JP2012533288A5 - - Google Patents

Download PDF

Info

Publication number
JP2012533288A5
JP2012533288A5 JP2012520048A JP2012520048A JP2012533288A5 JP 2012533288 A5 JP2012533288 A5 JP 2012533288A5 JP 2012520048 A JP2012520048 A JP 2012520048A JP 2012520048 A JP2012520048 A JP 2012520048A JP 2012533288 A5 JP2012533288 A5 JP 2012533288A5
Authority
JP
Japan
Prior art keywords
polypeptide
disease
syndrome
thrombosis
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2012520048A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012533288A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2010/060279 external-priority patent/WO2011006982A2/en
Publication of JP2012533288A publication Critical patent/JP2012533288A/ja
Publication of JP2012533288A5 publication Critical patent/JP2012533288A5/ja
Withdrawn legal-status Critical Current

Links

JP2012520048A 2009-07-17 2010-07-16 補体活性化の阻害剤 Withdrawn JP2012533288A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP09165770 2009-07-17
EP09165770.0 2009-07-17
EP09171941.9 2009-10-01
EP09171941 2009-10-01
US31104910P 2010-03-05 2010-03-05
US61/311,049 2010-03-05
PCT/EP2010/060279 WO2011006982A2 (en) 2009-07-17 2010-07-16 Inhibitors of complement activation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015203735A Division JP6290845B2 (ja) 2009-07-17 2015-10-15 補体活性化の阻害剤

Publications (2)

Publication Number Publication Date
JP2012533288A JP2012533288A (ja) 2012-12-27
JP2012533288A5 true JP2012533288A5 (enExample) 2013-07-25

Family

ID=43449884

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2012520048A Withdrawn JP2012533288A (ja) 2009-07-17 2010-07-16 補体活性化の阻害剤
JP2015203735A Active JP6290845B2 (ja) 2009-07-17 2015-10-15 補体活性化の阻害剤
JP2018018979A Active JP6820286B2 (ja) 2009-07-17 2018-02-06 補体活性化の阻害剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2015203735A Active JP6290845B2 (ja) 2009-07-17 2015-10-15 補体活性化の阻害剤
JP2018018979A Active JP6820286B2 (ja) 2009-07-17 2018-02-06 補体活性化の阻害剤

Country Status (10)

Country Link
US (2) US20120282285A1 (enExample)
EP (2) EP3395828A1 (enExample)
JP (3) JP2012533288A (enExample)
KR (2) KR102184713B1 (enExample)
CN (2) CN107513103A (enExample)
AU (1) AU2010272483B2 (enExample)
BR (1) BR112012001070B1 (enExample)
CA (1) CA2767755C (enExample)
WO (1) WO2011006982A2 (enExample)
ZA (1) ZA201200953B (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8840893B2 (en) 2004-06-10 2014-09-23 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
US9644035B2 (en) * 2011-04-08 2017-05-09 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
KR20220044616A (ko) 2011-04-08 2022-04-08 유니버시티 오브 레스터 Masp-2 의존적 보체 활성화와 관련된 질병을 치료하는 방법
US20140120105A1 (en) * 2011-06-28 2014-05-01 Kobenhavns Universitet Therapeutic targeting of ficolin-3
CA3087933A1 (en) * 2012-04-06 2013-12-05 Omeros Corporation Compositions and methods of inhibiting masp-1 and/or masp-2 and/or masp-3 for the treatment of paroxysmal nocturnal hemoglobinuria
CN118924900A (zh) * 2012-06-18 2024-11-12 奥默罗斯公司 抑制masp-1和/或masp-2和/或masp-3的组合物和方法
ES2878749T3 (es) 2013-02-20 2021-11-19 Innate Pharma Un compuesto que se une específicamente a KIR3DL2 para el uso en el tratamiento de linfoma de células T periférico
WO2015058143A1 (en) 2013-10-17 2015-04-23 Omeros Corporation Methods for treating conditions associated with masp-2 dependent complement activation
JP6634566B2 (ja) * 2015-03-06 2020-01-22 株式会社森永生科学研究所 コントロールスライド及びコントロール実験の方法
JOP20170154B1 (ar) 2016-08-01 2023-03-28 Omeros Corp تركيبات وطرق لتثبيط masp-3 لعلاج أمراض واضطرابات مختلفة
JP6143209B1 (ja) * 2016-10-31 2017-06-07 国立大学法人大阪大学 自己免疫疾患用または難治性血管炎用の治療剤、および、これらの疾患の診断のためのデータの取得方法
KR102094802B1 (ko) * 2017-10-24 2020-03-31 고려대학교 산학협력단 소변 대사체 분석을 이용한 베체트병의 진단방법
CN109829885B (zh) * 2018-12-24 2022-07-22 广州柏视医疗科技有限公司 一种基于深度语义分割网络的自动识别鼻咽癌原发肿瘤方法
KR102316999B1 (ko) * 2019-03-20 2021-10-26 (주)레티마크 실명 유발 주요 안질환 진단용 혈액 마커 및 이를 이용한 진단 방법
SG11202111587VA (en) * 2019-05-07 2021-11-29 Bayer Ag Masp inhibitory compounds and uses thereof

