JP2012533630A5 - - Google Patents
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- JP2012533630A5 JP2012533630A5 JP2012521700A JP2012521700A JP2012533630A5 JP 2012533630 A5 JP2012533630 A5 JP 2012533630A5 JP 2012521700 A JP2012521700 A JP 2012521700A JP 2012521700 A JP2012521700 A JP 2012521700A JP 2012533630 A5 JP2012533630 A5 JP 2012533630A5
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- JP
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- Prior art keywords
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- pharmaceutically acceptable
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- acceptable salt
- membered
- Prior art date
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- HZXBVTUZHCBOSI-UHFFFAOYSA-N C(COC1)C1OC1CCCCC1 Chemical compound C(COC1)C1OC1CCCCC1 HZXBVTUZHCBOSI-UHFFFAOYSA-N 0.000 description 2
- 0 C[C@](CC1)CC[C@]1C(*c1c(C(O)=O)[s]c(C#CC(C)(C)COC2CCOCC2)c1)=O Chemical compound C[C@](CC1)CC[C@]1C(*c1c(C(O)=O)[s]c(C#CC(C)(C)COC2CCOCC2)c1)=O 0.000 description 2
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- UUCQLJNFHZYTON-MVBYDDMTSA-N C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1Oc1nccc(CN(C)C)c1)c1c(C(O)=O)[s]c(C#CC2(CCC2)C(F)(F)F)c1)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1Oc1nccc(CN(C)C)c1)c1c(C(O)=O)[s]c(C#CC2(CCC2)C(F)(F)F)c1)=O UUCQLJNFHZYTON-MVBYDDMTSA-N 0.000 description 1
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- HWFPVIWQOUDLIC-REODPECZSA-N C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1S/C(/NN)=C/N)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1S/C(/NN)=C/N)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O HWFPVIWQOUDLIC-REODPECZSA-N 0.000 description 1
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- OYMKPOCENOJCMQ-KBQPQWKXSA-N C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1Sc1ccccn1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1Sc1ccccn1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O OYMKPOCENOJCMQ-KBQPQWKXSA-N 0.000 description 1
- JCGVRQXBRNGKFH-YSXIEMCBSA-N C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1Sc1nnc(C)[o]1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@@H]1Sc1nnc(C)[o]1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O JCGVRQXBRNGKFH-YSXIEMCBSA-N 0.000 description 1
- GSRQLELLPZXJEL-AGJYPBCPSA-N C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@H]1Oc1cccnc1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@H]1Oc1cccnc1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O GSRQLELLPZXJEL-AGJYPBCPSA-N 0.000 description 1
- HUDMIVJEYSDLFN-SVRSMAFJSA-N C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@H]1Oc1cncnc1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@H]1Oc1cncnc1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O HUDMIVJEYSDLFN-SVRSMAFJSA-N 0.000 description 1
- HSSVKHZTWZIETE-PVPVSOICSA-N C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@H]1Sc1ncc[s]1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N([C@H](CC1)CC[C@H]1Sc1ncc[s]1)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O HSSVKHZTWZIETE-PVPVSOICSA-N 0.000 description 1
- HYGZCHJAYASXHA-YDHSSHFGSA-N C[C@H](CC1)CC[C@@H]1C(N([C@H](CCOc1ccccn1)OC1=O)c2c1[s]c(C#CC(C)(C)C)c2)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N([C@H](CCOc1ccccn1)OC1=O)c2c1[s]c(C#CC(C)(C)C)c2)=O HYGZCHJAYASXHA-YDHSSHFGSA-N 0.000 description 1
- ICVBBGCKGONZJH-HDJSIYSDSA-N C[C@H](CC1)CC[C@@H]1[IH](N(C)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O Chemical compound C[C@H](CC1)CC[C@@H]1[IH](N(C)c1c(C(O)=O)[s]c(C#CC(C)(C)C)c1)=O ICVBBGCKGONZJH-HDJSIYSDSA-N 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22736709P | 2009-07-21 | 2009-07-21 | |
| US61/227,367 | 2009-07-21 | ||
| US24091109P | 2009-09-09 | 2009-09-09 | |
| US61/240,911 | 2009-09-09 | ||
| US35946610P | 2010-06-29 | 2010-06-29 | |
| US61/359,466 | 2010-06-29 | ||
| PCT/US2010/042394 WO2011011303A1 (en) | 2009-07-21 | 2010-07-19 | Inhibitors of flaviviridae viruses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015160807A Division JP2015205940A (ja) | 2009-07-21 | 2015-08-18 | フラビウイルス科ウイルスの阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012533630A JP2012533630A (ja) | 2012-12-27 |
| JP2012533630A5 true JP2012533630A5 (https=) | 2015-02-26 |
| JP5841531B2 JP5841531B2 (ja) | 2016-01-13 |
Family
ID=42711860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012521700A Expired - Fee Related JP5841531B2 (ja) | 2009-07-21 | 2010-07-19 | フラビウイルス科ウイルスの阻害剤 |
