EA201171230A1 - Ингибитор обратного захвата серотонина и норэпинефрина - Google Patents

Ингибитор обратного захвата серотонина и норэпинефрина

Info

Publication number
EA201171230A1
EA201171230A1 EA201171230A EA201171230A EA201171230A1 EA 201171230 A1 EA201171230 A1 EA 201171230A1 EA 201171230 A EA201171230 A EA 201171230A EA 201171230 A EA201171230 A EA 201171230A EA 201171230 A1 EA201171230 A1 EA 201171230A1
Authority
EA
Eurasian Patent Office
Prior art keywords
serotonin
norepinefrine
inhibitor
return capture
return
Prior art date
Application number
EA201171230A
Other languages
English (en)
Inventor
Николя Жак Франсуа Дрейфю
Сандра Энн Филла
Анетте Маргарета Йоханссон
Тьерри Ж. Маскелэн
Джикеш Арвинд Шах
Эрик Джордж Тромижак
Магнус Вильхельм Вальтер
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201171230A1 publication Critical patent/EA201171230A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Предложены ингибитор обратного захвата серотонина и норэпинефрина формулыего применение и способы его получения.
EA201171230A 2009-04-09 2010-04-06 Ингибитор обратного захвата серотонина и норэпинефрина EA201171230A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16807909P 2009-04-09 2009-04-09
PCT/US2010/030038 WO2010117979A2 (en) 2009-04-09 2010-04-06 Serotonin and norepinephrine reuptake inhibitor

Publications (1)

Publication Number Publication Date
EA201171230A1 true EA201171230A1 (ru) 2012-03-30

Family

ID=42698378

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201171230A EA201171230A1 (ru) 2009-04-09 2010-04-06 Ингибитор обратного захвата серотонина и норэпинефрина

Country Status (14)

Country Link
US (1) US8173821B2 (ru)
EP (1) EP2417124B1 (ru)
JP (1) JP2012523416A (ru)
KR (1) KR101378260B1 (ru)
CN (1) CN102388036A (ru)
AR (1) AR075988A1 (ru)
AU (1) AU2010234610B2 (ru)
BR (1) BRPI1014382A2 (ru)
CA (1) CA2758251C (ru)
EA (1) EA201171230A1 (ru)
ES (1) ES2446644T3 (ru)
MX (1) MX2011010658A (ru)
TW (1) TW201103908A (ru)
WO (1) WO2010117979A2 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888386B2 (en) 2008-07-24 2011-02-15 Theravance, Inc. 3-(phenoxyphenylmethyl)pyrrolidine compounds
EP2419405A1 (en) * 2009-04-15 2012-02-22 Theravance, Inc. 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds
WO2011008666A2 (en) 2009-07-13 2011-01-20 Theravance, Inc. 3-phenoxymethylpyrrolidine compounds
ES2495366T3 (es) 2009-07-21 2014-09-17 Theravance, Inc. Compuestos de 3-fenoximetilpirrolidina
US8471040B2 (en) 2010-10-11 2013-06-25 Theravance, Inc. Serotonin reuptake inhibitors
WO2012075239A1 (en) 2010-12-03 2012-06-07 Theravance, Inc. Serotonin reuptake inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1004346C2 (nl) 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.
PT950057E (pt) 1996-12-10 2003-04-30 Abbott Lab Enantiomeros de 3-piridilo e sua utilizacao como analgesicos
ES2221234T3 (es) 1997-12-19 2004-12-16 Abbott Laboratories Compuestos de eter y tioeter heterociclicos utilizados en la regulacion de la transmision sinaptica quimica.
JP2003529547A (ja) 1999-09-14 2003-10-07 アボット・ラボラトリーズ 化学シナプス伝達のコントロールに有効な３−ピロリジニルオキシ−３’−ピリジルエーテル化合物
US20020151712A1 (en) * 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
JP4185154B2 (ja) * 2004-04-30 2008-11-26 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー 中枢神経系障害治療用の置換モルホリン化合物
CN101506164A (zh) 2006-08-23 2009-08-12 辉瑞产品公司 哌啶衍生物
WO2008070692A2 (en) 2006-12-06 2008-06-12 Smithkline Beecham Corporation Bicyclic compounds and use as antidiabetics
US7888386B2 (en) 2008-07-24 2011-02-15 Theravance, Inc. 3-(phenoxyphenylmethyl)pyrrolidine compounds

Also Published As

Publication number Publication date
EP2417124A2 (en) 2012-02-15
AU2010234610A1 (en) 2011-10-06
AR075988A1 (es) 2011-05-11
ES2446644T3 (es) 2014-03-10
JP2012523416A (ja) 2012-10-04
KR101378260B1 (ko) 2014-03-27
AU2010234610B2 (en) 2013-04-18
US8173821B2 (en) 2012-05-08
WO2010117979A3 (en) 2011-02-17
US20100261762A1 (en) 2010-10-14
TW201103908A (en) 2011-02-01
CN102388036A (zh) 2012-03-21
EP2417124B1 (en) 2013-12-18
BRPI1014382A2 (pt) 2016-04-05
KR20110123287A (ko) 2011-11-14
MX2011010658A (es) 2011-10-21
CA2758251A1 (en) 2010-10-14
WO2010117979A2 (en) 2010-10-14
CA2758251C (en) 2013-08-06

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