JP2012519692A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012519692A5 JP2012519692A5 JP2011553061A JP2011553061A JP2012519692A5 JP 2012519692 A5 JP2012519692 A5 JP 2012519692A5 JP 2011553061 A JP2011553061 A JP 2011553061A JP 2011553061 A JP2011553061 A JP 2011553061A JP 2012519692 A5 JP2012519692 A5 JP 2012519692A5
- Authority
- JP
- Japan
- Prior art keywords
- suspension
- composition
- peg
- item
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000725 suspension Substances 0.000 claims description 85
- 239000000203 mixture Substances 0.000 claims description 44
- 239000013543 active substance Substances 0.000 claims description 26
- 229920001223 polyethylene glycol Polymers 0.000 claims description 20
- 229920002538 Polyethylene Glycol 20000 Polymers 0.000 claims description 14
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims description 14
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims description 14
- 239000003112 inhibitor Substances 0.000 claims description 12
- 239000002245 particle Substances 0.000 claims description 10
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 10
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 10
- 229920000053 polysorbate 80 Polymers 0.000 claims description 10
- 229940068968 polysorbate 80 Drugs 0.000 claims description 10
- 206010029113 Neovascularisation Diseases 0.000 claims description 9
- 208000022873 Ocular disease Diseases 0.000 claims description 9
- 229920002560 Polyethylene Glycol 3000 Polymers 0.000 claims description 8
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 8
- MPVGZUGXCQEXTM-UHFFFAOYSA-N linifanib Chemical group CC1=CC=C(F)C(NC(=O)NC=2C=CC(=CC=2)C=2C=3C(N)=NNC=3C=CC=2)=C1 MPVGZUGXCQEXTM-UHFFFAOYSA-N 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 7
- 239000007924 injection Substances 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- 229920001664 tyloxapol Polymers 0.000 claims description 6
- MDYZKJNTKZIUSK-UHFFFAOYSA-N tyloxapol Chemical compound O=C.C1CO1.CC(C)(C)CC(C)(C)C1=CC=C(O)C=C1 MDYZKJNTKZIUSK-UHFFFAOYSA-N 0.000 claims description 6
- 229960004224 tyloxapol Drugs 0.000 claims description 6
- 229940100654 ophthalmic suspension Drugs 0.000 claims description 5
- 239000008118 PEG 6000 Substances 0.000 claims description 4
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 4
- 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
- 206010064930 age-related macular degeneration Diseases 0.000 claims description 4
- 239000002736 nonionic surfactant Substances 0.000 claims description 4
- 239000008389 polyethoxylated castor oil Substances 0.000 claims description 4
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 4
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- 229940068977 polysorbate 20 Drugs 0.000 claims description 4
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims description 4
- 230000008728 vascular permeability Effects 0.000 claims description 4
- 206010012689 Diabetic retinopathy Diseases 0.000 claims description 2
- 208000008069 Geographic Atrophy Diseases 0.000 claims description 2
- 208000001344 Macular Edema Diseases 0.000 claims description 2
- 206010025415 Macular oedema Diseases 0.000 claims description 2
- 206010046851 Uveitis Diseases 0.000 claims description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 2
- 230000002137 anti-vascular effect Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 230000003902 lesion Effects 0.000 claims description 2
