JP2012521361A5 - - Google Patents
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- JP2012521361A5 JP2012521361A5 JP2012501021A JP2012501021A JP2012521361A5 JP 2012521361 A5 JP2012521361 A5 JP 2012521361A5 JP 2012501021 A JP2012501021 A JP 2012501021A JP 2012501021 A JP2012501021 A JP 2012501021A JP 2012521361 A5 JP2012521361 A5 JP 2012521361A5
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- 150000001875 compounds Chemical class 0.000 claims description 37
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 claims description 22
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 claims description 22
- 239000012472 biological sample Substances 0.000 claims description 18
- 230000000694 effects Effects 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 16
- 239000012634 fragment Substances 0.000 claims description 14
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- 230000007812 deficiency Effects 0.000 claims description 10
- 102100026383 Vasopressin-neurophysin 2-copeptin Human genes 0.000 claims description 8
- 201000010064 diabetes insipidus Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 7
- 239000002671 adjuvant Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims description 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims description 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims description 4
- 206010033645 Pancreatitis Diseases 0.000 claims description 4
- 208000006778 allergic bronchopulmonary aspergillosis Diseases 0.000 claims description 4
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 206010010356 Congenital anomaly Diseases 0.000 claims description 3
- 208000011580 syndromic disease Diseases 0.000 claims description 3
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- 206010008025 Cerebellar ataxia Diseases 0.000 claims description 2
- 206010010774 Constipation Diseases 0.000 claims description 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 2
- 206010013883 Dwarfism Diseases 0.000 claims description 2
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- 208000017701 Endocrine disease Diseases 0.000 claims description 2
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- 201000011240 Frontotemporal dementia Diseases 0.000 claims description 2
- 206010019860 Hereditary angioedema Diseases 0.000 claims description 2
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- 208000019693 Lung disease Diseases 0.000 claims description 2
- 208000007466 Male Infertility Diseases 0.000 claims description 2
- 208000008955 Mucolipidoses Diseases 0.000 claims description 2
- 206010072928 Mucolipidosis type II Diseases 0.000 claims description 2
- 208000002678 Mucopolysaccharidoses Diseases 0.000 claims description 2
- 102100026784 Myelin proteolipid protein Human genes 0.000 claims description 2
- 206010068871 Myotonic dystrophy Diseases 0.000 claims description 2
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims description 2
- 206010033799 Paralysis Diseases 0.000 claims description 2
- 208000018737 Parkinson disease Diseases 0.000 claims description 2
- 208000017493 Pelizaeus-Merzbacher disease Diseases 0.000 claims description 2
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims description 2
- 208000024777 Prion disease Diseases 0.000 claims description 2
- 201000005660 Protein C Deficiency Diseases 0.000 claims description 2
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- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims description 2
- 208000004622 abetalipoproteinemia Diseases 0.000 claims description 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 2
- 239000003242 anti bacterial agent Substances 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 229940088710 antibiotic agent Drugs 0.000 claims description 2
