JP2012528584A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012528584A5 JP2012528584A5 JP2012513641A JP2012513641A JP2012528584A5 JP 2012528584 A5 JP2012528584 A5 JP 2012528584A5 JP 2012513641 A JP2012513641 A JP 2012513641A JP 2012513641 A JP2012513641 A JP 2012513641A JP 2012528584 A5 JP2012528584 A5 JP 2012528584A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- polypeptide
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical group 0.000 claims 64
- 108090000765 processed proteins & peptides Proteins 0.000 claims 54
- 229920001184 polypeptide Polymers 0.000 claims 53
- 102000004196 processed proteins & peptides Human genes 0.000 claims 53
- 235000001014 amino acid Nutrition 0.000 claims 19
- 102220612213 Calcyclin-binding protein_E1D_mutation Human genes 0.000 claims 18
- 102220597331 Coiled-coil domain-containing protein 144A_Q108L_mutation Human genes 0.000 claims 18
- 102200133317 rs869025586 Human genes 0.000 claims 18
- 102220463950 rs7782939 Human genes 0.000 claims 16
- 101710160621 Fusion glycoprotein F0 Proteins 0.000 claims 11
- 102220571078 Growth arrest and DNA damage-inducible protein GADD45 gamma_A83R_mutation Human genes 0.000 claims 10
- 102220138536 rs146905561 Human genes 0.000 claims 10
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 8
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 8
- 102200007401 rs3755955 Human genes 0.000 claims 8
- 239000004475 Arginine Substances 0.000 claims 6
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 6
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 5
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical group 0.000 claims 5
- 239000002773 nucleotide Chemical group 0.000 claims 5
- 125000003729 nucleotide group Chemical group 0.000 claims 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 235000003704 aspartic acid Nutrition 0.000 claims 4
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 3
- 235000013922 glutamic acid Nutrition 0.000 claims 3
- 239000004220 glutamic acid Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 102220578068 ATPase MORC2_G78L_mutation Human genes 0.000 claims 2
- 102220549821 Ubiquitin-like protein 4A_R105E_mutation Human genes 0.000 claims 2
- 102220570985 Uncharacterized protein C7orf57_A74S_mutation Human genes 0.000 claims 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 102200092858 rs36084266 Human genes 0.000 claims 2
- 102220011971 rs397515737 Human genes 0.000 claims 2
- 206010006448 Bronchiolitis Diseases 0.000 claims 1
- 206010011224 Cough Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 206010013975 Dyspnoeas Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010024971 Lower respiratory tract infections Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 208000037656 Respiratory Sounds Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 206010046306 Upper respiratory tract infection Diseases 0.000 claims 1
- 206010047924 Wheezing Diseases 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940112141 dry powder inhaler Drugs 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 229930195712 glutamate Natural products 0.000 claims 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 102200043501 rs1800450 Human genes 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18439609P | 2009-06-05 | 2009-06-05 | |
