JP2012517479A5

JP2012517479A5 -

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Publication number: JP2012517479A5
Authority: JP; Japan
Prior art keywords: fluorophenyl; methyl; methylethyl; chloro; thio
Prior art date: 2010-02-12
Legal status : Pending

Application number

JP2011550244A

Other languages

English (en)

Japanese (ja)

Other versions

JP2012517479A (ja

Filing date

2010-02-12

Publication date

2013-01-31

2010-02-12 Application filed filed Critical

2010-02-12 Priority claimed from PCT/US2010/023981 external-priority patent/WO2010093845A1/en

2012-08-02 Publication of JP2012517479A publication Critical patent/JP2012517479A/ja

2013-01-31 Publication of JP2012517479A5 publication Critical patent/JP2012517479A5/ja

Status Pending legal-status Critical Current

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-1 —CF 3 Chemical group 0.000 claims description 394
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 193
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 191
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 177
125000000217 alkyl group Chemical group 0.000 claims description 176
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 163
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 153
KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims description 144
125000005843 halogen group Chemical group 0.000 claims description 142
229910052757 nitrogen Inorganic materials 0.000 claims description 105
229910052739 hydrogen Inorganic materials 0.000 claims description 100
239000001257 hydrogen Substances 0.000 claims description 100
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 98
229910052799 carbon Inorganic materials 0.000 claims description 95
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 79
150000001875 compounds Chemical class 0.000 claims description 77
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 68
150000003839 salts Chemical class 0.000 claims description 67
238000006467 substitution reaction Methods 0.000 claims description 62
125000001072 heteroaryl group Chemical group 0.000 claims description 60
125000000446 sulfanediyl group Chemical group *S* 0.000 claims description 34
125000001424 substituent group Chemical group 0.000 claims description 33
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 28
239000002253 acid Substances 0.000 claims description 26
125000004093 cyano group Chemical group *C#N 0.000 claims description 22
125000004122 cyclic group Chemical group 0.000 claims description 22
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 22
KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 20
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 20
125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 19
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 18
125000005037 alkyl phenyl group Chemical group 0.000 claims description 18
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 16
102220065736 rs543286136 Human genes 0.000 claims description 16
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 15
125000004076 pyridyl group Chemical group 0.000 claims description 15
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 14
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 14
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 14
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 13
125000004366 heterocycloalkenyl group Chemical group 0.000 claims description 13
125000001153 fluoro group Chemical group F* 0.000 claims description 11
GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims description 11
125000003118 aryl group Chemical group 0.000 claims description 10
125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims description 10
229940098779 methanesulfonic acid Drugs 0.000 claims description 10
125000000753 cycloalkyl group Chemical group 0.000 claims description 9
238000000034 method Methods 0.000 claims description 9
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 9
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 8
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 8
125000001309 chloro group Chemical group Cl* 0.000 claims description 8
229940124530 sulfonamide Drugs 0.000 claims description 8
208000008589 Obesity Diseases 0.000 claims description 7
239000000203 mixture Substances 0.000 claims description 7
235000020824 obesity Nutrition 0.000 claims description 7
208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 7
KTZQTRPPVKQPFO-UHFFFAOYSA-N 1,2-benzoxazole Chemical compound C1=CC=C2C=NOC2=C1 KTZQTRPPVKQPFO-UHFFFAOYSA-N 0.000 claims description 6
239000005711 Benzoic acid Substances 0.000 claims description 6
VQTLPLINWFTECA-UHFFFAOYSA-N CC(C)(C(N1C(C=C2)=CC=C2F)=CN=C1SCC(C=CC=C1)=C1Cl)C(C=C1)=CC(Cl)=C1Cl Chemical compound CC(C)(C(N1C(C=C2)=CC=C2F)=CN=C1SCC(C=CC=C1)=C1Cl)C(C=C1)=CC(Cl)=C1Cl VQTLPLINWFTECA-UHFFFAOYSA-N 0.000 claims description 6
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
235000010233 benzoic acid Nutrition 0.000 claims description 6
229960003104 ornithine Drugs 0.000 claims description 6
125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims description 6
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 6
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 6
125000003545 alkoxy group Chemical group 0.000 claims description 5
201000010099 disease Diseases 0.000 claims description 5
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims description 4
INHDNIUNHCQQAD-UHFFFAOYSA-N CC(C)(C1=CC(=C(C=C1)Cl)Cl)C2=CN=C(N2C3=CC=C(C=C3)F)SCC4=CC=C(C=C4)Cl Chemical compound CC(C)(C1=CC(=C(C=C1)Cl)Cl)C2=CN=C(N2C3=CC=C(C=C3)F)SCC4=CC=C(C=C4)Cl INHDNIUNHCQQAD-UHFFFAOYSA-N 0.000 claims description 4
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 4
DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 4
125000002877 alkyl aryl group Chemical group 0.000 claims description 4
150000001408 amides Chemical class 0.000 claims description 4
229940125708 antidiabetic agent Drugs 0.000 claims description 4
239000003472 antidiabetic agent Substances 0.000 claims description 4
239000003613 bile acid Substances 0.000 claims description 4
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 4
229910052736 halogen Inorganic materials 0.000 claims description 4
150000002367 halogens Chemical class 0.000 claims description 4
230000004060 metabolic process Effects 0.000 claims description 4
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 claims description 4
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 3
201000001320 Atherosclerosis Diseases 0.000 claims description 3
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
208000031226 Hyperlipidaemia Diseases 0.000 claims description 3
239000008280 blood Substances 0.000 claims description 3
210000004369 blood Anatomy 0.000 claims description 3
239000008103 glucose Substances 0.000 claims description 3
230000001939 inductive effect Effects 0.000 claims description 3
230000003914 insulin secretion Effects 0.000 claims description 3
HVDYKSSIBZLYDN-UHFFFAOYSA-N 1-(2-chloro-4-fluorophenyl)-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C(=CC(F)=CC=2)Cl)=CN=C1SCC1=C(F)C=CC=C1Cl HVDYKSSIBZLYDN-UHFFFAOYSA-N 0.000 claims description 2
GYPYJJOJXIHSES-UHFFFAOYSA-N 1-(2-chloro-4-fluorophenyl)-2-[(2-chloro-6-fluorophenyl)methylsulfonyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C(=CC=CC=2F)Cl)N1C1=CC=C(F)C=C1Cl GYPYJJOJXIHSES-UHFFFAOYSA-N 0.000 claims description 2
RRBFQCDOMYYXTF-UHFFFAOYSA-N 1-(2-chloro-6-fluorophenyl)-n-[[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methyl]methanamine Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CNCC1=C(F)C=CC=C1Cl RRBFQCDOMYYXTF-UHFFFAOYSA-N 0.000 claims description 2
GZEYVJFCYQHJIQ-UHFFFAOYSA-N 1-(3-chloro-4-fluorophenyl)-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(Cl)C(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl GZEYVJFCYQHJIQ-UHFFFAOYSA-N 0.000 claims description 2
LEYIGLQNENOYSM-UHFFFAOYSA-N 1-(4-chloro-2-fluorophenyl)-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C(=CC(Cl)=CC=2)F)=CN=C1SCC1=C(F)C=CC=C1Cl LEYIGLQNENOYSM-UHFFFAOYSA-N 0.000 claims description 2
ODKLEAWFBFWPQQ-UHFFFAOYSA-N 1-(4-chloro-3-fluorophenyl)-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(F)C(Cl)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl ODKLEAWFBFWPQQ-UHFFFAOYSA-N 0.000 claims description 2
NPNYOMRNTSQIAS-UHFFFAOYSA-N 1-(4-chloro-3-fluorophenyl)-n-[[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methyl]methanamine Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CNCC1=CC=C(Cl)C(F)=C1 NPNYOMRNTSQIAS-UHFFFAOYSA-N 0.000 claims description 2
XCEMNMOXKNCJKP-UHFFFAOYSA-N 1-[2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorophenoxy]-2-methylpropan-2-ol Chemical compound CC(C)(O)COC1=CC(F)=CC=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 XCEMNMOXKNCJKP-UHFFFAOYSA-N 0.000 claims description 2
BOXGSLKKHKIREO-UHFFFAOYSA-N 1-[2-chloro-4-[2-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]-2-methylpropan-2-ol Chemical compound C1=C(Cl)C(OCC(C)(O)C)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl BOXGSLKKHKIREO-UHFFFAOYSA-N 0.000 claims description 2
XYYNQJPIODNIBN-UHFFFAOYSA-N 1-[2-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]-4-methylpiperazine Chemical compound C1CN(C)CCN1C(C(=C1)Cl)=CC=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 XYYNQJPIODNIBN-UHFFFAOYSA-N 0.000 claims description 2
ZACNRBPGQRGGLV-UHFFFAOYSA-N 1-[2-chloro-5-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]-2-methylpropan-2-ol Chemical compound C1=C(Cl)C(OCC(C)(O)C)=CC(C(C)(C)C=2N(C(SCC=3C(=CC=CC=3F)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 ZACNRBPGQRGGLV-UHFFFAOYSA-N 0.000 claims description 2
HOMYQEYBHVSUDR-UHFFFAOYSA-N 1-[3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methoxy]phenyl]ethanone Chemical compound ClC1=CC(C(=O)C)=CC=C1OCC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 HOMYQEYBHVSUDR-UHFFFAOYSA-N 0.000 claims description 2
BZSTYYMHJSMBAE-UHFFFAOYSA-N 1-[3-chloro-4-[[5-[2-[3-chloro-4-(methylsulfamoyl)phenyl]propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]sulfonyl-3-pyrrolidin-1-ylurea Chemical compound C1=C(Cl)C(S(=O)(=O)NC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(S(=O)(=O)NC(=O)NN2CCCC2)C=C1Cl BZSTYYMHJSMBAE-UHFFFAOYSA-N 0.000 claims description 2
DUFFJFASBHNCEO-UHFFFAOYSA-N 1-[4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorophenyl]-4-methylpiperazine Chemical compound C1CN(C)CCN1C(C(=C1)F)=CC=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 DUFFJFASBHNCEO-UHFFFAOYSA-N 0.000 claims description 2