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203570A (en) 1978-08-23 1980-05-20 The Western States Machine Company Power-operated loading gate for centrifugal machines incorporating an auxiliary drive device
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
US4546082A (en) 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
US4599311A (en) 1982-08-13 1986-07-08 Kawasaki Glenn H Glycolytic promotersfor regulated protein expression: protease inhibitor
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
WO1984004330A1 (en) 1983-04-22 1984-11-08 Amgen Secretion of exogenous polypeptides from yeast
NZ207926A (en) 1983-04-25 1988-04-29 Genentech Inc Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
US4745051A (en) 1983-05-27 1988-05-17 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4879236A (en) 1984-05-16 1989-11-07 The Texas A&M University System Method for producing a recombinant baculovirus expression vector
US4931373A (en) 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
DK58285D0 (da) 1984-05-30 1985-02-08 Novo Industri As Peptider samt fremstilling og anvendelse deraf
US4766073A (en) 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US4885249A (en) 1984-12-05 1989-12-05 Allelix, Inc. Aspergillus niger transformation system
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
AU607398B2 (en) 1985-08-29 1991-03-07 Genencor Inc. Heterologous polypeptides expressed in filamentous fungi, processes for making same, and vectors for making same
US4754051A (en) * 1985-09-30 1988-06-28 Dainippon Ink And Chemicals, Inc. Optically active tolan derivative
US4882279A (en) 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
HU206897B (en) 1985-10-25 1993-01-28 Zymogenetics Inc Process for utilizing bar-1 gen for selecting strange proteins
US4935349A (en) * 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
GB8610600D0 (en) 1986-04-30 1986-06-04 Novo Industri As Transformation of trichoderma
GB8615942D0 (en) 1986-06-30 1986-08-06 Animal & Food Research Council Peptide production
NZ221259A (en) 1986-07-31 1990-05-28 Calgene Inc Seed specific transcriptional regulation
EP0832981A1 (en) 1987-02-17 1998-04-01 Pharming B.V. DNA sequences to target proteins to the mammary gland for efficient secretion
US4873316A (en) * 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
DE3856247T2 (de) 1987-07-24 1999-04-29 Chiron Corp., Emeryville, Calif. Züchtung von insektenzellen mit airlift-reaktoren
US5024947A (en) 1987-07-24 1991-06-18 Cetus Corporation Serum free media for the growth on insect cells and expression of products thereby
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
JP2703598B2 (ja) 1987-09-04 1998-01-26 ノボ―ノルディスク アクティーゼルスカブ アスペルギルス菌中でのタンパク質生産物の生産方法およびアスペルギルス菌中で使用するためのプロモーター
DK463887D0 (da) 1987-09-07 1987-09-07 Novo Industri As Gaerleader
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
GB8826446D0 (en) 1988-11-11 1988-12-14 Agricultural & Food Res Peptide production
WO1990005783A1 (en) 1988-11-18 1990-05-31 Cetus Corporation Insect signal peptide mediated secretion of recombinant proteins
GB8910962D0 (en) 1989-05-12 1989-06-28 Natural Environment Res Novel baculovirus expression vectors and use thereof in the expression of foreign proteins in insects or insect cells
US5077214A (en) 1989-07-07 1991-12-31 The Texas A&M University System Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells
US5162222A (en) 1989-07-07 1992-11-10 Guarino Linda A Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses
US5023328A (en) 1989-08-04 1991-06-11 The Texas A&M University System Lepidopteran AKH signal sequence
US5155037A (en) 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
US5073964A (en) 1989-08-04 1991-12-17 Aware, Inc. Signal processing device and method
DK300090D0 (da) 1990-12-19 1990-12-19 Novo Nordisk As Fremgangsmaade til fremstilling af leadersekvenser
JPH06507307A (ja) 1991-01-11 1994-08-25 アメリカン・レツド・クロス トランスジェニック動物の乳腺組織における活性ヒトプロテインcの発現
US6969601B2 (en) * 1997-04-03 2005-11-29 Jensenius Jens Chr MASP-2, a complement-fixing enzyme, and uses for it
AU785149B2 (en) 1999-12-02 2006-10-05 Jens Christian Jensenius MASP-3, a complement-fixing enzyme, and uses for it
WO2002006460A2 (en) 2000-07-13 2002-01-24 Jens Christian Jensenius Masp-2, a complement-fixing enzyme, and uses for it
JP2005526084A (ja) * 2002-03-15 2005-09-02 ナットイムネ・アクティーゼルスカブ マンノース結合レクチンを含む医薬組成物
US7666627B2 (en) 2002-08-08 2010-02-23 Targetex Kft. Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
CN1694961A (zh) * 2002-09-10 2005-11-09 内蒂穆恩公司 胶原凝集素-补体激活蛋白嵌合体
PL2465534T3 (pl) * 2004-06-10 2017-08-31 Omeros Corporation Sposoby leczenia stanów związanych z aktywacją dopełniacza zależną od masp-2
WO2007047995A2 (en) * 2005-10-21 2007-04-26 Catalyst Biosciences, Inc. Modified proteases that inhibit complement activation
EP2403870A1 (en) * 2009-03-03 2012-01-11 Metamorefix Ltd. Peptides derived from ficolin as surfactants

