JP2012531208A5 - - Google Patents
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- JP2012531208A5 JP2012531208A5 JP2012517785A JP2012517785A JP2012531208A5 JP 2012531208 A5 JP2012531208 A5 JP 2012531208A5 JP 2012517785 A JP2012517785 A JP 2012517785A JP 2012517785 A JP2012517785 A JP 2012517785A JP 2012531208 A5 JP2012531208 A5 JP 2012531208A5
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- 229920001184 polypeptide Polymers 0.000 claims 31
- 108090000765 processed proteins & peptides Proteins 0.000 claims 31
- 102000004196 processed proteins & peptides Human genes 0.000 claims 31
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 150000007523 nucleic acids Chemical class 0.000 claims 15
- 108010018324 Surrogate Immunoglobulin Light Chains Proteins 0.000 claims 12
- 102000002663 Surrogate Immunoglobulin Light Chains Human genes 0.000 claims 12
- 101000854886 Homo sapiens Immunoglobulin iota chain Proteins 0.000 claims 6
- 102100020744 Immunoglobulin iota chain Human genes 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 5
- 230000004927 fusion Effects 0.000 claims 5
- 230000003248 secreting effect Effects 0.000 claims 5
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 108091035707 Consensus sequence Proteins 0.000 claims 1
- 241000699802 Cricetulus griseus Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Claims (16)
- 代替軽鎖（ＳＬＣ）ポリペプチドの天然型分泌リーダー配列が抗体軽鎖の非相同性分泌リーダー配列により置換されている、ＳＬＣポリペプチドをコードする単離された核酸分子。
- ＳＬＣポリペプチドが、ＶｐｒｅＢポリペプチドを含み、ＶｐｒｅＢポリペプチドが、天然型ＶｐｒｅＢ１配列、天然型ＶｐｒｅＢ２配列、天然型ＶｐｒｅＢ３配列、ならびにそれらのフラグメントおよびバリアントからなる群より任意に選択され、さらには、配列番号１のＶｐｒｅＢ１、配列番号２及び３のＶｐｒｅＢ２、配列番号４のＶｐｒｅＢ３、配列番号５のＶｐｒｅＢ様ポリペプチド、配列番号６のＶｐｒｅＢ ｄＴａｉｌポリペプチド、ならびにそれらのフラグメントおよびバリアントからなる群より任意に選択される、請求項１記載の単離された核酸分子。
- ＳＬＣポリペプチドが、λ５ポリペプチドを含み、λ５ポリペプチドが、配列番号７のλ５様、配列番号８のλ５ポリペプチド、配列番号９のλ５ ｄＴａｉｌポリペプチド、ならびにそれらのフラグメントおよびバリアントからなる群より任意に選択される、請求項１記載の単離された核酸分子。
- ＳＬＣポリペプチドが、ＶｐｒｅＢ−λ５ポリペプチド融合体を含み、該融合体が配列番号３５の配列を任意で含む、請求項１記載の単離された核酸分子。
- 前記ＶｐｒｅＢポリペプチド配列およびλ５ポリペプチド配列の融合が、それぞれ前記ＶｐｒｅＢ配列および前記λ５配列のＣＤＲ３類似領域で、またはその周辺で起こるか、または、ＶｐｒｅＢポリペプチド配列が、カルボキシ末端で、λ５ポリペプチド配列のアミノ末端に連結されている、請求項４記載の単離された核酸分子。
- ＳＬＣポリペプチドが、Ｖκ様ポリペプチドを含み、Ｖκ様ポリペプチド配列が、配列番号１２〜２４、ならびにそれらのフラグメントおよびバリアントからなる群より任意に選択される、請求項１記載の単離された核酸分子。
- ＳＬＣポリペプチドが、ＪＣκポリペプチドを含み、ＪＣκポリペプチド配列が、配列番号２６〜３１、ならびにそれらのフラグメントおよびバリアントからなる群より任意に選択される、請求項１または６記載の単離された核酸分子。
- ＳＬＣポリペプチドが、Ｖκ様−ＪＣκポリペプチド融合体である、請求項１記載の単離された核酸分子。
- Ｖκ様ポリペプチド配列およびＪＣκポリペプチド配列の融合が、それぞれ前記Ｖκ様配列および前記ＪＣκ配列のＣＤＲ３類似領域で、またはその周辺で起こるか、または、Ｖκ様ポリペプチド配列が、カルボキシ末端で、ＪＣκポリペプチド配列のアミノ末端に融合されている、請求項８記載の単離された核酸分子。
- 前記非相同性分泌リーダー配列が、配列番号３６の配列を含む、請求項１〜９のいずれか記載の単離された核酸分子。
- 前記分泌リーダー配列が、天然型分泌リーダー配列のコンセンサス配列である、請求項１〜９のいずれか１項記載の単離された核酸分子。
- 代替軽鎖（ＳＬＣ）構造体をコードする、請求項１〜１１のいずれか１項記載の単離された核酸分子。
- 請求項１〜１２のいずれか１項記載の核酸分子を含むホ乳類発現ベクター。
- 請求項１〜１２のいずれか１項記載の核酸分子または請求項１３記載のベクターで形質転換された組換えホ乳類宿主細胞。
- 前記組換え宿主細胞を、請求項１〜１２のいずれか１項記載の核酸分子で形質転換することを含む、組換えホ乳類宿主細胞内での代替軽鎖（ＳＬＣ）ポリペプチドまたはＳＬＣ構造体の発現方法。
- 前記組換え宿主細胞が、チャイニーズハムスター卵巣（ＣＨＯ）細胞、またはヒト胚性腎（ＨＥＫ）２９３細胞である、請求項１５記載の方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22087809P | 2009-06-26 | 2009-06-26 | |
| US61/220,878 | 2009-06-26 | ||