VBWMQLGPUZINCJ-UHFFFAOYSA-N 1-[4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]piperidin-1-yl]ethanone Chemical compound C1CN(C(=O)C)CCC1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 VBWMQLGPUZINCJ-UHFFFAOYSA-N 0.000 claims description 2
VSHOWLFOHHRDOG-UHFFFAOYSA-N 1-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfonyl-6-fluoro-2-methyl-3,4-dihydro-2h-quinoline Chemical compound CC1CCC2=CC(F)=CC=C2N1S(=O)(=O)C1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 VSHOWLFOHHRDOG-UHFFFAOYSA-N 0.000 claims description 2
KPPQCSOLRHMOFN-UHFFFAOYSA-N 1-[5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorophenoxy]-2-methylpropan-2-ol Chemical compound C1=C(F)C(OCC(C)(O)C)=CC(CSC=2N(C(=CN=2)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)C=2C=CC(F)=CC=2)=C1 KPPQCSOLRHMOFN-UHFFFAOYSA-N 0.000 claims description 2
WAGXGDNOEZCWLI-UHFFFAOYSA-N 1-[5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorophenyl]-4-methylpiperazine Chemical compound C1CN(C)CCN1C1=CC(CSC=2N(C(=CN=2)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)C=2C=CC(F)=CC=2)=CC=C1F WAGXGDNOEZCWLI-UHFFFAOYSA-N 0.000 claims description 2
DLIDYEMXMOHYCN-UHFFFAOYSA-N 2-[(2,4-dichlorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(Cl)C=C1Cl DLIDYEMXMOHYCN-UHFFFAOYSA-N 0.000 claims description 2
DCWOAPVNFZVLDV-UHFFFAOYSA-N 2-[(2,4-dichlorophenyl)methylsulfonyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C(=CC(Cl)=CC=2)Cl)N1C1=CC=C(F)C=C1 DCWOAPVNFZVLDV-UHFFFAOYSA-N 0.000 claims description 2
YABSDWKXWYBGQE-UHFFFAOYSA-N 2-[(2,5-dichlorophenyl)methylsulfonyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C(=CC=C(Cl)C=2)Cl)N1C1=CC=C(F)C=C1 YABSDWKXWYBGQE-UHFFFAOYSA-N 0.000 claims description 2
FUAQVPOCGSYKLE-UHFFFAOYSA-N 2-[(2,6-dichlorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(Cl)C=CC=C1Cl FUAQVPOCGSYKLE-UHFFFAOYSA-N 0.000 claims description 2
YBNPMYXRBZGVIR-UHFFFAOYSA-N 2-[(2,6-dichlorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(Cl)C=CC=C1Cl YBNPMYXRBZGVIR-UHFFFAOYSA-N 0.000 claims description 2
DROPBSXDWDFZHL-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenoxy)methyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1COC1=CC=C(F)C=C1Cl DROPBSXDWDFZHL-UHFFFAOYSA-N 0.000 claims description 2
QBOFYCZNCOQNGC-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methoxymethyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1COCC1=CC=C(F)C=C1Cl QBOFYCZNCOQNGC-UHFFFAOYSA-N 0.000 claims description 2
TUNYHUCXSAVZIF-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-(3,4-dimethoxyphenyl)-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl TUNYHUCXSAVZIF-UHFFFAOYSA-N 0.000 claims description 2
JHWSDZBSTMGCNL-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[(3,4-difluorophenyl)methyl]-1-(4-fluorophenyl)imidazole Chemical compound C1=CC(F)=CC=C1N1C(SCC=2C(=CC(F)=CC=2)Cl)=NC=C1CC1=CC=C(F)C(F)=C1 JHWSDZBSTMGCNL-UHFFFAOYSA-N 0.000 claims description 2
LGJAZZSZIFREGM-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[(3,4-dimethoxyphenyl)methyl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1CC(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl LGJAZZSZIFREGM-UHFFFAOYSA-N 0.000 claims description 2
ZGHYRINNSLFIJE-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C2OCCOC2=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl ZGHYRINNSLFIJE-UHFFFAOYSA-N 0.000 claims description 2
SUMHCKYVLCXOBC-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(3,4-difluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(F)C(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl SUMHCKYVLCXOBC-UHFFFAOYSA-N 0.000 claims description 2
JCTBWYSWIHRAQN-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(3,5-difluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(F)C=C(F)C=2)=CN=C1SCC1=CC=C(F)C=C1Cl JCTBWYSWIHRAQN-UHFFFAOYSA-N 0.000 claims description 2
AMFKRSHCIVHPIE-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl AMFKRSHCIVHPIE-UHFFFAOYSA-N 0.000 claims description 2
YOQCBMSETSFEJA-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-difluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(F)C(F)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl YOQCBMSETSFEJA-UHFFFAOYSA-N 0.000 claims description 2
VBHSDTXDKWRVOY-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl VBHSDTXDKWRVOY-UHFFFAOYSA-N 0.000 claims description 2
GDNHJCNQNCRQCJ-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,5-dichloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(Cl)C(OC)=C(Cl)C=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl GDNHJCNQNCRQCJ-UHFFFAOYSA-N 0.000 claims description 2
AMGHIMYISROMJY-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl AMGHIMYISROMJY-UHFFFAOYSA-N 0.000 claims description 2
HYLNDAQPTGQWLX-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(F)=CC=3)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 HYLNDAQPTGQWLX-UHFFFAOYSA-N 0.000 claims description 2
QSPKQGHWICQOTO-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-[3-chloro-4-(trifluoromethoxy)phenyl]propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(OC(F)(F)F)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl QSPKQGHWICQOTO-UHFFFAOYSA-N 0.000 claims description 2
IYNOGGIKBWXVSB-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfonyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C(=CC(F)=CC=2)Cl)N1C1=CC=C(F)C=C1 IYNOGGIKBWXVSB-UHFFFAOYSA-N 0.000 claims description 2
OQUJGKIXXMHORR-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)methylsulfonyl]-5-[2-(3,4-difluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(F)C(F)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C(=CC(F)=CC=2)Cl)N1C1=CC=C(F)C=C1 OQUJGKIXXMHORR-UHFFFAOYSA-N 0.000 claims description 2
AEENFTZETWFYSH-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)sulfanylmethyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CSC1=CC=C(F)C=C1Cl AEENFTZETWFYSH-UHFFFAOYSA-N 0.000 claims description 2
SIBUOLUAFMJSJU-UHFFFAOYSA-N 2-[(2-chloro-4-fluorophenyl)sulfonylmethyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CS(=O)(=O)C1=CC=C(F)C=C1Cl SIBUOLUAFMJSJU-UHFFFAOYSA-N 0.000 claims description 2
KBPHHIMZAXXISL-UHFFFAOYSA-N 2-[(2-chloro-5-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC(F)=CC=C1Cl KBPHHIMZAXXISL-UHFFFAOYSA-N 0.000 claims description 2
XTEUDRUZPHOQBT-UHFFFAOYSA-N 2-[(2-chloro-5-fluorophenyl)methylsulfanyl]-5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC(F)=CC=C1Cl XTEUDRUZPHOQBT-UHFFFAOYSA-N 0.000 claims description 2
FUXSAEXSYROVEH-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenoxy)methyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1COC1=C(F)C=CC=C1Cl FUXSAEXSYROVEH-UHFFFAOYSA-N 0.000 claims description 2
IEWBZJWHGMUHJD-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenoxy)methyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1COC1=C(F)C=CC=C1Cl IEWBZJWHGMUHJD-UHFFFAOYSA-N 0.000 claims description 2
HIJRSCUCJNJXEH-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-(2,4-dichlorophenyl)-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C(=CC(Cl)=CC=2)Cl)=CN=C1SCC1=C(F)C=CC=C1Cl HIJRSCUCJNJXEH-UHFFFAOYSA-N 0.000 claims description 2
SXZCNJLXZMEPGR-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-(3,4-dichlorophenyl)-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(Cl)C(Cl)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl SXZCNJLXZMEPGR-UHFFFAOYSA-N 0.000 claims description 2
USKKVNSTKLSFDZ-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-5-[2-(3-methylsulfonylphenyl)propan-2-yl]imidazole Chemical compound C=1C=CC(S(C)(=O)=O)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl USKKVNSTKLSFDZ-UHFFFAOYSA-N 0.000 claims description 2
BWGBFGHHNMRFRM-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-5-[2-(4-fluorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(F)C=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl BWGBFGHHNMRFRM-UHFFFAOYSA-N 0.000 claims description 2
ZXIRTYKBNFTRPD-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-5-[2-(4-methoxyphenyl)propan-2-yl]imidazole Chemical compound C1=CC(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl ZXIRTYKBNFTRPD-UHFFFAOYSA-N 0.000 claims description 2
QGDVTFFTJBTCRP-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-5-[2-(4-methylsulfonylphenyl)propan-2-yl]imidazole Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl QGDVTFFTJBTCRP-UHFFFAOYSA-N 0.000 claims description 2
IPMWKDHDUWOHSU-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)-5-[2-[4-(trifluoromethyl)phenyl]propan-2-yl]imidazole Chemical compound C=1C=C(C(F)(F)F)C=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl IPMWKDHDUWOHSU-UHFFFAOYSA-N 0.000 claims description 2
AXINPRPHYQNQBD-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-cyclopentyl-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C2CCCC2)=CN=C1SCC1=C(F)C=CC=C1Cl AXINPRPHYQNQBD-UHFFFAOYSA-N 0.000 claims description 2
VRLUCPAWCDTWMK-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-(3,4-dimethoxyphenyl)-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl VRLUCPAWCDTWMK-UHFFFAOYSA-N 0.000 claims description 2
NAUFMFRMZTWLNH-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[(3,4-dichlorophenyl)-difluoromethyl]-1-(4-fluorophenyl)imidazole Chemical compound C1=CC(F)=CC=C1N1C(C(F)(F)C=2C=C(Cl)C(Cl)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl NAUFMFRMZTWLNH-UHFFFAOYSA-N 0.000 claims description 2
ZLQRYWXARSQWNW-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C2OCCOC2=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl ZLQRYWXARSQWNW-UHFFFAOYSA-N 0.000 claims description 2
AYTNRJAARIJUQT-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(2,4-difluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C(=CC(F)=CC=2)F)=CN=C1SCC1=C(F)C=CC=C1Cl AYTNRJAARIJUQT-UHFFFAOYSA-N 0.000 claims description 2
QGGJHTPRWDVAQN-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(3,4-difluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(F)C(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl QGGJHTPRWDVAQN-UHFFFAOYSA-N 0.000 claims description 2
VZSVSSOBCAWWDT-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)-4-phenylimidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=C(C=2C=CC=CC=2)N=C1SCC1=C(F)C=CC=C1Cl VZSVSSOBCAWWDT-UHFFFAOYSA-N 0.000 claims description 2
JQQSSFQKRKBKEK-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl JQQSSFQKRKBKEK-UHFFFAOYSA-N 0.000 claims description 2
WDHJMIKBZJHGDC-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-[(4-fluorophenyl)methyl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1CC=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl WDHJMIKBZJHGDC-UHFFFAOYSA-N 0.000 claims description 2
