CA2753690A1 - Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye - Google Patents
Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye Download PDFInfo
- Publication number
- CA2753690A1 CA2753690A1 CA2753690A CA2753690A CA2753690A1 CA 2753690 A1 CA2753690 A1 CA 2753690A1 CA 2753690 A CA2753690 A CA 2753690A CA 2753690 A CA2753690 A CA 2753690A CA 2753690 A1 CA2753690 A1 CA 2753690A1
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- aqueous solution
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- 230000006444 vascular growth Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15692209P | 2009-03-03 | 2009-03-03 | |
| US61/156,922 | 2009-03-03 | ||
| PCT/US2010/026033 WO2010101992A1 (en) | 2009-03-03 | 2010-03-03 | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2753690A1 true CA2753690A1 (en) | 2010-09-10 |
Family
ID=42678800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2753690A Abandoned CA2753690A1 (en) | 2009-03-03 | 2010-03-03 | Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (rtki) compounds to the eye |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20100227905A1 (https=) |
| EP (1) | EP2403335B1 (https=) |
| JP (1) | JP5583146B2 (https=) |
| KR (2) | KR20110130454A (https=) |
| CN (1) | CN102340991B (https=) |
| AU (1) | AU2010221369B2 (https=) |
| BR (1) | BRPI1012302A2 (https=) |
| CA (1) | CA2753690A1 (https=) |
| ES (1) | ES2508290T3 (https=) |
| MX (1) | MX2011008731A (https=) |
| WO (1) | WO2010101992A1 (https=) |
| ZA (1) | ZA201105505B (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007237096C1 (en) | 2006-04-07 | 2012-12-13 | EyePoint, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
| US7622593B2 (en) | 2006-06-27 | 2009-11-24 | The Procter & Gamble Company | Human protein tyrosine phosphatase inhibitors and methods of use |
| MY160399A (en) | 2009-07-06 | 2017-03-15 | Aerpio Therapeutics Inc | Compounds, compositions, and methods for preventing metastasis of cancer cells |
| EP2538929A4 (en) | 2010-02-25 | 2014-07-09 | Univ Johns Hopkins | DELAYED RELEASE OF THERAPIES IN A PART OF THE EYE |
| US20120022149A1 (en) * | 2010-07-21 | 2012-01-26 | Chowhan Masood A | Pharmaceutical composition with enhanced solubility characteristics |
| US10307372B2 (en) | 2010-09-10 | 2019-06-04 | The Johns Hopkins University | Rapid diffusion of large polymeric nanoparticles in the mammalian brain |
| WO2012109363A2 (en) | 2011-02-08 | 2012-08-16 | The Johns Hopkins University | Mucus penetrating gene carriers |
| US20140160236A1 (en) * | 2011-07-29 | 2014-06-12 | The Regents Of The University Of California | Lensfree holographic microscopy using wetting films |
| AU2012323856B2 (en) | 2011-10-13 | 2017-05-25 | EyePoint, Inc. | Methods for treating Vascular Leak Syndrome and cancer |
| CA2863632C (en) | 2012-01-19 | 2017-07-11 | The Johns Hopkins University | Nanoparticle formulations with enhanced mucosal penetration |
| US8962577B2 (en) | 2012-03-16 | 2015-02-24 | The Johns Hopkins University | Controlled release formulations for the delivery of HIF-1 inhibitors |
| JP6138904B2 (ja) | 2012-03-16 | 2017-05-31 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート |
| US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| AU2013256064B2 (en) | 2012-05-03 | 2018-01-04 | Alcon Inc. | Pharmaceutical nanoparticles showing improved mucosal transport |
| US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
| KR102310775B1 (ko) | 2012-05-03 | 2021-10-07 | 칼라 파마슈티컬스, 인크. | 개선된 점막 수송을 나타내는 제약 나노입자 |
| AU2013256008B2 (en) | 2012-05-04 | 2016-02-25 | The Johns Hopkins University | Lipid-based drug carriers for rapid penetration through mucus linings |
| WO2014124006A1 (en) | 2013-02-05 | 2014-08-14 | The Johns Hopkins University | Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof |
| US20150050277A1 (en) | 2013-03-15 | 2015-02-19 | Aerpio Therapeutics Inc. | Compositions and methods for treating ocular diseases |
| RU2646098C2 (ru) * | 2013-04-30 | 2018-03-01 | Интас Фармасьютикалс Лтд | Новый способ клонирования, экспрессии и очистки для получения ранибизумаба |
| WO2015127368A1 (en) | 2014-02-23 | 2015-08-27 | The Johns Hopkins University | Hypotonic microbicidal formulations and methods of use |
