JP2012526519A5 - - Google Patents
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- Publication number
- JP2012526519A5 JP2012526519A5 JP2011548451A JP2011548451A JP2012526519A5 JP 2012526519 A5 JP2012526519 A5 JP 2012526519A5 JP 2011548451 A JP2011548451 A JP 2011548451A JP 2011548451 A JP2011548451 A JP 2011548451A JP 2012526519 A5 JP2012526519 A5 JP 2012526519A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- apc
- amino acid
- agent
- ctl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 24
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 9
- 150000001413 amino acids Chemical group 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 8
- 239000002157 polynucleotide Substances 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 8
- 108091033319 polynucleotide Proteins 0.000 claims 8
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 230000001939 inductive effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 102000011786 HLA-A Antigens Human genes 0.000 claims 2
- 108010075704 HLA-A Antigens Proteins 0.000 claims 2
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 2
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 108091008874 T cell receptors Proteins 0.000 claims 2
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 210000001808 exosome Anatomy 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21601709P | 2009-05-11 | 2009-05-11 | |
| US61/216,017 | 2009-05-11 | ||
| PCT/JP2010/003166 WO2010131452A1 (en) | 2009-05-11 | 2010-05-10 | Ttk peptides and vaccines including the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012526519A JP2012526519A (ja) | 2012-11-01 |
| JP2012526519A5 true JP2012526519A5 (enExample) | 2013-06-27 |
| JP5786178B2 JP5786178B2 (ja) | 2015-09-30 |
Family
ID=43084837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011548451A Expired - Fee Related JP5786178B2 (ja) | 2009-05-11 | 2010-05-10 | Ｔｔｋペプチドおよびそれを含むワクチン |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8530430B2 (enExample) |
| EP (1) | EP2430039A4 (enExample) |
| JP (1) | JP5786178B2 (enExample) |
| KR (1) | KR20120029394A (enExample) |
| CN (1) | CN102459314B (enExample) |
| AU (1) | AU2010248702A1 (enExample) |
| BR (1) | BRPI1013938A2 (enExample) |
| CA (1) | CA2761393A1 (enExample) |
| MX (1) | MX2011012013A (enExample) |
| RU (1) | RU2531348C2 (enExample) |
| SG (1) | SG175998A1 (enExample) |
| TW (1) | TW201102081A (enExample) |
| WO (1) | WO2010131452A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10092634B2 (en) * | 2012-09-11 | 2018-10-09 | Oncotherapy Science, Inc. | UBE2T peptides and vaccines containing the same |
| WO2018090257A1 (zh) * | 2016-11-16 | 2018-05-24 | 深圳华大基因研究院 | 多肽及其应用 |
| WO2018098636A1 (zh) * | 2016-11-29 | 2018-06-07 | 深圳华大基因研究院 | 多肽及其应用 |
| ES2940087T3 (es) * | 2017-07-12 | 2023-05-03 | Nouscom Ag | Una vacuna universal basada en neoantígenos tumorales compartidos para la prevención y el tratamiento de cánceres con inestabilidad microsatelital (MSI) |
| CN120712104A (zh) * | 2022-10-14 | 2025-09-26 | 广东天科雅生物医药科技有限公司 | 针对神经胶质瘤的肽疫苗及其用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6187548B1 (en) * | 1993-05-23 | 2001-02-13 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Methods using human calcium sensor protein, fragments thereof and DNA encoding same |
| US20030045491A1 (en) | 2001-02-23 | 2003-03-06 | Christoph Reinhard | TTK in diagnosis and as a therapeutic target in cancer |