UVHVDRPZOQQDPD-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-propan-2-ylimidazole Chemical compound N=1C=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N(C(C)C)C=1SCC1=C(F)C=CC=C1Cl UVHVDRPZOQQDPD-UHFFFAOYSA-N 0.000 claims description 2
PRZUHRUGCUSRNY-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-difluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(F)C(F)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl PRZUHRUGCUSRNY-UHFFFAOYSA-N 0.000 claims description 2
NGCFQZZMKMQQAL-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl NGCFQZZMKMQQAL-UHFFFAOYSA-N 0.000 claims description 2
ZSBFGMYBKQOWLK-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-4-(4-fluorophenyl)-1-methylimidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C)=C(C=2C=CC(F)=CC=2)N=C1SCC1=C(F)C=CC=C1Cl ZSBFGMYBKQOWLK-UHFFFAOYSA-N 0.000 claims description 2
BSMNKXBVAVXUFK-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,5-dichloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(Cl)C(OC)=C(Cl)C=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl BSMNKXBVAVXUFK-UHFFFAOYSA-N 0.000 claims description 2
SZQIZEAGBSQINP-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3-chloro-4-fluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(F)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl SZQIZEAGBSQINP-UHFFFAOYSA-N 0.000 claims description 2
QIQDFXQHIFPNOL-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl QIQDFXQHIFPNOL-UHFFFAOYSA-N 0.000 claims description 2
XFCSOLIKYAGPSP-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(4-chloro-2-fluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C=C(F)C=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl XFCSOLIKYAGPSP-UHFFFAOYSA-N 0.000 claims description 2
OVQFXRULCGTMSO-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-4-methylimidazole Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC=CC=3F)Cl)=NC=2C)C=2C=CC(F)=CC=2)=C1 OVQFXRULCGTMSO-UHFFFAOYSA-N 0.000 claims description 2
YAKBTKXDFYZLQH-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC=CC=3F)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 YAKBTKXDFYZLQH-UHFFFAOYSA-N 0.000 claims description 2
QKKZWUOPUHORTH-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(4-chlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl QKKZWUOPUHORTH-UHFFFAOYSA-N 0.000 claims description 2
CFHAJESNAQDJFS-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfonyl]-1-(3,4-dichlorophenyl)-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C(=CC=CC=2F)Cl)N1C1=CC=C(Cl)C(Cl)=C1 CFHAJESNAQDJFS-UHFFFAOYSA-N 0.000 claims description 2
IDWASVJCHZPZOT-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfonyl]-1-(4-chlorophenyl)-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C(=CC=CC=2F)Cl)N1C1=CC=C(Cl)C=C1 IDWASVJCHZPZOT-UHFFFAOYSA-N 0.000 claims description 2
YCQHLGAECQMNLJ-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfonyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(2,4-difluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C(=CC=CC=2F)Cl)N1C1=CC=C(F)C=C1F YCQHLGAECQMNLJ-UHFFFAOYSA-N 0.000 claims description 2
ACEFDTQLERMZIZ-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)methylsulfonyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C(=CC=CC=2F)Cl)N1C1=CC=C(F)C=C1 ACEFDTQLERMZIZ-UHFFFAOYSA-N 0.000 claims description 2
ZMMKHBXCGGAXRN-UHFFFAOYSA-N 2-[(2-chloro-6-fluorophenyl)sulfanylmethyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CSC1=C(F)C=CC=C1Cl ZMMKHBXCGGAXRN-UHFFFAOYSA-N 0.000 claims description 2
METKUGUILMSFDI-UHFFFAOYSA-N 2-[(3,4-dichlorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(Cl)C(Cl)=C1 METKUGUILMSFDI-UHFFFAOYSA-N 0.000 claims description 2
KNMVGSNOMQAETF-UHFFFAOYSA-N 2-[(3,4-dichlorophenyl)methylsulfonyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 KNMVGSNOMQAETF-UHFFFAOYSA-N 0.000 claims description 2
OHFVNKRDTPDPIB-UHFFFAOYSA-N 2-[(3-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C(Cl)=C1 OHFVNKRDTPDPIB-UHFFFAOYSA-N 0.000 claims description 2
AMWBNFLEKSCGHQ-UHFFFAOYSA-N 2-[(3-chloro-4-fluorophenyl)methylsulfonyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C=C(Cl)C(F)=CC=2)N1C1=CC=C(F)C=C1 AMWBNFLEKSCGHQ-UHFFFAOYSA-N 0.000 claims description 2
RDOMVYMYZLRKCK-UHFFFAOYSA-N 2-[(3-chloro-5-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC(F)=CC(Cl)=C1 RDOMVYMYZLRKCK-UHFFFAOYSA-N 0.000 claims description 2
MXVWHQBVEDPIHZ-ACCUITESSA-N 2-[(e)-2-(2-chloro-6-fluorophenyl)ethenyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1\C=C\C1=C(F)C=CC=C1Cl MXVWHQBVEDPIHZ-ACCUITESSA-N 0.000 claims description 2
WVRZZQAOHJIQPL-UHFFFAOYSA-N 2-[1-(2-chloro-4-fluorophenyl)sulfanylethyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound N=1C=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N(C=2C=CC(F)=CC=2)C=1C(C)SC1=CC=C(F)C=C1Cl WVRZZQAOHJIQPL-UHFFFAOYSA-N 0.000 claims description 2
WRWCKVXIFCPIQB-UHFFFAOYSA-N 2-[1-(3,4-dichlorophenoxy)ethyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound N=1C=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N(C=2C=CC(F)=CC=2)C=1C(C)OC1=CC=C(Cl)C(Cl)=C1 WRWCKVXIFCPIQB-UHFFFAOYSA-N 0.000 claims description 2
GDELKNUEMJEFSO-UHFFFAOYSA-N 2-[2-(2-chloro-4-fluorophenyl)ethylsulfonyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C1=CN=C(S(=O)(=O)CCC=2C(=CC(F)=CC=2)Cl)N1C1=CC=C(F)C=C1 GDELKNUEMJEFSO-UHFFFAOYSA-N 0.000 claims description 2
PWTKSBKOHBGWBM-UHFFFAOYSA-N 2-[2-(2-chloro-6-fluorophenyl)ethyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CCC1=C(F)C=CC=C1Cl PWTKSBKOHBGWBM-UHFFFAOYSA-N 0.000 claims description 2
WQIUFXMBUQIINC-UHFFFAOYSA-N 2-[2-(2-chloro-6-fluorophenyl)ethyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CCC1=C(F)C=CC=C1Cl WQIUFXMBUQIINC-UHFFFAOYSA-N 0.000 claims description 2
QXNXZNQOYCDOIE-UHFFFAOYSA-N 2-[2-(2-chloro-6-fluorophenyl)propan-2-ylsulfonyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)C(C)(C)C=2C(=CC=CC=2F)Cl)N1C1=CC=C(F)C=C1 QXNXZNQOYCDOIE-UHFFFAOYSA-N 0.000 claims description 2
YEGVFBAQKSKDJF-UHFFFAOYSA-N 2-[2-(3,4-dichlorophenyl)ethylsulfonyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C1=CN=C(S(=O)(=O)CCC=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 YEGVFBAQKSKDJF-UHFFFAOYSA-N 0.000 claims description 2
NEXDDGWTIUQBMJ-UHFFFAOYSA-N 2-[2-(3-chloro-4-fluorophenyl)ethylsulfonyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C1=CN=C(S(=O)(=O)CCC=2C=C(Cl)C(F)=CC=2)N1C1=CC=C(F)C=C1 NEXDDGWTIUQBMJ-UHFFFAOYSA-N 0.000 claims description 2
XFMYKIQIAVCGOR-UHFFFAOYSA-N 2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-1-yl]-n,n-dimethylethanamine Chemical compound N=1C=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N(CCN(C)C)C=1SCC1=C(F)C=CC=C1Cl XFMYKIQIAVCGOR-UHFFFAOYSA-N 0.000 claims description 2
BPNVNWPLZBXVOL-UHFFFAOYSA-N 2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-1-yl]ethanol Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1CCO)=CN=C1SCC1=C(F)C=CC=C1Cl BPNVNWPLZBXVOL-UHFFFAOYSA-N 0.000 claims description 2
GHPIRRQMDDPVIN-UHFFFAOYSA-N 2-[2-[2-chloro-5-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-4-fluorophenoxy]ethyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(Cl)=C(OCCNC(N)=N)C=3)F)=NC=2)C=2C=CC(F)=CC=2)=C1 GHPIRRQMDDPVIN-UHFFFAOYSA-N 0.000 claims description 2
TYJXLBAZIHOMPZ-UHFFFAOYSA-N 2-[2-[3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorophenoxy]ethyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(OCCNC(N)=N)=CC=3F)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 TYJXLBAZIHOMPZ-UHFFFAOYSA-N 0.000 claims description 2
SBTUGLUNVHUTRC-UHFFFAOYSA-N 2-[2-[3-chloro-5-fluoro-4-[[5-[2-(4-fluoro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenoxy]ethyl]guanidine Chemical compound C1=C(F)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(OCCNC(N)=N)=CC=3F)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 SBTUGLUNVHUTRC-UHFFFAOYSA-N 0.000 claims description 2
YGLMALZVEIWMPR-UHFFFAOYSA-N 2-[2-[4-[[5-[2-(3-chloro-4-fluorophenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenoxy]ethyl]guanidine Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(OCCNC(N)=N)=CC=2F)F)C(C)(C)C=2C=C(Cl)C(F)=CC=2)=C1 YGLMALZVEIWMPR-UHFFFAOYSA-N 0.000 claims description 2
ITNKBVGJKSRPGI-UHFFFAOYSA-N 2-[2-[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenoxy]ethyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(OCCNC(N)=N)=CC=3F)F)=NC=2)C=2C=CC(F)=CC=2)=C1 ITNKBVGJKSRPGI-UHFFFAOYSA-N 0.000 claims description 2
VLQDTECSAKUSCB-UHFFFAOYSA-N 2-[2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorophenyl]propan-2-ol Chemical compound CC(C)(O)C1=CC=CC(F)=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 VLQDTECSAKUSCB-UHFFFAOYSA-N 0.000 claims description 2
SNYSCOJXPRYYDX-UHFFFAOYSA-N 2-[2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorophenoxy]-2-methylpropanoic acid Chemical compound OC(=O)C(C)(C)OC1=CC(F)=CC=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 SNYSCOJXPRYYDX-UHFFFAOYSA-N 0.000 claims description 2
BAIZMWHVBJDJNY-UHFFFAOYSA-N 2-[2-chloro-4-[2-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]-2-methylpropanoic acid Chemical compound C1=C(Cl)C(OC(C)(C)C(O)=O)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl BAIZMWHVBJDJNY-UHFFFAOYSA-N 0.000 claims description 2
BNHCLOGNOMHNKF-UHFFFAOYSA-N 2-[2-chloro-4-[2-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]acetic acid Chemical compound C=1C=C(OCC(O)=O)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl BNHCLOGNOMHNKF-UHFFFAOYSA-N 0.000 claims description 2
QLZLKIFCRLOKDU-UHFFFAOYSA-N 2-[2-chloro-4-[2-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenyl]propan-2-ol Chemical compound C1=C(Cl)C(C(C)(O)C)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl QLZLKIFCRLOKDU-UHFFFAOYSA-N 0.000 claims description 2
ODVVEYTZHACZFQ-UHFFFAOYSA-N 2-[2-chloro-5-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]-n,n-diethylethanamine Chemical compound C1=C(Cl)C(OCCN(CC)CC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC=CC=3F)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 ODVVEYTZHACZFQ-UHFFFAOYSA-N 0.000 claims description 2
UDIAULSPTRXFSQ-UHFFFAOYSA-N 2-[2-chloro-5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]propan-2-ol Chemical compound C1=C(Cl)C(C(C)(O)C)=CC(CSC=2N(C(=CN=2)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)C=2C=CC(F)=CC=2)=C1 UDIAULSPTRXFSQ-UHFFFAOYSA-N 0.000 claims description 2
DSGSBVXQVCWFIS-UHFFFAOYSA-N 2-[3-[2-chloro-4-fluoro-3-[[5-[2-(4-fluoro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenoxy]propyl]guanidine Chemical compound C1=C(F)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=C(OCCCNC(N)=N)C=CC=3F)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 DSGSBVXQVCWFIS-UHFFFAOYSA-N 0.000 claims description 2
