CA2753837A1 - Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye - Google Patents
Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye Download PDFInfo
- Publication number
- CA2753837A1 CA2753837A1 CA2753837A CA2753837A CA2753837A1 CA 2753837 A1 CA2753837 A1 CA 2753837A1 CA 2753837 A CA2753837 A CA 2753837A CA 2753837 A CA2753837 A CA 2753837A CA 2753837 A1 CA2753837 A1 CA 2753837A1
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- 230000006444 vascular growth Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15698409P | 2009-03-03 | 2009-03-03 | |
| US61/156,984 | 2009-03-03 | ||
| PCT/US2010/025998 WO2010101971A1 (en) | 2009-03-03 | 2010-03-03 | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2753837A1 true CA2753837A1 (en) | 2010-09-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2753837A Abandoned CA2753837A1 (en) | 2009-03-03 | 2010-03-03 | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100226992A1 (https=) |
| EP (1) | EP2403342A4 (https=) |
| JP (1) | JP5583145B2 (https=) |
| KR (1) | KR20110123789A (https=) |
| CN (2) | CN105362221A (https=) |
| AU (1) | AU2010221438C1 (https=) |
| BR (1) | BRPI1008920A2 (https=) |
| CA (1) | CA2753837A1 (https=) |
| MX (1) | MX2011008680A (https=) |
| WO (1) | WO2010101971A1 (https=) |
| ZA (1) | ZA201105506B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2494108C2 (ru) | 2006-04-07 | 2013-09-27 | Аерпио Терапетикс, Инк. | Антитела, которые связывают человеческий белок бета-тирозин фосфатазу (нртрвета), и их использование |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| TW201023912A (en) | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
| US8912236B2 (en) | 2009-03-03 | 2014-12-16 | Alcon Research, Ltd. | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye |
| ES2726946T3 (es) | 2009-07-06 | 2019-10-10 | Aerpio Therapeutics Inc | Derivados de benzosulfonamida, composiciones de los mismos y su uso en la prevención de la metástasis de las células cancerosas |
| WO2013056240A1 (en) | 2011-10-13 | 2013-04-18 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
| PE20142103A1 (es) * | 2011-12-14 | 2015-01-11 | Abbvie Inc | Composiciones que contienen inhibidores de quinasas |
| EP2825166A1 (en) * | 2012-03-12 | 2015-01-21 | Allergan, Inc. | Method of treating ophthalmic conditions with kinase inhibitors |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| KR20160060656A (ko) | 2013-09-20 | 2016-05-30 | 산텐 세이야꾸 가부시키가이샤 | 폴리에틸렌글리콜 함유 조성물 |
| EP3116503A4 (en) | 2014-03-14 | 2017-08-23 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| RU2768652C1 (ru) * | 2014-09-17 | 2022-03-24 | Паноптика, Инк. | Офтальмологические составы для доставки лекарств и защиты переднего отдела глаза |
| WO2016197005A1 (en) * | 2015-06-05 | 2016-12-08 | Kato Pharmaceuticals, Inc. | Extended release urea compositions |
| TWI700085B (zh) * | 2015-06-22 | 2020-08-01 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物的用途 |
| ES2894802T3 (es) | 2015-09-23 | 2022-02-15 | Aerpio Pharmaceuticals Inc | Activadores de Tie-2 para su uso en el tratamiento de la presión intraocular |
| EP3962482A4 (en) | 2019-04-29 | 2023-01-11 | EyePoint Pharmaceuticals, Inc. | TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL |
