JP2013531655A5 - - Google Patents

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Publication number
JP2013531655A5
JP2013531655A5 JP2013514691A JP2013514691A JP2013531655A5 JP 2013531655 A5 JP2013531655 A5 JP 2013531655A5 JP 2013514691 A JP2013514691 A JP 2013514691A JP 2013514691 A JP2013514691 A JP 2013514691A JP 2013531655 A5 JP2013531655 A5 JP 2013531655A5
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JP
Japan
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antibody
fragment
hybridoma
seq
produced
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JP2013514691A
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English (en)
Japanese (ja)
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JP2013531655A (ja
JP6081911B2 (ja
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Priority claimed from PCT/EP2011/059868 external-priority patent/WO2011157724A1/en
Publication of JP2013531655A publication Critical patent/JP2013531655A/ja
Publication of JP2013531655A5 publication Critical patent/JP2013531655A5/ja
Application granted granted Critical
Publication of JP6081911B2 publication Critical patent/JP6081911B2/ja
Expired - Fee Related legal-status Critical Current
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JP2013514691A 2010-06-14 2011-06-14 Ｓ１００ａ４抗体およびその治療上の使用 Expired - Fee Related JP6081911B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10382170.8 2010-06-14
EP10382170 2010-06-14
PCT/EP2011/059868 WO2011157724A1 (en) 2010-06-14 2011-06-14 S100a4 antibodies and therapeutic uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017007296A Division JP6564408B2 (ja) 2010-06-14 2017-01-19 Ｓ１００ａ４抗体およびその治療上の使用

Publications (3)

Publication Number Publication Date
JP2013531655A JP2013531655A (ja) 2013-08-08
JP2013531655A5 true JP2013531655A5 (enExample) 2014-07-31
JP6081911B2 JP6081911B2 (ja) 2017-02-15

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ID=43617041

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013514691A Expired - Fee Related JP6081911B2 (ja) 2010-06-14 2011-06-14 Ｓ１００ａ４抗体およびその治療上の使用
JP2017007296A Expired - Fee Related JP6564408B2 (ja) 2010-06-14 2017-01-19 Ｓ１００ａ４抗体およびその治療上の使用

Family Applications After (1)

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JP2017007296A Expired - Fee Related JP6564408B2 (ja) 2010-06-14 2017-01-19 Ｓ１００ａ４抗体およびその治療上の使用

Country Status (22)

Country Link
US (2) US8916152B2 (enExample)
EP (1) EP2580240B1 (enExample)
JP (2) JP6081911B2 (enExample)
KR (1) KR101869413B1 (enExample)
CN (1) CN103201290B (enExample)
AU (3) AU2011267089B2 (enExample)
BR (1) BR112012032008B1 (enExample)
CA (1) CA2802631C (enExample)
CL (1) CL2012003538A1 (enExample)
CY (1) CY1121742T1 (enExample)
DK (1) DK2580240T3 (enExample)
ES (1) ES2717908T3 (enExample)
IL (1) IL223667B (enExample)
LT (1) LT2580240T (enExample)
MX (1) MX347734B (enExample)
NZ (1) NZ604643A (enExample)
PL (1) PL2580240T3 (enExample)
PT (1) PT2580240T (enExample)
RU (1) RU2615684C2 (enExample)
SM (1) SMT201900219T1 (enExample)
TR (1) TR201903026T4 (enExample)
WO (1) WO2011157724A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103201290B (zh) * 2010-06-14 2016-09-28 莱克拉生物医学股份公司 S100a4抗体及其治疗用途
EP3252076B1 (en) 2011-01-14 2019-09-04 The Regents Of The University Of California Diagnostic use of antibodies against ror-1 protein
RU2484096C1 (ru) * 2012-02-08 2013-06-10 Общество с ограниченной ответственностью "Технофарма" ОДНОДОМЕННОЕ АНТИТЕЛО, СПЕЦИФИЧЕСКИ СВЯЗЫВАЮЩЕЕ БЕЛОК S100A4/Mts1, ПРИМЕНЕНИЕ ПОЛУЧЕННОГО АНТИТЕЛА ДЛЯ ДЕТЕКЦИИ ЭТОГО БЕЛКА
GB201219487D0 (en) 2012-10-30 2012-12-12 Cancer Rec Tech Ltd Anti-S100A4 antibody molecules and their uses
WO2014073653A1 (ja) * 2012-11-09 2014-05-15 国立大学法人福井大学 腎炎の病変部位の検査方法およびそのための試薬
JP2014094919A (ja) * 2012-11-09 2014-05-22 Univ Of Fukui 腎炎の予防または治療剤
ES2639227T3 (es) 2013-04-09 2017-10-25 Lykera Biomed S.A. Anticuerpos anti S100A7 para el tratamiento y diagnóstico de cáncer
CN107375923A (zh) * 2017-07-06 2017-11-24 北京多赢时代转化医学研究院 抗s100a4抗体在抗cd137抗体介导抗肿瘤免疫损伤中的应用
CN112083167B (zh) * 2019-06-14 2024-03-26 复旦大学附属华山医院 S100a4作为评估甲氨蝶呤干预银屑病的生物标记物及其用途
WO2021011608A1 (en) * 2019-07-15 2021-01-21 University Of Connecticut Metallothionein antibodies and their use
KR102151133B1 (ko) * 2019-12-27 2020-09-02 주식회사 인투앱 프로피오니박테리움 아크네스에 특이적으로 결합하는 신규한 항체 및 이의 용도
CN115052663B (zh) 2020-01-08 2026-06-09 辛瑟斯治疗股份有限公司 Alk5抑制剂缀合物及其用途
WO2022003042A1 (en) 2020-06-30 2022-01-06 Arxx Therapeutics As Anti-s100a4 antibodies for the treatment of systemic sclerosis
EP4291579A1 (en) * 2021-02-09 2023-12-20 Arxx Therapeutics AS Anti-s100a4 humanized antibodies, uses and methods
CN113718029A (zh) * 2021-10-22 2021-11-30 中国人民解放军北部战区总医院 S100a4蛋白在动脉粥样硬化性肾动脉狭窄诊断中的应用
EP4433084A1 (en) * 2021-11-19 2024-09-25 Lykera Biomed, S.A. Treatment and diagnosis of diseases associated to pathogenic fibrosis
CN117686722B (zh) * 2023-12-20 2024-08-09 内蒙古元牛繁育科技有限公司 一种s100a4纳米抗体及其应用