INHOHAYCKPCICV-UHFFFAOYSA-N 2-[3-[3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorophenoxy]propyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(OCCCNC(N)=N)=CC=3F)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 INHOHAYCKPCICV-UHFFFAOYSA-N 0.000 claims description 2
OPVDRCRUPSPCAT-UHFFFAOYSA-N 2-[3-[3-chloro-5-fluoro-4-[[5-[2-(4-fluoro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenoxy]propyl]guanidine Chemical compound C1=C(F)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(OCCCNC(N)=N)=CC=3F)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 OPVDRCRUPSPCAT-UHFFFAOYSA-N 0.000 claims description 2
RHKHIDJISHJIFX-UHFFFAOYSA-N 2-[3-[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenoxy]propyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(OCCCNC(N)=N)=CC=3F)F)=NC=2)C=2C=CC(F)=CC=2)=C1 RHKHIDJISHJIFX-UHFFFAOYSA-N 0.000 claims description 2
GLQRJQJRTLYSMK-UHFFFAOYSA-N 2-[3-[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]prop-2-ynyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C#CCNC(N)=N)F)=NC=2)C=2C=CC(F)=CC=2)=C1 GLQRJQJRTLYSMK-UHFFFAOYSA-N 0.000 claims description 2
PRHBBCJLEVKFHN-UHFFFAOYSA-N 2-[3-[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]propyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(CCCNC(N)=N)=CC=3F)F)=NC=2)C=2C=CC(F)=CC=2)=C1 PRHBBCJLEVKFHN-UHFFFAOYSA-N 0.000 claims description 2
GOJFHAKNGPPNHS-UHFFFAOYSA-N 2-[3-[[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]sulfonylamino]propyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)S(=O)(=O)NCCCNC(N)=N)F)=NC=2)C=2C=CC(F)=CC=2)=C1 GOJFHAKNGPPNHS-UHFFFAOYSA-N 0.000 claims description 2
OEOHGZPMPQYXTN-UHFFFAOYSA-N 2-[3-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-4-fluorophenyl]-2-methylpropanoic acid Chemical compound OC(=O)C(C)(C)C1=CC=C(F)C(CSC=2N(C(=CN=2)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)C=2C=CC(F)=CC=2)=C1 OEOHGZPMPQYXTN-UHFFFAOYSA-N 0.000 claims description 2
UEVILKXYQZSLGI-UHFFFAOYSA-N 2-[3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]propan-2-ol Chemical compound ClC1=CC(C(C)(O)C)=CC=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 UEVILKXYQZSLGI-UHFFFAOYSA-N 0.000 claims description 2
IEKUXJUUMJLONS-UHFFFAOYSA-N 2-[3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorophenyl]propan-2-ol Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(C)(C)O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 IEKUXJUUMJLONS-UHFFFAOYSA-N 0.000 claims description 2
MJUOLCCEUNDXOD-UHFFFAOYSA-N 2-[4-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]-n,n-dimethylethanamine Chemical compound C1=CC(OCCN(C)C)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl MJUOLCCEUNDXOD-UHFFFAOYSA-N 0.000 claims description 2
JSHFBMDOSSFEOY-UHFFFAOYSA-N 2-[4-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]acetic acid Chemical compound C=1C=C(OCC(O)=O)C=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl JSHFBMDOSSFEOY-UHFFFAOYSA-N 0.000 claims description 2
AURTZUFYDGLWLL-UHFFFAOYSA-N 2-[4-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]ethanol Chemical compound C=1C=C(OCCO)C=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl AURTZUFYDGLWLL-UHFFFAOYSA-N 0.000 claims description 2
SGJOMKIAOSTNFG-UHFFFAOYSA-N 2-[4-[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]butyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(CCCCNC(N)=N)=CC=3F)F)=NC=2)C=2C=CC(F)=CC=2)=C1 SGJOMKIAOSTNFG-UHFFFAOYSA-N 0.000 claims description 2
XOWCJNQWXSHPPI-UHFFFAOYSA-N 2-[4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-(2h-tetrazol-5-yl)phenoxy]-n,n-diethylethanamine Chemical compound C1=C(C=2NN=NN=2)C(OCCN(CC)CC)=CC=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 XOWCJNQWXSHPPI-UHFFFAOYSA-N 0.000 claims description 2
KELXJFJSQDUTKT-UHFFFAOYSA-N 2-[4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorophenyl]-2-methylpropanoic acid Chemical compound FC1=CC(C(C)(C(O)=O)C)=CC=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 KELXJFJSQDUTKT-UHFFFAOYSA-N 0.000 claims description 2
ADGVBTUYOGFCOL-UHFFFAOYSA-N 2-[4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorophenyl]propan-2-ol Chemical compound FC1=CC(C(C)(O)C)=CC=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 ADGVBTUYOGFCOL-UHFFFAOYSA-N 0.000 claims description 2
XXKZIUUVFGQSKT-UHFFFAOYSA-N 2-[4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]piperidin-1-yl]sulfonyl-n,n-diethylethanamine Chemical compound C1CN(S(=O)(=O)CCN(CC)CC)CCC1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 XXKZIUUVFGQSKT-UHFFFAOYSA-N 0.000 claims description 2
MFNSFYJVLURBNI-UHFFFAOYSA-N 2-[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]piperidin-1-yl]acetic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC3CCN(CC(O)=O)CC3)=NC=2)C=2C=CC(F)=CC=2)=C1 MFNSFYJVLURBNI-UHFFFAOYSA-N 0.000 claims description 2
CJHPUCFSWWEAHB-UHFFFAOYSA-N 2-[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]piperidin-1-yl]ethanol Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC3CCN(CCO)CC3)=NC=2)C=2C=CC(F)=CC=2)=C1 CJHPUCFSWWEAHB-UHFFFAOYSA-N 0.000 claims description 2
GCYLPPHBRPMNIM-UHFFFAOYSA-N 2-[5-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-1-yl]-2-fluorophenoxy]-2-methylpropanoic acid Chemical compound C1=C(F)C(OC(C)(C)C(O)=O)=CC(N2C(=CN=C2SCC=2C(=CC(F)=CC=2)Cl)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 GCYLPPHBRPMNIM-UHFFFAOYSA-N 0.000 claims description 2
BPXOCOLXEZKBQV-UHFFFAOYSA-N 2-[5-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-1-yl]-2-fluorophenoxy]acetic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(OCC(O)=O)C(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl BPXOCOLXEZKBQV-UHFFFAOYSA-N 0.000 claims description 2
HFVGOBMATJCZIJ-UHFFFAOYSA-N 2-[5-[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]pentyl]guanidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(CCCCCNC(N)=N)=CC=3F)F)=NC=2)C=2C=CC(F)=CC=2)=C1 HFVGOBMATJCZIJ-UHFFFAOYSA-N 0.000 claims description 2
TZWMTKKGLCSQRP-UHFFFAOYSA-N 2-[5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorophenoxy]-2-methylpropanoic acid Chemical compound C1=C(F)C(OC(C)(C)C(O)=O)=CC(CSC=2N(C(=CN=2)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)C=2C=CC(F)=CC=2)=C1 TZWMTKKGLCSQRP-UHFFFAOYSA-N 0.000 claims description 2
FKRYLSHMARZMHH-UHFFFAOYSA-N 2-[5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorophenyl]-2-methylpropanoic acid Chemical compound C1=C(F)C(C(C)(C(O)=O)C)=CC(CSC=2N(C(=CN=2)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)C=2C=CC(F)=CC=2)=C1 FKRYLSHMARZMHH-UHFFFAOYSA-N 0.000 claims description 2
QXJSGSVIMUAZQP-UHFFFAOYSA-N 2-[5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorophenyl]guanidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C(NC(N)=N)=C1 QXJSGSVIMUAZQP-UHFFFAOYSA-N 0.000 claims description 2
MWQCPFZFVSVRHD-UHFFFAOYSA-N 2-[5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorophenyl]propan-2-ol Chemical compound C1=C(F)C(C(C)(O)C)=CC(CSC=2N(C(=CN=2)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)C=2C=CC(F)=CC=2)=C1 MWQCPFZFVSVRHD-UHFFFAOYSA-N 0.000 claims description 2
NSOZLBQKFCCIEX-UHFFFAOYSA-N 2-[[3-chloro-4-[2-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]ethyl]-5-fluorobenzoyl]amino]ethanesulfonic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CCC1=C(F)C=C(C(=O)NCCS(O)(=O)=O)C=C1Cl NSOZLBQKFCCIEX-UHFFFAOYSA-N 0.000 claims description 2
TULCRVBIUALVLZ-UHFFFAOYSA-N 2-[[3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoyl]amino]ethanesulfonic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(=O)NCCS(O)(=O)=O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 TULCRVBIUALVLZ-UHFFFAOYSA-N 0.000 claims description 2
IOCIAQJWXQEQFO-UHFFFAOYSA-N 2-[[3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorophenyl]sulfonylamino]ethanesulfonic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)S(=O)(=O)NCCS(O)(=O)=O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 IOCIAQJWXQEQFO-UHFFFAOYSA-N 0.000 claims description 2
TZXHOKUJDGALAY-UHFFFAOYSA-N 2-[[4-[[1-(3-chloro-4-fluorophenyl)-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoyl]amino]ethanesulfonic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(Cl)C(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(=O)NCCS(O)(=O)=O)C=C1F TZXHOKUJDGALAY-UHFFFAOYSA-N 0.000 claims description 2
PTUFUGUAVLZIPH-UHFFFAOYSA-N 2-[[4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoyl]amino]ethanesulfonic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(=O)NCCS(O)(=O)=O)F)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 PTUFUGUAVLZIPH-UHFFFAOYSA-N 0.000 claims description 2
STODIHJNCFBLJU-UHFFFAOYSA-N 2-[[4-[[5-[2-(3-chloro-4-sulfamoylphenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoyl]amino]ethanesulfonic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(=O)NCCS(O)(=O)=O)F)C(C)(C)C=2C=C(Cl)C(=CC=2)S(N)(=O)=O)=C1 STODIHJNCFBLJU-UHFFFAOYSA-N 0.000 claims description 2
VNFNVPIKUOSHMF-UHFFFAOYSA-N 2-[[4-[[5-[2-(3-chloro-4-sulfamoylphenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoyl]amino]ethanesulfonic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2)C(=O)NCCS(O)(=O)=O)F)C(C)(C)C=2C=C(Cl)C(=CC=2)S(N)(=O)=O)=C1 VNFNVPIKUOSHMF-UHFFFAOYSA-N 0.000 claims description 2
BJOOQFYRHYRCRK-UHFFFAOYSA-N 2-[[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoyl]amino]ethanesulfonic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(=O)NCCS(O)(=O)=O)F)=NC=2)C=2C=CC(F)=CC=2)=C1 BJOOQFYRHYRCRK-UHFFFAOYSA-N 0.000 claims description 2
HMNWNYSSKKTPIU-UHFFFAOYSA-N 2-[[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]sulfonylamino]ethanesulfonic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)S(=O)(=O)NCCS(O)(=O)=O)F)=NC=2)C=2C=CC(F)=CC=2)=C1 HMNWNYSSKKTPIU-UHFFFAOYSA-N 0.000 claims description 2
YUXZQAHIKUTLHR-UHFFFAOYSA-N 2-[[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoyl]amino]ethanesulfonic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3)C(=O)NCCS(O)(=O)=O)F)=NC=2)C=2C=CC(F)=CC=2)=C1 YUXZQAHIKUTLHR-UHFFFAOYSA-N 0.000 claims description 2
VPMPFSBXYZSWLR-UHFFFAOYSA-N 2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1C(O)=O VPMPFSBXYZSWLR-UHFFFAOYSA-N 0.000 claims description 2
CEOYHLLNIPQMQD-UHFFFAOYSA-N 2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1C(N)=O CEOYHLLNIPQMQD-UHFFFAOYSA-N 0.000 claims description 2
XEHCJPXIPFZETL-UHFFFAOYSA-N 2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzenesulfonamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1S(N)(=O)=O XEHCJPXIPFZETL-UHFFFAOYSA-N 0.000 claims description 2
