JP2012519694A5 - - Google Patents
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- JP2012519694A5 JP2012519694A5 JP2011553071A JP2011553071A JP2012519694A5 JP 2012519694 A5 JP2012519694 A5 JP 2012519694A5 JP 2011553071 A JP2011553071 A JP 2011553071A JP 2011553071 A JP2011553071 A JP 2011553071A JP 2012519694 A5 JP2012519694 A5 JP 2012519694A5
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- Prior art keywords
- aqueous solution
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007864 aqueous solution Substances 0.000 claims description 48
- 239000000203 mixture Substances 0.000 claims description 30
- 239000013543 active substance Substances 0.000 claims description 18
- 229920001223 polyethylene glycol Polymers 0.000 claims description 12
- 239000000243 solution Substances 0.000 claims description 12
- 239000008118 PEG 6000 Substances 0.000 claims description 10
- 229920002538 Polyethylene Glycol 20000 Polymers 0.000 claims description 10
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 10
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 6
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 6
- 206010029113 Neovascularisation Diseases 0.000 claims description 5
- 208000022873 Ocular disease Diseases 0.000 claims description 5
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 4
- MPVGZUGXCQEXTM-UHFFFAOYSA-N linifanib Chemical group CC1=CC=C(F)C(NC(=O)NC=2C=CC(=CC=2)C=2C=3C(N)=NNC=3C=CC=2)=C1 MPVGZUGXCQEXTM-UHFFFAOYSA-N 0.000 claims description 4
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims description 4
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims description 4
- 230000008728 vascular permeability Effects 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 2
- 208000008069 Geographic Atrophy Diseases 0.000 claims description 2
- 208000001344 Macular Edema Diseases 0.000 claims description 2
- 206010025415 Macular oedema Diseases 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 206010046851 Uveitis Diseases 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 230000002137 anti-vascular effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 230000003902 lesion Effects 0.000 claims description 2
- 208000002780 macular degeneration Diseases 0.000 claims description 2
- 201000010230 macular retinal edema Diseases 0.000 claims description 2
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 9
- 230000033115 angiogenesis Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15692209P | 2009-03-03 | 2009-03-03 | |
| US61/156,922 | 2009-03-03 | ||
| PCT/US2010/026033 WO2010101992A1 (en) | 2009-03-03 | 2010-03-03 | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519694A JP2012519694A (ja) | 2012-08-30 |
| JP2012519694A5 true JP2012519694A5 (https=) | 2013-03-07 |
| JP5583146B2 JP5583146B2 (ja) | 2014-09-03 |
Family
ID=42678800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553071A Expired - Fee Related JP5583146B2 (ja) | 2009-03-03 | 2010-03-03 | レセプターチロシンキナーゼ阻害（ＲＴＫｉ）化合物の眼への送達のための薬学的組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20100227905A1 (https=) |
| EP (1) | EP2403335B1 (https=) |
| JP (1) | JP5583146B2 (https=) |
| KR (2) | KR20110130454A (https=) |
| CN (1) | CN102340991B (https=) |
| AU (1) | AU2010221369B2 (https=) |
| BR (1) | BRPI1012302A2 (https=) |
| CA (1) | CA2753690A1 (https=) |
| ES (1) | ES2508290T3 (https=) |
| MX (1) | MX2011008731A (https=) |
| WO (1) | WO2010101992A1 (https=) |
| ZA (1) | ZA201105505B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| MY160399A (en) | 2009-07-06 | 2017-03-15 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| EP2538929A4 (en) | 2010-02-25 | 2014-07-09 | Univ Johns Hopkins | DELAYED RELEASE OF THERAPIES IN A PART OF THE EYE |
| US20120022149A1 (en) * | 2010-07-21 | 2012-01-26 | Chowhan Masood A | Pharmaceutical composition with enhanced solubility characteristics |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| WO2012109363A2 (en) | 2011-02-08 | 2012-08-16 | The Johns Hopkins University | Mucus penetrating gene carriers |
| US20140160236A1 (en) * | 2011-07-29 | 2014-06-12 | The Regents Of The University Of California | Lensfree holographic microscopy using wetting films |
| AU2012323856B2 (en) | 2011-10-13 | 2017-05-25 | EyePoint, Inc. | Methods for treating Vascular Leak Syndrome and cancer |
