HUP0303194A2 - DKK-1 és antagonistái alkalmazásai - Google Patents

DKK-1 és antagonistái alkalmazásai

Info

Publication number
HUP0303194A2
HUP0303194A2 HU0303194A HUP0303194A HUP0303194A2 HU P0303194 A2 HUP0303194 A2 HU P0303194A2 HU 0303194 A HU0303194 A HU 0303194A HU P0303194 A HUP0303194 A HU P0303194A HU P0303194 A2 HUP0303194 A2 HU P0303194A2
Authority
HU
Hungary
Prior art keywords
dkk
treatment
antagonists
hypoinsulinemia
obesity
Prior art date
Application number
HU0303194A
Other languages
English (en)
Inventor
Venita I. Dealmeida
Timothy A. Stewart
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of HUP0303194A2 publication Critical patent/HUP0303194A2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Abstract

A találmány tárgya Dickkopf-1 (Dkk-1) fehérjék antagonistáinakalkalmazása inzulinrezisztenziával - például nem inzulinfüggő diabetesmellitus (NIDDM), hipoinsulinaemia - és izomsorvadással, traumávalvagy degenerációval járó elváltozások kezelésére szolgáló gyógyszerek,készítmények, illetve készletek előállítására. Előnyös, ha azantagonisták a Dkk-1 hatásainak gátlására alkalmas, Dkk-1 elleniantitesteket tartalmaznak. Továbbá, a találmány tárgya készletekelhízottság vagy hiperinzulinémia kezelésére emlősben, továbbá Dkk-1alkalmazása emlősben ilyen rendellenességek kezelésére szolgálókészítmények előállítására. Továbbá, a találmány tárgyát képezikinzulinnal szembeni rezisztencia, hiper- vagy hipoinzulinémia,elhízottság és ezekkel rokon elváltozások diagnosztizálására szolgálóeljárások Dkk-l-et, és dkk-1 nukleinsavat túlexpresszáló, embertőlkülönböző; transzgénikus állatok alkalmazásával. Ó
HU0303194A 2001-02-16 2002-02-15 DKK-1 és antagonistái alkalmazásai HUP0303194A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26943501P 2001-02-16 2001-02-16
PCT/US2002/004573 WO2002066509A2 (en) 2001-02-16 2002-02-15 Treatment involving dkk-1 or antagonists thereof

Publications (1)

Publication Number Publication Date
HUP0303194A2 true HUP0303194A2 (hu) 2003-12-29

Family

ID=23027234

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303194A HUP0303194A2 (hu) 2001-02-16 2002-02-15 DKK-1 és antagonistái alkalmazásai

Country Status (12)

Country Link
US (1) US20030165501A1 (hu)
EP (1) EP1360199A2 (hu)
JP (1) JP2005509402A (hu)
KR (1) KR20030087001A (hu)
AU (1) AU2002306505B2 (hu)
CA (1) CA2438245A1 (hu)
HU (1) HUP0303194A2 (hu)
IL (1) IL157328A0 (hu)
MX (1) MXPA03007327A (hu)
PL (1) PL374006A1 (hu)
WO (1) WO2002066509A2 (hu)
ZA (1) ZA200306232B (hu)

Families Citing this family (23)

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Publication number Priority date Publication date Assignee Title
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
JP2005512508A (ja) * 2001-05-17 2005-05-12 ゲノム　セラピューティックス　コーポレーション Ｄｋｋ媒介性相互作用を変調する試薬および方法
US20040038860A1 (en) * 2002-05-17 2004-02-26 Allen Kristina M. Reagents and methods for modulating dkk-mediated interactions
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
ATE459880T1 (de) 2002-04-17 2010-03-15 Deutsches Krebsforsch Verfahren zum screening einer substanz zur modulierung der wnt -signalkaskade.
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
WO2005032574A1 (en) * 2003-10-03 2005-04-14 The Board Of Trustees Of The Leland Stanford Junior University Modulation of gastrointestinal epithelium proliferation through the wnt signaling pathway
PT2157192E (pt) 2003-10-10 2013-11-28 Deutsches Krebsforsch Composições para diagnóstico e terapia de doenças associadas com a expressão aberrante de futrinas (r-espondinas)
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
WO2005095448A2 (en) * 2004-03-23 2005-10-13 Oscient Pharmaceuticals Corporation Method of synthesizing and purifying dkk proteins and dkk proteins obtained thereby
US7709611B2 (en) 2004-08-04 2010-05-04 Amgen Inc. Antibodies to Dkk-1
WO2006015497A1 (en) * 2004-08-13 2006-02-16 Val-Chum, S.E.C. Methods of use of a dkk1 protein, immunogenic polypeptides thereof, nucleic acid encoding the dkk1 protein or polypeptides, or ligands thereof for detecting tumors; and for eliciting immune response against tumors
CA2584224A1 (en) * 2004-11-03 2006-05-18 Arena Pharmaceuticals, Inc. Gpr41 and modulators thereof for the treatment of insulin-related disorders
WO2006089114A2 (en) * 2005-02-17 2006-08-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating an anthrax toxin mediated condition
AR060017A1 (es) 2006-01-13 2008-05-21 Novartis Ag Composiciones y metodos de uso para anticuerpos de dickkopf -1
KR20070113499A (ko) * 2006-05-24 2007-11-29 연세대학교 산학협력단 Ｄｋｋ1을 포함하는 혈관신생을 억제시키는 방법
EP2121755A1 (en) * 2007-02-08 2009-11-25 Merck & Co., Inc. Antibodies specific for dkk-1
EP2098244A1 (en) 2008-03-04 2009-09-09 Medizinische Hochschule Hannover Pharmaceutical composition for the treatment of myocardial infarction
AU2010245833B2 (en) * 2009-05-07 2014-03-27 Novartis Ag Compositions and methods of use for binding molecules to Dickkopf-1 or Dickkopf-4 or both
EP2430048A1 (en) * 2009-05-12 2012-03-21 Pfizer Inc. Blocking anti-dkk-1 antibodies and their uses
CN106191215B (zh) * 2015-04-29 2020-03-24 中国科学院上海生命科学研究院 肌肉萎缩相关的蛋白质分子标记Dkk-3的筛选及其应用
CN112121147B (zh) * 2019-06-24 2023-07-04 中国人民解放军海军特色医学中心 多肽在治疗或预防骨髓瘤药物中的应用、多肽、核酸、药物及重组表达载体
CN112180094A (zh) * 2019-07-04 2021-01-05 上海东慈生物科技有限公司 Dkk1抑制剂在预防和/或治疗肿瘤恶病质与糖尿病伴随疾病中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187991B1 (en) * 1995-05-23 2001-02-13 Pfizer Inc Transgenic animal models for type II diabetes mellitus
WO2000052047A2 (en) * 1999-03-05 2000-09-08 Millennium Pharmaceuticals, Inc. Human dickkopf-related protein and nucleic acid molecules and uses therefor

Also Published As

Publication number Publication date
WO2002066509A3 (en) 2003-01-23
MXPA03007327A (es) 2005-02-14
WO2002066509A2 (en) 2002-08-29
AU2002306505B2 (en) 2007-02-15
IL157328A0 (en) 2004-02-19
PL374006A1 (en) 2005-09-19
ZA200306232B (en) 2004-11-17
US20030165501A1 (en) 2003-09-04
CA2438245A1 (en) 2002-08-29
JP2005509402A (ja) 2005-04-14
EP1360199A2 (en) 2003-11-12
KR20030087001A (ko) 2003-11-12

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