JP5583145B2 - レセプターチロシンキナーゼ阻害(RTKi)化合物の眼への送達のための薬学的組成物 - Google Patents

レセプターチロシンキナーゼ阻害(RTKi)化合物の眼への送達のための薬学的組成物 Download PDF

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JP5583145B2
JP5583145B2 JP2011553061A JP2011553061A JP5583145B2 JP 5583145 B2 JP5583145 B2 JP 5583145B2 JP 2011553061 A JP2011553061 A JP 2011553061A JP 2011553061 A JP2011553061 A JP 2011553061A JP 5583145 B2 JP5583145 B2 JP 5583145B2
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suspension
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composition
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JP2012519692A5 (https=
JP2012519692A (ja
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バーグワティ ピー. カブラ,
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アルコン リサーチ, リミテッド
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011553061A 2009-03-03 2010-03-03 レセプターチロシンキナーゼ阻害(RTKi)化合物の眼への送達のための薬学的組成物 Expired - Fee Related JP5583145B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15698409P 2009-03-03 2009-03-03
US61/156,984 2009-03-03
PCT/US2010/025998 WO2010101971A1 (en) 2009-03-03 2010-03-03 Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye

Publications (3)

Publication Number Publication Date
JP2012519692A JP2012519692A (ja) 2012-08-30
JP2012519692A5 JP2012519692A5 (https=) 2013-03-07
JP5583145B2 true JP5583145B2 (ja) 2014-09-03

Family

ID=42678477

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011553061A Expired - Fee Related JP5583145B2 (ja) 2009-03-03 2010-03-03 レセプターチロシンキナーゼ阻害(RTKi)化合物の眼への送達のための薬学的組成物

Country Status (11)

Country Link
US (1) US20100226992A1 (https=)
EP (1) EP2403342A4 (https=)
JP (1) JP5583145B2 (https=)
KR (1) KR20110123789A (https=)
CN (2) CN105362221A (https=)
AU (1) AU2010221438C1 (https=)
BR (1) BRPI1008920A2 (https=)
CA (1) CA2753837A1 (https=)
MX (1) MX2011008680A (https=)
WO (1) WO2010101971A1 (https=)
ZA (1) ZA201105506B (https=)

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US8912236B2 (en) 2009-03-03 2014-12-16 Alcon Research, Ltd. Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
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AU2012323856B2 (en) 2011-10-13 2017-05-25 EyePoint, Inc. Methods for treating Vascular Leak Syndrome and cancer
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EP2825166A1 (en) * 2012-03-12 2015-01-21 Allergan, Inc. Method of treating ophthalmic conditions with kinase inhibitors
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EP3116503A4 (en) 2014-03-14 2017-08-23 Aerpio Therapeutics, Inc. Hptp-beta inhibitors
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EP3962482A4 (en) 2019-04-29 2023-01-11 EyePoint Pharmaceuticals, Inc. TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL
EP4028015A4 (en) * 2019-09-13 2023-11-15 Aldeyra Therapeutics, Inc. Ophthalmic formulations of methotrexate
AU2020354996B2 (en) 2019-09-27 2022-12-01 Virginia Commonwealth University Compositions and methods for restoring or increasing tissue perfusion
CN116251186B (zh) * 2021-12-09 2025-04-25 成都瑞沐生物医药科技有限公司 一种酪氨酸激酶抑制剂眼用制剂及其制备方法和用途

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Also Published As

Publication number Publication date
EP2403342A1 (en) 2012-01-11
CN105362221A (zh) 2016-03-02
WO2010101971A1 (en) 2010-09-10
AU2010221438B2 (en) 2014-10-16
MX2011008680A (es) 2011-09-08
ZA201105506B (en) 2012-09-26
JP2012519692A (ja) 2012-08-30
EP2403342A4 (en) 2013-06-05
AU2010221438C1 (en) 2015-01-29
CN102340993A (zh) 2012-02-01
AU2010221438A1 (en) 2011-08-25
BRPI1008920A2 (pt) 2015-08-25
CA2753837A1 (en) 2010-09-10
US20100226992A1 (en) 2010-09-09
KR20110123789A (ko) 2011-11-15

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