CKZAOTKVPRPSNE-UHFFFAOYSA-N 2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1C(O)=O CKZAOTKVPRPSNE-UHFFFAOYSA-N 0.000 claims description 2
QTFSFOSWOSJXFX-UHFFFAOYSA-N 2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzonitrile Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1C#N QTFSFOSWOSJXFX-UHFFFAOYSA-N 0.000 claims description 2
OKXGSVVOKAWAHW-UHFFFAOYSA-N 2-[[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoic acid Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1C(O)=O OKXGSVVOKAWAHW-UHFFFAOYSA-N 0.000 claims description 2
FLRMKFJFLWAOAE-UHFFFAOYSA-N 2-chloro-4-[2-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]benzonitrile Chemical compound C=1C=C(C#N)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl FLRMKFJFLWAOAE-UHFFFAOYSA-N 0.000 claims description 2
KLRAVMWKAHEJBH-UHFFFAOYSA-N 2-chloro-4-[2-[2-[(2-chloro-4-sulfamoylphenyl)methylsulfanyl]-3-(4-fluoro-3-methoxyphenyl)imidazol-4-yl]propan-2-yl]benzenesulfonamide Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2)S(N)(=O)=O)Cl)C(C)(C)C=2C=C(Cl)C(=CC=2)S(N)(=O)=O)=C1 KLRAVMWKAHEJBH-UHFFFAOYSA-N 0.000 claims description 2
SMYYKELFMXXOML-UHFFFAOYSA-N 2-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C(O)=O)C(Cl)=C1 SMYYKELFMXXOML-UHFFFAOYSA-N 0.000 claims description 2
HHZYVPDWZWNAJK-UHFFFAOYSA-N 2-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzonitrile Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C#N)C(Cl)=C1 HHZYVPDWZWNAJK-UHFFFAOYSA-N 0.000 claims description 2
RDMXHUMXJXGOPR-UHFFFAOYSA-N 2-chloro-5-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenol Chemical compound C=1C=C(Cl)C(O)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl RDMXHUMXJXGOPR-UHFFFAOYSA-N 0.000 claims description 2
AROPFGHNSCZIGK-UHFFFAOYSA-N 2-chloro-5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(Cl)C(C(O)=O)=C1 AROPFGHNSCZIGK-UHFFFAOYSA-N 0.000 claims description 2
QSNBKUFBQXSMSU-UHFFFAOYSA-N 2-chloro-5-[[5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(Cl)C(C(O)=O)=C1 QSNBKUFBQXSMSU-UHFFFAOYSA-N 0.000 claims description 2
QIBPXBISDGYZAH-UHFFFAOYSA-N 2-chloro-5-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-4-fluorobenzenesulfonamide Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(Cl)=C(C=3)S(N)(=O)=O)F)=NC=2)C=2C=CC(F)=CC=2)=C1 QIBPXBISDGYZAH-UHFFFAOYSA-N 0.000 claims description 2
KQGHPLPJGFJUQK-UHFFFAOYSA-N 2-chloro-n-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methyl]-6-fluoro-n-methylaniline Chemical compound FC=1C=CC=C(Cl)C=1N(C)CC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 KQGHPLPJGFJUQK-UHFFFAOYSA-N 0.000 claims description 2
WJCUYNCHFCCACX-UHFFFAOYSA-N 2-chloro-n-[[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methyl]-4-fluoroaniline Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CNC1=CC=C(F)C=C1Cl WJCUYNCHFCCACX-UHFFFAOYSA-N 0.000 claims description 2
BDZJZIYALJVTBQ-UHFFFAOYSA-N 2-chloro-n-[[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methyl]-6-fluoro-n-methylaniline Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CN(C)C1=C(F)C=CC=C1Cl BDZJZIYALJVTBQ-UHFFFAOYSA-N 0.000 claims description 2
RCUSPWLYMDXEDW-UHFFFAOYSA-N 2-chloro-n-[[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methyl]-6-fluoroaniline Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CNC1=C(F)C=CC=C1Cl RCUSPWLYMDXEDW-UHFFFAOYSA-N 0.000 claims description 2
125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 claims description 2
GUPYZDOXEOZCRM-UHFFFAOYSA-N 3,4-dichloro-n-[[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methyl]aniline Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CNC1=CC=C(Cl)C(Cl)=C1 GUPYZDOXEOZCRM-UHFFFAOYSA-N 0.000 claims description 2
QZMOGTSQYPIPJN-UHFFFAOYSA-N 3,5-difluoro-4-[[1-(4-fluoro-3-methoxyphenyl)-5-[2-(3-methylsulfonylphenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)F)C(C)(C)C=2C=C(C=CC=2)S(C)(=O)=O)=C1 QZMOGTSQYPIPJN-UHFFFAOYSA-N 0.000 claims description 2
PABWZFKEBRQOHP-UHFFFAOYSA-N 3,5-difluoro-4-[[1-(4-fluoro-3-methoxyphenyl)-5-[2-(4-methylsulfonylphenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)F)C(C)(C)C=2C=CC(=CC=2)S(C)(=O)=O)=C1 PABWZFKEBRQOHP-UHFFFAOYSA-N 0.000 claims description 2
QQNABAHFONGRLO-UHFFFAOYSA-N 3,5-difluoro-4-[[1-(4-fluoro-3-methoxyphenyl)-5-[2-(4-sulfamoylphenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)F)C(C)(C)C=2C=CC(=CC=2)S(N)(=O)=O)=C1 QQNABAHFONGRLO-UHFFFAOYSA-N 0.000 claims description 2
IVIIDGANIIUFJU-UHFFFAOYSA-N 3,5-difluoro-4-[[1-(4-fluorophenyl)-5-(2-naphthalen-2-ylpropan-2-yl)imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C=1C=C2C=CC=CC2=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F IVIIDGANIIUFJU-UHFFFAOYSA-N 0.000 claims description 2
SDSGLVOBAJECJH-UHFFFAOYSA-N 3,5-difluoro-4-[[1-(4-fluorophenyl)-5-[2-(4-methylsulfonylphenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F SDSGLVOBAJECJH-UHFFFAOYSA-N 0.000 claims description 2
CBKJFQJZPYOGSH-UHFFFAOYSA-N 3,5-difluoro-4-[[1-(5-fluoropyridin-2-yl)-5-[2-(4-methylsulfonylphenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C(C)(C)C(N1C=2N=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F CBKJFQJZPYOGSH-UHFFFAOYSA-N 0.000 claims description 2
KCMJJQVHGSHGDQ-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-1-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]propan-1-ol Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1C(O)CCC1=CC=C(Cl)C=C1Cl KCMJJQVHGSHGDQ-UHFFFAOYSA-N 0.000 claims description 2
VIJQXHNBSGGOMN-UHFFFAOYSA-N 3-(2,4-dichlorophenyl)-1-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]propan-1-one Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1C(=O)CCC1=CC=C(Cl)C=C1Cl VIJQXHNBSGGOMN-UHFFFAOYSA-N 0.000 claims description 2
GCIAEBRQIBMDKS-UHFFFAOYSA-N 3-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-1-yl]pyridine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=NC=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl GCIAEBRQIBMDKS-UHFFFAOYSA-N 0.000 claims description 2
QVQULIYFJDAYSP-UHFFFAOYSA-N 3-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]imidazol-1-yl]pyridine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC=CC=3F)Cl)=NC=2)C=2C=NC=CC=2)=C1 QVQULIYFJDAYSP-UHFFFAOYSA-N 0.000 claims description 2
PBGRVNXMOSSRLN-UHFFFAOYSA-N 3-[4-[[5-[2-(3,4-difluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]piperidin-1-yl]propane-1,2-diol Chemical compound C=1C=C(F)C(F)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1CCN(CC(O)CO)CC1 PBGRVNXMOSSRLN-UHFFFAOYSA-N 0.000 claims description 2
JMPPZDJVROJWPY-UHFFFAOYSA-N 3-[4-[[5-[2-(3-chloro-4-fluorophenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]-n,n-dimethylpropan-1-amine Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(CCCN(C)C)=CC=2F)F)C(C)(C)C=2C=C(Cl)C(F)=CC=2)=C1 JMPPZDJVROJWPY-UHFFFAOYSA-N 0.000 claims description 2
JPQPRUDOWHQXCO-UHFFFAOYSA-N 3-[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorophenyl]-2h-1,2,4-oxadiazol-5-one Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C=3NC(=O)ON=3)F)=NC=2)C=2C=CC(F)=CC=2)=C1 JPQPRUDOWHQXCO-UHFFFAOYSA-N 0.000 claims description 2
YFKAEDKXRCTHPJ-UHFFFAOYSA-N 3-[[3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]sulfonylcarbamoylamino]propanoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3)S(=O)(=O)NC(=O)NCCC(O)=O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 YFKAEDKXRCTHPJ-UHFFFAOYSA-N 0.000 claims description 2
DKEPDCKKWOVNEQ-UHFFFAOYSA-N 3-[[4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoyl]amino]propanoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(=O)NCCC(O)=O)F)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 DKEPDCKKWOVNEQ-UHFFFAOYSA-N 0.000 claims description 2
LTZUKWLHXPZLCM-UHFFFAOYSA-N 3-[[4-[[5-[2-(3-chloro-4-sulfamoylphenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoyl]amino]propanoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(=O)NCCC(O)=O)F)C(C)(C)C=2C=C(Cl)C(=CC=2)S(N)(=O)=O)=C1 LTZUKWLHXPZLCM-UHFFFAOYSA-N 0.000 claims description 2
LYFYWBYXIWUSIC-UHFFFAOYSA-N 3-[[4-[[5-[2-(3-chloro-4-sulfamoylphenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoyl]amino]propanoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2)C(=O)NCCC(O)=O)F)C(C)(C)C=2C=C(Cl)C(=CC=2)S(N)(=O)=O)=C1 LYFYWBYXIWUSIC-UHFFFAOYSA-N 0.000 claims description 2
YINKOADDSOJONO-UHFFFAOYSA-N 3-[[4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoyl]amino]propanoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3)C(=O)NCCC(O)=O)F)=NC=2)C=2C=CC(F)=CC=2)=C1 YINKOADDSOJONO-UHFFFAOYSA-N 0.000 claims description 2
UNZDSWVYQUPIEW-UHFFFAOYSA-N 3-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-(2h-tetrazol-5-yl)piperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC(C1)CCCN1C1=NN=NN1 UNZDSWVYQUPIEW-UHFFFAOYSA-N 0.000 claims description 2
NJYNSWOYMJGFSS-UHFFFAOYSA-N 3-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-methylsulfonylpiperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1CCCN(S(C)(=O)=O)C1 NJYNSWOYMJGFSS-UHFFFAOYSA-N 0.000 claims description 2
BDROVQVIPUSAFT-UHFFFAOYSA-N 3-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2,4-difluorobenzenesulfonamide Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=C(C=CC=3F)S(N)(=O)=O)F)=NC=2)C=2C=CC(F)=CC=2)=C1 BDROVQVIPUSAFT-UHFFFAOYSA-N 0.000 claims description 2
VKXONMARJPWWGQ-UHFFFAOYSA-N 3-chloro-2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methoxy]-5-(trifluoromethyl)pyridine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1COC1=NC=C(C(F)(F)F)C=C1Cl VKXONMARJPWWGQ-UHFFFAOYSA-N 0.000 claims description 2
JNTFCOOPAXTOCX-UHFFFAOYSA-N 3-chloro-2-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(Cl)C=CC=C1C(O)=O JNTFCOOPAXTOCX-UHFFFAOYSA-N 0.000 claims description 2
XIMVRBRUKGPNFQ-UHFFFAOYSA-N 3-chloro-4-[2-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]ethyl]-5-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CCC1=C(F)C=C(C(O)=O)C=C1Cl XIMVRBRUKGPNFQ-UHFFFAOYSA-N 0.000 claims description 2
FBHOIUWLZKIMBK-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)Cl)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 FBHOIUWLZKIMBK-UHFFFAOYSA-N 0.000 claims description 2
IVOZOZJLZYMFJC-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methoxy]-5-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1COC1=C(F)C=C(C(O)=O)C=C1Cl IVOZOZJLZYMFJC-UHFFFAOYSA-N 0.000 claims description 2
GDOOFRDTMWWQIW-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methoxy]benzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1COC1=CC=C(C(O)=O)C=C1Cl GDOOFRDTMWWQIW-UHFFFAOYSA-N 0.000 claims description 2