| JP2015160807A Withdrawn JP2015205940A (ja) | 2009-07-21 | 2015-08-18 | フラビウイルス科ウイルスの阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015160807A Withdrawn JP2015205940A (ja) | 2009-07-21 | 2015-08-18 | フラビウイルス科ウイルスの阻害剤 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8569302B2 (https=) |
| EP (1) | EP2475657B1 (https=) |
| JP (2) | JP5841531B2 (https=) |
| KR (1) | KR20120051022A (https=) |
| CN (1) | CN102471327A (https=) |
| AP (1) | AP3409A (https=) |
| AR (1) | AR077765A1 (https=) |
| AU (1) | AU2010276441B2 (https=) |
| CA (1) | CA2767088C (https=) |
| CL (1) | CL2012000147A1 (https=) |
| CO (1) | CO6491049A2 (https=) |
| CR (1) | CR20120081A (https=) |
| DK (1) | DK2475657T3 (https=) |
| EA (1) | EA020816B1 (https=) |
| EC (1) | ECSP12011684A (https=) |
| ES (1) | ES2427342T3 (https=) |
| IL (1) | IL217243A (https=) |
| MX (1) | MX2012000959A (https=) |
| NZ (1) | NZ597528A (https=) |
| PE (1) | PE20120666A1 (https=) |
| SG (1) | SG177709A1 (https=) |
| TW (1) | TW201116525A (https=) |
| UY (1) | UY32793A (https=) |
| WO (1) | WO2011011303A1 (https=) |
| ZA (1) | ZA201200940B (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011011303A1 (en) * | 2009-07-21 | 2011-01-27 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| ES2559437T3 (es) | 2009-09-09 | 2016-02-12 | Gilead Sciences, Inc. | Inhibidores de virus de la familia Flaviviridae |
| TWI483950B (zh) | 2009-09-21 | 2015-05-11 | Gilead Sciences Inc | 用於製備１’－取代碳核苷類似物之方法及中間物 |
| AP3576A (en) | 2010-01-15 | 2016-02-08 | Gilead Sciences Inc | Inhibitors of flaviviridae viruses |
| CA2785563C (en) | 2010-01-15 | 2019-05-14 | Gilead Sciences, Inc. | Inhibitors of flaviviridae viruses |
| AU2011276526A1 (en) * | 2010-06-28 | 2013-01-10 | Vertex Pharmaceuticals Incorporated | Compounds and methods for the treatment or prevention of Flavivirus infections |
| EP2595983A1 (en) * | 2010-07-22 | 2013-05-29 | Novartis AG | 2,3,5-trisubstituted thiophene compounds and uses thereof |
| BR122020020745B8 (pt) | 2010-07-22 | 2023-10-31 | Gilead Sciences Inc | Composto antiviral para o tratamento de infecções por paramyxoviridae e composição farmacêutica que o compreende |
| AU2012280959B2 (en) * | 2011-07-13 | 2015-08-06 | Gilead Sciences, Inc. | Thiophen-2-carboxylic acid derivatives useful as inhibitors of Flaviviridae viruses |
| SI2864291T1 (sl) | 2012-06-26 | 2017-01-31 | Bayer Pharma Aktiengesellschaft | N-(4-(kinolin-4-iloksi)cikloheksil(metil))(hetero)arilkarboksamidi kot antagonisti receptorja androgena, njihova izdelava in uporaba kot medicinski izdelki |
| US8841340B2 (en) | 2012-08-17 | 2014-09-23 | Gilead Sciences, Inc. | Solid forms of an antiviral compound |
| US8927741B2 (en) | 2012-08-17 | 2015-01-06 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| US8759544B2 (en) | 2012-08-17 | 2014-06-24 | Gilead Sciences, Inc. | Synthesis of an antiviral compound |
| CN102964295B (zh) * | 2012-12-17 | 2014-08-20 | 寿光富康制药有限公司 | 一种2-取代-4-（哌啶基甲基）吡啶的制备方法 |
| EP2762124A1 (en) * | 2013-01-31 | 2014-08-06 | IP Gesellschaft für Management mbH | Packaging comprising administration units of polymorphs, amorphous forms or solvates |
| US9492438B2 (en) * | 2014-07-25 | 2016-11-15 | Bette Pollard | Amphiphilic pyridinum compounds to treat epilepsy and other disorders of the nervous system |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| DK3236972T3 (en) | 2014-12-26 | 2021-10-04 | Univ Emory | Antivirale N4-hydroxycytidin-derivativer |
| SI3349758T1 (sl) | 2015-09-16 | 2022-08-31 | Gilead Sciences, Inc. | Postopki za zdravljenje okužb z virusom arenaviridae |
| EP4491236A3 (en) | 2016-05-10 | 2025-04-02 | C4 Therapeutics, Inc. | Heterocyclic degronimers for target protein degradation |
| EP3454862B1 (en) | 2016-05-10 | 2024-09-11 | C4 Therapeutics, Inc. | Spirocyclic degronimers for target protein degradation |
| CN109790143A (zh) | 2016-05-10 | 2019-05-21 | C4医药公司 | 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体 |
| CN109641874A (zh) | 2016-05-10 | 2019-04-16 | C4医药公司 | 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体 |
| EP4067368A1 (en) | 2016-06-01 | 2022-10-05 | Athira Pharma, Inc. | Compounds |
| US10682368B2 (en) | 2017-03-14 | 2020-06-16 | Gilead Sciences, Inc. | Methods of treating feline coronavirus infections |
| AU2018262501B2 (en) | 2017-05-01 | 2020-12-10 | Gilead Sciences, Inc. | Crystalline forms of (S) 2 ethylbutyl 2 (((S) (((2R,3S,4R,5R) 5 (4 aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2 yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
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