| EP4028015A4 (en) * | 2019-09-13 | 2023-11-15 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations of methotrexate |
| JP7653164B2 (ja) * | 2019-09-27 | 2025-03-28 | バージニア コモンウェルス ユニバーシティー | 組織を修復または増加させるための組成物および方法 |
| CN116251186B (zh) * | 2021-12-09 | 2025-04-25 | 成都瑞沐生物医药科技有限公司 | 一种酪氨酸激酶抑制剂眼用制剂及其制备方法和用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856919A (en) * | 1970-06-08 | 1974-12-24 | Burton Parsons Chemicals Inc | Ophthalmic solution |
| US4027020A (en) * | 1974-10-29 | 1977-05-31 | Millmaster Onyx Corporation | Randomly terminated capped polymers |
| US3931319A (en) * | 1974-10-29 | 1976-01-06 | Millmaster Onyx Corporation | Capped polymers |
| US4409205A (en) * | 1979-03-05 | 1983-10-11 | Cooper Laboratories, Inc. | Ophthalmic solution |
| US4525346A (en) * | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
| US4407791A (en) * | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US4836986A (en) * | 1984-09-28 | 1989-06-06 | Bausch & Lomb Incorporated | Disinfecting and preserving systems and methods of use |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| US5037647A (en) * | 1988-09-15 | 1991-08-06 | Alcon Laboratories, Inc. | Aqueous antimicrobial opthalmic solutions comprised of quaternary ammonium compound, citric acid, citrate and sodium chloride |
| US5461081A (en) * | 1989-09-28 | 1995-10-24 | Alcon Laboratories, Inc. | Topical ophthalmic pharmaceutical vehicles |
| US5932572A (en) * | 1992-02-21 | 1999-08-03 | Alcon Laboratories, Inc. | Topical anti-glaucoma compositions |
| US5300287A (en) * | 1992-11-04 | 1994-04-05 | Alcon Laboratories, Inc. | Polymeric antimicrobials and their use in pharmaceutical compositions |
| RU2108112C1 (ru) * | 1993-04-16 | 1998-04-10 | Вакамото Фармасьютикал Ко., Лтд. | Водная лекарственная композиция, обладающая свойством обратимого терморегулируемого гелеобразования |
| US6232343B1 (en) * | 1996-05-07 | 2001-05-15 | Toray Industries, Inc. | Ophthalmic preparations |
| DK1203808T3 (da) * | 1997-07-29 | 2005-01-31 | Alcon Lab Inc | Konditioneringsoplösninger til pleje af hårde kontaktlinser |
| JP4682495B2 (ja) * | 1999-09-06 | 2011-05-11 | 小野薬品工業株式会社 | 眼疾患の予防、治療剤 |
| JP2003510263A (ja) * | 1999-09-24 | 2003-03-18 | アルコン，インコーポレイテッド | シプロフロキサシンおよびデキサメタゾンを含有する局所用懸濁処方物 |
| WO2001039765A2 (en) * | 1999-12-03 | 2001-06-07 | Ista Pharmaceuticals, Inc. | Compositions and methods for the induction and treatment of retinal detachments |
| JP2003533464A (ja) * | 2000-05-15 | 2003-11-11 | フアルマシア・イタリア・エツセ・ピー・アー | 安定化ステロイド懸濁液 |
| JP2004504357A (ja) * | 2000-07-26 | 2004-02-12 | アルコン，インコーポレイテッド | ポリマー性懸濁化剤を含有しない薬学的懸濁組成物 |
| JP3450805B2 (ja) * | 2000-08-08 | 2003-09-29 | わかもと製薬株式会社 | 水性医薬組成物 |
| US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
| US6743439B1 (en) * | 2001-06-27 | 2004-06-01 | Alcon, Inc. | Ophthalmic compositions containing copolymers of sulfonated styrene and maleic anhydride |
| CN1231218C (zh) * | 2001-09-21 | 2005-12-14 | 爱尔康公司 | 药物组合物在制备用于治疗中耳感染的药物中的用途 |
| US7001615B1 (en) * | 2001-12-07 | 2006-02-21 | Alcon, Inc. | Sustained release ophthalmic, otic and nasal suspension |
| IL165383A0 (en) * | 2002-06-21 | 2006-01-15 | Transform Pharmaceuticals Inc | Pharmaceutical compositions with improved dissolution |