| ATE553112T1 (de) | 2001-02-21 | 2012-04-15 | Novartis Vaccines & Diagnostic | Ttk in der diagnose und als therapeutisches target bei krebs |
| US7501243B2 (en) * | 2001-02-21 | 2009-03-10 | Novartis Vaccines And Diagnostics, Inc. | Detection of colon or breast cancer by measuring TTK polypeptide expression |
| JP2005527180A (ja) | 2001-04-18 | 2005-09-15 | プロテイン デザイン ラブス， インコーポレイテッド | 肺がんの診断方法、肺がんの修飾因子の組成及びスクリーニングの方法 |
| WO2003073374A2 (en) * | 2002-02-27 | 2003-09-04 | Brands Michael Rik Frans | A data integration and knowledge management solution |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| CA2511907A1 (en) | 2003-01-06 | 2004-07-22 | Wyeth | Compositions and methods for diagnosing and treating colon cancers |
| WO2004070062A2 (en) | 2003-02-04 | 2004-08-19 | Wyeth | Compositions and methods for diagnosing and treating cancers |
| AU2003224132A1 (en) | 2003-04-24 | 2004-11-19 | Galapagos Genomics N.V. | Effective sirna knock-down constructs |
| US20050181385A1 (en) | 2003-09-22 | 2005-08-18 | Linsley Peter S. | Synthetic lethal screen using RNA interference |
| WO2005073374A1 (ja) * | 2004-01-29 | 2005-08-11 | Dainippon Sumitomo Pharma Co., Ltd. | 新規腫瘍抗原蛋白質及びその利用 |
| GB0426393D0 (en) | 2004-12-01 | 2005-01-05 | Cancer Rec Tech Ltd | Materials and methods relating to modulators of spindle checkpoint kinases |
| RU2403574C2 (ru) | 2004-12-08 | 2010-11-10 | Авентис Фармасьютикалз Инк. | Способ измерения резистентности или чувствительности к доцетакселу |
| JP5109131B2 (ja) | 2005-02-10 | 2012-12-26 | オンコセラピー・サイエンス株式会社 | 膀胱癌を診断する方法 |
| DK2325306T3 (en) | 2005-02-25 | 2014-03-03 | Oncotherapy Science Inc | Peptide vaccines against lung cancers expressing TTK, URLC10 or KOC1 polypeptide |
| EP2305811A1 (en) | 2005-07-27 | 2011-04-06 | Oncotherapy Science, Inc. | Method of diagnosing smal cell lung cancer |
| EP2311986B1 (en) | 2005-07-27 | 2015-04-15 | Oncotherapy Science, Inc. | Method of diagnosing esophageal cancer |
| JP2010512730A (ja) | 2006-12-13 | 2010-04-30 | オンコセラピー・サイエンス株式会社 | 肺癌の腫瘍マーカーおよび治療標的としてのｔｔｋ |
| TWI615403B (zh) * | 2007-02-21 | 2018-02-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| CA2708686A1 (en) | 2007-12-21 | 2009-07-02 | University Health Network | Methods of inhibiting tumor growth using ttk antagonists |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
-
2010
- 2010-05-05 TW TW099114328A patent/TW201102081A/zh unknown
- 2010-05-10 SG SG2011082963A patent/SG175998A1/en unknown
- 2010-05-10 CN CN201080031259.2A patent/CN102459314B/zh not_active Expired - Fee Related
- 2010-05-10 EP EP10774711A patent/EP2430039A4/en not_active Withdrawn
- 2010-05-10 BR BRPI1013938A patent/BRPI1013938A2/pt not_active IP Right Cessation
- 2010-05-10 US US13/320,022 patent/US8530430B2/en not_active Expired - Fee Related
- 2010-05-10 AU AU2010248702A patent/AU2010248702A1/en not_active Abandoned
- 2010-05-10 CA CA2761393A patent/CA2761393A1/en not_active Abandoned
- 2010-05-10 KR KR1020117027534A patent/KR20120029394A/ko not_active Withdrawn
- 2010-05-10 WO PCT/JP2010/003166 patent/WO2010131452A1/en not_active Ceased
- 2010-05-10 MX MX2011012013A patent/MX2011012013A/es active IP Right Grant
- 2010-05-10 RU RU2011150283/04A patent/RU2531348C2/ru not_active IP Right Cessation
- 2010-05-10 JP JP2011548451A patent/JP5786178B2/ja not_active Expired - Fee Related