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263428A (en) 1978-03-24 1981-04-21 The Regents Of The University Of California Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same
DE3169595D1 (en) 1980-11-10 1985-05-02 Gersonde Klaus Method of preparing lipid vesicles by ultrasonic treatment, the use of this method and apparatus for its application
JPS57106673A (en) 1980-12-24 1982-07-02 Chugai Pharmaceut Co Ltd Dibenzo(b,f)(1,4)oxazepin derivative
EP0088046B1 (de) 1982-02-17 1987-12-09 Ciba-Geigy Ag Lipide in wässriger Phase
EP0143949B1 (en) 1983-11-01 1988-10-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US6638504B1 (en) 1990-07-09 2003-10-28 Research Corporation Technologies, Inc. Methods for treating cancer
CA2086829A1 (en) * 1990-07-09 1992-01-10 Sayeeda Zain Diagnosis of metastatic cancer by the mts-1 gene
US5798257A (en) * 1990-07-09 1998-08-25 Research Corporation Technologies, Inc. Nucleic acid encoding human MTS-1 protein
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
JP3540315B2 (ja) 1991-09-23 2004-07-07 メディカル リサーチ カウンシル キメラ抗体の製造−組合せアプローチ
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
CA2163032C (en) 1993-06-03 2001-02-06 John Landon Antibody fragments in therapy
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
US6113898A (en) 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US5922845A (en) 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
GB9806530D0 (en) 1998-03-26 1998-05-27 Glaxo Group Ltd Inflammatory mediator
DE19915485A1 (de) 1999-04-07 2000-10-19 Hugo A Katus Therapie der Herzinsuffizienz
WO2000064468A2 (en) * 1999-04-23 2000-11-02 Research Corporation Technologies Therapeutic compositions and methods for enhancing angiogenesis
DE10017249A1 (de) 2000-04-06 2001-10-11 Peter Solisch In-Vitro-Verfahren zur Feststellung bösartiger Tumore in der Human- und Veterinärmedizin
GB0120238D0 (en) 2001-08-20 2001-10-10 Univ College Of London Sodium channel regulators and modulators
US20060270618A1 (en) 2001-12-18 2006-11-30 Dorian Bevec Novel pharmaceutical composition of interferon gamma or pirfenidone with molecular diagnostics for the improved treatment of interstitial lung diseases
JP2005532036A (ja) 2002-01-09 2005-10-27 理化学研究所 癌プロフィール
JP2004198419A (ja) 2002-12-13 2004-07-15 Bayer Healthcare Llc Ｔｉｍｐ１を用いた検出方法
US20040229225A1 (en) 2003-05-16 2004-11-18 Jose Remacle Determination of a general three-dimensional status of a cell by multiple gene expression analysis on micro-arrays
US20050208518A1 (en) 2003-05-16 2005-09-22 Longueville Francoise D Method and apparatus for determination of RNAi cell transfection effects by multiple gene expression analysis on micro-arrays
CA2530506A1 (en) 2003-07-04 2005-01-13 Johnson & Johnson Research Pty. Limited Method for detection of alkylated cytosine in dna
JP2007501002A (ja) 2003-08-01 2007-01-25 ザ ユニバーシティ オブ ウェスタン オーストラリア 癌治療の成功の可能性を予測するための方法及びキット
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
EP1759010A4 (en) 2004-01-07 2008-12-24 Bristol Myers Squibb Co BIOMARKERS AND METHOD FOR DETERMINING SENSITIVITY AGAINST MODULATORS OF EGF (EPIDERMAL GROWTH FACTOR) RECEPTORS
US20080193932A1 (en) 2004-11-05 2008-08-14 University Of Rochester Methods Of Inhibiting the Activity of Hsp90 and/or Aryl Hydrocarbon Receptor
KR100664589B1 (ko) 2004-12-28 2007-01-04 김현기 인간 암 억제 유전자, 이에 의해 코딩되는 단백질, 및이를 포함하는 발현 벡터
