JP2012526530A5 - - Google Patents
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- Publication number
- JP2012526530A5 JP2012526530A5 JP2012510274A JP2012510274A JP2012526530A5 JP 2012526530 A5 JP2012526530 A5 JP 2012526530A5 JP 2012510274 A JP2012510274 A JP 2012510274A JP 2012510274 A JP2012510274 A JP 2012510274A JP 2012526530 A5 JP2012526530 A5 JP 2012526530A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- acid sequence
- axl
- amino acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 150000007523 nucleic acids Chemical group 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 230000003463 hyperproliferative effect Effects 0.000 claims 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004196 processed proteins & peptides Human genes 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 206010027476 Metastases Diseases 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 1
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 1
- 101000795659 Homo sapiens Tuberin Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 102000019149 MAP kinase activity proteins Human genes 0.000 claims 1
- 108040008097 MAP kinase activity proteins Proteins 0.000 claims 1
- 108091008611 Protein Kinase B Proteins 0.000 claims 1
- 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims 1
- 102100024908 Ribosomal protein S6 kinase beta-1 Human genes 0.000 claims 1
- 101710108924 Ribosomal protein S6 kinase beta-1 Proteins 0.000 claims 1
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 102100031638 Tuberin Human genes 0.000 claims 1
- 230000033115 angiogenesis Effects 0.000 claims 1
- 230000006909 anti-apoptosis Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000012292 cell migration Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000007783 downstream signaling Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09006355.3 | 2009-05-11 | ||
| EP09006355A EP2270053A1 (en) | 2009-05-11 | 2009-05-11 | Humanized AXL antibodies |
| EP09006474 | 2009-05-13 | ||
| EP09006474.2 | 2009-05-13 | ||
| PCT/EP2010/056487 WO2010130751A1 (en) | 2009-05-11 | 2010-05-11 | Humanized axl antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015188556A Division JP2016011306A (ja) | 2009-05-11 | 2015-09-25 | ヒト化ａｘｌ抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526530A JP2012526530A (ja) | 2012-11-01 |
| JP2012526530A5 true JP2012526530A5 (enExample) | 2013-06-20 |
| JP5909442B2 JP5909442B2 (ja) | 2016-04-26 |
Family
ID=42272537
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510274A Expired - Fee Related JP5909442B2 (ja) | 2009-05-11 | 2010-05-11 | ヒト化ａｘｌ抗体 |
| JP2015188556A Pending JP2016011306A (ja) | 2009-05-11 | 2015-09-25 | ヒト化ａｘｌ抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015188556A Pending JP2016011306A (ja) | 2009-05-11 | 2015-09-25 | ヒト化ａｘｌ抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US8841424B2 (enExample) |
| EP (1) | EP2430050A1 (enExample) |
| JP (2) | JP5909442B2 (enExample) |
| KR (1) | KR20120035145A (enExample) |
| CN (1) | CN102421802B (enExample) |
| AR (1) | AR076564A1 (enExample) |
| AU (1) | AU2010247464B2 (enExample) |
| BR (1) | BRPI1013428A2 (enExample) |
| CA (1) | CA2759836A1 (enExample) |
| IL (1) | IL216147A (enExample) |
| MX (1) | MX2011011825A (enExample) |
| RU (2) | RU2571224C2 (enExample) |
| TW (2) | TWI526223B (enExample) |
| WO (1) | WO2010130751A1 (enExample) |
| ZA (1) | ZA201107529B (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5909442B2 (ja) * | 2009-05-11 | 2016-04-26 | ユー３・ファーマ・ゲーエムベーハー | ヒト化ａｘｌ抗体 |