Similar Documents

Publication Publication Date Title
JP2012533288A5 (enExample)
JP2013520979A5 (enExample)
JP6181145B2 (ja) 改善された特異性を有する新規免疫グロブリン結合タンパク質
JP2025066728A (ja) アネキシンvの製造プロセス
Dreier et al. Rapid selection of high-affinity binders using ribosome display
Gao et al. Anti-PD-L1 DNA aptamer antagonizes the interaction of PD-1/PD-L1 with antitumor effect
JP2014518883A5 (enExample)
RU2714156C2 (ru) С5-связующие полипептиды
US11598769B2 (en) Oligomerized protein-polymer conjugates
JP6657177B2 (ja) 改良型β−フルクトフラノシダーゼ
JP5550797B2 (ja) ヒト心筋由来トロポニンiに特異的にかつ速やかに結合できる変異体タンパク質
JP5528643B2 (ja) ヒト心筋由来トロポニンiに特異的にかつ速やかに結合できる組み換えタンパク質
JP2012514465A5 (enExample)
Grimm et al. Monitored whole gene in vitro evolution of an anti-hRaf-1 affibody molecule towards increased binding affinity
RU2011133060A (ru) Новые полипептиды и их применение
Jian et al. Multiple mechanisms are involved in repression of filamentous phage SW1 transcription by the DNA-binding protein FpsR
CN103804496B (zh) 一种特异性识别并结合Aβ42寡聚体的单链抗体及单链抗体基因
JP2013172663A (ja) ヒト心筋由来トロポニンIとの高い親和性を有するscFv抗体フラグメント
CN105237637B (zh) 抗人神经纤毛蛋白1的单域抗体及其制备方法
KR20160110903A (ko) 팔라듐 이온 특이적 dna 앱타머 및 이의 선별 방법
Ling et al. Interaction Affinity Determination of SUMO E1 Heterodimer Aos1/Uba2 and intermediates of activation cascade by Quantitative FRET Analysis
KR101679140B1 (ko) 팔라듐 이온 특이적 dna 앱타머 및 이의 선별 방법
CN119708236A (zh) 一种结合cdh17的重组c-型单域纳米抗体及其应用
JP2019535249A (ja) TNF−α結合アプタマー及びその治療的用途
CN109157654B (zh) Tmx1的用途