CN102388036A - 血清素和去甲肾上腺素再摄取抑制剂 - Google Patents

血清素和去甲肾上腺素再摄取抑制剂 Download PDF

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Publication number
CN102388036A
CN102388036A CN2010800160763A CN201080016076A CN102388036A CN 102388036 A CN102388036 A CN 102388036A CN 2010800160763 A CN2010800160763 A CN 2010800160763A CN 201080016076 A CN201080016076 A CN 201080016076A CN 102388036 A CN102388036 A CN 102388036A
Authority
CN
China
Prior art keywords
methyl
pyrrolidine
mmol
butyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2010800160763A
Other languages
English (en)
Chinese (zh)
Inventor
N.J.F.德里富斯
S.A.费拉
A.M.约翰松
T.J.马斯克林
J.A.沙
E.G.特罗米查克
M.W.沃特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN102388036A publication Critical patent/CN102388036A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2010800160763A 2009-04-09 2010-04-06 血清素和去甲肾上腺素再摄取抑制剂 Pending CN102388036A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16807909P 2009-04-09 2009-04-09
US61/168079 2009-04-09
PCT/US2010/030038 WO2010117979A2 (en) 2009-04-09 2010-04-06 Serotonin and norepinephrine reuptake inhibitor

Publications (1)

Publication Number Publication Date
CN102388036A true CN102388036A (zh) 2012-03-21

Family

ID=42698378

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010800160763A Pending CN102388036A (zh) 2009-04-09 2010-04-06 血清素和去甲肾上腺素再摄取抑制剂

Country Status (14)

Country Link
US (1) US8173821B2 (https=)
EP (1) EP2417124B1 (https=)
JP (1) JP2012523416A (https=)
KR (1) KR101378260B1 (https=)
CN (1) CN102388036A (https=)
AR (1) AR075988A1 (https=)
AU (1) AU2010234610B2 (https=)
BR (1) BRPI1014382A2 (https=)
CA (1) CA2758251C (https=)
EA (1) EA201171230A1 (https=)
ES (1) ES2446644T3 (https=)
MX (1) MX2011010658A (https=)
TW (1) TW201103908A (https=)
WO (1) WO2010117979A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010011811A2 (en) 2008-07-24 2010-01-28 Theravance, Inc. 3-(phenoxyphenylmethyl)pyrrolidine compounds
WO2010120910A1 (en) * 2009-04-15 2010-10-21 Theravance, Inc. 3-(phenoxypyrrolidin-3-yl-methyl)heteroaryl, 3-(phenylpyrrolidin-3-ylmethoxy)heteroaryl, and 3-(heteroarylpyrrolidin-3-ylmethoxy)heteroaryl compounds
AU2010273645B2 (en) * 2009-07-13 2014-12-04 Theravance Biopharma R&D Ip, Llc 3-phenoxymethylpyrrolidine compounds
US8273786B2 (en) 2009-07-21 2012-09-25 Theravance, Inc. 3-phenoxymethylpyrrolidine compounds
US8471040B2 (en) 2010-10-11 2013-06-25 Theravance, Inc. Serotonin reuptake inhibitors
US8501964B2 (en) 2010-12-03 2013-08-06 Theravance, Inc. Serotonin reuptake inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998025920A1 (en) * 1996-12-10 1998-06-18 Abbott Laboratories 3-pyridyl enantiomers and their use as analgesics
US20020151712A1 (en) * 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
WO2005105763A1 (en) * 2004-04-30 2005-11-10 Warner-Lambert Company Llc Substituted morpholine compounds for the treatment of central nervous system disorders
WO2008023258A1 (en) * 2006-08-23 2008-02-28 Pfizer Products Inc. Piperidine derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1004346C2 (nl) 1996-10-23 1998-04-24 Dsm Nv Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel.
DK1047690T3 (da) 1997-12-19 2004-07-05 Abbott Lab Heterocykliske ether- og thioetherforbindelser, som er anvendelige til regulering af kemisk, synaptisk overförsel
JP2003529547A (ja) 1999-09-14 2003-10-07 アボット・ラボラトリーズ 化学シナプス伝達のコントロールに有効な３−ピロリジニルオキシ−３’−ピリジルエーテル化合物
ATE528300T1 (de) 2006-12-06 2011-10-15 Glaxosmithkline Llc Bizyklische verbindungen und ihre verwendung als antidiabetika
WO2010011811A2 (en) 2008-07-24 2010-01-28 Theravance, Inc. 3-(phenoxyphenylmethyl)pyrrolidine compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998025920A1 (en) * 1996-12-10 1998-06-18 Abbott Laboratories 3-pyridyl enantiomers and their use as analgesics
US20020151712A1 (en) * 1999-09-14 2002-10-17 Nan-Horng Lin 3-pyrrolidinyloxy-3'-pyridyl ether compounds useful for controlling chemical synaptic transmission
WO2005105763A1 (en) * 2004-04-30 2005-11-10 Warner-Lambert Company Llc Substituted morpholine compounds for the treatment of central nervous system disorders
WO2008023258A1 (en) * 2006-08-23 2008-02-28 Pfizer Products Inc. Piperidine derivatives

Also Published As

Publication number Publication date
MX2011010658A (es) 2011-10-21
KR101378260B1 (ko) 2014-03-27
CA2758251A1 (en) 2010-10-14
AU2010234610B2 (en) 2013-04-18
US20100261762A1 (en) 2010-10-14
TW201103908A (en) 2011-02-01
WO2010117979A3 (en) 2011-02-17
BRPI1014382A2 (pt) 2016-04-05
US8173821B2 (en) 2012-05-08
ES2446644T3 (es) 2014-03-10
EP2417124A2 (en) 2012-02-15
EP2417124B1 (en) 2013-12-18
AR075988A1 (es) 2011-05-11
CA2758251C (en) 2013-08-06
EA201171230A1 (ru) 2012-03-30
JP2012523416A (ja) 2012-10-04
AU2010234610A1 (en) 2011-10-06
KR20110123287A (ko) 2011-11-14
WO2010117979A2 (en) 2010-10-14

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