| US61/184,396 | 2009-06-05 | ||
| US26501409P | 2009-11-30 | 2009-11-30 | |
| US61/265,014 | 2009-11-30 | ||
| PCT/EP2010/057921 WO2010139808A2 (en) | 2009-06-05 | 2010-06-07 | IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST HUMAN RESPIRATORY SYNCYTIAL VIRUS (hRSV) AND POLYPEPTIDES COMPRISING THE SAME FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY TRACT INFECTIONS |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017006690A Division JP6677659B2 (ja) | 2009-06-05 | 2017-01-18 | 気道感染症の予防及び／又は治療のためのヒト呼吸器合胞体ウイルス（ｈＲＳＶ）に指向性を有する改良アミノ酸配列及びこれを含むポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012528584A JP2012528584A (ja) | 2012-11-15 |
| JP2012528584A5 true JP2012528584A5 (enExample) | 2013-08-01 |
| JP6081196B2 JP6081196B2 (ja) | 2017-03-01 |
Family
ID=42333502
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513641A Expired - Fee Related JP6081196B2 (ja) | 2009-06-05 | 2010-06-07 | 気道感染症の予防及び／又は治療のためのヒト呼吸器合胞体ウイルス（ｈＲＳＶ）に指向性を有する改良アミノ酸配列及びこれを含むポリペプチド |
| JP2017006690A Expired - Fee Related JP6677659B2 (ja) | 2009-06-05 | 2017-01-18 | 気道感染症の予防及び／又は治療のためのヒト呼吸器合胞体ウイルス（ｈＲＳＶ）に指向性を有する改良アミノ酸配列及びこれを含むポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017006690A Expired - Fee Related JP6677659B2 (ja) | 2009-06-05 | 2017-01-18 | 気道感染症の予防及び／又は治療のためのヒト呼吸器合胞体ウイルス（ｈＲＳＶ）に指向性を有する改良アミノ酸配列及びこれを含むポリペプチド |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8945567B2 (enExample) |
| EP (2) | EP3205670A1 (enExample) |
| JP (2) | JP6081196B2 (enExample) |
| KR (1) | KR101852204B1 (enExample) |
| CN (2) | CN102459332B (enExample) |
| AU (1) | AU2010255638B2 (enExample) |
| BR (1) | BRPI1010830A2 (enExample) |
| CA (1) | CA2764398A1 (enExample) |
| CY (1) | CY1119265T1 (enExample) |
| DK (1) | DK2438087T3 (enExample) |
| ES (1) | ES2643034T3 (enExample) |
| HR (1) | HRP20171194T1 (enExample) |
| HU (1) | HUE035773T2 (enExample) |
| IL (1) | IL216341A0 (enExample) |
| LT (1) | LT2438087T (enExample) |
| MX (1) | MX340541B (enExample) |
| NZ (1) | NZ597314A (enExample) |
| PH (1) | PH12019500644A1 (enExample) |
| PL (1) | PL2438087T3 (enExample) |
| PT (1) | PT2438087T (enExample) |
| RU (2) | RU2577134C2 (enExample) |
| SG (1) | SG176095A1 (enExample) |
| SI (1) | SI2438087T1 (enExample) |
| SM (1) | SMT201700376T1 (enExample) |
| WO (1) | WO2010139808A2 (enExample) |
| ZA (1) | ZA201108892B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2285408T (lt) | 2008-06-05 | 2019-01-25 | Ablynx N.V. | Aminorūgščių sekos, nukreiptos prieš viruso apvalkalo baltymus, ir tokias sekas turintys polipeptidai, skirti virusinių ligų gydymui |
| PT2438087T (pt) | 2009-06-05 | 2017-08-04 | Ablynx Nv | Construções de nanobody trivalentes de vírus sincicial respiratório humano (hrsv) para a prevenção e/ou tratamento de infeções do trato respiratório |
| US9644022B2 (en) | 2009-11-30 | 2017-05-09 | Ablynx N.V. | Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
| EP3309176B1 (en) | 2009-12-14 | 2025-10-01 | Ablynx N.V. | Immunoglobulin single variable domain antibodies against ox40l, constructs and their therapeutic use |
| HUE044292T2 (hu) | 2010-02-11 | 2019-10-28 | Ablynx Nv | Eljárások és készítmények aeroszolok elõállítására |