| US20040235892A1 (en) * | 2003-05-22 | 2004-11-25 | Yujia Dai | Indazole and benzisoxazole kinase inhibitors |
| DK1638941T3 (da) * | 2003-05-22 | 2010-10-11 | Abbott Lab | Indazol-, benzisoxazol- og benzisothiazolkinaseinhibitorer |
| PL1755616T3 (pl) * | 2004-04-08 | 2014-10-31 | Eye Co Pty Ltd | Leczenie mineralokortykoidami retinopatii wysiękowej |
| TWI358290B (en) * | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| BRPI0609227A2 (pt) * | 2005-05-10 | 2010-03-09 | Alcon Inc | composições de suspensão de nepafenac e outros fármacos oftálmicos, bem como uso das referidas composições no tratamento tópico de distúrbios oftálmicos |
| DK1906916T3 (da) * | 2005-05-10 | 2009-01-19 | Alcon Inc | Oftalmisk suspension, der omfatter et oftalmisk lægemiddel, en poloxamin og et tonicitetsregulerende glycolbaseret middel, anvendelse af sammensætningen til fremstilling af et medikament til behandling af oftalmiske lidelser |
| US20070149480A1 (en) * | 2005-12-23 | 2007-06-28 | Alcon, Inc. | PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| EP1962803A1 (en) * | 2005-12-23 | 2008-09-03 | Alcon, Inc. | PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| US20070173538A1 (en) * | 2005-12-23 | 2007-07-26 | Alcon, Inc. | PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| US20070249546A1 (en) * | 2006-04-22 | 2007-10-25 | Sawaya Assad S | Ophthalmic and related aqueous solutions containing antifungal agents, uses therefor and methods for preparing them |
| KR20100051811A (ko) * | 2007-07-20 | 2010-05-18 | 알콘, 인코퍼레이티드 | 눈에 수용체 티로신 키나제 저해(ｒｔｋｉ) 화합물을 전달하기 위한 약제학적 제제 |
| TW201023912A (en) * | 2008-12-05 | 2010-07-01 | Alcon Res Ltd | Pharmaceutical suspension |
-
2010
- 2010-03-03 AU AU2010221438A patent/AU2010221438C1/en not_active Ceased
- 2010-03-03 JP JP2011553061A patent/JP5583145B2/ja not_active Expired - Fee Related
- 2010-03-03 CA CA2753837A patent/CA2753837A1/en not_active Abandoned
- 2010-03-03 CN CN201510767618.5A patent/CN105362221A/zh active Pending
- 2010-03-03 KR KR1020117023002A patent/KR20110123789A/ko not_active Ceased
- 2010-03-03 MX MX2011008680A patent/MX2011008680A/es active IP Right Grant
- 2010-03-03 WO PCT/US2010/025998 patent/WO2010101971A1/en not_active Ceased
- 2010-03-03 BR BRPI1008920-9A patent/BRPI1008920A2/pt not_active IP Right Cessation
- 2010-03-03 US US12/716,385 patent/US20100226992A1/en not_active Abandoned
- 2010-03-03 EP EP10749243.1A patent/EP2403342A4/en not_active Withdrawn
- 2010-03-03 CN CN2010800101411A patent/CN102340993A/zh active Pending
-
2011
- 2011-07-26 ZA ZA2011/05506A patent/ZA201105506B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201105506B (en) | 2012-09-26 |
| WO2010101971A1 (en) | 2010-09-10 |
| AU2010221438B2 (en) | 2014-10-16 |
| JP5583145B2 (ja) | 2014-09-03 |
| EP2403342A4 (en) | 2013-06-05 |
| MX2011008680A (es) | 2011-09-08 |
| CN102340993A (zh) | 2012-02-01 |
| US20100226992A1 (en) | 2010-09-09 |
| AU2010221438C1 (en) | 2015-01-29 |
| CN105362221A (zh) | 2016-03-02 |
| EP2403342A1 (en) | 2012-01-11 |
| KR20110123789A (ko) | 2011-11-15 |
| AU2010221438A1 (en) | 2011-08-25 |
| BRPI1008920A2 (pt) | 2015-08-25 |
| JP2012519692A (ja) | 2012-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20150227 |
|
| FZDE | Discontinued |
Effective date: 20180305 |