CN102725400A - 制造人源化的非人类哺乳动物的方法 - Google Patents

制造人源化的非人类哺乳动物的方法 Download PDF

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CN102725400A
CN102725400A CN2010800388479A CN201080038847A CN102725400A CN 102725400 A CN102725400 A CN 102725400A CN 2010800388479 A CN2010800388479 A CN 2010800388479A CN 201080038847 A CN201080038847 A CN 201080038847A CN 102725400 A CN102725400 A CN 102725400A
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cell
human mammal
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陈清风
陈建竹
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Massachusetts Institute of Technology
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2010800388479A 2009-06-29 2010-06-28 制造人源化的非人类哺乳动物的方法 Pending CN102725400A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US22143809P 2009-06-29 2009-06-29
US61/221,438 2009-06-29
PCT/US2010/040260 WO2011002727A1 (en) 2009-06-29 2010-06-28 Methods of producing humanized non-human mammals

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CN102725400A true CN102725400A (zh) 2012-10-10

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US (1) US20120157667A1 (enExample)
EP (1) EP2449094A4 (enExample)
JP (1) JP2012531896A (enExample)
CN (1) CN102725400A (enExample)
SG (2) SG176118A1 (enExample)
WO (1) WO2011002727A1 (enExample)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104918483A (zh) * 2012-11-05 2015-09-16 再生元制药公司 经遗传修饰的非人动物及其使用方法
CN106536546A (zh) * 2014-05-19 2017-03-22 再生元制药公司 表达人epo的经遗传修饰的非人动物
CN108347907A (zh) * 2015-11-30 2018-07-31 豪夫迈·罗氏有限公司 在免疫缺陷非人宿主中生成人巨噬细胞
CN108782459A (zh) * 2012-09-07 2018-11-13 再生元制药公司 经遗传修饰的非人动物及其使用方法
CN110269047A (zh) * 2014-05-07 2019-09-24 瑞泽恩制药公司 人源化IL-4和IL-4Rα动物
CN111172190A (zh) * 2018-12-25 2020-05-19 百奥赛图江苏基因生物技术有限公司 人源化细胞因子csf2基因改造非人动物的构建方法及应用
CN111315881A (zh) * 2017-11-17 2020-06-19 国立大学法人筑波大学 非人类动物及其生产方法
CN111304248A (zh) * 2018-12-25 2020-06-19 百奥赛图江苏基因生物技术有限公司 人源化细胞因子il15基因改造非人动物的构建方法及应用
CN111485001A (zh) * 2020-04-14 2020-08-04 澎立生物医药技术（上海）有限公司 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法
CN112042597A (zh) * 2020-07-22 2020-12-08 南京普恩瑞生物科技有限公司 一种双人源化肿瘤异种移植模型的构建方法
CN113424798A (zh) * 2015-04-13 2021-09-24 再生元制药公司 人源化SIRPα-IL15敲入小鼠及其使用方法
CN113473849A (zh) * 2019-01-28 2021-10-01 公益财团法人实验动物中央研究所 具有人il-34的非人动物及其用途
CN113614238A (zh) * 2019-03-28 2021-11-05 公益财团法人实验动物中央研究所 免疫缺陷小鼠
WO2022222958A1 (en) * 2021-04-20 2022-10-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric genes

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EP3417701B1 (en) 2009-10-06 2021-12-15 Regeneron Pharmaceuticals, Inc. Genetically modified mice and engraftment
RU2577978C2 (ru) 2011-02-15 2016-03-20 Ридженерон Фармасьютикалз, Инк. Гуманизированные m-csf мыши
SG11201402112RA (en) * 2011-12-06 2014-09-26 Massachusetts Inst Technology Use of humanized mice to determine toxicity
CN103387955B (zh) * 2012-05-10 2015-04-29 上海南方模式生物科技发展有限公司 非人哺乳动物b淋巴细胞缺陷动物模型的制备方法及其用途
US20150232539A1 (en) * 2012-09-05 2015-08-20 University Of Southern California Methods and Compositions for Detecting, Imaging, and Treating Small Cell Lung Cancer Utilizing Post-Translationally Modified Residues and Higher Molecular Weight Antigenic Complexes in Proteins
WO2014121840A1 (en) * 2013-02-07 2014-08-14 Medizinische Hochschule Hannover Induced dendritic cells and uses thereof
US20160135437A1 (en) * 2013-06-05 2016-05-19 Agency For Science, Technology And Research Humanized mouse model for study of bona fide hepatitis virus infection and use thereof
JP6654001B2 (ja) * 2015-05-27 2020-02-26 公益財団法人実験動物中央研究所 ヒトｉｌ−１５分泌免疫不全マウス
EP4650449A3 (en) * 2019-02-13 2025-12-17 The Jackson Laboratory Transgenic mouse models supporting innate immune function
WO2022011007A1 (en) * 2020-07-08 2022-01-13 The Jackson Laboratory Transgenic mouse models supporting human innate immune function