| EP3116503A4 (en) | 2014-03-14 | 2017-08-23 | Aerpio Therapeutics, Inc. | Hptp-beta inhibitors |
| CN107278151A (zh) | 2014-12-15 | 2017-10-20 | 约翰霍普金斯大学 | 舒尼替尼制剂及其在治疗青光眼中的使用方法 |
| CN107635545A (zh) | 2015-01-27 | 2018-01-26 | 约翰霍普金斯大学 | 用于增强粘膜表面处活性剂的输送的低渗水凝胶制剂 |
| ES2981607T3 (es) | 2015-09-23 | 2024-10-09 | Eyepoint Pharmaceuticals Inc | Activadores de Tie-2 para uso en el tratamiento de la presión intraocular |
| CN108367079B (zh) | 2015-11-12 | 2022-11-22 | 灰色视觉公司 | 用于治疗的聚集性微粒 |
| CA3056923A1 (en) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| US11160870B2 (en) | 2017-05-10 | 2021-11-02 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| US12496279B2 (en) | 2019-04-11 | 2025-12-16 | The Johns Hopkins University | Nanoparticles for drug delivery to brain |
| EP3962482A4 (en) | 2019-04-29 | 2023-01-11 | EyePoint Pharmaceuticals, Inc. | TIE 2 ACTIVATORS FACING THE SCHLEMM CHANNEL |
| ES2992596T3 (en) * | 2019-11-28 | 2024-12-16 | Caprika Srl | Rectal-use composition for the treatment of constipation |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4727064A (en) * | 1984-04-25 | 1988-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Pharmaceutical preparations containing cyclodextrin derivatives |
| US5002935A (en) * | 1987-12-30 | 1991-03-26 | University Of Florida | Improvements in redox systems for brain-targeted drug delivery |
| ES2141775T3 (es) * | 1993-04-16 | 2000-04-01 | Wakamoto Pharma Co Ltd | Composicion medicinal a base de agua termicamente gelificante reversible. |
| CA2226348A1 (en) * | 1996-05-07 | 1997-11-13 | Takashi Ikari | Ophthalmic preparations |
| JP4810427B2 (ja) * | 2003-05-22 | 2011-11-09 | アボット・ラボラトリーズ | インダゾール、ベンズイソオキサゾールおよびベンズイソチアゾールキナーゼ阻害剤 |
| TW200640443A (en) * | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| CN101006988A (zh) * | 2005-09-26 | 2007-08-01 | 刘凤鸣 | 葛根素的缓释制剂 |
| JP2009521493A (ja) * | 2005-12-23 | 2009-06-04 | アルコン，インコーポレイテッド | 眼への受容体チロシンキナーゼ阻害（ＲＴＫｉ）化合物の送達のための医薬製剤 |
| JP2009521510A (ja) * | 2005-12-23 | 2009-06-04 | アルコン，インコーポレイテッド | 眼への受容体チロシンキナーゼ阻害（ｒｔｋｉ）化合物の送達のための医薬製剤 |
| JP2010534201A (ja) * | 2007-07-20 | 2010-11-04 | アルコン，インコーポレイテッド | 受容体チロシンキナーゼ阻害（ＲＴＫｉ）化合物の目への送達のための医薬製剤 |
-
2010
- 2010-03-03 BR BRPI1012302A patent/BRPI1012302A2/pt not_active IP Right Cessation
- 2010-03-03 ES ES10749258.9T patent/ES2508290T3/es active Active
- 2010-03-03 US US12/716,663 patent/US20100227905A1/en not_active Abandoned
- 2010-03-03 KR KR1020117023001A patent/KR20110130454A/ko not_active Ceased
- 2010-03-03 CN CN201080010150.0A patent/CN102340991B/zh not_active Expired - Fee Related
- 2010-03-03 MX MX2011008731A patent/MX2011008731A/es active IP Right Grant
- 2010-03-03 CA CA2753690A patent/CA2753690A1/en not_active Abandoned
- 2010-03-03 EP EP10749258.9A patent/EP2403335B1/en not_active Not-in-force
- 2010-03-03 AU AU2010221369A patent/AU2010221369B2/en not_active Ceased
- 2010-03-03 JP JP2011553071A patent/JP5583146B2/ja not_active Expired - Fee Related
- 2010-03-03 KR KR1020167032103A patent/KR20160135372A/ko not_active Abandoned
- 2010-03-03 WO PCT/US2010/026033 patent/WO2010101992A1/en not_active Ceased
-
2011
- 2011-07-26 ZA ZA2011/05505A patent/ZA201105505B/en unknown
-
2013
- 2013-01-25 US US13/749,887 patent/US20130137741A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2403335A4 (en) | 2012-08-29 |
| WO2010101992A1 (en) | 2010-09-10 |
| ES2508290T3 (es) | 2014-10-16 |
| CN102340991A (zh) | 2012-02-01 |
| US20130137741A1 (en) | 2013-05-30 |
| AU2010221369A1 (en) | 2011-08-25 |
| MX2011008731A (es) | 2011-09-29 |
| EP2403335A1 (en) | 2012-01-11 |
| JP2012519694A (ja) | 2012-08-30 |
| US20100227905A1 (en) | 2010-09-09 |
| CN102340991B (zh) | 2014-02-26 |
| AU2010221369B2 (en) | 2014-03-13 |
| EP2403335B1 (en) | 2014-08-20 |
| ZA201105505B (en) | 2013-10-30 |
| KR20110130454A (ko) | 2011-12-05 |
| KR20160135372A (ko) | 2016-11-25 |
| JP5583146B2 (ja) | 2014-09-03 |
| BRPI1012302A2 (pt) | 2015-09-22 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20150220 |
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| FZDE | Dead |
Effective date: 20180305 |