| DK2632946T3 (en) | 2010-10-29 | 2018-03-12 | Ablynx Nv | PROCEDURE FOR MANUFACTURING VARIABLE IMMUNGLOBULIN SINGLE DOMAINS |
| EP3590950A1 (en) | 2011-05-09 | 2020-01-08 | Ablynx NV | Method for the production of immunoglobulin single varible domains |
| US11339208B1 (en) | 2012-05-31 | 2022-05-24 | United States Of America As Represented By The Secretary Of The Air Force | Camelidae single-domain antibodies against Yersinia pestis and methods of use |
| SG11201507424WA (en) | 2013-03-14 | 2015-10-29 | Macrogenics Inc | Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor |
| HK1225716A1 (zh) | 2013-08-21 | 2017-09-15 | Alios Biopharma, Inc. | 抗病毒化合物 |
| EP3177299A4 (en) * | 2014-08-05 | 2018-04-04 | Alios Biopharma, Inc. | Combination therapy for treating a paramyxovirus |
| MX386297B (es) | 2014-09-29 | 2025-03-18 | Univ Duke | Moleculas biespecificas que comprenden un brazo orientado a la envoltura vih-1. |
| RU2017115670A (ru) * | 2014-10-10 | 2018-11-15 | Аблинкс Н.В. | Лечение инфекции рсв |
| SG11201702699TA (en) | 2014-10-10 | 2017-04-27 | Ablynx Nv | Inhalation device for use in aerosol therapy of respiratory diseases |
| MA41614A (fr) | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
| EP3124042A1 (en) * | 2015-07-28 | 2017-02-01 | VIB, vzw | Immunoglobulin single variable domain antibody against rsv prefusion f protein |
| IL256315B2 (en) | 2015-06-18 | 2023-12-01 | Vib Vzw | Immunoglobulin single variable domain antibody against rsv prefusion f protein |
| US20190127447A1 (en) | 2016-05-02 | 2019-05-02 | Ablynx N.V. | Treatment of rsv infection |
| CA3029133C (en) | 2016-06-23 | 2024-04-30 | Ablynx N.V. | Improved pharmacokinetic assays for immunoglobulin single variable domains |
| CN106279410B (zh) * | 2016-09-29 | 2019-08-20 | 华南理工大学 | 一种二型登革热病毒ns1蛋白多价纳米抗体及制备方法 |
| CA3040893A1 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| CN110035771B (zh) | 2016-10-21 | 2024-03-08 | 阿迪马布有限责任公司 | 抗呼吸道合胞病毒抗体及其产生和使用方法 |
| WO2018075954A2 (en) | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| WO2018099968A1 (en) | 2016-11-29 | 2018-06-07 | Ablynx N.V. | Treatment of infection by respiratory syncytial virus (rsv) |
| US11725045B2 (en) | 2017-10-13 | 2023-08-15 | Mapp Biopharmaceutical, Inc. | Anti-respiratory syncytial virus antibodies, methods of their generation and use |
| JP7123607B2 (ja) * | 2018-04-09 | 2022-08-23 | シャープ株式会社 | ユーザ装置、制御装置、及び通信制御方法 |
| MX2021012335A (es) | 2019-04-10 | 2021-11-12 | Regeneron Pharma | Anticuerpos humanos que se unen a ret y metodos de uso de los mismos. |
| CN111748571B (zh) * | 2019-10-11 | 2022-05-03 | 浙江禾霖生物科技有限公司 | 一种将枯草芽孢杆菌工程化为生产纳米抗体的多功能稳定平台的方法 |
| WO2021108448A1 (en) | 2019-11-25 | 2021-06-03 | Mabloc, Llc | Anti-yellow fever virus antibodies, and methods of their generation and use |
| US20210230248A1 (en) * | 2020-01-25 | 2021-07-29 | Jun Chen | Multivalent pharmacophores for high avidity and overexpressed-target specific binding and uses thereof |
| US20240415974A1 (en) | 2022-12-23 | 2024-12-19 | Ablynx N.V. | Protein-based conjugation carriers |
| AR131869A1 (es) | 2023-02-17 | 2025-05-07 | Ablynx Nv | POLIPÉPTIDOS QUE SE UNEN AL RECEPTOR DE Fc NEONATAL |