- 208000002780 macular degeneration Diseases 0.000 claims description 2
- 201000010230 macular retinal edema Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 12
- 230000033115 angiogenesis Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15698409P | 2009-03-03 | 2009-03-03 | |
| US61/156,984 | 2009-03-03 | ||
| PCT/US2010/025998 WO2010101971A1 (en) | 2009-03-03 | 2010-03-03 | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519692A JP2012519692A (ja) | 2012-08-30 |
| JP2012519692A5 true JP2012519692A5 (https=) | 2013-03-07 |
| JP5583145B2 JP5583145B2 (ja) | 2014-09-03 |
Family
ID=42678477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553061A Expired - Fee Related JP5583145B2 (ja) | 2009-03-03 | 2010-03-03 | レセプターチロシンキナーゼ阻害（ＲＴＫｉ）化合物の眼への送達のための薬学的組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100226992A1 (https=) |
| EP (1) | EP2403342A4 (https=) |
| JP (1) | JP5583145B2 (https=) |
| KR (1) | KR20110123789A (https=) |
| CN (2) | CN105362221A (https=) |
| AU (1) | AU2010221438C1 (https=) |
| BR (1) | BRPI1008920A2 (https=) |
| CA (1) | CA2753837A1 (https=) |
| MX (1) | MX2011008680A (https=) |
| WO (1) | WO2010101971A1 (https=) |
| ZA (1) | ZA201105506B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| TW201023912A (en) | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
| US8912236B2 (en) | 2009-03-03 | 2014-12-16 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye |
| MY160399A (en) | 2009-07-06 | 2017-03-15 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| AU2012323856B2 (en) | 2011-10-13 | 2017-05-25 | EyePoint, Inc. | Methods for treating Vascular Leak Syndrome and cancer |
| KR20150000869A (ko) * | 2011-12-14 | 2015-01-05 | 애브비 인코포레이티드 | 키나제 억제제를 함유하는 조성물 |
| EP2825166A1 (en) * | 2012-03-12 | 2015-01-21 | Allergan, Inc. | Method of treating ophthalmic conditions with kinase inhibitors |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| BR112016006153A2 (pt) | 2013-09-20 | 2017-08-01 | Santen Pharmaceutical Co Ltd | composição contendo polietileno glicol |
| EP3116503A4 (en) | 2014-03-14 | 2017-08-23 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| ES2863601T3 (es) * | 2014-09-17 | 2021-10-11 | Panoptica Inc | Formulaciones oculares para administración de fármacos y protección del segmento anterior del ojo |
| WO2016197005A1 (en) * | 2015-06-05 | 2016-12-08 | Kato Pharmaceuticals, Inc. | Extended release urea compositions |
| TWI700085B (zh) * | 2015-06-22 | 2020-08-01 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物的用途 |
| ES2981607T3 (es) | 2015-09-23 | 2024-10-09 | Eyepoint Pharmaceuticals Inc | Activadores de Tie-2 para uso en el tratamiento de la presión intraocular |
| EP3962482A4 (en) | 2019-04-29 | 2023-01-11 | EyePoint Pharmaceuticals, Inc. | TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL |
| EP4028015A4 (en) * | 2019-09-13 | 2023-11-15 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations of methotrexate |
| AU2020354996B2 (en) | 2019-09-27 | 2022-12-01 | Virginia Commonwealth University | Compositions and methods for restoring or increasing tissue perfusion |
| CN116251186B (zh) * | 2021-12-09 | 2025-04-25 | 成都瑞沐生物医药科技有限公司 | 一种酪氨酸激酶抑制剂眼用制剂及其制备方法和用途 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856919A (en) * | 1970-06-08 | 1974-12-24 | Burton Parsons Chemicals Inc | Ophthalmic solution |
