JP2012521194A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012521194A5 JP2012521194A5 JP2012500979A JP2012500979A JP2012521194A5 JP 2012521194 A5 JP2012521194 A5 JP 2012521194A5 JP 2012500979 A JP2012500979 A JP 2012500979A JP 2012500979 A JP2012500979 A JP 2012500979A JP 2012521194 A5 JP2012521194 A5 JP 2012521194A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- tnf
- extracellular domain
- nucleic acid
- immunoglobulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000005962 receptors Human genes 0.000 claims 55
- 108020003175 receptors Proteins 0.000 claims 55
- 150000007523 nucleic acids Chemical class 0.000 claims 24
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 230000004927 fusion Effects 0.000 claims 17
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 16
- 102100040247 Tumor necrosis factor Human genes 0.000 claims 16
- 230000001588 bifunctional effect Effects 0.000 claims 15
- 108700015048 receptor decoy activity proteins Proteins 0.000 claims 15
- 108060003951 Immunoglobulin Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 14
- 102000018358 immunoglobulin Human genes 0.000 claims 14
- 238000000034 method Methods 0.000 claims 10
- 208000015114 central nervous system disease Diseases 0.000 claims 9
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 8
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 8
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 8
- 102000013275 Somatomedins Human genes 0.000 claims 8
- 230000006907 apoptotic process Effects 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 7
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 7
- 102000003746 Insulin Receptor Human genes 0.000 claims 7
- 108010001127 Insulin Receptor Proteins 0.000 claims 7
- 239000003446 ligand Substances 0.000 claims 6
- 230000000295 complement effect Effects 0.000 claims 5
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 4
- 102000050554 Eph Family Receptors Human genes 0.000 claims 4
- 108091008815 Eph receptors Proteins 0.000 claims 4
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims 4
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 4
- 102000011965 Lipoprotein Receptors Human genes 0.000 claims 4
- 108010061306 Lipoprotein Receptors Proteins 0.000 claims 4
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 4
- 102000007238 Transferrin Receptors Human genes 0.000 claims 4
- 108010033576 Transferrin Receptors Proteins 0.000 claims 4
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 4
- 101710097160 Tumor necrosis factor ligand superfamily member 10 Proteins 0.000 claims 4
- 239000000411 inducer Substances 0.000 claims 4
- 230000001939 inductive effect Effects 0.000 claims 4
- 102000005861 leptin receptors Human genes 0.000 claims 4
- 108010019813 leptin receptors Proteins 0.000 claims 4
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 101000852815 Homo sapiens Insulin receptor Proteins 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 102000047882 human INSR Human genes 0.000 claims 3
- 201000006474 Brain Ischemia Diseases 0.000 claims 2
- 206010008120 Cerebral ischaemia Diseases 0.000 claims 2
- 108010024777 Mating Factor Receptors Proteins 0.000 claims 2
- 108091008605 VEGF receptors Proteins 0.000 claims 2
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 206010008118 cerebral infarction Diseases 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 230000003511 endothelial effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000000626 neurodegenerative effect Effects 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- 229940124676 vascular endothelial growth factor receptor Drugs 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000014461 Ataxins Human genes 0.000 claims 1