RDXRVGJVCUAUMF-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1Cl RDXRVGJVCUAUMF-UHFFFAOYSA-N 0.000 claims description 2
JPOXXFIMTVAPLI-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzenesulfonic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(S(O)(=O)=O)C=C1Cl JPOXXFIMTVAPLI-UHFFFAOYSA-N 0.000 claims description 2
JLBRWMKZQDDDON-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C(O)=O)C=C1Cl JLBRWMKZQDDDON-UHFFFAOYSA-N 0.000 claims description 2
IKGLQNNDYPTQQC-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-[3-[2-(diethylamino)ethoxy]-4-fluorophenyl]imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C1=C(F)C(OCCN(CC)CC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)Cl)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 IKGLQNNDYPTQQC-UHFFFAOYSA-N 0.000 claims description 2
YMUHLXQGFPNHQM-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-[4-fluoro-3-(3-hydroxypropoxy)phenyl]imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(OCCCO)C(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1Cl YMUHLXQGFPNHQM-UHFFFAOYSA-N 0.000 claims description 2
MPDCHIJXSQRNCB-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3,4-difluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C=1C=C(F)C(F)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1Cl MPDCHIJXSQRNCB-UHFFFAOYSA-N 0.000 claims description 2
XZWCKSBJJXIUAE-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1Cl XZWCKSBJJXIUAE-UHFFFAOYSA-N 0.000 claims description 2
LKTKQNLQUVJTPJ-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(3-chloro-4-sulfamoylphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C=1C=C(S(N)(=O)=O)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1Cl LKTKQNLQUVJTPJ-UHFFFAOYSA-N 0.000 claims description 2
LQWBUJQWSKCKFK-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-4-methylimidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(O)=O)Cl)=NC=2C)C=2C=CC(F)=CC=2)=C1 LQWBUJQWSKCKFK-UHFFFAOYSA-N 0.000 claims description 2
ACQMKUAMPPWQJQ-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methoxy]-5-fluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(COC=3C(=CC(=CC=3F)C(O)=O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 ACQMKUAMPPWQJQ-UHFFFAOYSA-N 0.000 claims description 2
XMWBLVULHURXJR-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluoro-n-(2h-tetrazol-5-yl)benzamide Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(=O)NC=3NN=NN=3)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 XMWBLVULHURXJR-UHFFFAOYSA-N 0.000 claims description 2
OYDRXHILFZRYRH-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluoroaniline Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(N)=CC=3F)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 OYDRXHILFZRYRH-UHFFFAOYSA-N 0.000 claims description 2
CDALMNHTXIVRLE-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzenesulfonic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)S(O)(=O)=O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 CDALMNHTXIVRLE-UHFFFAOYSA-N 0.000 claims description 2
ZXUWSZCISLIYPN-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(O)=O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 ZXUWSZCISLIYPN-UHFFFAOYSA-N 0.000 claims description 2
WAFYYXCRKAUVGW-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(5-fluoropyridin-2-yl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(O)=O)Cl)=NC=2)C=2N=CC(F)=CC=2)=C1 WAFYYXCRKAUVGW-UHFFFAOYSA-N 0.000 claims description 2
CXJYZXVKUZQRTA-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-pyridin-3-ylimidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(O)=O)Cl)=NC=2)C=2C=NC=CC=2)=C1 CXJYZXVKUZQRTA-UHFFFAOYSA-N 0.000 claims description 2
UVLBFNYWCLYWCA-UHFFFAOYSA-N 3-chloro-4-[[5-[2-(4-chloro-3-sulfamoylphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(S(N)(=O)=O)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1Cl UVLBFNYWCLYWCA-UHFFFAOYSA-N 0.000 claims description 2
FGJLUIDNBYGECM-UHFFFAOYSA-N 3-chloro-4-[[5-[2-[4-chloro-3-(3-morpholin-4-ylpropoxy)phenyl]propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(OCCCN2CCOCC2)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1Cl FGJLUIDNBYGECM-UHFFFAOYSA-N 0.000 claims description 2
NDWNITAOPCOPGP-UHFFFAOYSA-N 3-chloro-n-[[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methyl]-4-fluoroaniline Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CNC1=CC=C(F)C(Cl)=C1 NDWNITAOPCOPGP-UHFFFAOYSA-N 0.000 claims description 2
YXWQULMXBJSZLP-UHFFFAOYSA-N 4-[(2-chloro-4-fluorophenyl)sulfanylmethyl]-2-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N(C=1)C=2C=CC(F)=CC=2)=NC=1CSC1=CC=C(F)C=C1Cl YXWQULMXBJSZLP-UHFFFAOYSA-N 0.000 claims description 2
VYTHODSXYQZWIQ-UHFFFAOYSA-N 4-[2-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]-n-methylbenzenesulfonamide Chemical compound C1=CC(S(=O)(=O)NC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl VYTHODSXYQZWIQ-UHFFFAOYSA-N 0.000 claims description 2
COKQCJXBFYIOGO-UHFFFAOYSA-N 4-[2-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]benzene-1,2-diol Chemical compound C=1C=C(O)C(O)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl COKQCJXBFYIOGO-UHFFFAOYSA-N 0.000 claims description 2
UFLQDAOOWLQVNP-UHFFFAOYSA-N 4-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]benzene-1,2-diol Chemical compound C=1C=C(O)C(O)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl UFLQDAOOWLQVNP-UHFFFAOYSA-N 0.000 claims description 2
HNUYTSOUGOHKDZ-UHFFFAOYSA-N 4-[2-[2-chloro-5-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]ethyl]morpholine Chemical compound C=1C=C(Cl)C(OCCN2CCOCC2)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl HNUYTSOUGOHKDZ-UHFFFAOYSA-N 0.000 claims description 2
PXZMYCPOJLNONQ-UHFFFAOYSA-N 4-[2-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]-2-fluoroethyl]-1-methylsulfonylpiperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1C(F)CC1CCN(S(C)(=O)=O)CC1 PXZMYCPOJLNONQ-UHFFFAOYSA-N 0.000 claims description 2
NDYOYWJNQWLNFO-UHFFFAOYSA-N 4-[3-[2-chloro-5-[2-[2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-3-(4-fluorophenyl)imidazol-4-yl]propan-2-yl]phenoxy]propyl]morpholine Chemical compound C=1C=C(Cl)C(OCCCN2CCOCC2)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl NDYOYWJNQWLNFO-UHFFFAOYSA-N 0.000 claims description 2
TYDLPVRAPOELHZ-UHFFFAOYSA-N 4-[4-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-1-yl]phenyl]morpholine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(=CC=2)N2CCOCC2)=CN=C1SCC1=CC=C(F)C=C1Cl TYDLPVRAPOELHZ-UHFFFAOYSA-N 0.000 claims description 2
UCUZFLHGNGGHBE-UHFFFAOYSA-N 4-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]-1-methylsulfonyl-3,6-dihydro-2h-pyridine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1C1=CCN(S(C)(=O)=O)CC1 UCUZFLHGNGGHBE-UHFFFAOYSA-N 0.000 claims description 2
PLNXQJZITSTREH-UHFFFAOYSA-N 4-[[1-(3,4-difluorophenyl)-5-[2-(4-methylsulfonylphenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C(C)(C)C(N1C=2C=C(F)C(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F PLNXQJZITSTREH-UHFFFAOYSA-N 0.000 claims description 2
NSZUBRQDGMGVOR-UHFFFAOYSA-N 4-[[1-(3-chloro-4-fluorophenyl)-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]-1-(2h-tetrazol-5-yl)piperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(Cl)C(F)=CC=2)=CN=C1SCC(CC1)CCN1C1=NN=NN1 NSZUBRQDGMGVOR-UHFFFAOYSA-N 0.000 claims description 2
ZFGPWWPMYYVZHF-UHFFFAOYSA-N 4-[[1-(3-chloro-4-fluorophenyl)-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]-1-methylsulfonylpiperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(Cl)C(F)=CC=2)=CN=C1SCC1CCN(S(C)(=O)=O)CC1 ZFGPWWPMYYVZHF-UHFFFAOYSA-N 0.000 claims description 2
AFLSSVOUNOUOCE-UHFFFAOYSA-N 4-[[3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-5-fluorobenzoyl]amino]butanoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(=O)NCCCC(O)=O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 AFLSSVOUNOUOCE-UHFFFAOYSA-N 0.000 claims description 2
YYHZNGNSTISRDT-UHFFFAOYSA-N 4-[[4-chloro-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=C(Cl)N=C1SCC1=C(F)C=C(C(O)=O)C=C1F YYHZNGNSTISRDT-UHFFFAOYSA-N 0.000 claims description 2
MULSKRSMWGDWGO-UHFFFAOYSA-N 4-[[4-chloro-5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-(2h-tetrazol-5-yl)piperidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC3CCN(CC3)C=3NN=NN=3)=NC=2Cl)C=2C=CC(F)=CC=2)=C1 MULSKRSMWGDWGO-UHFFFAOYSA-N 0.000 claims description 2
NJEIIORODWFKLP-UHFFFAOYSA-N 4-[[4-chloro-5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-methylsulfonylpiperidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC3CCN(CC3)S(C)(=O)=O)=NC=2Cl)C=2C=CC(F)=CC=2)=C1 NJEIIORODWFKLP-UHFFFAOYSA-N 0.000 claims description 2
SHYVHQLHNIHEAA-UHFFFAOYSA-N 4-[[5-[1-(3,4-dichlorophenyl)cyclopropyl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound FC1=CC(C(=O)O)=CC(F)=C1CSC1=NC=C(C2(CC2)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 SHYVHQLHNIHEAA-UHFFFAOYSA-N 0.000 claims description 2
ZPJLIYAHQAPVLP-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(3,4-difluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-(2h-tetrazol-5-yl)piperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(F)C(F)=CC=2)=CN=C1SCC(CC1)CCN1C1=NN=NN1 ZPJLIYAHQAPVLP-UHFFFAOYSA-N 0.000 claims description 2
KUFRRRJBXWWZNG-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(3,4-difluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-methylsulfonylpiperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(F)C(F)=CC=2)=CN=C1SCC1CCN(S(C)(=O)=O)CC1 KUFRRRJBXWWZNG-UHFFFAOYSA-N 0.000 claims description 2
LEMGEDNDBQKPJA-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-1-(2h-tetrazol-5-yl)piperidine Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC2CCN(CC2)C=2NN=NN=2)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 LEMGEDNDBQKPJA-UHFFFAOYSA-N 0.000 claims description 2
XVFRXYVMYCYHKD-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluoro-n-hydroxybenzamide Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(=O)NO)F)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 XVFRXYVMYCYHKD-UHFFFAOYSA-N 0.000 claims description 2
COGDGNOBDXFGAZ-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)F)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 COGDGNOBDXFGAZ-UHFFFAOYSA-N 0.000 claims description 2
PKOYVOPGDFSMBO-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluoro-3-methylphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C1=C(F)C(C)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)F)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 PKOYVOPGDFSMBO-UHFFFAOYSA-N 0.000 claims description 2