| US3931319A (en) * | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4027020A (en) * | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US4409205A (en) * | 1979-03-05 | 1983-10-11 | Cooper Laboratories, Inc. | Ophthalmic solution |
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4525346A (en) * | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US4836986A (en) * | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| US5037647A (en) * | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5461081A (en) * | 1989-09-28 | 1995-10-24 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| US5932572A (en) * | 1992-02-21 | 1999-08-03 | Alcon Laboratories, Inc. | Topical anti-glaucoma compositions |
| US5300287A (en) * | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| ES2141775T3 (es) * | 1993-04-16 | 2000-04-01 | Wakamoto Pharma Co Ltd | Composicion medicinal a base de agua termicamente gelificante reversible. |
| CA2226348A1 (en) * | 1996-05-07 | 1997-11-13 | Takashi Ikari | Ophthalmic preparations |
| CA2264290C (en) * | 1997-07-29 | 2005-11-29 | Alcon Laboratories, Inc. | Conditioning solutions for contact lens care |
| NZ517556A (en) * | 1999-09-06 | 2003-08-29 | Ono Pharmaceutical Co | N-[o-(p-pivaloyloxybenzenesulphonyl-amino)benzoyl]glycine as preventive and therapeutic agents for eye diseases |
| WO2001022936A1 (en) * | 1999-09-24 | 2001-04-05 | Alcon Universal Ltd. | Topical suspension formulations containing ciprofloxacin and dexamethasone |
| AU4511201A (en) * | 1999-12-03 | 2001-06-12 | Ista Pharmaceuticals, Inc | Compositions and methods for the induction and treatment of retinal detachments |
| WO2001087262A2 (en) * | 2000-05-15 | 2001-11-22 | Pharmacia Italia S.P.A. | Stabilized steroidal suspension |
| EP1318787A2 (en) * | 2000-07-26 | 2003-06-18 | Alcon Inc. | Pharmaceutical suspension compositions lacking a polymeric suspending agent |
| JP3450805B2 (ja) * | 2000-08-08 | 2003-09-29 | わかもと製薬株式会社 | 水性医薬組成物 |
| US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
| US6743439B1 (en) * | 2001-06-27 | 2004-06-01 | Alcon, Inc. | Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride |
| RU2295346C2 (ru) * | 2001-09-21 | 2007-03-20 | Алькон, Инк. | Способ лечения инфекций среднего уха |
| US7001615B1 (en) * | 2001-12-07 | 2006-02-21 | Alcon, Inc. | Sustained release ophthalmic, otic and nasal suspension |
| WO2004000284A1 (en) * | 2002-06-21 | 2003-12-31 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
| JP4810427B2 (ja) * | 2003-05-22 | 2011-11-09 | アボット・ラボラトリーズ | インダゾール、ベンズイソオキサゾールおよびベンズイソチアゾールキナーゼ阻害剤 |
| US20040235892A1 (en) * | 2003-05-22 | 2004-11-25 | Yujia Dai | Indazole and benzisoxazole kinase inhibitors |
| SI1755616T1 (sl) * | 2004-04-08 | 2014-04-30 | Eye Co Pty Ltd. | Zdravljenje eksudativne retinopatije z mineralkortikoidi |
| TWI358290B (en) * | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| CA2607608A1 (en) * | 2005-05-10 | 2006-11-16 | Alcon, Inc. | Suspension formulations of nepafenac and other ophthalmic drugs for topical treatment of ophthalmic disorders |
| PL1906916T3 (pl) * | 2005-05-10 | 2009-02-27 | Alcon Inc | Zawiesina do oczu obejmująca lek okulistyczny, poloksaminę i glikolowy środek regulujący toniczność, zastosowanie wymienionej kompozycji do wytwarzania leku do leczenia zaburzeń wzroku |