- 229960005475 antiinfective agent Drugs 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 208000006673 asthma Diseases 0.000 claims description 2
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- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims description 2
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- 206010006451 bronchitis Diseases 0.000 claims description 2
- 229940124630 bronchodilator Drugs 0.000 claims description 2
- 239000000168 bronchodilator agent Substances 0.000 claims description 2
- 210000003591 cerebellar nuclei Anatomy 0.000 claims description 2
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- 208000007451 chronic bronchitis Diseases 0.000 claims description 2
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- 239000003172 expectorant agent Substances 0.000 claims description 2
- 208000013746 hereditary thrombophilia due to congenital protein C deficiency Diseases 0.000 claims description 2
- 230000003451 hyperinsulinaemic effect Effects 0.000 claims description 2
- 201000008980 hyperinsulinism Diseases 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 208000019423 liver disease Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 208000020460 mucolipidosis II alpha/beta Diseases 0.000 claims description 2
- 229940066491 mucolytics Drugs 0.000 claims description 2
- 206010028093 mucopolysaccharidosis Diseases 0.000 claims description 2
- 208000000638 myeloperoxidase deficiency Diseases 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 201000001119 neuropathy Diseases 0.000 claims description 2
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- 235000015097 nutrients Nutrition 0.000 claims description 2
- 108010040003 polyglutamine Proteins 0.000 claims description 2
- 229920000155 polyglutamine Polymers 0.000 claims description 2
- 230000020978 protein processing Effects 0.000 claims description 2
- 201000009890 sinusitis Diseases 0.000 claims description 2
- 230000000391 smoking effect Effects 0.000 claims description 2
- 208000002320 spinal muscular atrophy Diseases 0.000 claims description 2
- 210000001215 vagina Anatomy 0.000 claims description 2
- 208000010693 Charcot-Marie-Tooth Disease Diseases 0.000 claims 1
- 208000020406 Creutzfeldt Jacob disease Diseases 0.000 claims 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
- 208000010859 Creutzfeldt-Jakob disease Diseases 0.000 claims 1
- 208000000563 Hyperlipoproteinemia Type II Diseases 0.000 claims 1
- 102100024640 Low-density lipoprotein receptor Human genes 0.000 claims 1
- 208000015439 Lysosomal storage disease Diseases 0.000 claims 1
- 206010045261 Type IIa hyperlipidaemia Diseases 0.000 claims 1
- 208000019409 dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome Diseases 0.000 claims 1
- 201000001386 familial hypercholesterolemia Diseases 0.000 claims 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 claims 1
- 208000021090 palsy Diseases 0.000 claims 1
- 201000002212 progressive supranuclear palsy Diseases 0.000 claims 1
- 210000000463 red nucleus Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
- 102100034452 Alternative prion protein Human genes 0.000 description 1
- JYPYTFLCNPMVBC-UHFFFAOYSA-N CC(C)(C)c(c(NC(C1=CNc2ccccc2C1=O)=O)c1)cc(C(C)(C)C(O)=O)c1O Chemical compound CC(C)(C)c(c(NC(C1=CNc2ccccc2C1=O)=O)c1)cc(C(C)(C)C(O)=O)c1O JYPYTFLCNPMVBC-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010062264 Congenital hyperthyroidism Diseases 0.000 description 1
- 208000001819 Crigler-Najjar Syndrome Diseases 0.000 description 1
- 108091000054 Prion Proteins 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- -1 cholesterol Lipid Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000003712 lysosome Anatomy 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16213009P | 2009-03-20 | 2009-03-20 | |
