JP2012518390A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012518390A5 JP2012518390A5 JP2011550396A JP2011550396A JP2012518390A5 JP 2012518390 A5 JP2012518390 A5 JP 2012518390A5 JP 2011550396 A JP2011550396 A JP 2011550396A JP 2011550396 A JP2011550396 A JP 2011550396A JP 2012518390 A5 JP2012518390 A5 JP 2012518390A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- antigen
- immunobinder
- cells
- expressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 82
- 210000004027 cell Anatomy 0.000 claims description 76
- 239000000427 antigen Substances 0.000 claims description 54
- 108091007433 antigens Proteins 0.000 claims description 54
- 102000036639 antigens Human genes 0.000 claims description 54
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 32
- 241001465754 Metazoa Species 0.000 claims description 9
- 101710160107 Outer membrane protein A Proteins 0.000 claims description 8
- 150000007523 nucleic acids Chemical group 0.000 claims description 8
- 102000018697 Membrane Proteins Human genes 0.000 claims description 6
- 108010052285 Membrane Proteins Proteins 0.000 claims description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 4
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 claims description 4
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 claims description 4
- 238000000423 cell based assay Methods 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 4
- 239000007850 fluorescent dye Substances 0.000 claims description 4
- 210000004962 mammalian cell Anatomy 0.000 claims description 4
- 210000005253 yeast cell Anatomy 0.000 claims description 4
- 108020004414 DNA Proteins 0.000 claims description 3
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 3
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 3
- 230000003053 immunization Effects 0.000 claims description 3
- 238000002372 labelling Methods 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims description 3
- AYMWCZFEDLLHMI-UHFFFAOYSA-N (2-Hydroxymethyl-cyclohexyl)-acetic acid lactone Chemical compound C1CCCC2COC(=O)CC21 AYMWCZFEDLLHMI-UHFFFAOYSA-N 0.000 claims description 2
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 claims description 2
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 claims description 2
- 102000003787 Anoctamin-1 Human genes 0.000 claims description 2
- 108090000160 Anoctamin-1 Proteins 0.000 claims description 2
- 108091008875 B cell receptors Proteins 0.000 claims description 2
- 102000012304 Bestrophin Human genes 0.000 claims description 2
- 108050002823 Bestrophin Proteins 0.000 claims description 2
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 claims description 2
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 claims description 2
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims description 2
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims description 2
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 claims description 2
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 claims description 2
- 102100037853 C-C chemokine receptor type 4 Human genes 0.000 claims description 2
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims description 2
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 claims description 2
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 claims description 2
- 102100036305 C-C chemokine receptor type 8 Human genes 0.000 claims description 2
- 102100025074 C-C chemokine receptor-like 2 Human genes 0.000 claims description 2
- 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 claims description 2
- 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 claims description 2
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims description 2
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims description 2
- 102100025618 C-X-C chemokine receptor type 6 Human genes 0.000 claims description 2
