JP2012531896A5 - - Google Patents
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- Publication number
- JP2012531896A5 JP2012531896A5 JP2012517837A JP2012517837A JP2012531896A5 JP 2012531896 A5 JP2012531896 A5 JP 2012531896A5 JP 2012517837 A JP2012517837 A JP 2012517837A JP 2012517837 A JP2012517837 A JP 2012517837A JP 2012531896 A5 JP2012531896 A5 JP 2012531896A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- cells
- mammal
- functional
- human mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 28
- 238000000034 method Methods 0.000 claims 27
- 102000004127 Cytokines Human genes 0.000 claims 21
- 108090000695 Cytokines Proteins 0.000 claims 21
- 108020004707 nucleic acids Proteins 0.000 claims 17
- 150000007523 nucleic acids Chemical class 0.000 claims 17
- 102000039446 nucleic acids Human genes 0.000 claims 17
- 210000003719 b-lymphocyte Anatomy 0.000 claims 13
- 210000000601 blood cell Anatomy 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 230000002163 immunogen Effects 0.000 claims 7
- 210000004443 dendritic cell Anatomy 0.000 claims 6
- 230000004069 differentiation Effects 0.000 claims 6
- 210000003743 erythrocyte Anatomy 0.000 claims 6
- 210000002540 macrophage Anatomy 0.000 claims 6
- 210000001616 monocyte Anatomy 0.000 claims 6
- 210000000822 natural killer cell Anatomy 0.000 claims 6
- 241000699670 Mus sp. Species 0.000 claims 5
- 102000003951 Erythropoietin Human genes 0.000 claims 4
- 108090000394 Erythropoietin Proteins 0.000 claims 4
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims 4
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims 4
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 4
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
- 102000003812 Interleukin-15 Human genes 0.000 claims 4
- 108090000172 Interleukin-15 Proteins 0.000 claims 4
- 102000000646 Interleukin-3 Human genes 0.000 claims 4
- 108010002386 Interleukin-3 Proteins 0.000 claims 4
- 102000004388 Interleukin-4 Human genes 0.000 claims 4
- 108090000978 Interleukin-4 Proteins 0.000 claims 4
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims 4
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 4
- 230000002708 enhancing effect Effects 0.000 claims 4
- 229940105423 erythropoietin Drugs 0.000 claims 4
- 229940076264 interleukin-3 Drugs 0.000 claims 4
- 229940028885 interleukin-4 Drugs 0.000 claims 4
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 210000004408 hybridoma Anatomy 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 102000013462 Interleukin-12 Human genes 0.000 claims 2
- 108010065805 Interleukin-12 Proteins 0.000 claims 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 2
- 241000276498 Pollachius virens Species 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 229940117681 interleukin-12 Drugs 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 210000000066 myeloid cell Anatomy 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 208000002491 severe combined immunodeficiency Diseases 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 1
- 108091061960 Naked DNA Proteins 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 102000003675 cytokine receptors Human genes 0.000 claims 1
- 108010057085 cytokine receptors Proteins 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 238000012423 maintenance Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22143809P | 2009-06-29 | 2009-06-29 | |
| US61/221,438 | 2009-06-29 | ||
| PCT/US2010/040260 WO2011002727A1 (en) | 2009-06-29 | 2010-06-28 | Methods of producing humanized non-human mammals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012531896A JP2012531896A (ja) | 2012-12-13 |
| JP2012531896A5 true JP2012531896A5 (enExample) | 2013-08-15 |
Family
ID=43411395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517837A Pending JP2012531896A (ja) | 2009-06-29 | 2010-06-28 | ヒト化非ヒト哺乳動物を製造する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120157667A1 (enExample) |
| EP (1) | EP2449094A4 (enExample) |
| JP (1) | JP2012531896A (enExample) |
| CN (1) | CN102725400A (enExample) |
| SG (2) | SG176118A1 (enExample) |
| WO (1) | WO2011002727A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3417701B1 (en) | 2009-10-06 | 2021-12-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| RU2577978C2 (ru) | 2011-02-15 | 2016-03-20 | Ридженерон Фармасьютикалз, Инк. | Гуманизированные m-csf мыши |
| SG11201402112RA (en) * | 2011-12-06 | 2014-09-26 | Massachusetts Inst Technology | Use of humanized mice to determine toxicity |
| CN103387955B (zh) * | 2012-05-10 | 2015-04-29 | 上海南方模式生物科技发展有限公司 | 非人哺乳动物b淋巴细胞缺陷动物模型的制备方法及其用途 |
| US20150232539A1 (en) * | 2012-09-05 | 2015-08-20 | University Of Southern California | Methods and Compositions for Detecting, Imaging, and Treating Small Cell Lung Cancer Utilizing Post-Translationally Modified Residues and Higher Molecular Weight Antigenic Complexes in Proteins |