| US20070149480A1 (en) * | 2005-12-23 | 2007-06-28 | Alcon, Inc. | PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| JP2009521493A (ja) * | 2005-12-23 | 2009-06-04 | アルコン，インコーポレイテッド | 眼への受容体チロシンキナーゼ阻害（ＲＴＫｉ）化合物の送達のための医薬製剤 |
| US20070173538A1 (en) * | 2005-12-23 | 2007-07-26 | Alcon, Inc. | PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| US20070249546A1 (en) * | 2006-04-22 | 2007-10-25 | Sawaya Assad S | Ophthalmic and related aqueous solutions containing antifungal agents, uses therefor and methods for preparing them |
| JP2010534201A (ja) * | 2007-07-20 | 2010-11-04 | アルコン，インコーポレイテッド | 受容体チロシンキナーゼ阻害（ＲＴＫｉ）化合物の目への送達のための医薬製剤 |
| TW201023912A (en) * | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
-
2010
- 2010-03-03 MX MX2011008680A patent/MX2011008680A/es active IP Right Grant
- 2010-03-03 CN CN201510767618.5A patent/CN105362221A/zh active Pending
- 2010-03-03 WO PCT/US2010/025998 patent/WO2010101971A1/en not_active Ceased
- 2010-03-03 CA CA2753837A patent/CA2753837A1/en not_active Abandoned
- 2010-03-03 AU AU2010221438A patent/AU2010221438C1/en not_active Ceased
- 2010-03-03 CN CN2010800101411A patent/CN102340993A/zh active Pending
- 2010-03-03 EP EP10749243.1A patent/EP2403342A4/en not_active Withdrawn
- 2010-03-03 US US12/716,385 patent/US20100226992A1/en not_active Abandoned
- 2010-03-03 BR BRPI1008920-9A patent/BRPI1008920A2/pt not_active IP Right Cessation
- 2010-03-03 KR KR1020117023002A patent/KR20110123789A/ko not_active Ceased
- 2010-03-03 JP JP2011553061A patent/JP5583145B2/ja not_active Expired - Fee Related
-
2011
- 2011-07-26 ZA ZA2011/05506A patent/ZA201105506B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012519692A5 (https=) | ||
| JP2012519694A5 (https=) | ||
| US11951103B2 (en) | Pharmaceutical composition | |
| HS Boddu et al. | Drug delivery to the back of the eye following topical administration: an update on research and patenting activity | |
| JP5583145B2 (ja) | レセプターチロシンキナーゼ阻害（ＲＴＫｉ）化合物の眼への送達のための薬学的組成物 | |
| JP2009521493A (ja) | 眼への受容体チロシンキナーゼ阻害（ＲＴＫｉ）化合物の送達のための医薬製剤 | |
| JP7716996B2 (ja) | 薬剤を含む水性組成物のｐＨを安定化させるための方法 | |
| TW202216119A (zh) | 眼用活性醫藥成分輸送的固態環糊精複合物製備 | |
| JP5934229B2 (ja) | 眼血管疾患の処置のための投与計画 | |
| RU2017112930A (ru) | Офтальмологические составы для доставки лекарств и защиты переднего отдела глаза | |
| JP2019524724A (ja) | テコビリマットの経口用医薬組成物及びその調製法 | |
| US20180009758A1 (en) | Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use | |
| US20170342033A1 (en) | Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use | |
| US20160376239A1 (en) | N-Acylalkyl Prodrugs of Multi-Tyrosine Kinase Inhibitors and Methods of Use | |
| Khan et al. | Ocular drug delivery: introduction and fundamental concept | |
| JP2019163227A (ja) | 医薬組成物 | |
| US10464902B1 (en) | Multi-tyrosine kinase inhibitors derivatives and methods of use | |
| US11623917B2 (en) | Multi-tyrosine kinase inhibitors derivatives and methods of use | |
| US20170020856A1 (en) | N-Acylalkyl Prodrugs of Multi-Tyrosine Kinase Inhibitors and Methods of Use | |
| US20170143688A1 (en) | Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use | |
| CA3036474C (en) | Therapeutic agent for an ophthalmic disease comprising a vegf receptor inhibitor | |
| KR20230089987A (ko) | 펩타이드 약물을 포함하는 안구 투여용 약학 조성물 | |
| EA050512B1 (ru) | СПОСОБ СТАБИЛИЗАЦИИ рН ВОДНОЙ КОМПОЗИЦИИ, СОДЕРЖАЩЕЙ ЛЕКАРСТВЕННОЕ СРЕДСТВО | |
| US20170112821A1 (en) | Multi-Tyrosine Kinase Inhibitors Derivatives and Methods of Use | |
| HK40007038B (en) | Medicinal composition comprising tivozanib |