- 241000282836 Camelus dromedarius Species 0.000 claims description 2
- 108091006146 Channels Proteins 0.000 claims description 2
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 claims description 2
- 238000011238 DNA vaccination Methods 0.000 claims description 2
- 102000005915 GABA Receptors Human genes 0.000 claims description 2
- 108010005551 GABA Receptors Proteins 0.000 claims description 2
- 241000287828 Gallus gallus Species 0.000 claims description 2
- 102000011714 Glycine Receptors Human genes 0.000 claims description 2
- 108010076533 Glycine Receptors Proteins 0.000 claims description 2
- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 claims description 2
- 101000716063 Homo sapiens C-C chemokine receptor type 8 Proteins 0.000 claims description 2
- 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 claims description 2
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims description 2
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims description 2
- 101000856683 Homo sapiens C-X-C chemokine receptor type 6 Proteins 0.000 claims description 2
- 101000631760 Homo sapiens Sodium channel protein type 1 subunit alpha Proteins 0.000 claims description 2
- 101000654356 Homo sapiens Sodium channel protein type 10 subunit alpha Proteins 0.000 claims description 2
- 101000640020 Homo sapiens Sodium channel protein type 11 subunit alpha Proteins 0.000 claims description 2
- 101000684826 Homo sapiens Sodium channel protein type 2 subunit alpha Proteins 0.000 claims description 2
- 101000684820 Homo sapiens Sodium channel protein type 3 subunit alpha Proteins 0.000 claims description 2
- 101000693993 Homo sapiens Sodium channel protein type 4 subunit alpha Proteins 0.000 claims description 2
- 101000694017 Homo sapiens Sodium channel protein type 5 subunit alpha Proteins 0.000 claims description 2
- 101000654381 Homo sapiens Sodium channel protein type 8 subunit alpha Proteins 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 108010018951 Interleukin-8B Receptors Proteins 0.000 claims description 2
- 108090000862 Ion Channels Proteins 0.000 claims description 2
- 102000004310 Ion Channels Human genes 0.000 claims description 2
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 2
- 108010003723 Single-Domain Antibodies Proteins 0.000 claims description 2
- 102100028910 Sodium channel protein type 1 subunit alpha Human genes 0.000 claims description 2
- 102100031374 Sodium channel protein type 10 subunit alpha Human genes 0.000 claims description 2
- 102100033974 Sodium channel protein type 11 subunit alpha Human genes 0.000 claims description 2
- 102100023150 Sodium channel protein type 2 subunit alpha Human genes 0.000 claims description 2
- 102100023720 Sodium channel protein type 3 subunit alpha Human genes 0.000 claims description 2
- 102100027195 Sodium channel protein type 4 subunit alpha Human genes 0.000 claims description 2
- 102100027198 Sodium channel protein type 5 subunit alpha Human genes 0.000 claims description 2
- 102100031371 Sodium channel protein type 8 subunit alpha Human genes 0.000 claims description 2
- 101150052500 cic-1 gene Proteins 0.000 claims description 2
- 102000034287 fluorescent proteins Human genes 0.000 claims description 2
- 108091006047 fluorescent proteins Proteins 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 238000007860 single-cell PCR Methods 0.000 claims description 2
- 101001128969 Homo sapiens Neuron navigator 1 Proteins 0.000 claims 1
- 102100031225 Neuron navigator 1 Human genes 0.000 claims 1
- 101000654386 Homo sapiens Sodium channel protein type 9 subunit alpha Proteins 0.000 description 1
- 102100031367 Sodium channel protein type 9 subunit alpha Human genes 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15504109P | 2009-02-24 | 2009-02-24 | |
| US15510509P | 2009-02-24 | 2009-02-24 | |