- 108010078286 Ataxins Proteins 0.000 claims 1
- 208000022526 Canavan disease Diseases 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 208000024412 Friedreich ataxia Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000026072 Motor neurone disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
- 201000007737 Retinal degeneration Diseases 0.000 claims 1
- 208000006289 Rett Syndrome Diseases 0.000 claims 1
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 208000026911 Tuberous sclerosis complex Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 1
- 102000003675 cytokine receptors Human genes 0.000 claims 1
- 108010057085 cytokine receptors Proteins 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000001749 optic atrophy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000004258 retinal degeneration Effects 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 208000009174 transverse myelitis Diseases 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 208000009999 tuberous sclerosis Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16132009P | 2009-03-18 | 2009-03-18 | |
| US61/161,320 | 2009-03-18 | ||
| PCT/US2010/027882 WO2010108048A2 (en) | 2009-03-18 | 2010-03-18 | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012521194A JP2012521194A (ja) | 2012-09-13 |
| JP2012521194A5 true JP2012521194A5 (enExample) | 2013-05-02 |
| JP5873003B2 JP5873003B2 (ja) | 2016-03-01 |
Family
ID=42740242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500979A Active JP5873003B2 (ja) | 2009-03-18 | 2010-03-18 | ＩｇＧデコイ受容体融合タンパク質の血液脳関門送達のための組成物および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9533055B2 (enExample) |
| EP (1) | EP2408474B1 (enExample) |
| JP (1) | JP5873003B2 (enExample) |
| CA (1) | CA2748889A1 (enExample) |
| WO (1) | WO2010108048A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8741260B2 (en) * | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
| JP5959795B2 (ja) * | 2006-08-18 | 2016-08-02 | アーメイゲン・テクノロジーズ・インコーポレイテッドＡｒｍａｇｅｎ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． | 血液脳関門送達のための物質 |
| EP2182980A4 (en) * | 2007-07-27 | 2012-04-18 | Armagen Technologies Inc | METHOD AND COMPOSITIONS FOR INCREASED ALPHA IDURONIDASE ACTIVITY IN THE CNS |
| CA2748889A1 (en) | 2009-03-18 | 2010-09-23 | Armagen Technologies, Inc. | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
| HRP20190690T1 (hr) | 2009-10-09 | 2019-06-28 | Armagen, Inc. | Postupci i pripravci za povećanje aktiviteta iduronat-2-sulfataze u centralnom nervnom sustavu |
| DK2646470T3 (en) | 2010-11-30 | 2017-05-08 | Hoffmann La Roche | ANTI-TRANSFERRIN RECEPTOR ANTIBODIES WITH LOW AFFINITY AND ITS USE FOR TRANSPORTING THERAPEUTIC SCFV OVER THE BLOOD-BRAIN BARRIER |
| EP2785378B1 (en) | 2011-12-02 | 2020-05-13 | Armagen, Inc. | Methods and compositions for increasing arylsulfatase a activity in the cns |
| WO2013106485A2 (en) | 2012-01-09 | 2013-07-18 | The Scripps Research Institute | Ultralong complementarity determining regions and uses thereof |
| PL2908837T3 (pl) * | 2012-10-19 | 2019-08-30 | Vect-Horus | Kompozycje do dostarczania leku |
| CN105073781A (zh) | 2013-01-11 | 2015-11-18 | 加州生物医学研究所 | 牛融合抗体 |
| WO2014168548A2 (en) * | 2013-04-12 | 2014-10-16 | El Andaloussi, Samir | Therapeutic delivery vesicles |
| WO2015031673A2 (en) | 2013-08-28 | 2015-03-05 | Bioasis Technologies Inc. | Cns-targeted conjugates having modified fc regions and methods of use thereof |
