JP2012523416A5 - - Google Patents
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- Publication number
- JP2012523416A5 JP2012523416A5 JP2012504759A JP2012504759A JP2012523416A5 JP 2012523416 A5 JP2012523416 A5 JP 2012523416A5 JP 2012504759 A JP2012504759 A JP 2012504759A JP 2012504759 A JP2012504759 A JP 2012504759A JP 2012523416 A5 JP2012523416 A5 JP 2012523416A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- methyl
- isobutyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- -1 chloro, bromo, methyl Chemical group 0.000 claims 4
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 3
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims 2
- 125000004981 cycloalkylmethyl group Chemical group 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- SNNRWIBSGBMYRF-ZFWWWQNUSA-N 6-methoxy-2-methyl-3-[(1s)-3-methyl-1-[(3s)-pyrrolidin-3-yl]butoxy]pyridine Chemical compound CC1=NC(OC)=CC=C1O[C@@H](CC(C)C)[C@@H]1CNCC1 SNNRWIBSGBMYRF-ZFWWWQNUSA-N 0.000 claims 1
- 208000000094 Chronic Pain Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16807909P | 2009-04-09 | 2009-04-09 | |
| US61/168,079 | 2009-04-09 | ||
| PCT/US2010/030038 WO2010117979A2 (en) | 2009-04-09 | 2010-04-06 | Serotonin and norepinephrine reuptake inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012523416A JP2012523416A (ja) | 2012-10-04 |
| JP2012523416A5 true JP2012523416A5 (https=) | 2013-05-09 |
Family
ID=42698378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012504759A Pending JP2012523416A (ja) | 2009-04-09 | 2010-04-06 | セロトニンおよびノルエピネフリン再取り込み阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8173821B2 (https=) |
| EP (1) | EP2417124B1 (https=) |
| JP (1) | JP2012523416A (https=) |
| KR (1) | KR101378260B1 (https=) |
| CN (1) | CN102388036A (https=) |
| AR (1) | AR075988A1 (https=) |
| AU (1) | AU2010234610B2 (https=) |
| BR (1) | BRPI1014382A2 (https=) |
| CA (1) | CA2758251C (https=) |
| EA (1) | EA201171230A1 (https=) |
| ES (1) | ES2446644T3 (https=) |
| MX (1) | MX2011010658A (https=) |
| TW (1) | TW201103908A (https=) |
| WO (1) | WO2010117979A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010011811A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | 3-(phenoxyphenylmethyl)pyrrolidine compounds |
| WO2010120910A1 (en) * | 2009-04-15 | 2010-10-21 | Theravance, Inc. | 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds |
| AU2010273645B2 (en) * | 2009-07-13 | 2014-12-04 | Theravance Biopharma R&D Ip, Llc | 3-phenoxymethylpyrrolidine compounds |
| US8273786B2 (en) | 2009-07-21 | 2012-09-25 | Theravance, Inc. | 3-phenoxymethylpyrrolidine compounds |
| US8471040B2 (en) | 2010-10-11 | 2013-06-25 | Theravance, Inc. | Serotonin reuptake inhibitors |
| US8501964B2 (en) | 2010-12-03 | 2013-08-06 | Theravance, Inc. | Serotonin reuptake inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1004346C2 (nl) | 1996-10-23 | 1998-04-24 | Dsm Nv | Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel. |
| CA2698384C (en) * | 1996-12-10 | 2012-05-01 | Abbott Laboratories | 3-pyridyl enantiomers and their use as analgesics |
| DK1047690T3 (da) | 1997-12-19 | 2004-07-05 | Abbott Lab | Heterocykliske ether- og thioetherforbindelser, som er anvendelige til regulering af kemisk, synaptisk overförsel |
| JP2003529547A (ja) | 1999-09-14 | 2003-10-07 | アボット・ラボラトリーズ | 化学シナプス伝達のコントロールに有効な３−ピロリジニルオキシ−３’−ピリジルエーテル化合物 |
| US20020151712A1 (en) | 1999-09-14 | 2002-10-17 | Nan-Horng Lin | 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission |
| BRPI0510453A (pt) | 2004-04-30 | 2007-10-30 | Warner Lambert Co | composto substituìdos com morfolina para o tratamento de distúrbios do sistema nervoso central |
| EP2066630A1 (en) * | 2006-08-23 | 2009-06-10 | Pfizer Products Incorporated | Piperidine derivatives |
| ATE528300T1 (de) | 2006-12-06 | 2011-10-15 | Glaxosmithkline Llc | Bizyklische verbindungen und ihre verwendung als antidiabetika |
| WO2010011811A2 (en) | 2008-07-24 | 2010-01-28 | Theravance, Inc. | 3-(phenoxyphenylmethyl)pyrrolidine compounds |
-
2010
- 2010-03-29 AR ARP100101017A patent/AR075988A1/es unknown
- 2010-04-02 TW TW099110421A patent/TW201103908A/zh unknown
- 2010-04-06 US US12/754,800 patent/US8173821B2/en not_active Expired - Fee Related
- 2010-04-06 JP JP2012504759A patent/JP2012523416A/ja active Pending
- 2010-04-06 CN CN2010800160763A patent/CN102388036A/zh active Pending
- 2010-04-06 ES ES10713753.1T patent/ES2446644T3/es active Active
- 2010-04-06 MX MX2011010658A patent/MX2011010658A/es active IP Right Grant
- 2010-04-06 WO PCT/US2010/030038 patent/WO2010117979A2/en not_active Ceased
- 2010-04-06 BR BRPI1014382A patent/BRPI1014382A2/pt not_active IP Right Cessation
- 2010-04-06 EA EA201171230A patent/EA201171230A1/ru unknown
- 2010-04-06 AU AU2010234610A patent/AU2010234610B2/en not_active Ceased
- 2010-04-06 KR KR1020117023570A patent/KR101378260B1/ko not_active Expired - Fee Related
- 2010-04-06 CA CA2758251A patent/CA2758251C/en not_active Expired - Fee Related
- 2010-04-06 EP EP10713753.1A patent/EP2417124B1/en not_active Not-in-force