| US61/155,105 | 2009-02-24 | ||
| US61/155,041 | 2009-02-24 | ||
| CH8322009 | 2009-06-02 | ||
| CH832/09 | 2009-06-02 | ||
| CHPCT/CH2009/000222 | 2009-06-25 | ||
| PCT/CH2009/000222 WO2009155726A2 (en) | 2008-06-25 | 2009-06-25 | Humanization of rabbit antibodies using a universal antibody framework |
| PCT/CH2010/000044 WO2010096941A1 (en) | 2009-02-24 | 2010-02-22 | Methods for identifying immunobinders of cell-surface antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015101581A Division JP6161655B2 (ja) | 2009-02-24 | 2015-05-19 | 細胞表面抗原のイムノバインダーを同定するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012518390A JP2012518390A (ja) | 2012-08-16 |
| JP2012518390A5 true JP2012518390A5 (enExample) | 2013-02-14 |
| JP5764071B2 JP5764071B2 (ja) | 2015-08-12 |
Family
ID=42631310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550396A Active JP5764071B2 (ja) | 2009-02-24 | 2010-02-22 | 細胞表面抗原のイムノバインダーを同定するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (7) | US8227199B2 (enExample) |
| EP (2) | EP2321354B2 (enExample) |
| JP (1) | JP5764071B2 (enExample) |
| KR (1) | KR101595808B1 (enExample) |
| CN (1) | CN102239181A (enExample) |
| AU (1) | AU2010217120B2 (enExample) |
| CA (1) | CA2744103C (enExample) |
| IL (1) | IL212738A (enExample) |
| MX (1) | MX2011007049A (enExample) |
| WO (1) | WO2010096941A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102164958A (zh) * | 2008-06-25 | 2011-08-24 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 使用通用抗体构架进行的兔抗体的人源化 |
| CA2727992C (en) * | 2008-06-25 | 2017-10-17 | Esbatech, An Alcon Biomedical Research Unit Llc | Stable and soluble antibodies inhibiting tnf.alpha. |
| CA2744103C (en) | 2009-02-24 | 2018-01-02 | Esbatech, An Alcon Biomedical Research Unit Llc | Methods for identifying immunobinders of cell-surface antigens |
| TWI386645B (zh) * | 2010-07-19 | 2013-02-21 | Univ Kaohsiung Medical | 可定量任何聚乙二醇分子與其修飾物之抗聚乙二醇表現細胞 |
| US9329180B2 (en) * | 2010-07-19 | 2016-05-03 | Kaohsiung Medical University | Preparation of anti-PEG antibody expressing cell and application thereof |
| WO2012062713A1 (en) | 2010-11-08 | 2012-05-18 | Novartis Ag | Cxcr2 binding polypeptides |
| US8748587B2 (en) | 2011-06-02 | 2014-06-10 | Novartis Ag | Molecules and methods for modulating TMEM16A activities |
| RU2627597C2 (ru) * | 2011-11-23 | 2017-08-09 | Ф. Хоффманн-Ля Рош Аг | Клетки млекопитающих, экспрессирующие лиганд cd40l, и их применение |
| US9328174B2 (en) | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| US9045546B2 (en) | 2012-05-31 | 2015-06-02 | Novartis Ag | Molecules and methods for modulating TMEM16A activities |
| KR102309517B1 (ko) | 2013-06-28 | 2021-10-07 | 엑스-바디 인코포레이티드 | 표적 항원 발견, 표현형 선별 및 표적 세포 특이성 표적 에피토프를 규명하기 위한 그의 용도 |
| WO2015048413A1 (en) * | 2013-09-30 | 2015-04-02 | X-Body Biosciences, Inc. | Antigen receptor screening assay |
| CN111413298A (zh) * | 2020-05-27 | 2020-07-14 | 深圳市天安至远传感科技有限公司 | 一种光纤表面等离子体共振传感器、制备方法及检测系统 |
| WO2022120215A1 (en) * | 2020-12-03 | 2022-06-09 | The Johns Hopkins University | Nanobodies with specific affinity for voltage gated sodium channels |
| WO2025257154A1 (en) | 2024-06-10 | 2025-12-18 | Charité - Universitätsmedizin Berlin Körperschaft des öffentlichen Rechts | Flow cytometry method for determining physically interacting cells |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US20030036092A1 (en) * | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| US5675063A (en) * | 1995-02-28 | 1997-10-07 | Loyola University Of Chicago | Immortalized rabbit hybridoma fusion partner |
| EP0822830B1 (en) | 1995-04-27 | 2008-04-02 | Amgen Fremont Inc. | Human anti-IL-8 antibodies, derived from immunized xenomice |
| ES2176484T3 (es) | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| WO1998002462A1 (en) | 1996-07-16 | 1998-01-22 | Morphosys Gesellschaft Für Proteinoptimierung Mbh | Immunoglobulin superfamily domains and fragments with increased solubility |
