DK11171399T patent/DK2368882T3/en active
- 2008-09-17 SI SI200830433T patent/SI2203431T1/sl unknown
- 2008-09-17 SI SI200831329T patent/SI2368882T1/sl unknown
- 2008-09-17 DK DK08832330T patent/DK2203431T3/da active
- 2008-09-17 AT AT08832330T patent/ATE519746T1/de active
- 2008-09-17 CN CN201410659529.4A patent/CN104628655A/zh active Pending
- 2008-09-17 CN CN200880113534.8A patent/CN101842360B/zh active Active
- 2008-09-17 PT PT08832330T patent/PT2203431E/pt unknown
- 2008-09-17 MX MX2010002902A patent/MX2010002902A/es active IP Right Grant
- 2008-09-17 ES ES11171399.6T patent/ES2523864T3/es active Active
- 2008-09-17 ES ES12182277.9T patent/ES2592961T3/es active Active
- 2008-09-17 CN CN201410657922.XA patent/CN104628654A/zh active Pending
- 2008-09-17 US US12/212,323 patent/US8188104B2/en active Active
- 2008-09-17 ES ES08832330T patent/ES2368879T3/es active Active
- 2008-09-17 PL PL11171399T patent/PL2368882T3/pl unknown
- 2008-09-17 PT PT121822779T patent/PT2639226T/pt unknown
- 2008-09-17 RU RU2010114827/04A patent/RU2539570C2/ru active
- 2008-09-17 EP EP20110171399 patent/EP2368882B1/en active Active
- 2008-09-17 CN CN201210167588.0A patent/CN102746240B/zh not_active Expired - Fee Related
- 2008-09-17 RU RU2014147354/04A patent/RU2014147354A/ru not_active Application Discontinuation
- 2008-09-17 WO PCT/US2008/076592 patent/WO2009039134A1/en active Application Filing
- 2008-09-17 JP JP2010525103A patent/JP5734655B2/ja active Active
- 2008-09-17 EP EP20080832330 patent/EP2203431B1/en active Active
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2011
- 2011-03-08 HK HK11102295.5A patent/HK1148273A1/xx unknown
- 2011-10-03 HK HK11110421.5A patent/HK1156033A1/xx not_active IP Right Cessation
- 2011-11-02 HR HR20110809T patent/HRP20110809T1/hr unknown
- 2011-11-03 CY CY20111101065T patent/CY1115514T1/el unknown
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2012
- 2012-04-20 US US13/451,889 patent/US8501238B2/en active Active
- 2012-10-04 JP JP2012221886A patent/JP5931683B2/ja not_active Expired - Fee Related
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2013
- 2013-03-15 US US13/838,223 patent/US9139536B2/en active Active
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2014
- 2014-11-12 HR HRP20141102 patent/HRP20141102T1/hr unknown
- 2014-11-12 CY CY20141100943T patent/CY1115893T1/el unknown
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2015
- 2015-02-25 LU LU92666C patent/LU92666I2/xx unknown
- 2015-03-04 LT LTPA2015013C patent/LTC2203431I2/lt unknown
- 2015-03-17 HU HUS1500013C patent/HUS1500013I1/hu unknown
- 2015-03-26 CY CY2015013C patent/CY2015013I1/el unknown
- 2015-04-08 NL NL300729C patent/NL300729I2/nl unknown
- 2015-04-14 JP JP2015082240A patent/JP2015187106A/ja active Pending
- 2015-04-22 NO NO2015011C patent/NO2015011I1/no not_active IP Right Cessation