| CN116693673B (zh) * | 2023-07-26 | 2023-10-20 | 中国人民解放军军事科学院军事医学研究院 | 广谱抗SARS和SARS-CoV-2的纳米抗体、多价纳米抗体及其应用 |
| WO2025133253A2 (en) | 2023-12-22 | 2025-06-26 | Ablynx Nv | Protein-based conjugation carriers for intranuclear delivery |
Family Cites Families (102)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1120945A (en) | 1964-08-11 | 1968-07-24 | Fisons Pharmaceuticals Ltd | Applicator in combination with a pressurised aerosol dispensing container |
| CA2001774C (en) | 1988-10-28 | 2001-10-16 | James A. Wells | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
| ATE102631T1 (de) | 1988-11-11 | 1994-03-15 | Medical Res Council | Klonierung von immunglobulin sequenzen aus den variabelen domaenen. |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| WO1991015581A1 (en) | 1990-04-05 | 1991-10-17 | Roberto Crea | Walk-through mutagenesis |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| WO1994002610A1 (en) | 1992-07-17 | 1994-02-03 | Dana-Farber Cancer Institute | Method of intracellular binding of target molecules |
| DE69330523D1 (de) | 1992-08-21 | 2001-09-06 | Vrije Universiteit Brussel Bru | Immunoglobuline ohne leichte ketten |
| ATE301201T1 (de) | 1993-06-07 | 2005-08-15 | Vical Inc | Für die gentherapie verwendbare plasmide |
| ES2155854T3 (es) | 1993-06-09 | 2001-06-01 | Unilever Nv | Procedimiento de produccion de proteinas de fusion que comprende fragmentos de scfv con la ayuda de un molde transformado. |
| US6091639A (en) | 1993-08-27 | 2000-07-18 | Kabushiki Kaisha Toshiba | Non-volatile semiconductor memory device and data programming method |
| DE69435112D1 (de) | 1993-09-10 | 2008-08-21 | Univ Columbia | Verwendung von grünem fluoreszenzprotein |
| WO1995021191A1 (en) | 1994-02-04 | 1995-08-10 | William Ward | Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein |
| WO1995022618A1 (en) | 1994-02-22 | 1995-08-24 | Dana-Farber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
| US5625048A (en) | 1994-11-10 | 1997-04-29 | The Regents Of The University Of California | Modified green fluorescent proteins |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| US5693492A (en) | 1995-05-05 | 1997-12-02 | Merck & Co., Inc. | DNA encoding glutamate gated chloride channels |
| US5811524A (en) * | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| AU723325B2 (en) | 1995-06-23 | 2000-08-24 | President And Fellows Of Harvard College | Transcriptional regulation of genes encoding vascular endothelial growth factor receptors |
| CA2232727C (en) | 1995-09-22 | 2002-03-26 | Novo Nordisk A/S | Novel variants of green fluorescent protein, gfp |
| US6027881A (en) | 1996-05-08 | 2000-02-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Mutant Aequorea victoria fluorescent proteins having increased cellular fluorescence |
| US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
| US6124128A (en) | 1996-08-16 | 2000-09-26 | The Regents Of The University Of California | Long wavelength engineered fluorescent proteins |
| JP2001510329A (ja) * | 1996-11-01 | 2001-07-31 | スミスクライン・ビーチャム・コーポレイション | ヒトモノクローナル抗体 |
| WO1998021355A1 (en) | 1996-11-15 | 1998-05-22 | Life Technologies, Inc. | Mutants of green fluorescent protein |