| US61/162,130 | 2009-03-20 | ||
| PCT/US2010/028062 WO2010108155A1 (en) | 2009-03-20 | 2010-03-19 | Modulators of cystic fibrosis transmembrane conductance regulator |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014179861A Division JP2015013881A (ja) | 2009-03-20 | 2014-09-04 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521361A JP2012521361A (ja) | 2012-09-13 |
| JP2012521361A5 true JP2012521361A5 (cg-RX-API-DMAC10.html) | 2013-05-02 |
| JP5636418B2 JP5636418B2 (ja) | 2014-12-03 |
Family
ID=42136194
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012501021A Active JP5636418B2 (ja) | 2009-03-20 | 2010-03-19 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
| JP2014179861A Withdrawn JP2015013881A (ja) | 2009-03-20 | 2014-09-04 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
| JP2016002485A Pending JP2016104788A (ja) | 2009-03-20 | 2016-01-08 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014179861A Withdrawn JP2015013881A (ja) | 2009-03-20 | 2014-09-04 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
| JP2016002485A Pending JP2016104788A (ja) | 2009-03-20 | 2016-01-08 | 嚢胞性線維症膜コンダクタンス制御因子のモジュレーター |
Country Status (23)
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2006111093A (ru) | 2003-09-06 | 2007-10-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы атр-связывающих кассетных транспортеров |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| CN104788328B (zh) | 2004-06-24 | 2017-09-12 | 沃泰克斯药物股份有限公司 | Atp‑结合弹夹转运蛋白的调控剂 |
| JP5143738B2 (ja) | 2005-08-11 | 2013-02-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | 嚢胞性線維症膜コンダクタンス制御因子の調節物質 |
| DK2774925T3 (en) | 2005-11-08 | 2017-02-27 | Vertex Pharma | Heterocyclic modulators of ATP binding cassette transporters |
| WO2007079139A2 (en) | 2005-12-28 | 2007-07-12 | Vertex Pharmaceuticals, Inc. | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| ES2398319T3 (es) | 2005-12-28 | 2013-03-15 | Vertex Pharmaceuticals Incorporated | Derivados de 1-(benzo[D][1,3]dioxol-5-il)-N-(fenil)ciclopropano-carboxamida y compuestos relacionados como moduladores de transportadores de casetes de unión a ATP para el tratamiento de la fibrosis quística |
| USRE50453E1 (en) | 2006-04-07 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| EP2007756B1 (en) | 2006-04-07 | 2015-08-26 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| AU2008251504B2 (en) | 2007-05-09 | 2013-07-18 | Vertex Pharmaceuticals Incorporated | Modulators of CFTR |
| AU2008302598B2 (en) | 2007-08-24 | 2014-07-17 | Vertex Pharmaceuticals Incorporated | Isothiazolopyridinones useful for the treatment of (inter alia) Cystic Fibrosis |
| DK2217572T3 (da) | 2007-11-16 | 2014-02-03 | Vertex Pharma | Isoquinoliner som modulatorer af ATP-bindingskassettetransportører |
| US20100036130A1 (en) | 2007-12-07 | 2010-02-11 | Vertex Pharmaceuticals Incorporated | Processes for producing cycloalkylcarboxamido-pyridine benzoic acids |
| EP2639222B1 (en) | 2007-12-07 | 2016-08-31 | Vertex Pharmaceuticals Incorporated | Process for producing cycloalkylcarboxiamido-pyridine benzoic acids |
| LT2225230T (lt) | 2007-12-07 | 2017-01-25 | Vertex Pharmaceuticals Incorporated | 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il) benzoinės rūgšties kietos formos |
| CN102245573B (zh) | 2008-02-28 | 2013-11-20 | 沃泰克斯药物股份有限公司 | 作为cftr调节剂的杂芳基衍生物 |
| JP5622285B2 (ja) | 2008-03-31 | 2014-11-12 | バーテックスファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓｉｎｃｏｒｐｏｒａｔｅｄ | Ｃｆｔｒモジュレーターとしてのピリジル誘導体 |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| CN102164587A (zh) * | 2008-09-29 | 2011-08-24 | 沃泰克斯药物股份有限公司 | 3-(6-(1-(2,2-二氟苯并[d][1,3]间二氧杂环戊烯-5-基)环丙烷甲酰氨基)-3-甲基吡啶-2-基)苯甲酸的剂量单元 |
| DK2349263T3 (da) * | 2008-10-23 | 2014-07-21 | Vertex Pharma | Modulatorer af transmembranledningsevneregulatoren for cystisk fibrose |