US20080307537A1 (en) 2005-03-31 2008-12-11 Dana-Farber Cancer Institute, Inc. Compositions and Methods for the Identification, Assessment, Prevention, and Therapy of Neurological Diseases, Disorders and Conditions
US20060269948A1 (en) 2005-05-16 2006-11-30 Halloran Philip F Tissue rejection
US7666596B2 (en) 2005-05-23 2010-02-23 University Of Alberta Tissue rejection
WO2007072225A2 (en) 2005-12-01 2007-06-28 Medical Prognosis Institute Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
EP2121740A2 (en) * 2005-12-20 2009-11-25 Copenhagen University Neuritogenic and neuronal survival promoting peptides derived from the family of s-100 proteins
US7972785B2 (en) 2006-01-24 2011-07-05 Industrial Technology Research Institute (Itri) Biomarkers for liver fibrotic injury
JP2007263896A (ja) 2006-03-29 2007-10-11 Univ Nagoya 肺癌患者の術後予後予測のための生物マーカー及びその方法
JP5420396B2 (ja) 2006-04-28 2014-02-19 シンガポール ヘルス サービシーズ ピーティーイー リミテッド 粘膜乾燥状態に関する検討
WO2008030278A2 (en) 2006-06-05 2008-03-13 Fred Hutchinson Cancer Research Center Assays for radiation exposure
US7811778B2 (en) 2006-09-06 2010-10-12 Vanderbilt University Methods of screening for gastrointestinal cancer
WO2008037432A2 (en) 2006-09-27 2008-04-03 Charité - Universitätsmedizin Berlin METHODS FOR DIAGNOSING METASTASIS BY ANALYZING MUTATIONS IN β-CATENIN
EP2092075A2 (en) 2006-11-06 2009-08-26 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring and treatment of melanoma
US20100196889A1 (en) 2006-11-13 2010-08-05 Bankaitis-Davis Danute M Gene Expression Profiling for Identification, Monitoring and Treatment of Colorectal Cancer
EP2087140A2 (en) 2006-11-13 2009-08-12 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring, and treatment of lung cancer
DE102006056784A1 (de) 2006-12-01 2008-06-05 Meyer, Helmut E., Prof.Dr. Biomarker für die Diagnose von Pankreaskrebs
WO2008073290A1 (en) 2006-12-08 2008-06-19 The Board Of Trustees Of The University Of Arkansas Tp53 gene expression and uses thereof
WO2008079269A2 (en) 2006-12-19 2008-07-03 Genego, Inc. Novel methods for functional analysis of high-throughput experimental data and gene groups identified therfrom
WO2008079406A2 (en) 2006-12-19 2008-07-03 Genentech, Inc. Gene expression markers for inflammatory bowel disease
US20080161203A1 (en) 2006-12-27 2008-07-03 Su Chun-Lin Markers identified for liver fibrosis and cirrhosis and the microarray panel thereof
JP2010517510A (ja) 2007-01-09 2010-05-27 ブリストル−マイヤーズ スクイブ カンパニー 前立腺細胞中のタンパク質チロシンキナーゼおよび／またはタンパク質チロシンキナーゼ経路と相互作用しかつ／またはそれを調節する化合物の活性を予測するためのポリヌクレオチドの同定
EP2155897A2 (en) 2007-03-30 2010-02-24 Source Precision Medicine, Inc. d/b/a Source MDX. Gene expression profiling for identification, monitoring, and treatment of prostate cancer
AU2007350900A1 (en) 2007-04-05 2008-10-16 Source Precision Medicine, Inc. Gene expression profiling for identification, monitoring and treatment of ovarian cancer
CA2682916A1 (en) 2007-04-06 2008-11-27 Source Precision Medicine, Inc. D/B/A Source Mdx Gene expression profiling for identification, monitoring, and treatment of cervical cancer
WO2008137552A2 (en) 2007-05-02 2008-11-13 Medimmune, Llc Anti-rage antibodies and methods of use thereof
WO2009046267A1 (en) 2007-10-05 2009-04-09 University Of Virginia Patent Foundation Protein-based biomarkers for abdominal aortic aneurysm
CN103201290B (zh) * 2010-06-14 2016-09-28 莱克拉生物医学股份公司 S100a4抗体及其治疗用途

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