| AU7298398A (en) | 1996-11-19 | 1998-06-10 | Sangstat Medical Corporation | Enhanced effects for hapten conjugated therapeutics |
| US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| FR2766826B1 (fr) | 1997-08-04 | 2001-05-18 | Pasteur Institut | Vecteurs derives d'anticorps pour le transfert de substances dans les cellules |
| CN1316910A (zh) | 1998-02-19 | 2001-10-10 | 埃克斯西特治疗公司 | 用于调节淋巴细胞活化的组合物及方法 |
| GB9824632D0 (en) | 1998-11-10 | 1999-01-06 | Celltech Therapeutics Ltd | Biological compounds |
| WO2000046383A2 (en) | 1999-02-05 | 2000-08-10 | Rijksuniversiteit Leiden | Method of modulating metabolite biosynthesis in recombinant cells |
| AP1447A (en) | 1999-04-22 | 2005-08-12 | Unilever Plc | Inhibition of viral infection using monovalent antigen-binding proteins. |
| AR030019A1 (es) * | 1999-05-18 | 2003-08-13 | Smithkline Beecham Corp | Anticuerpos monoclonales humanos y fragmentos funcionales del mismo, un procedimiento para su produccion, composiciones farmaceuticas que los comprenden, una molecula aislada de acido nucleico, un plasmido recombinante, una celula hospedante y el uso de dichos anticuerpos para la manufactura de un m |
| EP1198572A2 (en) | 1999-08-02 | 2002-04-24 | Keygene N.V. | Method for generating cgmmv resistant plants, genetic constructs, and obtained cgmmv-resistant plants |
| GB9922124D0 (en) | 1999-09-17 | 1999-11-17 | Pfizer Ltd | Phosphodiesterase enzymes |
| US6849425B1 (en) | 1999-10-14 | 2005-02-01 | Ixsys, Inc. | Methods of optimizing antibody variable region binding affinity |
| DE19955408A1 (de) | 1999-11-18 | 2001-05-23 | Bayer Ag | GABA-B-Rezeptoren |
| JP2003518075A (ja) | 1999-12-24 | 2003-06-03 | ジェネンテック・インコーポレーテッド | 生理活性化合物の消失半減期延長のための方法及び組成物 |
| US6741957B1 (en) | 2000-07-21 | 2004-05-25 | Daimlerchrysler Corporation | Analytical tire model for vehicle durability and ride comfort analysis |
| US6818216B2 (en) | 2000-11-28 | 2004-11-16 | Medimmune, Inc. | Anti-RSV antibodies |
| US7054297B1 (en) | 2000-12-28 | 2006-05-30 | Cisco Technology, Inc. | Distribution of packets to high data rate communications devices using multicast protocols |
| US7829084B2 (en) | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| EP2316951A1 (en) | 2001-01-17 | 2011-05-04 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| CA2440582A1 (en) | 2001-03-09 | 2002-10-03 | Dyax Corp. | Serum albumin binding moieties |
| US20060073141A1 (en) | 2001-06-28 | 2006-04-06 | Domantis Limited | Compositions and methods for treating inflammatory disorders |
| WO2003002609A2 (en) | 2001-06-28 | 2003-01-09 | Domantis Limited | Dual-specific ligand and its use |
| EP1425694A2 (en) | 2001-08-03 | 2004-06-09 | Medical Research Council | Method of identifying a consensus sequence for intracellular antibodies |
| FR2829940A1 (fr) | 2001-09-27 | 2003-03-28 | Synt Em | Compositions pour la vectorisation d'anticorps a travers la barriere hematoencephalique et leur utilisation pour le diagnostic ou le traitement des maladies du systeme nerveux central |
| KR100599789B1 (ko) | 2001-12-03 | 2006-07-12 | 삼성에스디아이 주식회사 | 방열효율이 향상된 플라즈마 디스플레이 장치 및 그 제조방법 |
| AU2002351896A1 (en) | 2001-12-11 | 2003-06-23 | Ablynx N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| CA2468690A1 (en) | 2001-12-18 | 2003-06-26 | Innogenetics N.V. | Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use |