| WO1998049286A2 (en) * | 1997-05-01 | 1998-11-05 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| US6060272A (en) * | 1997-05-07 | 2000-05-09 | Human Genome Sciences, Inc. | Human G-protein coupled receptors |
| FR2777007B1 (fr) * | 1998-04-01 | 2000-05-26 | Orstom | Mutants de glycoproteines d'enveloppes de retrovirus et leurs applications biologiques |
| US7157418B1 (en) * | 1998-07-22 | 2007-01-02 | Osprey Pharmaceuticals, Ltd. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
| US6905668B1 (en) | 1998-09-25 | 2005-06-14 | Tokyo Gas Company Limited | Diagnostic agents for pancreatic exocrine function |
| DE19852800C1 (de) * | 1998-11-16 | 2000-04-13 | Univ Albert Ludwigs Freiburg | Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist |
| PT1230932E (pt) * | 1999-01-13 | 2005-04-29 | Igeneon Krebs Immuntherapie | Uso de anticorpos para vacinacao contra o cancro |
| JP5291279B2 (ja) | 2000-09-08 | 2013-09-18 | ウニヴェルジテート・チューリッヒ | 反復モジュールを含む反復タンパク質の集合体 |
| ES2405944T3 (es) | 2000-11-30 | 2013-06-04 | Medarex, Inc. | Ácidos nucleicos que codifican las secuencias de inmunoglobulina humana reorganizadas a partir de ratones transcromoscómicos transgénicos zadas |
| CN105175535A (zh) | 2002-05-22 | 2015-12-23 | 艾斯巴技术-诺华有限责任公司 | 在胞内环境中表现出增强的稳定性的免疫球蛋白构架及其鉴定方法 |
| US20040067496A1 (en) * | 2002-10-07 | 2004-04-08 | Robert Pytela | System for production and screening of monoclonal antibodies |
| AU2003298112A1 (en) | 2002-11-13 | 2004-06-03 | Micromet Ag | Method for identifying antigen specific b cells |
| PT1570267E (pt) | 2002-12-03 | 2012-01-03 | Ucb Pharma Sa | Ensaio para a identificação de células produtoras de anticorpos |
| JP4336812B2 (ja) * | 2003-03-07 | 2009-09-30 | 博夫 岩田 | 細胞に発現する表面抗原を迅速に同定するための分析方法 |
| DE10314412A1 (de) | 2003-03-28 | 2004-10-14 | Genovac Ag | Genetische Immunisierung mit multiplen Expressionskonstrukten zur Herstellung von monoklonalen Antikörpern |
| WO2004100902A1 (ja) | 2003-05-13 | 2004-11-25 | The Nisshin Oillio Group, Ltd. | 油性化粧料 |
| EP1623229A2 (en) * | 2003-05-15 | 2006-02-08 | Cytos Biotechnology AG | Selection of b cells with specificity of interest: method of preparation and use |
| CN100415765C (zh) * | 2003-08-07 | 2008-09-03 | 宜康公司 | 兔单克隆抗体的人源化方法 |
| JP2004107355A (ja) | 2003-10-20 | 2004-04-08 | Kokyu Alcohol Kogyo Co Ltd | 油性固形化粧料 |
| KR101132905B1 (ko) | 2003-11-20 | 2012-04-03 | 미츠비시 가스 가가쿠 가부시키가이샤 | 액상 시클로헥산트리카르복실산 무수물 |
| WO2005103074A2 (en) * | 2004-03-18 | 2005-11-03 | Board Of Regents, The University Of Texas System | Combinatorial protein library screening by periplasmic expression |
| JP2008531060A (ja) * | 2005-03-04 | 2008-08-14 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 相補性決定残基の合理的改変を介して免疫グロブリン可変領域をヒト化する方法 |
| CA2655511C (en) * | 2005-07-01 | 2017-03-21 | John Schrader | Methods of isolating cells and generating monoclonal antibodies |
| US20070134249A1 (en) * | 2005-12-08 | 2007-06-14 | Genitope Corporation | Combination therapy and antibody panels |
| US8017119B2 (en) | 2005-12-28 | 2011-09-13 | Daiichi Sankyo Company, Ltd. | Antibody against periostin, and a pharmaceutical composition comprising it for preventing or treating a disease in which periostin is involved |
| EP1918302A3 (en) | 2006-05-18 | 2009-11-18 | AvantGen, Inc. | Methods for the identification and the isolation of epitope specific antibodies |
| PL2374818T3 (pl) * | 2006-06-02 | 2013-05-31 | Regeneron Pharma | Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6 |
| CN101505794B (zh) | 2006-07-10 | 2013-09-04 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 穿过上皮和/或内皮层的scFV抗体 |
| BRPI0720565A2 (pt) * | 2006-12-20 | 2013-09-17 | Mmr Information Systems Inc | anticorpos e mÉtodos para a sua preparaÇço e seu uso |