| AU2015213988B2 (en) | 2014-02-10 | 2019-07-11 | Merck Patent Gmbh | Targeted TGFbeta inhibition |
| US10538589B2 (en) | 2015-01-14 | 2020-01-21 | Armagen Inc. | Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU |
| US9553885B2 (en) * | 2015-06-08 | 2017-01-24 | Illusive Networks Ltd. | System and method for creation, deployment and management of augmented attacker map |
| US10940185B2 (en) | 2016-12-28 | 2021-03-09 | Jcr Pharmaceuticals Co., Ltd. | Lyophilized preparation |
| SG11202013210XA (en) | 2018-07-09 | 2021-01-28 | Regeneron Pharma | Tuning of release kinetics in hydrogels |
| WO2020146359A1 (en) * | 2019-01-08 | 2020-07-16 | Armagen, Inc. | Methods and compositions for increasing galactosidase beta-1 activity in the cns |
| CA3128035A1 (en) | 2020-08-13 | 2022-02-13 | Bioasis Technologies, Inc. | Combination therapies for delivery across the blood brain barrier |
| EP4359430A4 (en) * | 2021-06-23 | 2025-07-16 | Lycia Therapeutics Inc | BIFUNCTIONAL COMPOUNDS CONTAINING IGF-2 POLYPEPTIDES |
| WO2023288033A1 (en) | 2021-07-14 | 2023-01-19 | Lycia Therapeutics, Inc. | Asgpr cell surface receptor binding compounds and conjugates |
| WO2024080843A1 (ko) * | 2022-10-14 | 2024-04-18 | 주식회사 아임뉴런 | 뇌혈관장벽 투과성 융합 단백질 및 이의 용도 |
Family Cites Families (94)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5618920A (en) | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4801575A (en) | 1986-07-30 | 1989-01-31 | The Regents Of The University Of California | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5180820A (en) | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
| US5229500A (en) | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
| NZ235148A (en) * | 1989-09-05 | 1991-12-23 | Immunex Corp | Tumour necrosis factor receptor protein and dna sequences |
| US6541610B1 (en) * | 1989-09-05 | 2003-04-01 | Immunex Corporation | Fusion proteins comprising tumor necrosis factor receptor |
| US5672683A (en) | 1989-09-07 | 1997-09-30 | Alkermes, Inc. | Transferrin neuropharmaceutical agent fusion protein |
| US5977307A (en) | 1989-09-07 | 1999-11-02 | Alkermes, Inc. | Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins |
| US5182107A (en) | 1989-09-07 | 1993-01-26 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates |
| US5154924A (en) | 1989-09-07 | 1992-10-13 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
| US6329508B1 (en) | 1989-09-07 | 2001-12-11 | Alkermes, Inc. | Transferrin receptor reactive chimeric antibodies |
| US5527527A (en) | 1989-09-07 | 1996-06-18 | Alkermes, Inc. | Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
| DK0939121T4 (da) * | 1989-09-12 | 2008-02-04 | Ahp Mfg B V | TNF-bindende proteiner |
| TW279133B (enExample) | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| US6060069A (en) | 1991-05-20 | 2000-05-09 | Dura Pharmaceuticals, Inc. | Pulmonary delivery of pharmaceuticals |
| US6287792B1 (en) | 1991-06-17 | 2001-09-11 | The Regents Of The University Of California | Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology |
| ATE188708T1 (de) | 1991-08-21 | 2000-01-15 | Novartis Ag | Antikörperderivate |
| GEP20002243B (en) | 1991-09-20 | 2000-09-25 | Amgen Inc | Glial Derived Neurotrophic Factor |
| JPH06228199A (ja) | 1992-11-27 | 1994-08-16 | Takeda Chem Ind Ltd | 血液脳関門通過可能なペプチド結合体 |
| CA2115900A1 (en) | 1993-02-22 | 1994-08-23 | Gerald W. Becker | Pharmaceutical screens and antibodies |
| US5997501A (en) | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
| PT706799E (pt) | 1994-09-16 | 2002-05-31 | Merck Patent Gmbh | Imunoconjugados ii |
