JP2012526139A5 - - Google Patents
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- JP2012526139A5 JP2012526139A5 JP2012509967A JP2012509967A JP2012526139A5 JP 2012526139 A5 JP2012526139 A5 JP 2012526139A5 JP 2012509967 A JP2012509967 A JP 2012509967A JP 2012509967 A JP2012509967 A JP 2012509967A JP 2012526139 A5 JP2012526139 A5 JP 2012526139A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- seq
- inhibitor
- agent
- cdr2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17631709P | 2009-05-07 | 2009-05-07 | |
| US61/176,317 | 2009-05-07 | ||
| PCT/US2010/033845 WO2010129752A1 (en) | 2009-05-07 | 2010-05-06 | Compositions and methods of use for binding molecules to dickkopf-1 or dickkopf-4 or both |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012526139A JP2012526139A (ja) | 2012-10-25 |
| JP2012526139A5 true JP2012526139A5 (cg-RX-API-DMAC10.html) | 2013-12-05 |
Family
ID=42272427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012509967A Pending JP2012526139A (ja) | 2009-05-07 | 2010-05-06 | Ｄｉｃｋｋｏｐｆ−１もしくはＤｉｃｋｋｏｐｆ−４または両方に対する結合分子の組成物および使用方法 |
Country Status (11)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR075989A1 (es) * | 2009-04-10 | 2011-05-11 | Lilly Co Eli | Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria |
| CN103608037B (zh) * | 2011-02-01 | 2016-04-13 | 香港大学 | 抗dkk1单克隆抗体用于治疗肝癌的用途 |
| CN103487581A (zh) * | 2012-06-08 | 2014-01-01 | 上海市肿瘤研究所 | 血清dkk1在制备甲胎蛋白阴性肝细胞癌的诊断试剂中的用途 |
| CN103472226A (zh) * | 2012-06-08 | 2013-12-25 | 上海市肿瘤研究所 | 血清dkk1在制备早期肝细胞癌或小肝细胞癌的诊断试剂中的用途 |
| DK2839860T3 (da) | 2012-10-12 | 2019-06-17 | Medimmune Ltd | Pyrrolobenzodiazepiner og konjugater deraf |
| CN103083686B (zh) * | 2013-02-18 | 2014-09-10 | 上海交通大学医学院附属仁济医院 | Dkk4基因及其编码蛋白在制备药物中的应用 |
| ES2687439T3 (es) | 2013-03-13 | 2018-10-25 | Medimmune Limited | Pirrolobenzodiazepinas y conjugados de las mismas |
| EP3193940A1 (en) | 2014-09-10 | 2017-07-26 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| CN104258397A (zh) * | 2014-09-29 | 2015-01-07 | 武汉大学 | Dickkopf-3在治疗动脉粥样硬化中的功能和应用 |
| CN105145470A (zh) * | 2015-07-08 | 2015-12-16 | 上海交通大学医学院附属瑞金医院 | 成熟脂肪组织β-catenin敲除的小鼠模型的构建方法 |
| CN109862919A (zh) | 2016-10-11 | 2019-06-07 | 免疫医疗有限公司 | 抗体-药物缀合物联合免疫介导的治疗剂 |
| CA3041325A1 (en) | 2016-10-26 | 2018-05-03 | Leap Therapeutics, Inc. | Use of beta-catenin as a biomarker for treating cancers using anti-dkk-1 antibody |
| CN106811545B (zh) * | 2017-04-10 | 2020-04-03 | 北京医院 | 一种预测高甘油三酯血症的易感性的方法与试剂 |
| CA3098103A1 (en) | 2018-05-23 | 2019-11-28 | Adc Therapeutics Sa | Molecular adjuvant |
| BR112021001798A2 (pt) * | 2018-07-31 | 2021-04-27 | F. Hoffmann-La Roche Ag | métodos para avaliar a fibrilação atrial, para diagnosticar insuficiência cardíaca, para auxiliar na avaliação da fibrilação atrial, para prever o risco de acidente vascular cerebral e para aprimorar a precisão da previsão, usos e kit |
| CN112121147B (zh) * | 2019-06-24 | 2023-07-04 | 中国人民解放军海军特色医学中心 | 多肽在治疗或预防骨髓瘤药物中的应用、多肽、核酸、药物及重组表达载体 |
| CN112180094A (zh) * | 2019-07-04 | 2021-01-05 | 上海东慈生物科技有限公司 | Dkk1抑制剂在预防和/或治疗肿瘤恶病质与糖尿病伴随疾病中的应用 |
| US20230372528A1 (en) | 2020-10-16 | 2023-11-23 | University Of Georgia Research Foundation, Inc. | Glycoconjugates |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| CN117980327A (zh) | 2021-11-03 | 2024-05-03 | 杭州多禧生物科技有限公司 | 抗体的特异性偶联 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0303194A2 (hu) * | 2001-02-16 | 2003-12-29 | Genentech, Inc. | DKK-1 és antagonistái alkalmazásai |
| EP1395285A4 (en) * | 2001-05-17 | 2005-06-01 | Genome Therapeutics Corp | REAGENTS AND METHODS FOR MODULATING DKK-MEDIATED INTERACTIONS |
| ES2414460T3 (es) * | 2004-08-04 | 2013-07-19 | Amgen Inc. | Anticuerpos para Dkk-1 |
| AR060017A1 (es) * | 2006-01-13 | 2008-05-21 | Novartis Ag | Composiciones y metodos de uso para anticuerpos de dickkopf -1 |
| CA2685737A1 (en) * | 2007-04-30 | 2008-11-06 | Washington University | Methods and compositions for the treatment of cancer |
| EP3211011A1 (en) * | 2007-11-16 | 2017-08-30 | Nuvelo, Inc. | Antibodies to lrp6 |
-
2010
- 2010-05-06 KR KR1020117029170A patent/KR20120117621A/ko not_active Withdrawn
- 2010-05-06 CA CA2759078A patent/CA2759078A1/en not_active Abandoned
- 2010-05-06 MX MX2011011768A patent/MX2011011768A/es unknown
- 2010-05-06 RU RU2011149358/02A patent/RU2011149358A/ru unknown
- 2010-05-06 US US13/265,900 patent/US20120052070A1/en not_active Abandoned
- 2010-05-06 CN CN201080019959XA patent/CN102421798A/zh active Pending
- 2010-05-06 AU AU2010245833A patent/AU2010245833B2/en not_active Ceased
- 2010-05-06 JP JP2012509967A patent/JP2012526139A/ja active Pending
- 2010-05-06 WO PCT/US2010/033845 patent/WO2010129752A1/en not_active Ceased
- 2010-05-06 BR BRPI1014535A patent/BRPI1014535A2/pt not_active IP Right Cessation
- 2010-05-06 EP EP10719858A patent/EP2427490A1/en not_active Withdrawn
-
2013
- 2013-06-12 US US13/915,723 patent/US20140134173A1/en not_active Abandoned
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