| SMT201800416T1 (it) * | 2009-03-20 | 2018-09-13 | Vertex Pharma | Modulatori del regolatore di conduttanza trans-membrana della fibrosi cistica |
| SG10201504084QA (en) | 2009-03-20 | 2015-06-29 | Vertex Pharma | Process for making modulators of cystic fibrosis transmembrane conductance regulator |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| CN102933206A (zh) | 2010-04-07 | 2013-02-13 | 弗特克斯药品有限公司 | 3-(6-(1-(2，2-二氟苯并[d][1，3]二氧杂环戊烯-5-基)环丙烷甲酰胺基)-3-甲基吡啶-2-基)苯甲酸的固体形式 |
| LT3150198T (lt) | 2010-04-07 | 2021-12-10 | Vertex Pharmaceuticals Incorporated | 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiridin-2-il)benzoinės rūgšties farmacinė kompozicija ir jos įvedimas |
| EP3381899B1 (en) | 2010-04-22 | 2021-01-06 | Vertex Pharmaceuticals Incorporated | Intermediate compound for process of producing cycloalkylcarboxamido-indole compounds |
| US8563593B2 (en) | 2010-06-08 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| IN2014KN00885A (cg-RX-API-DMAC10.html) | 2011-11-08 | 2015-10-02 | Vertex Pharma | |
| JP2015504920A (ja) | 2012-01-25 | 2015-02-16 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の製剤 |
| CN109966264A (zh) | 2012-02-27 | 2019-07-05 | 沃泰克斯药物股份有限公司 | 药物组合物及其施用 |
| US8674108B2 (en) | 2012-04-20 | 2014-03-18 | Vertex Pharmaceuticals Incorporated | Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| AU2013290444B2 (en) | 2012-07-16 | 2018-04-26 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof |
| CN104030981A (zh) * | 2013-03-06 | 2014-09-10 | 上海特化医药科技有限公司 | Ivacaftor的制备方法及其中间体 |
| WO2014141110A2 (en) * | 2013-03-14 | 2014-09-18 | Curadev Pharma Pvt. Ltd. | Aminonitriles as kynurenine pathway inhibitors |
| US9345023B2 (en) * | 2013-04-24 | 2016-05-17 | Alcatel Lucent | Method and apparatus for determination of almost blank subframe pattern by network listening |
| KR102280372B1 (ko) | 2013-11-12 | 2021-07-22 | 버텍스 파마슈티칼스 인코포레이티드 | Cftr 매개된 질환 치료용 약제학적 조성물의 제조 방법 |
| JP6543268B2 (ja) | 2014-04-15 | 2019-07-10 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | 嚢胞性線維症膜コンダクタンス調節因子が媒介する疾患を処置するための医薬組成物 |
| SMT202000540T1 (it) | 2014-10-06 | 2020-11-10 | Vertex Pharma | Modulatori di regolatore di conduttanza transmembrana di fibrosi cistica |
| US9701639B2 (en) | 2014-10-07 | 2017-07-11 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| KR101721029B1 (ko) | 2014-10-16 | 2017-03-29 | 연세대학교 산학협력단 | 인돌리지노[3,2-c]퀴놀린 유도체, 이의 약제학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 낭포성 섬유증 예방 또는 치료용 약학조성물 |
| PL3221692T3 (pl) | 2014-11-18 | 2021-12-06 | Vertex Pharmaceuticals Inc. | Sposób przeprowadzania testowania o wysokiej przepustowości za pomocą wysokosprawnej chromatografii cieczowej |
| CA2999529A1 (en) | 2015-09-25 | 2017-03-30 | Vertex Pharmaceuticals (Europe) Limited | Deuterated cftr potentiators |
| JP7100583B2 (ja) | 2016-02-22 | 2022-07-13 | マース インコーポレーテッド | ペットフード |
| WO2018029336A1 (en) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway. |
| UY37513A (es) | 2016-12-09 | 2018-07-31 | Vertex Pharma | Modulador del regulador de conductancia transmembrana de fibrosis quística, composiciones farmacéuticas, métodos de tratamiento y proceso para producir el modulador |
| US11253509B2 (en) | 2017-06-08 | 2022-02-22 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| BR112020000941A2 (pt) | 2017-07-17 | 2020-07-21 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
| WO2019070962A1 (en) | 2017-10-04 | 2019-04-11 | Ohio State Innovation Foundation | BICYCLIC PEPTIDE INHIBITORS |
| IL305169B2 (en) | 2017-12-01 | 2025-07-01 | Vertex Pharma | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| US11465985B2 (en) | 2017-12-08 | 2022-10-11 | Vertex Pharmaceuticals Incorporated | Processes for making modulators of cystic fibrosis transmembrane conductance regulator |