| US5656284A (en) | 1995-04-24 | 1997-08-12 | Balkin; Michael S. | Oral transmucosal delivery tablet and method of making it |
| AU6163196A (en) | 1995-06-07 | 1996-12-30 | Smithkline Beecham Corporation | Method for obtaining receptor agonist antibodies |
| AU719613B2 (en) | 1995-09-19 | 2000-05-11 | Astellas Pharma Inc. | Aerosol compositions |
| US6015662A (en) | 1996-01-23 | 2000-01-18 | Abbott Laboratories | Reagents for use as calibrators and controls |
| US5837231A (en) | 1996-06-27 | 1998-11-17 | Regents Of The University Of Minnesota | GM-CSF administration for the treatment and prevention of recurrence of brain tumors |
| US8173127B2 (en) | 1997-04-09 | 2012-05-08 | Intellect Neurosciences, Inc. | Specific antibodies to amyloid beta peptide, pharmaceutical compositions and methods of use thereof |
| AU8269898A (en) | 1997-06-27 | 1999-01-19 | Regents Of The University Of California, The | Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor |
| WO1999000951A1 (en) | 1997-06-30 | 1999-01-07 | Motorola Inc. | Circuit and packet switched network interconnection |
| US6482923B1 (en) | 1997-09-17 | 2002-11-19 | Human Genome Sciences, Inc. | Interleukin 17-like receptor protein |
| US6016800A (en) | 1997-10-24 | 2000-01-25 | Century; Theodore J. | Intrapulmonary aerosolizer |
| US6165783A (en) | 1997-10-24 | 2000-12-26 | Neuro Spheres Holdings Ltd. | Erythropoietin-mediated neurogenesis |
| US6743427B1 (en) | 1997-12-02 | 2004-06-01 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| WO1999029298A2 (en) | 1997-12-11 | 1999-06-17 | Alza Corporation | Device for enhancing transdermal agent flux |
| US6348210B1 (en) | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
| US6375975B1 (en) | 1998-12-21 | 2002-04-23 | Generex Pharmaceuticals Incorporated | Pharmaceutical compositions for buccal and pulmonary application |
| CA2355976C (en) | 1998-12-22 | 2012-07-17 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists and uses thereof |
| US6284262B1 (en) | 1999-01-26 | 2001-09-04 | Virgil A. Place | Compact dosage unit for buccal administration of a pharmacologically active agent |
| US7214658B2 (en) * | 2004-07-06 | 2007-05-08 | Tact Ip, Llc | Method of delivering a TNF antagonist to the brain of a human by perispinal administration without direct intrathecal injection |
| KR20020068262A (ko) | 1999-03-05 | 2002-08-27 | 에피제네시스 파마슈티칼스 아이엔씨 | 타겟 및 경로 유효/무효화 방법 |
| US7410941B1 (en) | 1999-04-13 | 2008-08-12 | The Kenneth S. Warren Institute, Inc. | Methods for treatment of neurodegenerative conditions by peripherally administered erythropoietin |
| WO2000077178A1 (en) | 1999-06-16 | 2000-12-21 | Boston Biomedical Research Institute | IMMUNOLOGICAL CONTROL OF β-AMYLOID LEVELS IN VIVO |
| CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| JP3589912B2 (ja) | 1999-09-03 | 2004-11-17 | 泰久 福井 | ホスファチジルイノシトール−３，４−二リン酸を認識するモノクローナル抗体 |
| US20020052311A1 (en) | 1999-09-03 | 2002-05-02 | Beka Solomon | Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders |
| US6585971B1 (en) | 1999-11-12 | 2003-07-01 | Harbor-Ucla Research And Education Institute | Recombinant α-L-iduronidase, methods for producing and purifying the same and methods for treating disease caused by deficiencies thereof |
| NZ520171A (en) * | 1999-12-20 | 2005-07-29 | Immunex Corp | Tweak receptor |
| US6248262B1 (en) | 2000-02-03 | 2001-06-19 | General Electric Company | Carbon-reinforced thermoplastic resin composition and articles made from same |
| US6531309B1 (en) | 2000-02-29 | 2003-03-11 | Lexicon Genetics Incorporated | Human transporter proteins and polynucleotides encoding the same |