| KR100708398B1 (ko) | 2002-03-22 | 2007-04-18 | (주) 에이프로젠 | 인간화 항체 및 이의 제조방법 |
| US7132100B2 (en) * | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| AU2003244817B2 (en) | 2002-06-28 | 2010-08-26 | Domantis Limited | Antigen-binding immunoglobulin single variable domains and dual-specific constructs |
| US7004940B2 (en) | 2002-10-10 | 2006-02-28 | Ethicon, Inc. | Devices for performing thermal ablation having movable ultrasound transducers |
| AU2003284891A1 (en) | 2002-10-23 | 2004-05-13 | Ludwig Institute For Cancer Research | A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same |
| AU2003286002B2 (en) | 2002-11-08 | 2011-06-16 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| JP2006519763A (ja) | 2002-11-08 | 2006-08-31 | アブリンクス エン．ヴェー． | 治療用ポリペプチドの投与法およびそのためのポリペプチド |
| GB0230203D0 (en) | 2002-12-27 | 2003-02-05 | Domantis Ltd | Fc fusion |
| KR101025143B1 (ko) | 2002-12-31 | 2011-04-01 | 넥타르 테라퓨틱스 | 가수분해상으로 안정한 말레이미드－종결 중합체 |
| EP2390270A1 (en) | 2003-01-10 | 2011-11-30 | Ablynx N.V. | Therapeutic polypeptides, homologues thereof, fragments thereof and for use in modulating platelet-mediated aggregation |
| EP2395017A3 (en) | 2003-05-30 | 2012-12-19 | Merus B.V. | Design and use of paired variable regions of specific binding molecules |
| US7070786B2 (en) | 2003-06-06 | 2006-07-04 | Centocor, Inc. | RSV proteins, antibodies, compositions, methods and uses |
| WO2005003345A2 (en) | 2003-06-27 | 2005-01-13 | R. Crea & Co. | Look-through mutagenesis |
| DE502004012374D1 (de) | 2003-06-30 | 2011-05-19 | Siemens Ag | Verfahren zur überwachung des programmlaufs in einem mikro-computer |
| DE602004017726D1 (de) | 2003-06-30 | 2008-12-24 | Domantis Ltd | Pegylierte Single-domain-antikörper (dAb) |
| WO2005018629A1 (en) | 2003-08-12 | 2005-03-03 | Yarbrough William M | Treatment for acne vulgaris and method of use |
| EP1512696A1 (en) | 2003-08-14 | 2005-03-09 | Diatos | Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei |
| JP5912211B2 (ja) | 2004-01-20 | 2016-04-27 | メルス ビー．ヴィー． | 結合タンパク質の混合物 |
| WO2005079479A2 (en) * | 2004-02-17 | 2005-09-01 | Absalus, Inc. | Super-humanized antibodies against respiratory syncytial virus |
| US7207410B2 (en) | 2004-04-29 | 2007-04-24 | Daimlerchrysler Corporation | Apparatus and method for enhanced impact sensing |
| MXPA06014684A (es) | 2004-06-18 | 2007-02-12 | Ambrx Inc | Novedosos polipeptidos de enlace antigeno y sus usos. |
| US9012369B2 (en) | 2004-07-06 | 2015-04-21 | Pfizer Inc. | Look-through mutagenesis for developing altered polypeptides with enhanced properties |
| US7180370B2 (en) | 2004-09-01 | 2007-02-20 | Micron Technology, Inc. | CMOS amplifiers with frequency compensating capacitors |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| JP2008513540A (ja) | 2004-09-21 | 2008-05-01 | メディミューン，インコーポレーテッド | 呼吸器合胞体ウイルスに対する抗体及び該ウイルス用のワクチンを製造する方法 |
| JP5113523B2 (ja) | 2004-10-13 | 2013-01-09 | アブリンクス ナームローゼ フェンノートシャップ | アミロイド−βに対するナノ抗体及びアルツハイマー病のような神経変性疾患の治療のためのナノ抗体ＴＭを含むポリペプチド |
| TW200636064A (en) * | 2004-10-28 | 2006-10-16 | Centocor Inc | Anti-respiratory syncytial virus antibodies, antigens and uses thereof |