| PCT/US2010/040052 WO2010151808A1 (en) | 2009-06-26 | 2010-06-25 | Expression of surrogate light chains |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015256676A Division JP2016105714A (ja) | 2009-06-26 | 2015-12-28 | 代替軽鎖の発現 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012531208A JP2012531208A (ja) | 2012-12-10 |
| JP2012531208A5 true JP2012531208A5 (ja) | 2013-08-08 |
Family
ID=42563044
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012517785A Withdrawn JP2012531208A (ja) | 2009-06-26 | 2010-06-25 | 代替軽鎖の発現 |
| JP2015256676A Pending JP2016105714A (ja) | 2009-06-26 | 2015-12-28 | 代替軽鎖の発現 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015256676A Pending JP2016105714A (ja) | 2009-06-26 | 2015-12-28 | 代替軽鎖の発現 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8969082B2 (ja) |
| EP (2) | EP2446032B8 (ja) |
| JP (2) | JP2012531208A (ja) |
| KR (2) | KR20180017231A (ja) |
| CN (1) | CN102498210B (ja) |
| AU (1) | AU2010265949B2 (ja) |
| BR (1) | BRPI1015916A2 (ja) |
| CA (1) | CA2764729C (ja) |
| IL (1) | IL216796A (ja) |
| MX (1) | MX2012000129A (ja) |
| TW (1) | TWI560271B (ja) |
| WO (1) | WO2010151808A1 (ja) |
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| AU2010249046A1 (en) | 2009-05-13 | 2011-12-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to influenza viruses |
| ES2965212T3 (es) | 2009-07-08 | 2024-04-11 | Kymab Ltd | Modelos de animales y moléculas terapéuticas |
| US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| CA2806252C (en) | 2010-07-29 | 2019-05-14 | Xencor, Inc. | Antibodies with modified isoelectric points |
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| CA2846322A1 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
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-
2010
- 2010-06-25 US US12/824,058 patent/US8969082B2/en active Active
- 2010-06-25 CN CN201080034274.2A patent/CN102498210B/zh not_active Expired - Fee Related
- 2010-06-25 AU AU2010265949A patent/AU2010265949B2/en not_active Ceased
- 2010-06-25 JP JP2012517785A patent/JP2012531208A/ja not_active Withdrawn
- 2010-06-25 EP EP10729033.0A patent/EP2446032B8/en active Active
- 2010-06-25 CA CA2764729A patent/CA2764729C/en not_active Expired - Fee Related
- 2010-06-25 MX MX2012000129A patent/MX2012000129A/es active IP Right Grant
- 2010-06-25 TW TW099120923A patent/TWI560271B/zh not_active IP Right Cessation
- 2010-06-25 WO PCT/US2010/040052 patent/WO2010151808A1/en active Application Filing
- 2010-06-25 BR BRPI1015916-9A patent/BRPI1015916A2/pt not_active IP Right Cessation
- 2010-06-25 KR KR1020187003713A patent/KR20180017231A/ko not_active Application Discontinuation
- 2010-06-25 KR KR1020127001902A patent/KR101829073B1/ko active IP Right Grant
- 2010-06-25 EP EP16205172.6A patent/EP3205723A1/en not_active Withdrawn
-
2011
- 2011-12-06 IL IL216796A patent/IL216796A/en not_active IP Right Cessation
-
2015
- 2015-12-28 JP JP2015256676A patent/JP2016105714A/ja active Pending
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