| US6372250B1 (en) | 2000-04-25 | 2002-04-16 | The Regents Of The University Of California | Non-invasive gene targeting to the brain |
| US6696274B2 (en) | 2000-05-03 | 2004-02-24 | Supratek Pharma, Inc. | Ligand for enhancing oral and CNS delivery of biological agents |
| US7078376B1 (en) | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
| AU2002246580A1 (en) | 2000-12-04 | 2002-07-24 | The Regents Of The University Of California | Antisense imaging of gene expression of the brain in vivo |
| US6908902B2 (en) | 2001-02-02 | 2005-06-21 | Ortho-Mcneil Pharmaceutical, Inc. | Treatment of neurological dysfunction comprising fructopyranose sulfamates and erythropoietin |
| RU2003125637A (ru) | 2001-02-06 | 2005-03-10 | Мерк Патент ГмбХ (DE) | Модифицированный нейтрофический фактор выделенный из мозга человека (bdnf) с уменьшенной иммуногенностью |
| WO2003009815A2 (en) | 2001-07-25 | 2003-02-06 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| PT1944040E (pt) | 2001-08-17 | 2012-10-31 | Univ Washington | Método de avaliação para a doença de alzheimer |
| US7125843B2 (en) | 2001-10-19 | 2006-10-24 | Neose Technologies, Inc. | Glycoconjugates including more than one peptide |
| US7053202B2 (en) | 2001-10-19 | 2006-05-30 | Millennium Pharmaceuticals, Inc. | Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor |
| EP2135879A3 (en) | 2002-06-28 | 2010-06-23 | Domantis Limited | Ligand |
| US7388079B2 (en) | 2002-11-27 | 2008-06-17 | The Regents Of The University Of California | Delivery of pharmaceutical agents via the human insulin receptor |
| US20050142141A1 (en) | 2002-11-27 | 2005-06-30 | Pardridge William M. | Delivery of enzymes to the brain |
| US20040102369A1 (en) | 2002-11-27 | 2004-05-27 | The Regents Of The University Of California | Transport of basic fibroblast growth factor across the blood brain barrier |
| DK2325302T3 (en) | 2003-02-11 | 2016-03-14 | Shire Human Genetic Therapies | Cells expressing a sulfatase and a C-formylglycine-generating enzyme and methods and uses thereof |
| AU2003286870A1 (en) | 2003-06-05 | 2005-01-04 | Salk Institute For Biological Studies | Targeting polypeptides to the central nervous system |
| US7294704B2 (en) | 2003-08-15 | 2007-11-13 | Diadexus, Inc. | Pro108 antibody compositions and methods of use and use of Pro108 to assess cancer risk |
| EP1548031A1 (en) | 2003-12-22 | 2005-06-29 | Dubai Genetics FZ-LLC | Nature-identical erythropoietin |
| NZ576986A (en) | 2004-01-30 | 2010-12-24 | Shire Pharmaceuticals Ireland Ltd | Production and purification of recombinant arylsulfatase A |
| US7939490B2 (en) | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| EP1841455A1 (en) | 2005-01-24 | 2007-10-10 | Amgen Inc. | Humanized anti-amyloid antibody |
| AU2006278573A1 (en) | 2005-08-03 | 2007-02-15 | Immunogen, Inc. | Immunoconjugate formulations |
| EP1937720B1 (en) | 2005-08-18 | 2014-04-09 | Ramot at Tel-Aviv University Ltd. | Single chain antibodies against beta-amyloid peptide |
| US8124095B2 (en) | 2005-10-07 | 2012-02-28 | Armagen Technologies, Inc. | Fusion proteins for delivery of erythropoietin to the CNS |
| US8142781B2 (en) | 2005-10-07 | 2012-03-27 | Armagen Technologies, Inc. | Fusion proteins for blood-brain barrier delivery |
| US8741260B2 (en) | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
| JP5959795B2 (ja) | 2006-08-18 | 2016-08-02 | アーメイゲン・テクノロジーズ・インコーポレイテッドＡｒｍａｇｅｎ Ｔｅｃｈｎｏｌｏｇｉｅｓ， Ｉｎｃ． | 血液脳関門送達のための物質 |
| JP2010510794A (ja) | 2006-11-28 | 2010-04-08 | ハナル ファーマシューティカル カンパニー リミテッド | 修飾型エリスロポエチンポリペプチド及びこの治療用用途 |