| CA2585891A1 (en) | 2004-10-29 | 2006-05-11 | Medimmune, Inc. | Methods of preventing and treating rsv infections and related conditions |
| CA2588892A1 (en) * | 2004-12-02 | 2006-06-08 | Dormantis Limited | Anti-il-1r1 single domain antibodies and therapeutic uses |
| CA2604032C (en) * | 2005-04-06 | 2017-08-22 | Ibc Pharmaceuticals, Inc. | Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses |
| JP4976376B2 (ja) | 2005-04-08 | 2012-07-18 | メディミューン，エルエルシー | 哺乳動物メタニューモウイルスに対する抗体 |
| EP2949668B1 (en) | 2005-05-18 | 2019-08-14 | Ablynx N.V. | Improved nanobodies tm against tumor necrosis factor-alpha |
| AU2007285695B2 (en) | 2006-08-18 | 2012-05-24 | Ablynx N.V. | Amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of diseases and disorders associated with IL-6-mediated signalling |
| EP2069402A2 (en) | 2006-09-08 | 2009-06-17 | Ablynx N.V. | Serum albumin binding proteins with long half-lives |
| US20100034194A1 (en) | 2006-10-11 | 2010-02-11 | Siemens Communications Inc. | Eliminating unreachable subscribers in voice-over-ip networks |
| EP2086998B1 (en) | 2006-10-11 | 2011-12-07 | Ablynx N.V. | Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the ph, compounds comprising the same, and use thereof |
| EP2081960B1 (en) | 2006-10-27 | 2018-06-27 | Ablynx N.V. | Intranasal delivery of polypeptides and proteins |
| US20080267949A1 (en) | 2006-12-05 | 2008-10-30 | Ablynx N.V. | Peptides capable of binding to serum proteins |
| WO2008077945A2 (en) | 2006-12-22 | 2008-07-03 | Ablynx N.V. | Anti-chemokine (ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain antibodies |
| AU2008270274B2 (en) | 2007-07-03 | 2012-06-28 | Ablynx N.V. | Providing improved immunoglobulin sequences by mutating CDR and/or FR positions |
| AU2008328779B2 (en) | 2007-11-27 | 2014-06-05 | Ablynx N.V. | Amino acid sequences directed against HER2 and polypeptides comprising the same for the treatment of cancers and/or tumors |
| EP2096121A1 (en) | 2008-02-29 | 2009-09-02 | Institut Pasteur Of Shanghai | Antiviral peptides comprising lipid attachment signals and methods of use |
| LT2285408T (lt) | 2008-06-05 | 2019-01-25 | Ablynx N.V. | Aminorūgščių sekos, nukreiptos prieš viruso apvalkalo baltymus, ir tokias sekas turintys polipeptidai, skirti virusinių ligų gydymui |
| AU2010205627B2 (en) | 2009-01-14 | 2015-04-02 | Ablynx Nv | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| WO2010125187A2 (en) | 2009-04-30 | 2010-11-04 | Ablynx Nv | Method for the production of domain antibodies |
| PT2438087T (pt) | 2009-06-05 | 2017-08-04 | Ablynx Nv | Construções de nanobody trivalentes de vírus sincicial respiratório humano (hrsv) para a prevenção e/ou tratamento de infeções do trato respiratório |
| US9644022B2 (en) | 2009-11-30 | 2017-05-09 | Ablynx N.V. | Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections |
-
2010
- 2010-06-07 PT PT107244972T patent/PT2438087T/pt unknown
- 2010-06-07 CN CN201080024764.4A patent/CN102459332B/zh not_active Expired - Fee Related
- 2010-06-07 SM SM20170376T patent/SMT201700376T1/it unknown
- 2010-06-07 PL PL10724497T patent/PL2438087T3/pl unknown
- 2010-06-07 LT LTEP10724497.2T patent/LT2438087T/lt unknown