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Cited By (25)

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Publication number Priority date Publication date Assignee Title
CN108782459B (zh) * 2012-09-07 2021-11-05 再生元制药公司 经遗传修饰的非人动物及其使用方法
CN108782459A (zh) * 2012-09-07 2018-11-13 再生元制药公司 经遗传修饰的非人动物及其使用方法
CN104918483A (zh) * 2012-11-05 2015-09-16 再生元制药公司 经遗传修饰的非人动物及其使用方法
CN104918483B (zh) * 2012-11-05 2018-05-11 再生元制药公司 生成及使用经遗传修饰的非人动物的方法
CN110269047B (zh) * 2014-05-07 2021-11-02 瑞泽恩制药公司 人源化IL-4和IL-4Rα动物
CN110269047A (zh) * 2014-05-07 2019-09-24 瑞泽恩制药公司 人源化IL-4和IL-4Rα动物
CN106536546B (zh) * 2014-05-19 2021-04-30 再生元制药公司 表达人epo的经遗传修饰的非人动物
CN113045639A (zh) * 2014-05-19 2021-06-29 再生元制药公司 表达人epo的经遗传修饰的非人动物
CN106536546A (zh) * 2014-05-19 2017-03-22 再生元制药公司 表达人epo的经遗传修饰的非人动物
CN113424798A (zh) * 2015-04-13 2021-09-24 再生元制药公司 人源化SIRPα-IL15敲入小鼠及其使用方法
CN113424798B (zh) * 2015-04-13 2023-01-13 再生元制药公司 人源化SIRPα-IL15敲入小鼠及其使用方法
CN108347907A (zh) * 2015-11-30 2018-07-31 豪夫迈·罗氏有限公司 在免疫缺陷非人宿主中生成人巨噬细胞
CN111315881B (zh) * 2017-11-17 2023-10-10 国立大学法人筑波大学 非人类动物及其生产方法
CN111315881A (zh) * 2017-11-17 2020-06-19 国立大学法人筑波大学 非人类动物及其生产方法
CN111172190A (zh) * 2018-12-25 2020-05-19 百奥赛图江苏基因生物技术有限公司 人源化细胞因子csf2基因改造非人动物的构建方法及应用
CN111172190B (zh) * 2018-12-25 2021-07-30 百奥赛图江苏基因生物技术有限公司 人源化细胞因子csf2基因改造非人动物的构建方法及应用
WO2020135518A1 (en) * 2018-12-25 2020-07-02 Biocytogen Jiangsu Co., Ltd. Genetically modified non-human animal with human or chimeric il15
CN111304248A (zh) * 2018-12-25 2020-06-19 百奥赛图江苏基因生物技术有限公司 人源化细胞因子il15基因改造非人动物的构建方法及应用
US11234421B2 (en) 2018-12-25 2022-02-01 Biocytogen Jiangsu Co., Ltd. Genetically modified non-human animal with human or chimeric IL15
US11419317B2 (en) 2019-01-28 2022-08-23 Central Institute For Experimental Animals Non-human animal having human IL-34 and use Thereof
CN113473849A (zh) * 2019-01-28 2021-10-01 公益财团法人实验动物中央研究所 具有人il-34的非人动物及其用途
CN113614238A (zh) * 2019-03-28 2021-11-05 公益财团法人实验动物中央研究所 免疫缺陷小鼠
CN111485001A (zh) * 2020-04-14 2020-08-04 澎立生物医药技术（上海）有限公司 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法
CN112042597A (zh) * 2020-07-22 2020-12-08 南京普恩瑞生物科技有限公司 一种双人源化肿瘤异种移植模型的构建方法
WO2022222958A1 (en) * 2021-04-20 2022-10-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric genes

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WO2011002727A1 (en) 2011-01-06
WO2011002727A9 (en) 2011-02-24
SG10201403703XA (en) 2014-10-30
EP2449094A1 (en) 2012-05-09
EP2449094A4 (en) 2013-07-10
SG176118A1 (en) 2011-12-29
US20120157667A1 (en) 2012-06-21
JP2012531896A (ja) 2012-12-13

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Application publication date: 20121010