| EP2483289B2 (en) | 2009-10-02 | 2025-03-26 | Biogen MA Inc. | Methods of preventing and removing trisulfide bonds |
| US9562252B2 (en) | 2011-05-13 | 2017-02-07 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
| US9409988B2 (en) * | 2011-06-22 | 2016-08-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Anti-Axl antibodies and uses thereof |
| JP6033293B2 (ja) * | 2011-06-22 | 2016-11-30 | インサーム（インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル）Ｉｎｓｅｒｍ（Ｉｎｓｔｉｔｕｔ Ｎａｔｉｏｎａｌ Ｄｅｌａ Ｓａｎｔｅ Ｅｔ Ｄｅ Ｌａ Ｒｅｃｈｅｒｃｈｅ Ｍｅｄｉｃａｌｅ） | 抗Ａｘｌ抗体及びその使用 |
| EP2589609A1 (en) * | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
| US9879061B2 (en) | 2011-12-15 | 2018-01-30 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of AXL/GAS6 signaling in the treatment of liver fibrosis |
| CA2890265C (en) * | 2012-11-05 | 2023-01-17 | Pierre Fabre Medicament | Antigen binding proteins and their use as addressing product for the treatment of cancer |
| PT3326622T (pt) | 2012-12-14 | 2021-04-07 | Univ Leland Stanford Junior | Péptidos axl modificados e sua utilização na inibição da sinalização de axl em terapêutica anti-metastática |
| EP3229836B1 (en) * | 2014-12-09 | 2019-11-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Human monoclonal antibodies against axl |
| EP3233119A2 (en) | 2014-12-18 | 2017-10-25 | Bergen Teknologioverforing AS | Anti-axl antagonistic antibodies |
| GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
| US10787517B2 (en) | 2015-05-18 | 2020-09-29 | Agensys, Inc. | Antibodies that bind to AXL proteins |
| JP6857138B2 (ja) * | 2015-05-18 | 2021-04-14 | アジェンシス，インコーポレイテッド | Ａｘｌタンパク質に結合する抗体 |
| GB201509338D0 (en) | 2015-05-29 | 2015-07-15 | Bergenbio As | Combination therapy |
| CA2991805A1 (en) | 2015-07-10 | 2017-01-19 | Genmab A/S | Axl-specific antibody-drug conjugates for cancer treatment |
| EP4349997A3 (en) | 2015-09-24 | 2024-07-10 | Daiichi Sankyo Company, Limited | Anti-garp antibody |
| AU2017248644B2 (en) * | 2016-04-15 | 2019-10-31 | Bioatla, Llc | Anti-Axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
| GB201610902D0 (en) | 2016-06-22 | 2016-08-03 | Bergen Teknologioverforing As And Bergenbio As | Anti-Axl Antagonistic Antibodies |
| CN110536703B (zh) | 2017-04-20 | 2024-07-12 | Adc治疗有限公司 | 使用抗axl抗体-药物缀合物的组合疗法 |
| CN110540592B (zh) * | 2018-05-29 | 2022-08-09 | 杭州尚健生物技术有限公司 | 结合axl蛋白的抗体及其应用 |
| CN109160941B (zh) * | 2018-09-29 | 2020-09-04 | 未名生物医药有限公司 | 蛋白序列17e11及其用途 |
| RU2678569C1 (ru) * | 2018-10-31 | 2019-01-30 | Гордейчук Владимир Евгеньевич | Способ подавления метастазирования опухолей |
| GB201912059D0 (en) | 2019-08-22 | 2019-10-09 | Bergenbio As | Combaination therapy of a patient subgroup |
| CN110982791A (zh) * | 2019-12-26 | 2020-04-10 | 百泰生物药业有限公司 | 一种分泌axl抗体的杂交瘤细胞的制备筛选方法 |
| EP4087657A1 (en) | 2020-01-08 | 2022-11-16 | Synthis Therapeutics, Inc. | Alk5 inhibitor conjugates and uses thereof |
| BR112022015977A2 (pt) * | 2020-02-28 | 2022-10-11 | Symphogen As | Anticorpos anti-axl e composições |
| GB202004189D0 (en) | 2020-03-23 | 2020-05-06 | Bergenbio As | Combination therapy |
| IL297132A (en) | 2020-04-08 | 2022-12-01 | Bergenbio Asa | axl inhibitors for antiviral therapy |
| GB202006072D0 (en) | 2020-04-24 | 2020-06-10 | Bergenbio Asa | Method of selecting patients for treatment with cmbination therapy |
| MX2023008744A (es) | 2021-01-29 | 2023-10-02 | Illimis Therapeutics Inc | Molecula de fusion que tiene actividad no inflamatoria inductora de la fagocitosis. |
| GB202104037D0 (en) | 2021-03-23 | 2021-05-05 | Bergenbio Asa | Combination therapy |
| CN115927243A (zh) * | 2022-09-13 | 2023-04-07 | 中山大学 | 一种akt1蛋白的抑制性磷酸化位点及其应用 |