| JP2010222255A (ja) * | 2007-06-18 | 2010-10-07 | Mitsubishi Tanabe Pharma Corp | 抗体のスクリーニング方法およびそれにより得られる抗体 |
| JP5022818B2 (ja) | 2007-08-10 | 2012-09-12 | 株式会社 資生堂 | 毛髪化粧料 |
| CN102164958A (zh) | 2008-06-25 | 2011-08-24 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 使用通用抗体构架进行的兔抗体的人源化 |
| CA2727992C (en) | 2008-06-25 | 2017-10-17 | Esbatech, An Alcon Biomedical Research Unit Llc | Stable and soluble antibodies inhibiting tnf.alpha. |
| KR102095257B1 (ko) | 2008-06-25 | 2020-04-01 | 노바르티스 아게 | Ｖｅｇｆ를 억제하는 안정하고 가용성인 항체 |
| CA2744103C (en) | 2009-02-24 | 2018-01-02 | Esbatech, An Alcon Biomedical Research Unit Llc | Methods for identifying immunobinders of cell-surface antigens |
| JP5926896B2 (ja) | 2010-09-17 | 2016-05-25 | 株式会社 資生堂 | 唇用固形化粧料 |
-
2010
- 2010-02-22 CA CA2744103A patent/CA2744103C/en active Active
- 2010-02-22 CN CN2010800034510A patent/CN102239181A/zh active Pending
- 2010-02-22 MX MX2011007049A patent/MX2011007049A/es unknown
- 2010-02-22 KR KR1020117014643A patent/KR101595808B1/ko active Active
- 2010-02-22 AU AU2010217120A patent/AU2010217120B2/en active Active
- 2010-02-22 EP EP10705086.6A patent/EP2321354B2/en active Active
- 2010-02-22 JP JP2011550396A patent/JP5764071B2/ja active Active
- 2010-02-22 EP EP16202099.4A patent/EP3181583A1/en not_active Withdrawn
- 2010-02-22 WO PCT/CH2010/000044 patent/WO2010096941A1/en not_active Ceased
- 2010-02-23 US US12/710,579 patent/US8227199B2/en active Active
-
2011
- 2011-05-05 IL IL212738A patent/IL212738A/en active IP Right Grant
-
2012
- 2012-06-22 US US13/530,241 patent/US20120288878A1/en not_active Abandoned
- 2012-09-14 US US13/616,267 patent/US8465937B2/en active Active
-
2014
- 2014-05-08 US US14/273,231 patent/US9221905B2/en active Active
-
2015
- 2015-11-20 US US14/947,133 patent/US9908940B2/en active Active
-
2018
- 2018-01-17 US US15/873,022 patent/US20180142028A1/en not_active Abandoned
-
2019
- 2019-08-29 US US16/555,674 patent/US20190382498A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012518390A5 (enExample) | ||
| US10175249B2 (en) | Proteomic identification of antibodies | |
| Steichen et al. | Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates | |
| Adler et al. | A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library | |
| EP3833976A1 (en) | Systems and methods for simultaneous detection of antigens and antigen specific antibodies | |
| RU2016103262A (ru) | Способы идентификации иммунных связующих веществ поверхностных антигенов клетки | |
| JP2013509878A5 (enExample) | ||
| NZ572807A (en) | Culture method for obtaining a clonal population of antigen-specific b cells | |
| JP2013517761A (ja) | 酵母細胞の表面上にポリペプチドをディスプレイするための方法および組成物 | |
| JP2012527881A5 (enExample) | ||
| US20220363712A1 (en) | Methods and systems for generating, validating and using monoclonal antibodies | |
| JP2015508056A5 (enExample) | ||
| US20190002558A1 (en) | Compositions and methods for the identification and isolation of cell-membrane protein specific binding moieties | |
| CN107428827A (zh) | 通过b细胞淘选和增殖高通量产生单克隆抗体 | |
| Medina-Cucurella et al. | Preferential identification of agonistic OX40 antibodies by using cell lysate to pan natively paired, humanized mouse-derived yeast surface display libraries | |
| WO2023242125A1 (en) | Methods of isolating anti-ligands | |
| WO2014096389A1 (en) | Method for identifying antibody producing cells | |
| CN118829658A (zh) | 产生针对芬太尼的高亲和力抗体的方法 | |
| RU2017135831A (ru) | Способы идентификации иммунных связующих веществ поверхностных антигенов клетки | |
| US20250115898A1 (en) | Systems and methods for simultaneous detection of antigens and ligands thereof | |
| Ayyar et al. | Production and Use of Antibodies | |
| CN117836308A (zh) | 用于选择特异性结合剂的手段和方法 | |
| CN112094345A (zh) | 可应用于肿瘤细胞捕获的小鼠抗免疫球蛋白关联βCD79b的单克隆抗体 | |
| EP4453034A1 (en) | Parallel antibody engineering compositions and methods | |
| CN107109423A (zh) | 用于生产双特异性抗体的细胞的制备和挑选 |