SG176118A1 - Methods of producing humanized non-human mammals - Google Patents
Methods of producing humanized non-human mammals Download PDFInfo
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- SG176118A1 SG176118A1 SG2011084647A SG2011084647A SG176118A1 SG 176118 A1 SG176118 A1 SG 176118A1 SG 2011084647 A SG2011084647 A SG 2011084647A SG 2011084647 A SG2011084647 A SG 2011084647A SG 176118 A1 SG176118 A1 SG 176118A1
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- human
- cells
- mammal
- cytokines
- human mammal
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- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2893—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD52
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0381—Animal model for diseases of the hematopoietic system
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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| EP3417701B1 (en) | 2009-10-06 | 2021-12-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| RU2577978C2 (ru) | 2011-02-15 | 2016-03-20 | Ридженерон Фармасьютикалз, Инк. | Гуманизированные m-csf мыши |
| SG11201402112RA (en) * | 2011-12-06 | 2014-09-26 | Massachusetts Inst Technology | Use of humanized mice to determine toxicity |
| CN103387955B (zh) * | 2012-05-10 | 2015-04-29 | 上海南方模式生物科技发展有限公司 | 非人哺乳动物b淋巴细胞缺陷动物模型的制备方法及其用途 |
| US20150232539A1 (en) * | 2012-09-05 | 2015-08-20 | University Of Southern California | Methods and Compositions for Detecting, Imaging, and Treating Small Cell Lung Cancer Utilizing Post-Translationally Modified Residues and Higher Molecular Weight Antigenic Complexes in Proteins |
| NZ746089A (en) * | 2012-09-07 | 2020-05-29 | Institute For Res In Biomedicine Irb | Genetically modified non-human animals and methods of use thereof |
| ES2748662T3 (es) | 2012-11-05 | 2020-03-17 | Institute For Res In Biomedicine Irb | Roedores inmunodeficientes modificados genéticamente y métodos de uso de los mismos |
| WO2014121840A1 (en) * | 2013-02-07 | 2014-08-14 | Medizinische Hochschule Hannover | Induced dendritic cells and uses thereof |
| US20160135437A1 (en) * | 2013-06-05 | 2016-05-19 | Agency For Science, Technology And Research | Humanized mouse model for study of bona fide hepatitis virus infection and use thereof |
| NO2785538T3 (enExample) * | 2014-05-07 | 2018-08-04 | ||
| KR102821645B1 (ko) * | 2014-05-19 | 2025-06-19 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 epo를 발현하는 유전자 변형된 비-인간 동물 |
| SG10202103445QA (en) | 2015-04-13 | 2021-05-28 | Regeneron Pharma | Humanized sirpa-il15 knockin mice and methods of use thereof |
| JP6654001B2 (ja) * | 2015-05-27 | 2020-02-26 | 公益財団法人実験動物中央研究所 | ヒトｉｌ−１５分泌免疫不全マウス |
| JP2019508014A (ja) * | 2015-11-30 | 2019-03-28 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 免疫不全の非ヒト宿主におけるヒトマクロファージの生成 |
| US20200315147A1 (en) * | 2017-11-17 | 2020-10-08 | University Of Tsukuba | Non-human animal and method for producing same |
| CN111172190B (zh) * | 2018-12-25 | 2021-07-30 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子csf2基因改造非人动物的构建方法及应用 |
| CN111304248B (zh) | 2018-12-25 | 2021-08-24 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子il15基因改造非人动物的构建方法及应用 |
| JP6886524B2 (ja) | 2019-01-28 | 2021-06-16 | 公益財団法人実験動物中央研究所 | ヒトｉｌ−３４を有する非ヒト動物及びその使用 |
| EP4650449A3 (en) * | 2019-02-13 | 2025-12-17 | The Jackson Laboratory | Transgenic mouse models supporting innate immune function |
| US20220192166A1 (en) * | 2019-03-28 | 2022-06-23 | Central Institute For Experimental Animals | Immunodeficient rodent |
| CN111485001A (zh) * | 2020-04-14 | 2020-08-04 | 澎立生物医药技术（上海）有限公司 | 具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法 |
| WO2022011007A1 (en) * | 2020-07-08 | 2022-01-13 | The Jackson Laboratory | Transgenic mouse models supporting human innate immune function |
| CN112042597B (zh) * | 2020-07-22 | 2022-04-29 | 南京普恩瑞生物科技有限公司 | 一种双人源化肿瘤异种移植模型的构建方法 |
| CN114853871B (zh) * | 2021-04-20 | 2024-04-05 | 百奥赛图(北京)医药科技股份有限公司 | Csf1和/或csf1r基因人源化的非人动物及其构建方法和应用 |
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| ES2071620T3 (es) * | 1987-12-23 | 1995-07-01 | Univ Leland Stanford Junior | Mamiferos inmunodeficientes quimericos y su utilizacion. |
| US5639939A (en) * | 1987-12-23 | 1997-06-17 | The Board Of Trustees For The Leland Stanford Junior University | Chimeric immunocompromised mammal comprosing vascularized fetal organ tissue |
| DE69433851D1 (de) * | 1993-12-17 | 2004-07-22 | Novartis Ag | Tiermodell zum testen von arzneistoffen zur behandlung von leukämie oder hiv |
| US6015554A (en) * | 1995-06-07 | 2000-01-18 | Systemix, Inc. | Method of reconstituting human lymphoid and dendritic cells |
| US6060643A (en) * | 1995-08-04 | 2000-05-09 | Emory University | Mouse model with human immune system |
| US20070021364A1 (en) * | 1995-12-13 | 2007-01-25 | Hans Herweijer | Methods for genetic immunization |
| AU4214799A (en) * | 1998-05-28 | 1999-12-13 | St. Jude Children's Research Hospital | Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof |
| CA2330208A1 (en) * | 1998-05-29 | 1999-12-02 | Thomas Jefferson University | Compositions and methods for use in affecting hematopoietic stem cell populations in mammals |
| EP1532255A1 (en) * | 2002-06-24 | 2005-05-25 | Genzyme Corporation | Methods of delivering gene therapy agents |
| GB0406728D0 (en) * | 2004-03-25 | 2004-04-28 | Hydrodynamic Gene Delivery Ltd | Gene therapy |
| CN105168250B (zh) * | 2004-10-25 | 2019-02-05 | 塞勒兰特治疗公司 | 增殖骨髓细胞群体的方法及其应用 |
| EP3712258B1 (en) * | 2006-04-14 | 2025-01-01 | Astellas Institute for Regenerative Medicine | Hemangio-colony forming cells |
| JP2010521170A (ja) * | 2007-03-13 | 2010-06-24 | ナショナル ジューイッシュ ヘルス | 抗体の生成方法 |
| CA2636876A1 (en) * | 2008-02-25 | 2009-08-25 | Gestion Univalor Inc. | Methods and kits for expanding hematopoietic stem cells |
| WO2010115115A1 (en) * | 2009-04-03 | 2010-10-07 | Inserm ( Institut National De La Sante Et De La Recherche) | Dendritic cell-boosted humanized immune system mice |
| JP2012531894A (ja) * | 2009-06-29 | 2012-12-13 | レスコフ，イリヤ，ビー． | ヒト血液癌の非ヒト哺乳動物モデル |
| EP3417701B1 (en) * | 2009-10-06 | 2021-12-15 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
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| WO2011002727A9 (en) | 2011-02-24 |
| SG10201403703XA (en) | 2014-10-30 |
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| EP2449094A4 (en) | 2013-07-10 |
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