| CN116715774B (zh) * | 2023-05-12 | 2023-11-24 | 武汉爱博泰克生物科技有限公司 | 针对人axl的兔单克隆抗体及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4931385A (en) * | 1985-06-24 | 1990-06-05 | Hygeia Sciences, Incorporated | Enzyme immunoassays and immunologic reagents |
| DE3900534A1 (de) | 1989-01-10 | 1990-07-12 | Boehringer Mannheim Gmbh | Diagnostischer nachweis unter verwendung von chimaeren antikoerpern |
| US5468634A (en) | 1991-06-24 | 1995-11-21 | The University Of North Carolina At Chapel Hill | Axl oncogene |
| JP2000511403A (ja) * | 1996-03-20 | 2000-09-05 | イムノメディクス，インコーポレイテッド | 抗癌胎児抗原抗イディオタイプ抗体のヒト化と腫瘍ワクチンとしての使用及びターゲッティング用途のための使用 |
| JP2003501096A (ja) | 1999-06-07 | 2003-01-14 | ネオルクス コーポレイション | ストレプトアビジン発現性遺伝子融合およびその使用方法 |
| EP1382969A1 (en) * | 2002-07-17 | 2004-01-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Diagnosis and prevention of cancer cell invasion |
| HN2004000285A (es) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| EP2385069A3 (en) | 2003-11-12 | 2012-05-30 | Biogen Idec MA Inc. | Neonatal Fc rReceptor (FcRn)- binding polypeptide variants, dimeric Fc binding proteins and methods related thereto |
| JP2008520186A (ja) | 2004-10-01 | 2008-06-19 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 哺乳類ｅａｇ１イオンチャネルタンパク質に対する新規の抗体 |
| LT2620450T (lt) | 2005-03-08 | 2019-02-11 | Pfizer Products Inc. | Anti-ctla-4 antikūnų kompozicijos |
| WO2006104989A2 (en) | 2005-03-29 | 2006-10-05 | Verenium Corporation | Altered antibody fc regions and uses thereof |
| DK2390267T3 (da) * | 2005-06-07 | 2013-08-26 | Esbatech A Novartis Co Llc | Stabile og opløselige antistoffer, der hæmmer TNF(alfa) |
| WO2009005813A1 (en) | 2007-07-02 | 2009-01-08 | Wyeth | Modulators of axl for use in treating bone disorders |
| EP2217716A4 (en) * | 2007-11-09 | 2011-02-09 | Salk Inst For Biological Studi | USE OF TAM RECEPTOR INHIBITORS AS ANTIMICROBIAL AGENTS |
| CA2705164A1 (en) * | 2007-11-12 | 2009-05-22 | U3 Pharma Gmbh | Axl antibodies |
| JP5909442B2 (ja) * | 2009-05-11 | 2016-04-26 | ユー３・ファーマ・ゲーエムベーハー | ヒト化ａｘｌ抗体 |
-
2010
- 2010-05-11 JP JP2012510274A patent/JP5909442B2/ja not_active Expired - Fee Related
- 2010-05-11 MX MX2011011825A patent/MX2011011825A/es active IP Right Grant
- 2010-05-11 CN CN201080020597.6A patent/CN102421802B/zh not_active Expired - Fee Related
- 2010-05-11 CA CA2759836A patent/CA2759836A1/en not_active Abandoned
- 2010-05-11 RU RU2011150183/10A patent/RU2571224C2/ru not_active IP Right Cessation
- 2010-05-11 AU AU2010247464A patent/AU2010247464B2/en not_active Ceased
- 2010-05-11 TW TW103142582A patent/TWI526223B/zh not_active IP Right Cessation
- 2010-05-11 TW TW099114946A patent/TW201105348A/zh unknown
- 2010-05-11 US US13/320,060 patent/US8841424B2/en not_active Expired - Fee Related
- 2010-05-11 AR ARP100101604A patent/AR076564A1/es unknown
- 2010-05-11 EP EP10718217A patent/EP2430050A1/en not_active Withdrawn
- 2010-05-11 BR BRPI1013428A patent/BRPI1013428A2/pt not_active IP Right Cessation
- 2010-05-11 WO PCT/EP2010/056487 patent/WO2010130751A1/en not_active Ceased
- 2010-05-11 KR KR1020117026757A patent/KR20120035145A/ko not_active Ceased
-
2011
- 2011-10-13 ZA ZA2011/07529A patent/ZA201107529B/en unknown
- 2011-11-03 IL IL216147A patent/IL216147A/en not_active IP Right Cessation
-
2014
- 2014-07-15 US US14/331,709 patent/US20150037323A1/en not_active Abandoned
-
2015
- 2015-09-25 JP JP2015188556A patent/JP2016011306A/ja active Pending
- 2015-11-03 RU RU2015147287A patent/RU2015147287A/ru not_active Application Discontinuation
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