XHXVLEQLYSXBDV-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methoxy]-1-methylsulfonylpiperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1COC1CCN(S(C)(=O)=O)CC1 XHXVLEQLYSXBDV-UHFFFAOYSA-N 0.000 claims description 2
DKQNRQMGVJOQFH-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]methoxy]quinoline Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(COC=2C3=CC=CC=C3N=CC=2)N1C1=CC=C(F)C=C1 DKQNRQMGVJOQFH-UHFFFAOYSA-N 0.000 claims description 2
IIBHJAOSDSGQTE-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]oxymethyl]-1-(2h-tetrazol-5-yl)piperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1OCC(CC1)CCN1C1=NN=NN1 IIBHJAOSDSGQTE-UHFFFAOYSA-N 0.000 claims description 2
XBOUQIYPFNSLQA-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-(2h-tetrazol-5-yl)piperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC(CC1)CCN1C1=NN=NN1 XBOUQIYPFNSLQA-UHFFFAOYSA-N 0.000 claims description 2
SFQPCANLCJDCQD-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-(4-fluorophenyl)piperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC(CC1)CCN1C1=CC=C(F)C=C1 SFQPCANLCJDCQD-UHFFFAOYSA-N 0.000 claims description 2
PWERAJSJKNVHES-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-methylsulfonylpiperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1CCN(S(C)(=O)=O)CC1 PWERAJSJKNVHES-UHFFFAOYSA-N 0.000 claims description 2
GDZGXGUWGKXAHD-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorobenzamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C(N)=O)C(F)=C1 GDZGXGUWGKXAHD-UHFFFAOYSA-N 0.000 claims description 2
YDDPWEMRSYYYQE-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorobenzenesulfonamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(S(N)(=O)=O)C(F)=C1 YDDPWEMRSYYYQE-UHFFFAOYSA-N 0.000 claims description 2
CKSKXVYVUIKXRW-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C(O)=O)C(F)=C1 CKSKXVYVUIKXRW-UHFFFAOYSA-N 0.000 claims description 2
HQDKJYHIAQPBLV-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluoro-n-hydroxybenzamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(=O)NO)C=C1F HQDKJYHIAQPBLV-UHFFFAOYSA-N 0.000 claims description 2
NTVCIHXGLLGMOK-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(N)=O)C=C1F NTVCIHXGLLGMOK-UHFFFAOYSA-N 0.000 claims description 2
RCLZEKWMANTMMA-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F RCLZEKWMANTMMA-UHFFFAOYSA-N 0.000 claims description 2
GTPJKAJFVXZGME-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzonitrile Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C#N)C=C1F GTPJKAJFVXZGME-UHFFFAOYSA-N 0.000 claims description 2
XNMZXXJDURLSBU-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C(N)=O)C=C1F XNMZXXJDURLSBU-UHFFFAOYSA-N 0.000 claims description 2
AKVVASBCZWKMML-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzenesulfonamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(S(N)(=O)=O)C=C1F AKVVASBCZWKMML-UHFFFAOYSA-N 0.000 claims description 2
NVMSYNARCIIYMY-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C(O)=O)C=C1F NVMSYNARCIIYMY-UHFFFAOYSA-N 0.000 claims description 2
UCJCOGTUWIBNDQ-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]piperidine Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1CCNCC1 UCJCOGTUWIBNDQ-UHFFFAOYSA-N 0.000 claims description 2
BNYSJRAKUOPWLG-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-[3-(difluoromethyl)-4-fluorophenyl]imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(C(F)=CC=2)C(F)F)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F BNYSJRAKUOPWLG-UHFFFAOYSA-N 0.000 claims description 2
NVGBHXRLNIYOJB-UHFFFAOYSA-N 4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-4-(4-fluoro-3-methoxyphenyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=NN=C2SCC=2C(=CC(=CC=2F)C(O)=O)F)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)=C1 NVGBHXRLNIYOJB-UHFFFAOYSA-N 0.000 claims description 2
WJVQNDYRTJVOBA-UHFFFAOYSA-N 4-[[5-[2-(3,4-difluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-methylsulfonylpiperidine Chemical compound C=1C=C(F)C(F)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1CCN(S(C)(=O)=O)CC1 WJVQNDYRTJVOBA-UHFFFAOYSA-N 0.000 claims description 2
JKBKIPUTBMSHTG-UHFFFAOYSA-N 4-[[5-[2-(3,4-difluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(F)C(F)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F JKBKIPUTBMSHTG-UHFFFAOYSA-N 0.000 claims description 2
VJEIFNDLDWTGFG-UHFFFAOYSA-N 4-[[5-[2-(3,4-difluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoic acid Chemical compound C=1C=C(F)C(F)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C(O)=O)C=C1F VJEIFNDLDWTGFG-UHFFFAOYSA-N 0.000 claims description 2
CLGWNWDLWPWLLV-UHFFFAOYSA-N 4-[[5-[2-(3,4-difluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-n-pyrrolidin-1-ylpiperidine-1-carboxamide Chemical compound C=1C=C(F)C(F)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC(CC1)CCN1C(=O)NN1CCCC1 CLGWNWDLWPWLLV-UHFFFAOYSA-N 0.000 claims description 2
HGJXXWDOPBFRHI-UHFFFAOYSA-N 4-[[5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzamide Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C(N)=O)C=C1F HGJXXWDOPBFRHI-UHFFFAOYSA-N 0.000 claims description 2
SLJMKDQFDGMGKT-UHFFFAOYSA-N 4-[[5-[2-(3,5-dichloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzenesulfonamide Chemical compound C1=C(Cl)C(OC)=C(Cl)C=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(S(N)(=O)=O)C=C1F SLJMKDQFDGMGKT-UHFFFAOYSA-N 0.000 claims description 2
CZAREGRPFFPVBC-UHFFFAOYSA-N 4-[[5-[2-(3-amino-1,2-benzoxazol-5-yl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)F)C(C)(C)C=2C=C3C(N)=NOC3=CC=2)=C1 CZAREGRPFFPVBC-UHFFFAOYSA-N 0.000 claims description 2
ZNPGHAARTGMWCD-UHFFFAOYSA-N 4-[[5-[2-(3-amino-1,2-benzoxazol-5-yl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C2ON=C(N)C2=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F ZNPGHAARTGMWCD-UHFFFAOYSA-N 0.000 claims description 2
NTSGITRNDSAXLK-UHFFFAOYSA-N 4-[[5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F NTSGITRNDSAXLK-UHFFFAOYSA-N 0.000 claims description 2
MIEVAMRJHPVBIU-UHFFFAOYSA-N 4-[[5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzonitrile Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C#N)C=C1F MIEVAMRJHPVBIU-UHFFFAOYSA-N 0.000 claims description 2
BHDJXJOOPLWDES-UHFFFAOYSA-N 4-[[5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(C(O)=O)C=C1F BHDJXJOOPLWDES-UHFFFAOYSA-N 0.000 claims description 2
SKVDADCFRHIWDC-UHFFFAOYSA-N 4-[[5-[2-(3-chloro-4-sulfamoylphenyl)propan-2-yl]-1-(3,4-difluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(S(N)(=O)=O)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(F)C(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F SKVDADCFRHIWDC-UHFFFAOYSA-N 0.000 claims description 2
HQWAAKMTRKSFQO-UHFFFAOYSA-N 4-[[5-[2-(3-chloro-4-sulfamoylphenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)F)C(C)(C)C=2C=C(Cl)C(=CC=2)S(N)(=O)=O)=C1 HQWAAKMTRKSFQO-UHFFFAOYSA-N 0.000 claims description 2
IVWNQEXFTLHDNG-UHFFFAOYSA-N 4-[[5-[2-(3-chloro-4-sulfamoylphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(S(N)(=O)=O)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F IVWNQEXFTLHDNG-UHFFFAOYSA-N 0.000 claims description 2
CFKGTXYIJFXQGK-UHFFFAOYSA-N 4-[[5-[2-(3-chloro-4-sulfamoylphenyl)propan-2-yl]-1-(5-fluoropyridin-2-yl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(S(N)(=O)=O)C(Cl)=CC=1C(C)(C)C(N1C=2N=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F CFKGTXYIJFXQGK-UHFFFAOYSA-N 0.000 claims description 2
FUIYQEOHVUHSMC-UHFFFAOYSA-N 4-[[5-[2-(3-cyano-4-fluorophenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C(=CC(=CC=2F)C(O)=O)F)C(C)(C)C=2C=C(C(F)=CC=2)C#N)=C1 FUIYQEOHVUHSMC-UHFFFAOYSA-N 0.000 claims description 2
MOFSJQGPCQMLHH-UHFFFAOYSA-N 4-[[5-[2-(3-cyano-4-fluorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(F)C(C#N)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F MOFSJQGPCQMLHH-UHFFFAOYSA-N 0.000 claims description 2
ONYPDDCEWWGSCZ-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-hydroxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(Cl)C(O)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F ONYPDDCEWWGSCZ-UHFFFAOYSA-N 0.000 claims description 2
UWBYQENAPFZHCM-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-(2h-tetrazol-5-yl)piperidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC3CCN(CC3)C=3NN=NN=3)=NC=2)C=2C=CC(F)=CC=2)=C1 UWBYQENAPFZHCM-UHFFFAOYSA-N 0.000 claims description 2
YQXFLCOSRHHBNO-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-1-methylsulfonylpiperidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC3CCN(CC3)S(C)(=O)=O)=NC=2)C=2C=CC(F)=CC=2)=C1 YQXFLCOSRHHBNO-UHFFFAOYSA-N 0.000 claims description 2
GDPNEWSJBURWBG-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C=C(F)C(C(O)=O)=CC=3)=NC=2)C=2C=CC(F)=CC=2)=C1 GDPNEWSJBURWBG-UHFFFAOYSA-N 0.000 claims description 2
FMNBKCRZYJKZLS-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluoro-n-hydroxybenzamide Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(=O)NO)F)=NC=2)C=2C=CC(F)=CC=2)=C1 FMNBKCRZYJKZLS-UHFFFAOYSA-N 0.000 claims description 2
SHGLTCIFVZKBGG-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzenesulfonamide Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)S(N)(=O)=O)F)=NC=2)C=2C=CC(F)=CC=2)=C1 SHGLTCIFVZKBGG-UHFFFAOYSA-N 0.000 claims description 2
COKKWUWEIIENJL-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3F)C(O)=O)F)=NC=2)C=2C=CC(F)=CC=2)=C1 COKKWUWEIIENJL-UHFFFAOYSA-N 0.000 claims description 2
WLZFPHOQOWVFEK-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3-fluorobenzoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3)C(O)=O)F)=NC=2)C=2C=CC(F)=CC=2)=C1 WLZFPHOQOWVFEK-UHFFFAOYSA-N 0.000 claims description 2
CBMOOCAXIZLYTK-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]pyridin-2-amine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C=C(N)N=CC=3)=NC=2)C=2C=CC(F)=CC=2)=C1 CBMOOCAXIZLYTK-UHFFFAOYSA-N 0.000 claims description 2
ULWUSHQJDCSSJH-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfonylmethyl]-1-methylsulfonylpiperidine Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(=NC=2)S(=O)(=O)CC2CCN(CC2)S(C)(=O)=O)C=2C=CC(F)=CC=2)=C1 ULWUSHQJDCSSJH-UHFFFAOYSA-N 0.000 claims description 2
UQGWROUVLAZZNW-UHFFFAOYSA-N 4-[[5-[2-(4-chloro-3-sulfamoylphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-3,5-difluorobenzoic acid Chemical compound C=1C=C(Cl)C(S(N)(=O)=O)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(C(O)=O)C=C1F UQGWROUVLAZZNW-UHFFFAOYSA-N 0.000 claims description 2
GKCYJDCZRQDCCB-UHFFFAOYSA-N 4-chloro-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=C(Cl)N=C1SCC1=C(F)C=CC=C1Cl GKCYJDCZRQDCCB-UHFFFAOYSA-N 0.000 claims description 2
VURMGVBXRXREKH-UHFFFAOYSA-N 4-chloro-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=C(Cl)N=C1SCC1=C(F)C=CC=C1Cl VURMGVBXRXREKH-UHFFFAOYSA-N 0.000 claims description 2