| WO2019148195A2 (en) | 2018-01-29 | 2019-08-01 | Ohio State Innovation Foundation | Cyclic peptidyl inhibitors of cal-pdz binding domain |
| CR20230120A (es) | 2020-08-07 | 2023-09-01 | Vertex Pharma | Moduladores del regulador de la conductancia transmembrana de la fibrosis quística |
| US12324802B2 (en) | 2020-11-18 | 2025-06-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2236751B (en) | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| RU2047614C1 (ru) * | 1992-06-15 | 1995-11-10 | Джон Вайс энд Бразер Лимитед | Гетероциклические соединения, или их фармацевтически приемлемые аддитивные соли кислоты, или n-оксид гетероциклического соединения, или его аддитивная соль кислоты |
| US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6248739B1 (en) | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| CN104788328B (zh) * | 2004-06-24 | 2017-09-12 | 沃泰克斯药物股份有限公司 | Atp‑结合弹夹转运蛋白的调控剂 |
| EP1979367A2 (en) * | 2005-12-24 | 2008-10-15 | Vertex Pharmaceuticals Incorporated | Quinolin-4-one derivatives as modulators of abc transporters |
| CA2635214A1 (en) * | 2005-12-27 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Compounds useful in cftr assays and methods therewith |
| WO2007079139A2 (en) | 2005-12-28 | 2007-07-12 | Vertex Pharmaceuticals, Inc. | Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide |
| CA2699382C (en) * | 2007-09-14 | 2016-05-10 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| SMT201800416T1 (it) * | 2009-03-20 | 2018-09-13 | Vertex Pharma | Modulatori del regolatore di conduttanza trans-membrana della fibrosi cistica |
-
2010
- 2010-03-19 SM SM20180416T patent/SMT201800416T1/it unknown
- 2010-03-19 DK DK10710748.4T patent/DK2408749T3/en active
- 2010-03-19 ES ES10710748.4T patent/ES2683633T3/es active Active
- 2010-03-19 CA CA2755969A patent/CA2755969C/en active Active
- 2010-03-19 SI SI201031726T patent/SI2408749T1/sl unknown
- 2010-03-19 BR BRPI1012549A patent/BRPI1012549B8/pt active IP Right Grant
- 2010-03-19 LT LTEP10710748.4T patent/LT2408749T/lt unknown
- 2010-03-19 NZ NZ595151A patent/NZ595151A/xx unknown
- 2010-03-19 MX MX2011009868A patent/MX2011009868A/es active IP Right Grant
- 2010-03-19 HU HUE10710748A patent/HUE038854T2/hu unknown
- 2010-03-19 PL PL10710748T patent/PL2408749T3/pl unknown
- 2010-03-19 EP EP10710748.4A patent/EP2408749B1/en active Active
- 2010-03-19 WO PCT/US2010/028062 patent/WO2010108155A1/en not_active Ceased
- 2010-03-19 AU AU2010226393A patent/AU2010226393B2/en active Active
- 2010-03-19 HR HRP20181261TT patent/HRP20181261T1/hr unknown
- 2010-03-19 CN CN2010800126048A patent/CN102361856A/zh active Pending
- 2010-03-19 JP JP2012501021A patent/JP5636418B2/ja active Active
- 2010-03-19 PT PT10710748T patent/PT2408749T/pt unknown
- 2010-03-19 RU RU2011142297/04A patent/RU2518897C2/ru active
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2011
- 2011-09-09 ZA ZA2011/06618A patent/ZA201106618B/en unknown
- 2011-09-20 IL IL215261A patent/IL215261A/en active IP Right Grant
- 2011-09-20 US US13/237,303 patent/US8614325B2/en active Active
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2013
- 2013-11-19 US US14/084,203 patent/US8796308B2/en active Active
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2014
- 2014-06-20 US US14/310,634 patent/US20140303205A1/en not_active Abandoned
- 2014-09-04 JP JP2014179861A patent/JP2015013881A/ja not_active Withdrawn
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2015
- 2015-12-31 US US14/985,650 patent/US20160221952A1/en not_active Abandoned
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2016
- 2016-01-08 JP JP2016002485A patent/JP2016104788A/ja active Pending
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2018
- 2018-08-13 CY CY181100855T patent/CY1120593T1/el unknown
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