| CA2863632C (en) | 2012-01-19 | 2017-07-11 | The Johns Hopkins University | Nanoparticle formulations with enhanced mucosal penetration |
| US8962577B2 (en) | 2012-03-16 | 2015-02-24 | The Johns Hopkins University | Controlled release formulations for the delivery of HIF-1 inhibitors |
| JP6138904B2 (ja) | 2012-03-16 | 2017-05-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート |
| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| AU2013256064B2 (en) | 2012-05-03 | 2018-01-04 | Alcon Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| KR102310775B1 (ko) | 2012-05-03 | 2021-10-07 | 칼라 파마슈티컬스, 인크. | 개선된 점막 수송을 나타내는 제약 나노입자 |
| AU2013256008B2 (en) | 2012-05-04 | 2016-02-25 | The Johns Hopkins University | Lipid-based drug carriers for rapid penetration through mucus linings |
| WO2014124006A1 (en) | 2013-02-05 | 2014-08-14 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| RU2646098C2 (ru) * | 2013-04-30 | 2018-03-01 | Интас Фармасьютикалс Лтд | Новый способ клонирования, экспрессии и очистки для получения ранибизумаба |
| WO2015127368A1 (en) | 2014-02-23 | 2015-08-27 | The Johns Hopkins University | Hypotonic microbicidal formulations and methods of use |
| EP3116503A4 (en) | 2014-03-14 | 2017-08-23 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| CN107278151A (zh) | 2014-12-15 | 2017-10-20 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗青光眼中的使用方法 |
| CN107635545A (zh) | 2015-01-27 | 2018-01-26 | 约翰霍普金斯大学 | 用于增强粘膜表面处活性剂的输送的低渗水凝胶制剂 |
| ES2981607T3 (es) | 2015-09-23 | 2024-10-09 | Eyepoint Pharmaceuticals Inc | Activadores de Tie-2 para uso en el tratamiento de la presión intraocular |
| CN108367079B (zh) | 2015-11-12 | 2022-11-22 | 灰色视觉公司 | 用于治疗的聚集性微粒 |
| CA3056923A1 (en) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| US11160870B2 (en) | 2017-05-10 | 2021-11-02 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| US12496279B2 (en) | 2019-04-11 | 2025-12-16 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
| EP3962482A4 (en) | 2019-04-29 | 2023-01-11 | EyePoint Pharmaceuticals, Inc. | TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL |
| ES2992596T3 (en) * | 2019-11-28 | 2024-12-16 | Caprika Srl | Rectal-use composition for the treatment of constipation |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| ES2141775T3 (es) * | 1993-04-16 | 2000-04-01 | Wakamoto Pharma Co Ltd | Composicion medicinal a base de agua termicamente gelificante reversible. |
| CA2226348A1 (en) * | 1996-05-07 | 1997-11-13 | Takashi Ikari | Ophthalmic preparations |
| JP4810427B2 (ja) * | 2003-05-22 | 2011-11-09 | アボット・ラボラトリーズ | インダゾール、ベンズイソオキサゾールおよびベンズイソチアゾールキナーゼ阻害剤 |
| TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| CN101006988A (zh) * | 2005-09-26 | 2007-08-01 | 刘凤鸣 | 葛根素的缓释制剂 |
| JP2009521493A (ja) * | 2005-12-23 | 2009-06-04 | アルコン，インコーポレイテッド | 眼への受容体チロシンキナーゼ阻害（ＲＴＫｉ）化合物の送達のための医薬製剤 |
| JP2009521510A (ja) * | 2005-12-23 | 2009-06-04 | アルコン，インコーポレイテッド | 眼への受容体チロシンキナーゼ阻害（ｒｔｋｉ）化合物の送達のための医薬製剤 |
| JP2010534201A (ja) * | 2007-07-20 | 2010-11-04 | アルコン，インコーポレイテッド | 受容体チロシンキナーゼ阻害（ＲＴＫｉ）化合物の目への送達のための医薬製剤 |
-
2010
- 2010-03-03 BR BRPI1012302A patent/BRPI1012302A2/pt not_active IP Right Cessation
- 2010-03-03 ES ES10749258.9T patent/ES2508290T3/es active Active
- 2010-03-03 US US12/716,663 patent/US20100227905A1/en not_active Abandoned
- 2010-03-03 KR KR1020117023001A patent/KR20110130454A/ko not_active Ceased
- 2010-03-03 CN CN201080010150.0A patent/CN102340991B/zh not_active Expired - Fee Related
- 2010-03-03 MX MX2011008731A patent/MX2011008731A/es active IP Right Grant
- 2010-03-03 CA CA2753690A patent/CA2753690A1/en not_active Abandoned
- 2010-03-03 EP EP10749258.9A patent/EP2403335B1/en not_active Not-in-force
- 2010-03-03 AU AU2010221369A patent/AU2010221369B2/en not_active Ceased
- 2010-03-03 JP JP2011553071A patent/JP5583146B2/ja not_active Expired - Fee Related
- 2010-03-03 KR KR1020167032103A patent/KR20160135372A/ko not_active Abandoned
- 2010-03-03 WO PCT/US2010/026033 patent/WO2010101992A1/en not_active Ceased
-
2011
- 2011-07-26 ZA ZA2011/05505A patent/ZA201105505B/en unknown
-
2013
- 2013-01-25 US US13/749,887 patent/US20130137741A1/en not_active Abandoned
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