CZYAABYYIJWCLN-UHFFFAOYSA-N 4-chloro-3-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC(C(O)=O)=CC=C1Cl CZYAABYYIJWCLN-UHFFFAOYSA-N 0.000 claims description 2
ISHTYFBATCFZIJ-UHFFFAOYSA-N 4-chloro-3-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzonitrile Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC(C#N)=CC=C1Cl ISHTYFBATCFZIJ-UHFFFAOYSA-N 0.000 claims description 2
VHFUVDKCDJANBQ-UHFFFAOYSA-N 4-chloro-3-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]benzoic acid Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC=C(C=3)C(O)=O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 VHFUVDKCDJANBQ-UHFFFAOYSA-N 0.000 claims description 2
XPQMXLVSJRRDEK-UHFFFAOYSA-N 4-chloro-5-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]-2-fluorobenzenesulfonamide Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(F)=C(C=3)S(N)(=O)=O)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 XPQMXLVSJRRDEK-UHFFFAOYSA-N 0.000 claims description 2
125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 2
QMMKWFCOGOQERE-UHFFFAOYSA-N 5-[1-[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfonylpiperidin-2-yl]-2-methoxypyridine Chemical compound C1=NC(OC)=CC=C1C1N(S(=O)(=O)C=2N(C(=CN=2)C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)C=2C=CC(F)=CC=2)CCCC1 QMMKWFCOGOQERE-UHFFFAOYSA-N 0.000 claims description 2
HSCTZIAAEMTPMM-UHFFFAOYSA-N 5-[2,4-dichloro-5-[[5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC(C=2NN=NN=2)=C(Cl)C=C1Cl HSCTZIAAEMTPMM-UHFFFAOYSA-N 0.000 claims description 2
UMSUXACQKBKNHQ-UHFFFAOYSA-N 5-[2-(1,3-benzodioxol-5-yl)propan-2-yl]-2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C2OCOC2=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1Cl UMSUXACQKBKNHQ-UHFFFAOYSA-N 0.000 claims description 2
UCAXGZNQXUQFDL-UHFFFAOYSA-N 5-[2-(1,3-benzodioxol-5-yl)propan-2-yl]-2-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C2OCOC2=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1Cl UCAXGZNQXUQFDL-UHFFFAOYSA-N 0.000 claims description 2
DGEAOCVZQLQPQP-UHFFFAOYSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-1,2-bis(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1C1=CC=C(F)C=C1 DGEAOCVZQLQPQP-UHFFFAOYSA-N 0.000 claims description 2
WWLVBSABMAPOPP-UHFFFAOYSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)-2-[(1-methylsulfonylpyrrolidin-3-yl)methylsulfanyl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1CCN(S(C)(=O)=O)C1 WWLVBSABMAPOPP-UHFFFAOYSA-N 0.000 claims description 2
LQEHHOOTOLUSBM-UHFFFAOYSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)-2-[(2,4,6-trifluorophenyl)methylsulfanyl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=C(F)C=C1F LQEHHOOTOLUSBM-UHFFFAOYSA-N 0.000 claims description 2
GFTRFKZXMYRUID-UHFFFAOYSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)-2-[[4-fluoro-3-(trifluoromethyl)phenyl]methylsulfonyl]imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C=C(C(F)=CC=2)C(F)(F)F)N1C1=CC=C(F)C=C1 GFTRFKZXMYRUID-UHFFFAOYSA-N 0.000 claims description 2
NUJYPPXEWHQMAC-HSZRJFAPSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)-n-[(1s)-2-hydroxy-1-phenylethyl]imidazole-2-sulfonamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)N[C@H](CO)C=2C=CC=CC=2)N1C1=CC=C(F)C=C1 NUJYPPXEWHQMAC-HSZRJFAPSA-N 0.000 claims description 2
VMQPIYOIEFFEHL-UHFFFAOYSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-2-[(2,6-difluorophenyl)methylsulfanyl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1F VMQPIYOIEFFEHL-UHFFFAOYSA-N 0.000 claims description 2
YRWMNHPVEODBMT-UHFFFAOYSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-2-[(3,4-dichlorophenyl)sulfanylmethyl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1CSC1=CC=C(Cl)C(Cl)=C1 YRWMNHPVEODBMT-UHFFFAOYSA-N 0.000 claims description 2
GTRPOAGRGKKIAJ-UHFFFAOYSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-2-[(3,4-difluorophenyl)methylsulfonyl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)CC=2C=C(F)C(F)=CC=2)N1C1=CC=C(F)C=C1 GTRPOAGRGKKIAJ-UHFFFAOYSA-N 0.000 claims description 2
SQDTZIIACZAKQC-UHFFFAOYSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-2-[(4-fluoro-2-methylsulfonylphenyl)methylsulfanyl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C=C1S(C)(=O)=O SQDTZIIACZAKQC-UHFFFAOYSA-N 0.000 claims description 2
GPGQJTWZGQUGCW-UHFFFAOYSA-N 5-[2-(3,4-dichlorophenyl)propan-2-yl]-2-[(4-fluoro-3-methylsulfonylphenyl)methylsulfanyl]-1-(4-fluorophenyl)imidazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(F)C(S(C)(=O)=O)=C1 GPGQJTWZGQUGCW-UHFFFAOYSA-N 0.000 claims description 2
HGMWJSOLLYDNRA-UHFFFAOYSA-N 5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-2-[[2-fluoro-6-(trifluoromethyl)phenyl]methylsulfanyl]imidazole Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=C(F)C=CC=C1C(F)(F)F HGMWJSOLLYDNRA-UHFFFAOYSA-N 0.000 claims description 2
QWDLBOZMFNZANX-UHFFFAOYSA-N 5-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-1-yl]-2-fluorobenzamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(C(F)=CC=2)C(N)=O)=CN=C1SCC1=CC=C(F)C=C1Cl QWDLBOZMFNZANX-UHFFFAOYSA-N 0.000 claims description 2
QHMOXCOHQQGVKY-UHFFFAOYSA-N 5-[2-[(2-chloro-4-fluorophenyl)methylsulfanyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-1-yl]-2-fluorobenzonitrile Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(C(F)=CC=2)C#N)=CN=C1SCC1=CC=C(F)C=C1Cl QHMOXCOHQQGVKY-UHFFFAOYSA-N 0.000 claims description 2
VPOFCIUGZLNDKL-UHFFFAOYSA-N 5-[2-chloro-4-[[4-chloro-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=C(Cl)N=C1SCC(C=C1Cl)=CC=C1C1=NN=NN1 VPOFCIUGZLNDKL-UHFFFAOYSA-N 0.000 claims description 2
GFICVWNSKNTLOS-UHFFFAOYSA-N 5-[2-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC(C=C1Cl)=CC=C1C1=NN=NN1 GFICVWNSKNTLOS-UHFFFAOYSA-N 0.000 claims description 2
XEKHVFICDQBCDS-UHFFFAOYSA-N 5-[2-chloro-5-[[1-(3,4-difluorophenyl)-5-[2-(4-methylsulfonylphenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C(C)(C)C(N1C=2C=C(F)C(F)=CC=2)=CN=C1SCC(C=1)=CC=C(Cl)C=1C1=NN=NN1 XEKHVFICDQBCDS-UHFFFAOYSA-N 0.000 claims description 2
XBNREQDXSPWAAQ-UHFFFAOYSA-N 5-[2-chloro-5-[[1-(3-chlorophenyl)-5-[2-(3,4-dichlorophenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(Cl)C=CC=2)=CN=C1SCC(C=1)=CC=C(Cl)C=1C1=NN=NN1 XBNREQDXSPWAAQ-UHFFFAOYSA-N 0.000 claims description 2
SBVNSWRAKAFKAX-UHFFFAOYSA-N 5-[2-chloro-5-[[1-(4-fluoro-3-methoxyphenyl)-5-[2-(4-methylsulfonylphenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C=C(C(Cl)=CC=2)C=2NN=NN=2)C(C)(C)C=2C=CC(=CC=2)S(C)(=O)=O)=C1 SBVNSWRAKAFKAX-UHFFFAOYSA-N 0.000 claims description 2
HOUSOQDQLFWXEK-UHFFFAOYSA-N 5-[2-chloro-5-[[1-(4-fluorophenyl)-5-[2-(4-methylsulfonylphenyl)propan-2-yl]imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C=1C=C(S(C)(=O)=O)C=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC(C=1)=CC=C(Cl)C=1C1=NN=NN1 HOUSOQDQLFWXEK-UHFFFAOYSA-N 0.000 claims description 2
XMDMOILDXUFQSF-UHFFFAOYSA-N 5-[2-chloro-5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(3-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=C(F)C=CC=2)=CN=C1SCC(C=1)=CC=C(Cl)C=1C1=NN=NN1 XMDMOILDXUFQSF-UHFFFAOYSA-N 0.000 claims description 2
LWZKMSSUDMAQHA-UHFFFAOYSA-N 5-[2-chloro-5-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC(C=1)=CC=C(Cl)C=1C1=NN=NN1 LWZKMSSUDMAQHA-UHFFFAOYSA-N 0.000 claims description 2
WEALCQXJNFSRDJ-UHFFFAOYSA-N 5-[2-chloro-5-[[5-[2-(3-chloro-4-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C1=C(Cl)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1SCC1=CC=C(Cl)C(C=2NN=NN=2)=C1 WEALCQXJNFSRDJ-UHFFFAOYSA-N 0.000 claims description 2
CUIRJGTUZWXJAT-UHFFFAOYSA-N 5-[2-chloro-5-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluoro-3-methoxyphenyl)imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C1=C(F)C(OC)=CC(N2C(=CN=C2SCC=2C=C(C(Cl)=CC=2)C=2NN=NN=2)C(C)(C)C=2C=C(OC)C(Cl)=CC=2)=C1 CUIRJGTUZWXJAT-UHFFFAOYSA-N 0.000 claims description 2
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HHCAIRMYTDDGTR-UHFFFAOYSA-N 5-[2-chloro-5-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]-2h-tetrazole Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C=C(C(Cl)=CC=3)C=3NN=NN=3)=NC=2)C=2C=CC(F)=CC=2)=C1 HHCAIRMYTDDGTR-UHFFFAOYSA-N 0.000 claims description 2
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FAQWWVJCVUQGKM-UHFFFAOYSA-N n-(2-chloro-6-fluorophenyl)-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)-n-methylimidazole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1C(=O)N(C)C1=C(F)C=CC=C1Cl FAQWWVJCVUQGKM-UHFFFAOYSA-N 0.000 claims description 2
RSMPNXUQLQZTLI-UHFFFAOYSA-N n-(3,4-dichlorophenyl)-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1C(=O)NC1=CC=C(Cl)C(Cl)=C1 RSMPNXUQLQZTLI-UHFFFAOYSA-N 0.000 claims description 2
PATDAPJVHSYOEV-UHFFFAOYSA-N n-(3-chloro-4-fluorophenyl)-5-[2-(3,4-dimethoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole-2-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(C)(C)C(N1C=2C=CC(F)=CC=2)=CN=C1C(=O)NC1=CC=C(F)C(Cl)=C1 PATDAPJVHSYOEV-UHFFFAOYSA-N 0.000 claims description 2
HJWVBQKPFYSAJW-UHFFFAOYSA-N n-[(2-chloro-4-fluorophenyl)methyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole-2-sulfonamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)NCC=2C(=CC(F)=CC=2)Cl)N1C1=CC=C(F)C=C1 HJWVBQKPFYSAJW-UHFFFAOYSA-N 0.000 claims description 2
FUBIKIICGFGWEV-UHFFFAOYSA-N n-[(2-chloro-6-fluorophenyl)methyl]-5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazole-2-sulfonamide Chemical compound C=1C=C(Cl)C(Cl)=CC=1C(C)(C)C1=CN=C(S(=O)(=O)NCC=2C(=CC=CC=2F)Cl)N1C1=CC=C(F)C=C1 FUBIKIICGFGWEV-UHFFFAOYSA-N 0.000 claims description 2
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DOVNFLJDQZKMRX-UHFFFAOYSA-N n-[3-chloro-4-[[5-[2-(3,4-dichlorophenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]sulfonylacetamide Chemical compound ClC1=CC(S(=O)(=O)NC(=O)C)=CC=C1CSC1=NC=C(C(C)(C)C=2C=C(Cl)C(Cl)=CC=2)N1C1=CC=C(F)C=C1 DOVNFLJDQZKMRX-UHFFFAOYSA-N 0.000 claims description 2
BZHOFFWOCDSOGA-UHFFFAOYSA-N n-[3-chloro-4-[[5-[2-(4-chloro-3-methoxyphenyl)propan-2-yl]-1-(4-fluorophenyl)imidazol-2-yl]sulfanylmethyl]phenyl]sulfonylpyrrolidine-1-carboxamide Chemical compound C1=C(Cl)C(OC)=CC(C(C)(C)C=2N(C(SCC=3C(=CC(=CC=3)S(=O)(=O)NC(=O)N3CCCC3)Cl)=NC=2)C=2C=CC(F)=CC=2)=C1 BZHOFFWOCDSOGA-UHFFFAOYSA-N 0.000 claims description 2
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SYOKIDBDQMKNDQ-XWTIBIIYSA-N vildagliptin Chemical group C1C(O)(C2)CC(C3)CC1CC32NCC(=O)N1CCC[C@H]1C#N SYOKIDBDQMKNDQ-XWTIBIIYSA-N 0.000 description 1

JP2011550244A 2009-02-12 2010-02-12 糖尿病および肥満の処置においてｔｇｒ５アゴニストとして使用するためのトリアゾールおよびイミダゾール誘導体 Pending JP2012517479A (ja)