| NZ746089A (en) * | 2012-09-07 | 2020-05-29 | Institute For Res In Biomedicine Irb | Genetically modified non-human animals and methods of use thereof |
| ES2748662T3 (es) | 2012-11-05 | 2020-03-17 | Institute For Res In Biomedicine Irb | Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos |
| WO2014121840A1 (en) * | 2013-02-07 | 2014-08-14 | Medizinische Hochschule Hannover | Induced dendritic cells and uses thereof |
| US20160135437A1 (en) * | 2013-06-05 | 2016-05-19 | Agency For Science, Technology And Research | Humanized mouse model for study of bona fide hepatitis virus infection and use thereof |
| NO2785538T3 (enExample) * | 2014-05-07 | 2018-08-04 | ||
| KR102821645B1 (ko) * | 2014-05-19 | 2025-06-19 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 epo를 발현하는 유전자 변형된 비-인간 동물 |
| SG10202103445QA (en) | 2015-04-13 | 2021-05-28 | Regeneron Pharma | Humanized sirpa-il15 knockin mice and methods of use thereof |
| JP6654001B2 (ja) * | 2015-05-27 | 2020-02-26 | 公益財団法人実験動物中央研究所 | ヒトｉｌ−１５分泌免疫不全マウス |
| JP2019508014A (ja) * | 2015-11-30 | 2019-03-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 免疫不全の非ヒト宿主におけるヒトマクロファージの生成 |
| US20200315147A1 (en) * | 2017-11-17 | 2020-10-08 | University Of Tsukuba | Non-human animal and method for producing same |
| CN111172190B (zh) * | 2018-12-25 | 2021-07-30 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子csf2基因改造非人动物的构建方法及应用 |
| CN111304248B (zh) | 2018-12-25 | 2021-08-24 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子il15基因改造非人动物的构建方法及应用 |
| JP6886524B2 (ja) | 2019-01-28 | 2021-06-16 | 公益財団法人実験動物中央研究所 | ヒトｉｌ−３４を有する非ヒト動物及びその使用 |
| EP4650449A3 (en) * | 2019-02-13 | 2025-12-17 | The Jackson Laboratory | Transgenic mouse models supporting innate immune function |
| US20220192166A1 (en) * | 2019-03-28 | 2022-06-23 | Central Institute For Experimental Animals | Immunodeficient rodent |
| CN111485001A (zh) * | 2020-04-14 | 2020-08-04 | 澎立生物医药技术（上海）有限公司 | 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法 |
| WO2022011007A1 (en) * | 2020-07-08 | 2022-01-13 | The Jackson Laboratory | Transgenic mouse models supporting human innate immune function |
| CN112042597B (zh) * | 2020-07-22 | 2022-04-29 | 南京普恩瑞生物科技有限公司 | 一种双人源化肿瘤异种移植模型的构建方法 |
| CN114853871B (zh) * | 2021-04-20 | 2024-04-05 | 百奥赛图(北京)医药科技股份有限公司 | Csf1和/或csf1r基因人源化的非人动物及其构建方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2071620T3 (es) * | 1987-12-23 | 1995-07-01 | Univ Leland Stanford Junior | Mamiferos inmunodeficientes quimericos y su utilizacion. |
| US5639939A (en) * | 1987-12-23 | 1997-06-17 | The Board Of Trustees For The Leland Stanford Junior University | Chimeric immunocompromised mammal comprosing vascularized fetal organ tissue |
| DE69433851D1 (de) * | 1993-12-17 | 2004-07-22 | Novartis Ag | Tiermodell zum testen von arzneistoffen zur behandlung von leukämie oder hiv |
| US6015554A (en) * | 1995-06-07 | 2000-01-18 | Systemix, Inc. | Method of reconstituting human lymphoid and dendritic cells |
| US6060643A (en) * | 1995-08-04 | 2000-05-09 | Emory University | Mouse model with human immune system |
| US20070021364A1 (en) * | 1995-12-13 | 2007-01-25 | Hans Herweijer | Methods for genetic immunization |
| AU4214799A (en) * | 1998-05-28 | 1999-12-13 | St. Jude Children's Research Hospital | Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof |
| CA2330208A1 (en) * | 1998-05-29 | 1999-12-02 | Thomas Jefferson University | Compositions and methods for use in affecting hematopoietic stem cell populations in mammals |
| EP1532255A1 (en) * | 2002-06-24 | 2005-05-25 | Genzyme Corporation | Methods of delivering gene therapy agents |
| GB0406728D0 (en) * | 2004-03-25 | 2004-04-28 | Hydrodynamic Gene Delivery Ltd | Gene therapy |
| CN105168250B (zh) * | 2004-10-25 | 2019-02-05 | 塞勒兰特治疗公司 | 增殖骨髓细胞群体的方法及其应用 |
| EP3712258B1 (en) * | 2006-04-14 | 2025-01-01 | Astellas Institute for Regenerative Medicine | Hemangio-colony forming cells |
| JP2010521170A (ja) * | 2007-03-13 | 2010-06-24 | ナショナル ジューイッシュ ヘルス | 抗体の生成方法 |
| CA2636876A1 (en) * | 2008-02-25 | 2009-08-25 | Gestion Univalor Inc. | Methods and kits for expanding hematopoietic stem cells |
| WO2010115115A1 (en) * | 2009-04-03 | 2010-10-07 | Inserm ( Institut National De La Sante Et De La Recherche) | Dendritic cell-boosted humanized immune system mice |
| JP2012531894A (ja) * | 2009-06-29 | 2012-12-13 | レスコフ，イリヤ，ビー． | ヒト血液癌の非ヒト哺乳動物モデル |
| EP3417701B1 (en) * | 2009-10-06 | 2021-12-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
-
2010
- 2010-06-28 CN CN2010800388479A patent/CN102725400A/zh active Pending
- 2010-06-28 US US13/381,313 patent/US20120157667A1/en not_active Abandoned
- 2010-06-28 WO PCT/US2010/040260 patent/WO2011002727A1/en not_active Ceased
- 2010-06-28 SG SG2011084647A patent/SG176118A1/en unknown
- 2010-06-28 SG SG10201403703XA patent/SG10201403703XA/en unknown
- 2010-06-28 JP JP2012517837A patent/JP2012531896A/ja active Pending
- 2010-06-28 EP EP10794611.3A patent/EP2449094A4/en not_active Withdrawn
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