- 2010-06-07 NZ NZ597314A patent/NZ597314A/xx not_active IP Right Cessation
- 2010-06-07 AU AU2010255638A patent/AU2010255638B2/en not_active Ceased
- 2010-06-07 RU RU2011153239/10A patent/RU2577134C2/ru active
- 2010-06-07 DK DK10724497.2T patent/DK2438087T3/en active
- 2010-06-07 EP EP17162779.7A patent/EP3205670A1/en not_active Withdrawn
- 2010-06-07 BR BRPI1010830A patent/BRPI1010830A2/pt not_active IP Right Cessation
- 2010-06-07 SI SI201031523T patent/SI2438087T1/sl unknown
- 2010-06-07 EP EP10724497.2A patent/EP2438087B1/en active Active
- 2010-06-07 JP JP2012513641A patent/JP6081196B2/ja not_active Expired - Fee Related
- 2010-06-07 RU RU2016103067A patent/RU2016103067A/ru unknown
- 2010-06-07 ES ES10724497.2T patent/ES2643034T3/es active Active
- 2010-06-07 WO PCT/EP2010/057921 patent/WO2010139808A2/en not_active Ceased
- 2010-06-07 KR KR1020127000199A patent/KR101852204B1/ko not_active Expired - Fee Related
- 2010-06-07 CN CN201510509040.3A patent/CN105061592A/zh active Pending
- 2010-06-07 SG SG2011084274A patent/SG176095A1/en unknown
- 2010-06-07 CA CA2764398A patent/CA2764398A1/en not_active Abandoned
- 2010-06-07 HR HRP20171194TT patent/HRP20171194T1/hr unknown
- 2010-06-07 US US13/375,357 patent/US8945567B2/en active Active
- 2010-06-07 MX MX2011013013A patent/MX340541B/es active IP Right Grant
- 2010-06-07 HU HUE10724497A patent/HUE035773T2/en unknown
-
2011
- 2011-11-02 ZA ZA2011/08892A patent/ZA201108892B/en unknown
- 2011-11-14 IL IL216341A patent/IL216341A0/en unknown
-
2014
- 2014-09-29 US US14/499,772 patent/US9803001B2/en active Active
-
2017
- 2017-01-18 JP JP2017006690A patent/JP6677659B2/ja not_active Expired - Fee Related
- 2017-08-08 CY CY20171100847T patent/CY1119265T1/el unknown
- 2017-09-22 US US15/712,247 patent/US11028151B2/en active Active
-
2019
- 2019-03-25 PH PH12019500644A patent/PH12019500644A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012528584A5 (enExample) | ||
| RU2011153239A (ru) | Улучшенные аминокислотные последовательности, направленные против респираторно-синцитиального вируса человека (hrsv), и полипептиды, включающие такие последовательности, для профилактики и/или лечения инфекций дыхательных путей | |
| CN113563463B (zh) | 一种抗新型冠状病毒SARS-CoV-2的中和纳米抗体及其应用 | |
| JP6790212B2 (ja) | ヌクレオチド・ライブラリー | |
| JP2012095652A5 (enExample) | ||
| JP2011087580A5 (enExample) | ||
| JP7330517B2 (ja) | 異種タンパク質産生のための人工分泌ペプチド | |
| JP2010518833A5 (enExample) | ||
| JP2008536483A5 (enExample) | ||
| JP2016533332A5 (enExample) | ||
| CN104233474A (zh) | 一种合成的噬菌体展示纳米抗体文库及其应用 | |
| US20170305988A1 (en) | Method of using a peptide library | |
| JP2019502404A5 (enExample) | ||
| JP2019520083A5 (enExample) | ||
| CN107903307B (zh) | 一种高亲和力edb-fn蛋白靶向肽及其应用 | |
| CN102757482A (zh) | 一种多肽及其应用 | |
| CN118420715B (zh) | 一种结合fgfr2受体的多肽及其用途 | |
| WO2017149117A1 (en) | Polypeptide library | |
| CN106928358A (zh) | 一种CD105纳米抗体Nb168 | |
| EP3517542B1 (en) | Dendritic-cell-targeted peptide, fusion peptide utilizing said peptide, and vaccine utilizing said fusion peptide | |
| CN116120438B (zh) | 靶向新型冠状病毒rbd结构域的纳米抗体及其衍生蛋白 | |
| JP2011512120A5 (enExample) | ||
| CN106928360A (zh) | 一种CD105纳米抗体Nb68 | |
| JP6951713B2 (ja) | ＩｇＧ結合性ペプチド | |
| CN106928359B (zh) | 一种CD105纳米抗体Nb59 |