| US20100172919A1 (en) | 2007-06-15 | 2010-07-08 | Jan Grimm | Noveltreatment for neurological disorders |
| EP2182980A4 (en) | 2007-07-27 | 2012-04-18 | Armagen Technologies Inc | METHOD AND COMPOSITIONS FOR INCREASED ALPHA IDURONIDASE ACTIVITY IN THE CNS |
| WO2009070597A2 (en) | 2007-11-26 | 2009-06-04 | Armagen Technologies, Inc. | Fusion proteins for delivery of gdnf to the cns |
| EP2313109A2 (en) * | 2008-07-02 | 2011-04-27 | Emergent Product Development Seattle, LLC | Il6 immunotherapeutics |
| US20100077498A1 (en) | 2008-09-11 | 2010-03-25 | Pardridge William M | Compositions and methods for blood-brain barrier delivery in the mouse |
| US20100098693A1 (en) | 2008-10-07 | 2010-04-22 | Pardridge William M | Compositions and methods for blood-brain barrier delivery of organophosphatases |
| CA2748889A1 (en) | 2009-03-18 | 2010-09-23 | Armagen Technologies, Inc. | Compositions and methods for blood-brain barrier delivery of igg-decoy receptor fusion proteins |
| CA2765889A1 (en) | 2009-06-24 | 2010-12-29 | Opko Curna, Llc | Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2 |
| HRP20190690T1 (hr) | 2009-10-09 | 2019-06-28 | Armagen, Inc. | Postupci i pripravci za povećanje aktiviteta iduronat-2-sulfataze u centralnom nervnom sustavu |
| US9320711B2 (en) | 2010-06-25 | 2016-04-26 | Shire Human Genetic Therapies, Inc. | Methods and compositions for CNS delivery of heparan N-sulfatase |
| EP2785378B1 (en) | 2011-12-02 | 2020-05-13 | Armagen, Inc. | Methods and compositions for increasing arylsulfatase a activity in the cns |
| EP3024848B1 (en) | 2013-07-22 | 2020-07-08 | Armagen, Inc. | Methods and compositions for increasing enzyme activity in the cns |
-
2010
- 2010-03-18 CA CA2748889A patent/CA2748889A1/en not_active Abandoned
- 2010-03-18 JP JP2012500979A patent/JP5873003B2/ja active Active
- 2010-03-18 WO PCT/US2010/027882 patent/WO2010108048A2/en not_active Ceased
- 2010-03-18 EP EP10754139.3A patent/EP2408474B1/en active Active
- 2010-03-18 US US13/141,682 patent/US9533055B2/en not_active Expired - Fee Related
-
2016
- 2016-11-21 US US15/357,894 patent/US20170066832A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012521194A5 (enExample) | ||
| HRP20180516T1 (hr) | Humanizirana protutijela specifična za protofibrilni oblik amiloidnog-beta peptida | |
| AU2016357460B2 (en) | Improved serum albumin binders | |
| AU2016351710B2 (en) | Improved serum albumin-binding immunoglobulin variable domains | |
| KR101921767B1 (ko) | 단백질 정제 | |
| JP2020506898A5 (enExample) | ||
| JP2012507557A5 (enExample) | ||
| SI2699601T1 (en) | PROTITOLIC POLYPETIDES AS THE CD40 ANTAGONISTS | |
| JP2011526792A5 (enExample) | ||
| JP2019500862A5 (enExample) | ||
| US12384822B2 (en) | TAM receptor-binding fusion molecule having non-inflammatory phagocytosis inducing activity | |
| TW200840821A (en) | Methods of purifying anti A beta antibodies | |
| JP2017506075A5 (enExample) | ||
| FI2968461T3 (fi) | Fuusioproteiineja, jotka käsittävät pdgf:ää ja vegf:ää sitovia osia, ja menetelmiä niiden käyttämiseksi | |
| EP3218411A2 (en) | Variable new antigen receptors (vnars) directed against transferrin receptor (tfr) and their use | |
| JP2015530983A5 (enExample) | ||
| EP2281000A2 (en) | Antibody purification process | |
| HRP20192267T1 (hr) | Terapeutski agens ili profilaktički agens za demenciju | |
| JP2015537190A5 (enExample) | ||
| CA3066251A1 (en) | Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins | |
| JP2013538566A5 (enExample) | ||
| JP2018505651A5 (enExample) | ||
| JP2016525545A5 (enExample) | ||
| CN103201288A (zh) | 通过混合模式层析捕捉抗体的优化方法 | |
| JP2014530001A5 (enExample) |