JP2012531896A - ヒト化非ヒト哺乳動物を製造する方法 - Google Patents

ヒト化非ヒト哺乳動物を製造する方法 Download PDF

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JP2012531896A
JP2012531896A JP2012517837A JP2012517837A JP2012531896A JP 2012531896 A JP2012531896 A JP 2012531896A JP 2012517837 A JP2012517837 A JP 2012517837A JP 2012517837 A JP2012517837 A JP 2012517837A JP 2012531896 A JP2012531896 A JP 2012531896A
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cells
mammal
cytokines
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JP2012531896A5 (enExample
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チェン，チンフェン
チェン，チエンチュ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012517837A 2009-06-29 2010-06-28 ヒト化非ヒト哺乳動物を製造する方法 Pending JP2012531896A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22143809P 2009-06-29 2009-06-29
US61/221,438 2009-06-29
PCT/US2010/040260 WO2011002727A1 (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

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JP2012531896A true JP2012531896A (ja) 2012-12-13
JP2012531896A5 JP2012531896A5 (enExample) 2013-08-15

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US (1) US20120157667A1 (enExample)
EP (1) EP2449094A4 (enExample)
JP (1) JP2012531896A (enExample)
CN (1) CN102725400A (enExample)
SG (2) SG176118A1 (enExample)
WO (1) WO2011002727A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017515471A (ja) * 2014-05-19 2017-06-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトｅｐｏを発現する遺伝子改変された非ヒト動物
WO2019098362A1 (ja) * 2017-11-17 2019-05-23 国立大学法人筑波大学 非ヒト動物及びその製造方法
JP2020168024A (ja) * 2012-09-07 2020-10-15 イエール ユニバーシティ 遺伝学的に修飾された非ヒト動物およびその使用法
JP2022520237A (ja) * 2019-02-13 2022-03-29 ザ ジャクソン ラボラトリー 自然免疫機能を支持するトランスジェニックマウスモデル

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EP3417701B1 (en) 2009-10-06 2021-12-15 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
RU2577978C2 (ru) 2011-02-15 2016-03-20 Ридженерон Фармасьютикалз, Инк. Гуманизированные m-csf мыши
SG11201402112RA (en) * 2011-12-06 2014-09-26 Massachusetts Inst Technology Use of humanized mice to determine toxicity
CN103387955B (zh) * 2012-05-10 2015-04-29 上海南方模式生物科技发展有限公司 非人哺乳动物b淋巴细胞缺陷动物模型的制备方法及其用途
US20150232539A1 (en) * 2012-09-05 2015-08-20 University Of Southern California Methods and Compositions for Detecting, Imaging, and Treating Small Cell Lung Cancer Utilizing Post-Translationally Modified Residues and Higher Molecular Weight Antigenic Complexes in Proteins
ES2748662T3 (es) 2012-11-05 2020-03-17 Institute For Res In Biomedicine Irb Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos
WO2014121840A1 (en) * 2013-02-07 2014-08-14 Medizinische Hochschule Hannover Induced dendritic cells and uses thereof
US20160135437A1 (en) * 2013-06-05 2016-05-19 Agency For Science, Technology And Research Humanized mouse model for study of bona fide hepatitis virus infection and use thereof
NO2785538T3 (enExample) * 2014-05-07 2018-08-04
SG10202103445QA (en) 2015-04-13 2021-05-28 Regeneron Pharma Humanized sirpa-il15 knockin mice and methods of use thereof
JP6654001B2 (ja) * 2015-05-27 2020-02-26 公益財団法人実験動物中央研究所 ヒトｉｌ−１５分泌免疫不全マウス
JP2019508014A (ja) * 2015-11-30 2019-03-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 免疫不全の非ヒト宿主におけるヒトマクロファージの生成
CN111172190B (zh) * 2018-12-25 2021-07-30 百奥赛图江苏基因生物技术有限公司 人源化细胞因子csf2基因改造非人动物的构建方法及应用
CN111304248B (zh) 2018-12-25 2021-08-24 百奥赛图江苏基因生物技术有限公司 人源化细胞因子il15基因改造非人动物的构建方法及应用
JP6886524B2 (ja) 2019-01-28 2021-06-16 公益財団法人実験動物中央研究所 ヒトｉｌ−３４を有する非ヒト動物及びその使用
US20220192166A1 (en) * 2019-03-28 2022-06-23 Central Institute For Experimental Animals Immunodeficient rodent
CN111485001A (zh) * 2020-04-14 2020-08-04 澎立生物医药技术（上海）有限公司 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法
WO2022011007A1 (en) * 2020-07-08 2022-01-13 The Jackson Laboratory Transgenic mouse models supporting human innate immune function
CN112042597B (zh) * 2020-07-22 2022-04-29 南京普恩瑞生物科技有限公司 一种双人源化肿瘤异种移植模型的构建方法
CN114853871B (zh) * 2021-04-20 2024-04-05 百奥赛图(北京)医药科技股份有限公司 Csf1和/或csf1r基因人源化的非人动物及其构建方法和应用

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EP3417701B1 (en) * 2009-10-06 2021-12-15 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020168024A (ja) * 2012-09-07 2020-10-15 イエール ユニバーシティ 遺伝学的に修飾された非ヒト動物およびその使用法
JP7066785B2 (ja) 2012-09-07 2022-05-13 イエール ユニバーシティ 遺伝学的に修飾された非ヒト動物およびその使用法
JP2017515471A (ja) * 2014-05-19 2017-06-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトｅｐｏを発現する遺伝子改変された非ヒト動物
JP2022109288A (ja) * 2014-05-19 2022-07-27 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトｅｐｏを発現する遺伝子改変された非ヒト動物
JP7385703B2 (ja) 2014-05-19 2023-11-22 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトｅｐｏを発現する遺伝子改変された非ヒト動物
JP2024009054A (ja) * 2014-05-19 2024-01-19 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトｅｐｏを発現する遺伝子改変された非ヒト動物
JP7620688B2 (ja) 2014-05-19 2025-01-23 リジェネロン・ファーマシューティカルズ・インコーポレイテッド ヒトｅｐｏを発現する遺伝子改変された非ヒト動物
WO2019098362A1 (ja) * 2017-11-17 2019-05-23 国立大学法人筑波大学 非ヒト動物及びその製造方法
JPWO2019098362A1 (ja) * 2017-11-17 2021-01-14 国立大学法人 筑波大学 非ヒト動物及びその製造方法
JP7136474B2 (ja) 2017-11-17 2022-09-13 国立大学法人 筑波大学 非ヒト動物及びその製造方法
JP2022520237A (ja) * 2019-02-13 2022-03-29 ザ ジャクソン ラボラトリー 自然免疫機能を支持するトランスジェニックマウスモデル
US12378574B2 (en) 2019-02-13 2025-08-05 The Jackson Laboratory Transgenic mouse models supporting innate immune function

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Publication number Publication date
WO2011002727A1 (en) 2011-01-06
WO2011002727A9 (en) 2011-02-24
SG10201403703XA (en) 2014-10-30
EP2449094A1 (en) 2012-05-09
EP2449094A4 (en) 2013-07-10
SG176118A1 (en) 2011-12-29
CN102725400A (zh) 2012-10-10
US20120157667A1 (en) 2012-06-21

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